SPEN

General Information

Gene Name : SPEN
Gene ID : ENSG00000065526.10
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: SPEN)

Not Available

Antibody Validation

Not Avaiable

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	SPEN	ENSG00000065526.10	28.42	39.93	34.17	ENCSR000AEF
HepG2	SPEN	ENSG00000065526.10	24.89	19.72	22.30	ENCSR985KAT
K562	SPEN	ENSG00000065526.10	63.29	58.82	61.05	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

No Antibody Primary Validation image or Secondary image available

KD RNA-Seq

No KD RNA-Seq experiment available

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for SPEN is not avaliable on ENCORE database.

Proteins bound to RNA

SPEN RNA is bound by 61 proteins.

CanvasJS.com

eCLIP assay for SPEN is not avaliable on ENCORE database.

61 proteins are bound to SPEN RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr1	16262472	16262547	+	CDS	7.08438	52.23130	HepG2	PCBP2
chr1	16255317	16255499	+	CDS	4.17062	38.21444	K562	UCHL5
chr1	16254814	16254918	+	CDS	4.03239	32.40390	K562	UCHL5
chr1	16255202	16255317	+	CDS	4.44972	29.03261	K562	UCHL5
chr1	16257578	16257678	+	CDS	4.27753	28.40246	K562	UCHL5
chr1	16199559	16199633	+	CDS,intron-Proximal	6.00595	27.54500	K562	RBM15
chr1	16199878	16199922	+	intron-Distal	6.92028	26.78079	K562	RBM15
chr1	16255646	16255721	+	CDS	4.50826	26.56618	K562	UCHL5
chr1	16258364	16258465	+	CDS	5.49045	26.53259	K562	UCHL5
chr1	16257760	16257917	+	CDS	3.59200	24.92768	K562	ZNF622
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 299 entries

eCLIP assay for SPEN is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for SPEN is not available on ENCORE database.
100 RBPs can affect the levels of SPEN.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for SPEN is not available on ENCORE database.

100 RBPs can affect the gene expression of SPEN :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
SPEN	ENSG00000065526.6	5688.03690	9385.84400	-0.72260	32.41850	30.56340	K562	AGGF1
SPEN	ENSG00000065526.6	16960.33700	8133.26460	1.06020	29.79390	28.07020	K562	AQR
SPEN	ENSG00000065526.6	5009.74140	9685.59120	-0.95110	21.55090	20.06160	K562	PUS1
SPEN	ENSG00000065526.6	6781.87440	3526.54490	0.94330	20.03020	18.29170	HepG2	U2AF1
SPEN	ENSG00000065526.6	5945.24610	9437.14380	-0.66660	19.38810	17.78370	K562	RBM15
SPEN	ENSG00000065526.6	7209.05750	4347.46480	0.72950	18.87820	16.45820	K562	SF3B4
SPEN	ENSG00000065526.6	7063.81560	13548.66550	-0.93960	17.23770	15.37760	K562	HSPD1
SPEN	ENSG00000065526.6	9207.02980	5322.65240	0.79050	16.74970	14.59660	K562	EIF4A3
SPEN	ENSG00000065526.6	3350.95040	2422.71990	0.46780	14.10310	12.98140	HepG2	PUM1
SPEN	ENSG00000065526.6	2926.82550	1797.97840	0.70290	13.66350	12.23200	HepG2	RBM25
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 111 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for SPEN is not available on ENCORE database.

9 RBPs can affect the splicing of SPEN :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	SPEN	ENSG00000065526.6	chr1	+	16265212	16265371	16264306	16264501	16265790	16266955	-0.24100	0.00000	0.00013	excluded	K562	PRPF8
SE	SPEN	ENSG00000065526.6	chr1	+	16265212	16265371	16264306	16264501	16265790	16266955	-0.23000	0.00000	0.00000	excluded	HepG2	U2AF1
SE	SPEN	ENSG00000065526.6	chr1	+	16265212	16265371	16264306	16264501	16265790	16266955	-0.21900	0.00000	0.00000	excluded	K562	AQR
SE	SPEN	ENSG00000065526.6	chr1	+	16265212	16265371	16264306	16264501	16265790	16266955	-0.17100	0.00000	0.00000	excluded	K562	SF3B1
A3SS	SPEN	ENSG00000065526.6	chr1	+	16235791	16235976	16235815	16235976	16202696	16203173	0.13600	0.00000	0.00003	longer	K562	AQR
RI	SPEN	ENSG00000065526.6	chr1	+	16263657	16264140	16263657	16263885	16263981	16264140	0.06000	0.00000	0.00003	included	HepG2	U2AF1
RI	SPEN	ENSG00000065526.6	chr1	+	16263657	16264140	16263657	16263885	16263981	16264140	-0.07400	0.00003	0.00506	excluded	K562	FXR2
SE	SPEN	ENSG00000065526.6	chr1	+	16265212	16265371	16264306	16264501	16265790	16266955	-0.08000	0.00031	0.06133	excluded	K562	APOBEC3C
SE	SPEN	ENSG00000065526.6	chr1	+	16265212	16265371	16264306	16264501	16265790	16266955	-0.15000	0.00032	0.02124	excluded	K562	EFTUD2
SE	SPEN	ENSG00000065526.6	chr1	+	16245898	16246012	16245420	16245546	16247364	16247401	-0.05500	0.00120	0.01645	excluded	HepG2	U2AF2

Showing 1 to 10 of 11 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

SPEN

General Information

Functions

Localization

Domains (AlphaFold: SPEN)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for SPEN is not avaliable on ENCORE database.

61 proteins are bound to SPEN RNA:

eCLIP assay for SPEN is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for SPEN is not available on ENCORE database.

100 RBPs can affect the gene expression of SPEN :

The Knockdown/knockout RNA-Seq assay for SPEN is not available on ENCORE database.

9 RBPs can affect the splicing of SPEN :

The Knockdown/knockout RNA-Seq assay for SPEN is not avaliable on ENCORE database.