APEX2

General Information

Gene Name       : APEX2
Gene ID             : ENSG00000169188.4
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: APEX2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878APEX2ENSG00000169188.415.4924.3219.91ENCSR000AEF
HepG2APEX2ENSG00000169188.414.9912.2313.61ENCSR985KAT
K562APEX2ENSG00000169188.419.8019.4219.61ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
APEX2Ribo-STAMP-293TshRNAAPEX2-BGRSLV03-5,APEX2-BGRSLV03-6NT-BGRSLV03-1,NT-BGRSLV03-2,SubmittedENCORE2
APEX2Ribo-STAMP-293TshRNABGRSDLV02-5,BGRSDLV02-6BGRSDLV02-1,BGRSDLV02-2SubmittedENCORE2
APEX2Ribo-STAMP-293TshRNAAPEX2-BGRSDLV02-7dox,APEX2-BGRSDLV02-8doxAPEX2-BGRSDLV02-5,APEX2-BGRSDLV02-6,SubmittedENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for APEX2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • APEX2 RNA is bound by 8 proteins.  







eCLIP assay for APEX2 is not avaliable on ENCORE database.





8 proteins are bound to APEX2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chrX5503404055034119+3'-UTR4.359706.58258HepG2PCBP2
chrX5503397255034108+3'-UTR4.280786.59840HepG2LARP4
chrX5503392355033978+3'-UTR3.652544.59413K562PCBP1
chrX5503397855034034+3'-UTR4.592757.53622K562PCBP1
chrX5503393255034040+3'-UTR6.8285821.44822HepG2PCBP2
chrX5503402255034112+3'-UTR3.274275.81564K562PABPC4
chrX5502683455026909+5'-UTR,CDS6.4927213.29746K562DDX3X
chrX5503292255033046+CDS,intron-Proximal3.037403.05068HepG2U2AF2
chrX5502690955026953+CDS5.281665.39850K562DDX3X
chrX5503303855033103+CDS4.530335.61640K562YBX3
chrX5502744855027694+intron-Distal5.9639011.22511HepG2PCBP2
chrX5502954155029589+intron-Proximal4.653074.65563K562AQR
chrX5503030155030359+intron-Proximal4.734823.62536K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for APEX2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for APEX2 is not available on ENCORE database.

  • 98 RBPs can affect the levels of APEX2.  








The Knockdown/knockout RNA-Seq assay for APEX2 is not available on ENCORE database.





98 RBPs can affect the gene expression of APEX2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
APEX2ENSG00000169188.41274.61630406.589001.6483065.1089063.15120HepG2ACO1
APEX2ENSG00000169188.4598.04150429.438100.477702.494501.98720HepG2AKAP1
APEX2ENSG00000169188.4806.18360376.547801.0982012.8641010.83180HepG2AKAP8
APEX2ENSG00000169188.4533.19330408.543300.384102.927702.13960HepG2AKAP8L
APEX2ENSG00000169188.4889.82800664.775300.420604.602003.75570HepG2AUH
APEX2ENSG00000169188.4295.35060447.80120-0.600403.643602.62250HepG2BCLAF1
APEX2ENSG00000169188.4680.08160332.116001.033907.599706.34240HepG2CNOT7
APEX2ENSG00000169188.4407.12740559.99530-0.459902.765602.07890HepG2CPSF6
APEX2ENSG00000169188.41173.15080621.982800.9153019.6970018.29840HepG2CELF1
APEX2ENSG00000169188.4545.50830668.83370-0.294002.545101.82850HepG2DAZAP1
APEX2ENSG00000169188.4233.50760324.41870-0.474402.200601.39700HepG2DDX24
APEX2ENSG00000169188.4961.61930506.722300.924208.973507.67180HepG2DDX55
APEX2ENSG00000169188.4361.44760505.58030-0.484202.681301.68430HepG2DDX5
APEX2ENSG00000169188.4286.92890411.93750-0.521703.288502.22420HepG2DHX30
APEX2ENSG00000169188.4274.03490423.29440-0.627306.308905.38190HepG2DNAJC2
APEX2ENSG00000169188.4519.76510355.635800.547403.370202.36000HepG2EEF2
APEX2ENSG00000169188.4420.21440296.521400.502902.893901.76080HepG2EFTUD2
APEX2ENSG00000169188.4497.34260288.724700.784405.936004.64540HepG2EIF3D
APEX2ENSG00000169188.4522.66430659.80290-0.336202.707301.87750HepG2EIF4G1
APEX2ENSG00000169188.4372.87630539.26800-0.532303.830602.55910HepG2ESF1
APEX2ENSG00000169188.4553.20870763.28660-0.464405.358204.56970HepG2ETF1
APEX2ENSG00000169188.4623.59210397.357100.650106.222104.96960HepG2EWSR1
APEX2ENSG00000169188.41887.79130628.676101.5862030.3079028.28080HepG2FIP1L1
APEX2ENSG00000169188.4271.55690421.76170-0.635203.780902.30710HepG2FKBP4
APEX2ENSG00000169188.4161.29340560.91680-1.7981011.065309.07550HepG2FTO
APEX2ENSG00000169188.4199.85700280.14740-0.487202.362801.63370HepG2FUBP3
APEX2ENSG00000169188.4537.13730371.057000.533602.499001.43610HepG2FUS
APEX2ENSG00000169188.4672.66510378.777800.828407.636406.52980HepG2FXR1
APEX2ENSG00000169188.4366.90380257.080200.513102.680301.79800HepG2GEMIN5
APEX2ENSG00000169188.4629.31090422.232900.575602.776101.75690HepG2GNB2L1
APEX2ENSG00000169188.4409.95740634.84890-0.630904.311303.52330HepG2GPKOW
APEX2ENSG00000169188.4650.30950977.81470-0.588404.892003.97230HepG2HNRNPF
APEX2ENSG00000169188.4301.53630605.84340-1.006608.604607.56020HepG2HNRNPLL
APEX2ENSG00000169188.4562.51130962.87820-0.7755010.564409.23730HepG2IGF2BP1
APEX2ENSG00000169188.4566.44810413.790600.452902.535801.45090HepG2LARP7
APEX2ENSG00000169188.41033.49810302.196001.773909.803907.95410HepG2METAP2
APEX2ENSG00000169188.4665.56030508.688300.387702.382601.62840HepG2MSI2
APEX2ENSG00000169188.4321.60170617.77100-0.941806.044904.58500HepG2MTPAP
APEX2ENSG00000169188.4208.01460537.15940-1.3687013.6458012.11760HepG2NSUN2
APEX2ENSG00000169188.4473.36630303.561300.640902.876001.96950HepG2PABPC1
APEX2ENSG00000169188.4632.62730471.620500.423603.777302.80510HepG2PARN
APEX2ENSG00000169188.4308.71970424.95610-0.461003.164302.38170HepG2PPIL4
APEX2ENSG00000169188.4331.22810495.31540-0.580504.827703.83720HepG2PRPF4
APEX2ENSG00000169188.4239.36060390.85610-0.707504.359603.36950HepG2PRPF8
APEX2ENSG00000169188.4717.49410354.323501.017807.647806.82910HepG2PTBP1
APEX2ENSG00000169188.4349.60040633.07970-0.856709.612008.59290HepG2PUF60
APEX2ENSG00000169188.4880.44840672.025900.389604.708203.97730HepG2PUM1
APEX2ENSG00000169188.4250.61070383.74630-0.614704.279403.52690HepG2QKI
APEX2ENSG00000169188.41170.46970616.101000.9257016.4208014.61680HepG2RBM15
APEX2ENSG00000169188.41681.25010637.958901.3979040.1402038.61770HepG2RBM22
APEX2ENSG00000169188.4559.75190394.330100.505304.236703.59240HepG2NELFE
APEX2ENSG00000169188.4840.290901053.19780-0.325802.038101.44080HepG2RPLP0
APEX2ENSG00000169188.4185.95800333.06590-0.840802.465701.57360HepG2RPS10
APEX2ENSG00000169188.4514.25370280.915900.872208.790007.76810HepG2RPS19
APEX2ENSG00000169188.4217.67410386.63380-0.828805.254704.20390HepG2RRP9
APEX2ENSG00000169188.4403.47510281.983800.516803.020802.03610HepG2SERBP1
APEX2ENSG00000169188.4652.65760474.937400.458502.395501.76930HepG2SF3A3
APEX2ENSG00000169188.4312.75370599.69450-0.939206.386905.35190HepG2SF3B1
APEX2ENSG00000169188.4495.27050368.900900.424903.000702.38850HepG2SF3B4
APEX2ENSG00000169188.4415.18070606.99160-0.547906.188205.20570HepG2SLBP
APEX2ENSG00000169188.4846.21480494.828100.7740014.7174013.41840HepG2SMN1
APEX2ENSG00000169188.4466.90000667.25480-0.515102.412501.68540HepG2SNRNP70
APEX2ENSG00000169188.4902.47070720.538000.324702.919302.40880HepG2SRFBP1
APEX2ENSG00000169188.4702.73820385.050900.8678012.5438011.69460HepG2SRSF1
APEX2ENSG00000169188.4715.66300960.63640-0.424704.593503.73040HepG2SRSF7
APEX2ENSG00000169188.4479.54290313.257900.614206.167705.40110HepG2SRSF9
APEX2ENSG00000169188.4357.41970625.57460-0.8076011.6179010.70930HepG2SSB
APEX2ENSG00000169188.4201.04850290.13070-0.529202.339501.34180HepG2STIP1
APEX2ENSG00000169188.4918.73370710.875900.369903.862603.15040HepG2SUCLG1
APEX2ENSG00000169188.4681.76750504.422900.434502.238801.62150HepG2SUPV3L1
APEX2ENSG00000169188.4260.68980346.09380-0.408802.338001.81560HepG2TAF15
APEX2ENSG00000169188.4382.15320590.37570-0.627504.355203.47260HepG2TARDBP
APEX2ENSG00000169188.4287.43460463.01400-0.687806.106805.41670HepG2TIAL1
APEX2ENSG00000169188.4338.57400467.09310-0.464203.967403.31570HepG2TRIM56
APEX2ENSG00000169188.4486.83860618.46570-0.345302.202901.42940HepG2TUFM
APEX2ENSG00000169188.4793.33740406.648900.964107.766306.84380HepG2UTP3
APEX2ENSG00000169188.4356.51460496.54930-0.478002.628201.92160HepG2XRN2
APEX2ENSG00000169188.4338.86520488.78800-0.528504.770003.92800HepG2ZC3H8
APEX2ENSG00000169188.4572.02060463.235800.304202.374001.85610HepG2ZNF622
APEX2ENSG00000169188.41234.71420990.841700.317403.516802.88950K562AGGF1
APEX2ENSG00000169188.41911.80060951.964101.0059018.2546016.91420K562AQR
APEX2ENSG00000169188.4919.62540600.493100.614805.486804.24670K562BOP1
APEX2ENSG00000169188.41523.02020920.949800.725604.725303.28800K562CNOT7
APEX2ENSG00000169188.4839.47910638.465000.394803.146702.30930K562CPSF6
APEX2ENSG00000169188.41923.823901535.845900.324803.436602.34760K562CELF1
APEX2ENSG00000169188.41285.935001045.028900.299203.187102.49500K562DDX47
APEX2ENSG00000169188.4906.33830660.515300.456403.232102.24040K562EFTUD2
APEX2ENSG00000169188.4741.30880529.743800.484703.829702.86830K562EIF4A3
APEX2ENSG00000169188.41011.24330811.218100.317902.139301.39050K562FIP1L1
APEX2ENSG00000169188.4845.05040649.683900.379202.511301.69680K562FMR1
APEX2ENSG00000169188.4708.95150550.907700.363802.888002.27210K562FXR1
APEX2ENSG00000169188.4156.22610364.45110-1.222106.842805.61950K562G3BP2
APEX2ENSG00000169188.41025.88250827.316200.310302.649601.53160K562GLRX3
APEX2ENSG00000169188.4896.24450609.551800.556005.291704.20100K562GPKOW
APEX2ENSG00000169188.41758.171701308.724200.425804.356003.41180K562GRSF1
APEX2ENSG00000169188.41445.23670981.212100.558608.587807.02620K562HNRNPU
APEX2ENSG00000169188.4710.69990499.034000.510003.103801.99670K562IGF2BP2
APEX2ENSG00000169188.4822.26200595.001200.466602.978502.06780K562METAP2
APEX2ENSG00000169188.41248.26240869.801600.521108.278306.94870K562MTPAP
APEX2ENSG00000169188.41309.88350966.503400.438507.247306.12040K562NSUN2
APEX2ENSG00000169188.41322.37700884.764500.579703.528402.11590K562PABPC1
APEX2ENSG00000169188.41030.66550650.976900.662802.770701.77920K562PABPN1
APEX2ENSG00000169188.41888.886601298.934000.540105.047003.92350K562PCBP3
APEX2ENSG00000169188.41477.41160996.308500.568307.959106.62120K562POLR2G
APEX2ENSG00000169188.41168.10630920.899600.343002.445301.67720K562PPIG
APEX2ENSG00000169188.41710.154801420.387900.267702.812101.84530K562PUM2
APEX2ENSG00000169188.41381.37270996.256200.471405.500004.68890K562RBM15
APEX2ENSG00000169188.4751.27010488.217600.621705.074903.89770K562RBM22
APEX2ENSG00000169188.41688.40260953.579600.8241019.3268017.33310K562SF3A3
APEX2ENSG00000169188.4882.84330579.797000.606504.755903.45610K562SF3B1
APEX2ENSG00000169188.4543.41530378.721600.520802.995602.10460K562SF3B4
APEX2ENSG00000169188.41189.52240976.952700.283902.706901.77930K562SRPK2
APEX2ENSG00000169188.4818.84040499.322000.713508.430007.20260K562SRSF1
APEX2ENSG00000169188.4207.40910357.73140-0.786402.829301.35010K562TAF15
APEX2ENSG00000169188.4673.27620505.280900.414002.442701.77530K562TARDBP
APEX2ENSG00000169188.4902.97960707.341600.352202.112501.30180K562TRIM56
APEX2ENSG00000169188.41952.141701536.602200.345203.252501.71680K562UBE2L3
APEX2ENSG00000169188.41437.689001127.901500.350003.093601.71950K562WRN
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for APEX2 is not available on ENCORE database.





4 RBPs can affect the splicing of APEX2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEAPEX2ENSG00000169188.4chrX+550286835502886455027978550280625502939455029541-0.274000.000000.00012excludedK562SRSF1
SEAPEX2ENSG00000169188.4chrX+550286835502886455027978550280625502939455029541-0.145000.007200.09777excludedK562SF3B4
A3SSAPEX2ENSG00000169188.4chrX+5502866355028864550286835502886455027826550280620.188000.000000.00000longerK562AQR
A5SSAPEX2ENSG00000169188.4chrX+550293945502954155029394550294055503023155030301-0.262000.000000.00123shorterK562PRPF8
MXEAPEX2ENSG00000169188.4chrX+5502868355028864550293035502940555027978550280625503023155030301-0.179000.000050.002372includedK562PRPF8

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for APEX2 is not avaliable on ENCORE database.