TOP2B

General Information

Gene Name : TOP2B
Gene ID : ENSG00000077097.15
Essential Gene : No

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: TOP2B)

Not Available

Antibody Validation

Not Avaiable

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	TOP2B	ENSG00000077097.15	115.23	90.89	103.06	ENCSR000AEF
HepG2	TOP2B	ENSG00000077097.15	33.89	67.23	50.56	ENCSR985KAT
K562	TOP2B	ENSG00000077097.15	101.52	111.82	106.67	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

No Antibody Primary Validation image or Secondary image available

KD RNA-Seq

No KD RNA-Seq experiment available

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for TOP2B is not avaliable on ENCORE database.

Proteins bound to RNA

TOP2B RNA is bound by 45 proteins.

CanvasJS.com

eCLIP assay for TOP2B is not avaliable on ENCORE database.

45 proteins are bound to TOP2B RNA:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr3	25639627	25639697	-	3'-UTR,intron-Distal	3.57035	4.82028	HepG2	FUBP3
chr3	25639712	25639738	-	3'-UTR,intron-Distal	4.80872	3.81167	HepG2	SUB1
chr3	25639877	25639945	-	3'-UTR,CDS,intron-Distal	3.33049	11.67184	K562	UCHL5
chr3	25640929	25640949	-	3'-UTR,CDS,intron-Distal	5.53766	8.53277	K562	ZNF622
chr3	25639544	25639630	-	3'-UTR,intron-Distal,intron-Proximal	3.60170	10.95837	K562	NOLC1
chr3	25646300	25646319	-	3'-UTR,CDS,intron-Distal	3.33038	5.79926	HepG2	BCLAF1
chr3	25639627	25639712	-	3'-UTR,intron-Distal	5.77315	21.55934	HepG2	SUB1
chr3	25639535	25639620	-	3'-UTR,intron-Distal,intron-Proximal	4.71898	15.17670	K562	TIA1
chr3	25639620	25639675	-	3'-UTR,intron-Distal	3.98542	3.21228	K562	TIA1
chr3	25642595	25642620	-	3'-UTR,CDS,intron-Distal	4.08887	8.79898	HepG2	BCLAF1
chr3	25639708	25639754	-	3'-UTR,intron-Distal	4.46221	5.86481	K562	NOLC1
chr3	25639630	25639708	-	3'-UTR,intron-Distal	4.58025	12.43486	K562	NOLC1
chr3	25648662	25648694	-	3'-UTR,CDS,intron-Distal	3.71314	11.10779	HepG2	BCLAF1
chr3	25641009	25641019	-	3'-UTR,CDS,intron-Distal	3.91363	8.19556	HepG2	BCLAF1
chr3	25639521	25639627	-	3'-UTR,intron-Distal,intron-Proximal	5.56143	21.07591	HepG2	SUB1
chr3	25640929	25640964	-	3'-UTR,CDS,intron-Distal	4.04314	3.34184	HepG2	GRWD1
chr3	25654144	25654200	-	5'-UTR,CDS,intron-Distal	3.09580	7.56298	K562	UCHL5
chr3	25654020	25654094	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.05293	3.28485	K562	CPSF6
chr3	25650822	25650835	-	5'-UTR,CDS,intron-Distal	3.43852	5.87745	K562	BUD13
chr3	25660205	25660248	-	5'-UTR,CDS,intron-Distal	5.09508	12.44336	HepG2	BCLAF1
chr3	25657040	25657085	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.86972	9.06910	K562	U2AF2
chr3	25705808	25705913	-	5'-UTR,intron-Distal,intron-Proximal	3.03758	7.66134	K562	FMR1
chr3	25705797	25705884	-	5'-UTR,intron-Distal,intron-Proximal	4.01594	11.67526	K562	GEMIN5
chr3	25657031	25657089	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.04578	13.48685	K562	SF3B4
chr3	25654115	25654200	-	5'-UTR,CDS,intron-Distal	3.14703	5.20763	K562	SRSF1
chr3	25651103	25651198	-	5'-UTR,CDS,intron-Distal	3.21031	6.64482	HepG2	FXR2
chr3	25651096	25651204	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.95947	23.81299	K562	UCHL5
chr3	25650793	25650813	-	5'-UTR,CDS,intron-Distal	5.64129	10.71076	HepG2	BCLAF1
chr3	25654181	25654229	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.17131	3.59236	HepG2	AQR
chr3	25650800	25650835	-	5'-UTR,CDS,intron-Distal	3.06849	4.34307	K562	YBX3
chr3	25705725	25705805	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.32171	11.34683	K562	FXR2
chr3	25650783	25650835	-	5'-UTR,CDS,intron-Distal	3.67450	10.31263	K562	ZNF622
chr3	25654167	25654204	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.30743	4.57930	K562	GPKOW
chr3	25705925	25705990	-	5'-UTR,intron-Distal,intron-Proximal	3.38275	7.31899	HepG2	DDX3X
chr3	25650788	25650836	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.96439	6.45305	HepG2	FXR2
chr3	25705938	25706021	-	5'-UTR,intron-Distal,intron-Proximal	3.56908	6.07803	K562	FMR1
chr3	25705823	25705931	-	5'-UTR,intron-Distal,intron-Proximal	3.09036	5.55082	K562	SLTM
chr3	25660146	25660157	-	5'-UTR,CDS,intron-Distal	4.08034	9.39582	HepG2	BCLAF1
chr3	25654068	25654138	-	5'-UTR,CDS,intron-Distal	3.28086	5.71737	K562	GRWD1
chr3	25654009	25654135	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.98248	6.77022	HepG2	ZNF800
chr3	25651115	25651200	-	5'-UTR,CDS,intron-Distal	5.43942	27.82740	HepG2	BCLAF1
chr3	25705689	25705797	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.74600	17.60875	K562	GEMIN5
chr3	25705806	25705914	-	5'-UTR,intron-Distal,intron-Proximal	3.51458	15.00679	K562	FXR2
chr3	25651175	25651202	-	5'-UTR,CDS,intron-Distal	3.07525	6.25786	K562	ZNF622
chr3	25656741	25656787	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.86226	4.06574	K562	U2AF2
chr3	25706340	25706396	-	5'-UTR,intron-Distal	4.15369	6.19788	K562	DDX3X
chr3	25654147	25654192	-	5'-UTR,CDS,intron-Distal	3.81936	11.19453	HepG2	BCLAF1
chr3	25650764	25650832	-	5'-UTR,CDS,intron-Distal	3.12485	12.29919	K562	UCHL5
chr3	25650820	25650834	-	5'-UTR,CDS,intron-Distal	5.62255	10.71076	HepG2	BCLAF1
chr3	25650745	25650804	-	5'-UTR,CDS,intron-Distal	3.45608	5.42118	K562	GRWD1
chr3	25651058	25651109	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.44621	3.31827	HepG2	GRWD1
chr3	25654008	25654060	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.84927	7.26028	HepG2	FXR2
chr3	25705799	25705905	-	5'-UTR,intron-Distal,intron-Proximal	3.72066	26.91999	HepG2	DDX3X
chr3	25705720	25705808	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.01786	5.68277	K562	FMR1
chr3	25657041	25657087	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.49687	8.99762	HepG2	U2AF2
chr3	25654163	25654195	-	5'-UTR,CDS,intron-Distal	3.24622	4.98614	K562	AGGF1
chr3	25651057	25651098	-	5'-UTR,CDS,intron-Distal,intron-Proximal	5.04200	15.46734	K562	ZNF622
chr3	25654005	25654037	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.24035	8.23345	K562	UCHL5
chr3	25651058	25651093	-	5'-UTR,CDS,intron-Distal,intron-Proximal	6.04866	15.35511	HepG2	BCLAF1
chr3	25654011	25654201	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.71085	15.47761	K562	ZNF800
chr3	25705731	25705799	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.95888	16.45778	HepG2	DDX3X
chr3	25651058	25651103	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.11372	8.07615	HepG2	FXR2
chr3	25654104	25654132	-	5'-UTR,CDS,intron-Distal	3.44591	8.38234	K562	UCHL5
chr3	25654009	25654066	-	5'-UTR,CDS,intron-Distal,intron-Proximal	6.62558	23.79114	HepG2	BCLAF1
chr3	25677435	25677496	-	CDS,intron-Distal	4.03470	3.25521	K562	LIN28B
chr3	25666186	25666250	-	CDS,intron-Distal	4.75915	6.10169	K562	LIN28B
chr3	25685144	25685195	-	CDS,intron-Distal,intron-Proximal	5.05219	4.02817	HepG2	PRPF8
chr3	25668263	25668305	-	CDS,intron-Distal,intron-Proximal	4.61875	17.55697	HepG2	BCLAF1
chr3	25666186	25666227	-	CDS,intron-Distal	4.64987	14.21310	HepG2	BCLAF1
chr3	25665101	25665153	-	CDS,intron-Distal	3.81415	3.92527	K562	FXR1
chr3	25675331	25675376	-	CDS,intron-Distal,intron-Proximal	3.71586	8.76312	K562	PUM2
chr3	25685209	25685237	-	CDS,intron-Distal	3.36864	3.50904	K562	LIN28B
chr3	25668264	25668319	-	CDS,intron-Distal,intron-Proximal	3.00655	4.87371	HepG2	FXR2
chr3	25683849	25683906	-	CDS,intron-Distal,intron-Proximal	3.86965	9.31583	K562	SF3B4
chr3	25672372	25672438	-	CDS,intron-Distal,intron-Proximal	3.55506	4.97118	HepG2	U2AF2
chr3	25675417	25675466	-	CDS,intron-Distal	3.60543	6.00726	K562	YBX3
chr3	25668099	25668164	-	CDS,intron-Distal,intron-Proximal	3.54059	5.70944	K562	FXR1
chr3	25668262	25668312	-	CDS,intron-Distal,intron-Proximal	3.80263	7.17722	K562	FXR1
chr3	25674268	25674286	-	CDS,intron-Distal,intron-Proximal	3.28318	5.13860	K562	PUM2
chr3	25670439	25670494	-	CDS,intron-Distal,intron-Proximal	4.88920	9.53610	K562	SF3B4
chr3	25665180	25665231	-	CDS,intron-Distal	3.91205	4.11230	K562	FXR1
chr3	25668079	25668117	-	CDS,intron-Distal	3.15289	4.97511	K562	YBX3
chr3	25666172	25666235	-	CDS,intron-Distal,intron-Proximal	3.07572	4.24993	HepG2	PPIG
chr3	25685147	25685192	-	CDS,intron-Distal,intron-Proximal	3.65865	3.54718	K562	PRPF8
chr3	25674262	25674311	-	CDS,intron-Distal,intron-Proximal	4.16213	5.16342	K562	SF3B4
chr3	25674245	25674294	-	CDS,intron-Distal,intron-Proximal	3.66784	8.44069	K562	U2AF2
chr3	25679655	25679698	-	CDS,intron-Distal,intron-Proximal	4.61886	4.34615	K562	LIN28B
chr3	25685237	25685260	-	CDS,intron-Distal	4.27483	4.34615	K562	LIN28B
chr3	25674245	25674291	-	CDS,intron-Distal,intron-Proximal	3.48486	4.57751	HepG2	U2AF2
chr3	25661431	25661443	-	CDS,intron-Distal,intron-Proximal	4.21209	7.65975	HepG2	BCLAF1
chr3	25659923	25659962	-	CDS,intron-Distal	3.09491	7.90382	HepG2	BCLAF1
chr3	25683830	25683872	-	CDS,intron-Distal	3.36755	5.26861	K562	DDX24
chr3	25678750	25678804	-	CDS,intron-Distal,intron-Proximal	4.99389	6.10169	K562	LIN28B
chr3	25665083	25665121	-	CDS,intron-Distal	3.73218	10.64917	HepG2	BCLAF1
chr3	25668094	25668155	-	CDS,intron-Distal	3.00320	3.17174	K562	SAFB
chr3	25668262	25668306	-	CDS,intron-Distal,intron-Proximal	4.16023	6.52856	K562	FXR2
chr3	25688748	25688909	-	intron-Distal	4.85532	18.79790	K562	KHSRP
chr3	25672442	25672549	-	intron-Distal,intron-Proximal	3.24249	7.47863	K562	KHSRP
chr3	25689459	25689512	-	intron-Distal	3.41070	3.43829	K562	EXOSC5
chr3	25672763	25672852	-	intron-Distal	3.36220	3.29213	HepG2	KHSRP
chr3	25643213	25643269	-	intron-Distal	3.74665	4.93120	K562	KHSRP
chr3	25706283	25706337	-	intron-Distal	4.01306	5.84843	HepG2	DDX3X
chr3	25679552	25679601	-	intron-Distal,intron-Proximal	3.90158	3.42844	K562	KHSRP
chr3	25705270	25705369	-	intron-Distal	3.06729	6.68509	K562	CSTF2T
chr3	25662066	25662118	-	intron-Distal,intron-Proximal	5.10656	5.58842	K562	EFTUD2
chr3	25683753	25683795	-	intron-Distal,intron-Proximal	3.88889	4.89208	K562	AQR
chr3	25706083	25706113	-	intron-Distal,intron-Proximal	3.64745	3.61036	K562	GEMIN5
chr3	25695178	25695226	-	intron-Distal	4.21450	4.61447	HepG2	SUGP2
chr3	25705381	25705426	-	intron-Distal	3.28161	3.58549	K562	NONO
chr3	25657089	25657122	-	intron-Distal,intron-Proximal	3.73972	6.26407	K562	SF3B4
chr3	25696365	25696387	-	intron-Distal	3.16477	3.14999	K562	EXOSC5
chr3	25706157	25706247	-	intron-Distal	3.74044	11.89201	K562	FXR2
chr3	25693715	25693781	-	intron-Distal	4.75483	5.58061	HepG2	SUGP2
chr3	25673681	25673782	-	intron-Distal	3.02132	6.28168	K562	KHSRP
chr3	25694706	25694745	-	intron-Distal	3.22941	5.98150	K562	EXOSC5
chr3	25673174	25673220	-	intron-Distal	4.55361	3.77802	HepG2	U2AF2
chr3	25693845	25693925	-	intron-Distal	3.91590	3.29197	K562	HNRNPM
chr3	25705495	25705541	-	intron-Distal	3.18627	4.92335	K562	NONO
chr3	25670444	25670496	-	intron-Distal,intron-Proximal	5.30809	5.43043	K562	EFTUD2
chr3	25684906	25684986	-	intron-Distal	3.05629	3.17926	K562	KHSRP
chr3	25688568	25688608	-	intron-Distal	3.08231	3.28806	K562	KHSRP
chr3	25672549	25672610	-	intron-Distal	3.45932	9.04868	K562	KHSRP
chr3	25695273	25695320	-	intron-Distal	4.16473	4.03915	HepG2	SUGP2
chr3	25672550	25672608	-	intron-Distal	3.04126	3.06355	HepG2	KHSRP
chr3	25694785	25694859	-	intron-Distal	4.20241	15.40887	K562	EXOSC5
chr3	25643269	25643358	-	intron-Distal	3.03185	4.23631	K562	KHSRP
chr3	25656649	25656676	-	intron-Distal,intron-Proximal	5.20412	6.75320	K562	AQR
chr3	25706006	25706083	-	intron-Distal,intron-Proximal	4.21976	7.10584	K562	GEMIN5
chr3	25694508	25694516	-	intron-Distal	4.01499	3.30696	K562	EXOSC5
chr3	25649661	25649778	-	intron-Distal	3.37522	3.90146	K562	KHSRP
chr3	25695277	25695335	-	intron-Distal	3.04023	5.64262	K562	EXOSC5
chr3	25684297	25684382	-	intron-Distal	3.70730	5.32884	K562	KHSRP
chr3	25683795	25683813	-	intron-Distal,intron-Proximal	3.42935	3.08090	K562	AQR
chr3	25673788	25673858	-	intron-Distal,intron-Proximal	3.29044	8.65519	K562	KHSRP
chr3	25706270	25706305	-	intron-Distal	3.11025	3.56284	K562	FMR1
chr3	25689522	25689569	-	intron-Distal	5.18684	7.14250	K562	HNRNPM
chr3	25673858	25673904	-	intron-Distal,intron-Proximal	3.86498	5.56048	K562	KHSRP
chr3	25693637	25693696	-	intron-Distal	4.70850	4.80399	K562	EXOSC5
chr3	25696513	25696598	-	intron-Distal	3.11323	3.32889	K562	MATR3
chr3	25668586	25668648	-	intron-Distal,intron-Proximal	3.08361	4.80096	K562	TIA1
chr3	25705231	25705307	-	intron-Distal	4.48743	5.71021	K562	TARDBP
chr3	25696498	25696587	-	intron-Distal	3.83644	5.30446	HepG2	SUGP2
chr3	25694196	25694261	-	intron-Distal	3.38375	3.56409	K562	MATR3
chr3	25672861	25672916	-	intron-Distal	3.42378	3.68839	K562	KHSRP
chr3	25706234	25706271	-	intron-Distal	3.38736	4.22460	K562	RBM15
chr3	25696344	25696388	-	intron-Distal	4.10150	3.79098	HepG2	SUGP2
chr3	25671418	25671465	-	intron-Distal,intron-Proximal	4.11637	3.45799	HepG2	U2AF2
chr3	25667947	25667993	-	intron-Distal,intron-Proximal	3.88126	3.66668	K562	KHSRP
chr3	25694973	25695027	-	intron-Distal	5.57895	11.33292	K562	EXOSC5
chr3	25695563	25695645	-	intron-Distal	5.27585	7.91717	K562	PTBP1
chr3	25693876	25693912	-	intron-Distal	4.06476	3.30696	K562	EXOSC5
chr3	25695679	25695703	-	intron-Distal	3.50702	4.31711	K562	EXOSC5
chr3	25696142	25696211	-	intron-Distal	3.12954	4.61989	HepG2	SUGP2
chr3	25706037	25706193	-	intron-Distal,intron-Proximal	4.00703	18.64327	HepG2	DDX3X
chr3	25694745	25694785	-	intron-Distal	3.14353	6.26462	K562	EXOSC5
chr3	25693770	25693912	-	intron-Distal	4.32356	8.74918	K562	TARDBP
chr3	25698038	25698099	-	intron-Distal	5.95384	11.26038	K562	QKI
chr3	25689419	25689512	-	intron-Distal	3.98277	10.35553	K562	HNRNPM
chr3	25696152	25696251	-	intron-Distal	3.63854	4.73075	K562	MATR3
chr3	25694962	25695014	-	intron-Distal	3.65173	4.33009	HepG2	SUGP2
chr3	25697312	25697399	-	intron-Distal	3.82737	6.09502	K562	QKI
chr3	25705588	25705627	-	intron-Distal,intron-Proximal	4.25537	4.72743	K562	NONO
chr3	25691033	25691097	-	intron-Distal	3.20955	3.18966	K562	MATR3
chr3	25693733	25693848	-	intron-Distal	5.90466	15.31952	K562	EXOSC5
chr3	25689526	25689570	-	intron-Distal	5.15134	6.19745	HepG2	HNRNPM
chr3	25688909	25689013	-	intron-Distal	3.64281	6.59733	K562	KHSRP
chr3	25690300	25690353	-	intron-Distal	3.55354	3.10640	HepG2	SUGP2
chr3	25706233	25706337	-	intron-Distal	4.40970	5.31704	K562	FUS
chr3	25706247	25706295	-	intron-Distal	3.78346	7.33300	K562	FXR2
chr3	25689883	25689939	-	intron-Distal	3.57135	4.08528	HepG2	SUGP2
chr3	25672631	25672716	-	intron-Distal	3.21057	7.63715	K562	KHSRP
chr3	25667185	25667271	-	intron-Distal	5.53409	10.58144	K562	DGCR8
chr3	25706208	25706270	-	intron-Distal	3.05323	5.64871	K562	FMR1
chr3	25689444	25689511	-	intron-Distal	5.15134	8.59719	HepG2	HNRNPM
chr3	25705342	25705421	-	intron-Distal	3.42999	3.67595	K562	EWSR1
chr3	25693759	25693836	-	intron-Distal	4.30112	3.62366	HepG2	HNRNPM
chr3	25696182	25696225	-	intron-Distal	4.38196	3.62238	HepG2	MATR3
chr3	25685341	25685416	-	intron-Distal,intron-Proximal	4.81214	6.28383	K562	KHSRP
chr3	25706149	25706208	-	intron-Distal	4.16451	6.49839	K562	FMR1
chr3	25668585	25668643	-	intron-Distal,intron-Proximal	3.90872	4.29034	K562	U2AF2
chr3	25706271	25706334	-	intron-Distal	4.11928	11.54638	K562	GEMIN5
chr3	25688181	25688234	-	intron-Distal	3.76048	6.19377	K562	KHSRP
chr3	25647452	25647519	-	intron-Distal,intron-Proximal	3.66893	5.83621	K562	AQR
chr3	25690123	25690181	-	intron-Distal	3.06027	5.91066	HepG2	SUGP2
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

eCLIP assay for TOP2B is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for TOP2B is not available on ENCORE database.
110 RBPs can affect the levels of TOP2B.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for TOP2B is not available on ENCORE database.

110 RBPs can affect the gene expression of TOP2B :

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
TOP2B	ENSG00000077097.9	3887.13130	3117.42350	0.31830	5.55470	4.50160	HepG2	AKAP8L
TOP2B	ENSG00000077097.9	4190.17940	4963.05220	-0.24420	3.91940	3.12870	HepG2	AUH
TOP2B	ENSG00000077097.9	1885.25530	2626.33150	-0.47830	3.56720	2.50490	HepG2	BCCIP
TOP2B	ENSG00000077097.9	1518.84280	2282.18040	-0.58740	5.69560	4.45480	HepG2	BCLAF1
TOP2B	ENSG00000077097.9	1256.42550	3693.31710	-1.55560	50.24110	48.31750	HepG2	BOP1
TOP2B	ENSG00000077097.9	3762.76980	5535.64810	-0.55700	2.99290	1.97730	HepG2	CCAR1
TOP2B	ENSG00000077097.9	2680.09630	3390.66500	-0.33930	2.94860	2.24230	HepG2	CPSF6
TOP2B	ENSG00000077097.9	2439.68400	2842.63850	-0.22050	2.39590	1.45250	HepG2	YBX3
TOP2B	ENSG00000077097.9	3026.71330	3954.27760	-0.38570	7.12660	6.18550	HepG2	CELF1
TOP2B	ENSG00000077097.9	3398.21980	4251.92730	-0.32330	7.88590	6.73010	HepG2	DAZAP1
TOP2B	ENSG00000077097.9	1353.53460	2545.06580	-0.91100	14.49270	13.08440	HepG2	DDX21
TOP2B	ENSG00000077097.9	2111.07830	2692.16870	-0.35080	3.41450	2.33170	HepG2	DHX30
TOP2B	ENSG00000077097.9	1961.30530	2791.26170	-0.50910	10.05670	8.78210	HepG2	DNAJC21
TOP2B	ENSG00000077097.9	1829.58790	2766.60860	-0.59660	19.92890	18.33030	HepG2	DNAJC2
TOP2B	ENSG00000077097.9	2775.35430	2218.92280	0.32270	2.62220	1.73980	HepG2	EIF3D
TOP2B	ENSG00000077097.9	1978.62770	3297.93600	-0.73710	8.49010	7.37230	HepG2	EIF4A3
TOP2B	ENSG00000077097.9	5187.06450	3210.97770	0.69180	6.43210	5.41520	HepG2	EIF4B
TOP2B	ENSG00000077097.9	2282.01460	5698.25790	-1.32020	82.73180	80.34290	HepG2	ETF1
TOP2B	ENSG00000077097.9	2377.92450	1759.42800	0.43450	4.91820	3.88500	HepG2	FUBP3
TOP2B	ENSG00000077097.9	1381.37370	1975.69900	-0.51630	5.19830	3.96780	HepG2	GEMIN5
TOP2B	ENSG00000077097.9	2339.75430	3843.57950	-0.71610	9.09440	7.97540	HepG2	GPKOW
TOP2B	ENSG00000077097.9	2512.24270	2962.32720	-0.23780	3.11890	2.08470	HepG2	HDGF
TOP2B	ENSG00000077097.9	1932.15140	3134.50530	-0.69800	11.78510	10.44260	HepG2	HNRNPC
TOP2B	ENSG00000077097.9	2352.34950	2993.57670	-0.34780	5.61830	4.64000	HepG2	HNRNPF
TOP2B	ENSG00000077097.9	3809.49870	3125.52180	0.28540	2.34140	1.69640	HepG2	HNRNPK
TOP2B	ENSG00000077097.9	3149.65920	3873.21310	-0.29830	6.84500	5.82870	HepG2	HNRNPL
TOP2B	ENSG00000077097.9	2163.06320	3667.99900	-0.76190	11.79650	10.61210	HepG2	HNRNPLL
TOP2B	ENSG00000077097.9	1659.78230	3113.78190	-0.90770	36.81190	34.82660	HepG2	HNRNPU
TOP2B	ENSG00000077097.9	2350.32280	2947.83480	-0.32680	3.51140	2.70300	HepG2	IGF2BP1
TOP2B	ENSG00000077097.9	1322.00510	3180.62550	-1.26660	86.42720	83.49430	HepG2	ILF2
TOP2B	ENSG00000077097.9	4304.09700	5841.79960	-0.44070	2.34520	1.58490	HepG2	LARP4
TOP2B	ENSG00000077097.9	2416.01060	3328.59980	-0.46230	4.33280	3.51520	HepG2	MAGOH
TOP2B	ENSG00000077097.9	2773.17970	3426.08780	-0.30500	2.03890	1.49140	HepG2	NCBP2
TOP2B	ENSG00000077097.9	3032.31570	4216.19660	-0.47550	8.72880	7.39910	HepG2	NOL12
TOP2B	ENSG00000077097.9	2105.16460	3051.17950	-0.53540	5.49920	4.49220	HepG2	PABPC4
TOP2B	ENSG00000077097.9	3447.09510	3048.81000	0.17700	2.09360	1.55380	HepG2	PCBP1
TOP2B	ENSG00000077097.9	2280.85070	2777.24500	-0.28410	3.51150	2.69120	HepG2	PPIL4
TOP2B	ENSG00000077097.9	2530.36460	4024.69850	-0.66950	12.33800	11.19930	HepG2	PUF60
TOP2B	ENSG00000077097.9	2322.26160	3160.44210	-0.44460	10.94690	9.86000	HepG2	PUS1
TOP2B	ENSG00000077097.9	3602.25170	4762.68710	-0.40290	7.83770	7.06900	HepG2	RBM22
TOP2B	ENSG00000077097.9	4224.64910	3452.55100	0.29110	4.94820	4.26120	HepG2	NELFE
TOP2B	ENSG00000077097.9	3704.23990	3215.65270	0.20400	2.60390	2.00360	HepG2	RECQL
TOP2B	ENSG00000077097.9	2199.45880	3224.57130	-0.55200	7.44170	6.40260	HepG2	RPLP0
TOP2B	ENSG00000077097.9	2198.92730	2962.46210	-0.43000	2.39540	1.51560	HepG2	RPS10
TOP2B	ENSG00000077097.9	1809.19670	2159.00370	-0.25500	2.02690	1.49340	HepG2	RPS19
TOP2B	ENSG00000077097.9	2417.50520	2772.96150	-0.19790	2.63770	2.00630	HepG2	SAFB2
TOP2B	ENSG00000077097.9	2935.51670	3630.59240	-0.30660	2.75950	2.05360	HepG2	SF3B1
TOP2B	ENSG00000077097.9	3170.52840	3858.98590	-0.28350	5.91930	4.95460	HepG2	SLBP
TOP2B	ENSG00000077097.9	2647.90730	3233.74350	-0.28840	6.23170	5.32660	HepG2	SMN1
TOP2B	ENSG00000077097.9	4002.00290	5379.27620	-0.42670	12.01850	11.16970	HepG2	SRFBP1
TOP2B	ENSG00000077097.9	5466.23510	3371.28460	0.69710	29.06060	27.88640	HepG2	SRSF1
TOP2B	ENSG00000077097.9	2224.37280	2941.03380	-0.40290	7.51070	6.45450	HepG2	SRSF7
TOP2B	ENSG00000077097.9	3518.05590	4670.47900	-0.40880	9.98000	9.12190	HepG2	SSB
TOP2B	ENSG00000077097.9	1835.70280	2570.60160	-0.48580	3.96080	3.17410	HepG2	SUPV3L1
TOP2B	ENSG00000077097.9	3562.43430	3030.33730	0.23330	2.66560	2.11430	HepG2	TAF15
TOP2B	ENSG00000077097.9	2300.03840	3575.17260	-0.63640	9.36870	8.14980	HepG2	TARDBP
TOP2B	ENSG00000077097.9	3263.61470	2784.36610	0.22900	2.11260	1.38030	HepG2	TIA1
TOP2B	ENSG00000077097.9	1670.83720	3025.62760	-0.85670	22.29490	21.12770	HepG2	TIAL1
TOP2B	ENSG00000077097.9	2109.66080	3052.66740	-0.53310	13.68480	12.56630	HepG2	TRIM56
TOP2B	ENSG00000077097.9	2388.29990	4773.52830	-0.99910	3.34500	2.25740	HepG2	U2AF2
TOP2B	ENSG00000077097.9	3011.96760	3534.63100	-0.23090	3.43620	2.67160	HepG2	UPF1
TOP2B	ENSG00000077097.9	1476.87920	2354.11000	-0.67260	4.92360	3.56010	HepG2	UPF2
TOP2B	ENSG00000077097.9	1818.91150	3412.53740	-0.90780	38.36810	36.50980	HepG2	UTP3
TOP2B	ENSG00000077097.9	1936.77690	2530.47280	-0.38570	2.88620	2.14560	HepG2	XRN2
TOP2B	ENSG00000077097.9	2330.77550	2854.76130	-0.29260	5.41340	4.52440	HepG2	ZC3H8
TOP2B	ENSG00000077097.9	2509.79280	3887.40830	-0.63120	27.03310	25.77090	HepG2	ZNF622
TOP2B	ENSG00000077097.9	6420.17670	7633.46200	-0.24970	4.60200	3.90230	K562	AGGF1
TOP2B	ENSG00000077097.9	5779.46970	10137.42060	-0.81070	17.42390	16.11470	K562	AQR
TOP2B	ENSG00000077097.9	4230.70070	5624.27760	-0.41080	10.62630	8.73600	K562	BCLAF1
TOP2B	ENSG00000077097.9	3688.76400	5877.97230	-0.67220	10.36940	8.63090	K562	BOP1
TOP2B	ENSG00000077097.9	2055.19310	2671.44300	-0.37830	3.50380	2.28900	K562	CCAR1
TOP2B	ENSG00000077097.9	8256.89950	11630.95700	-0.49430	2.72790	1.67810	K562	CNOT7
TOP2B	ENSG00000077097.9	4581.04380	6249.94310	-0.44820	7.08120	5.81940	K562	CPSF6
TOP2B	ENSG00000077097.9	3653.70520	4266.85270	-0.22380	2.63430	1.60600	K562	CSTF2
TOP2B	ENSG00000077097.9	5203.46320	6381.98030	-0.29450	4.72640	3.12090	K562	DDX21
TOP2B	ENSG00000077097.9	4086.91910	4931.42330	-0.27100	4.27550	2.61300	K562	DDX27
TOP2B	ENSG00000077097.9	10371.88240	11566.64670	-0.15730	2.02090	1.44870	K562	DDX47
TOP2B	ENSG00000077097.9	4588.96790	5705.17190	-0.31410	4.75860	2.88330	K562	DDX6
TOP2B	ENSG00000077097.9	9788.45070	8547.68750	0.19540	2.25130	1.47230	K562	DKC1
TOP2B	ENSG00000077097.9	4133.11560	5527.38720	-0.41940	2.79670	1.50960	K562	EEF2
TOP2B	ENSG00000077097.9	4086.52230	5341.03370	-0.38620	3.00620	2.05420	K562	EFTUD2
TOP2B	ENSG00000077097.9	4982.61760	6180.71420	-0.31090	5.78000	4.00160	K562	EIF2S1
TOP2B	ENSG00000077097.9	5163.62750	6037.16590	-0.22550	2.83760	2.03140	K562	EIF3G
TOP2B	ENSG00000077097.9	3717.81260	5878.93120	-0.66110	11.65580	9.93610	K562	EIF4A3
TOP2B	ENSG00000077097.9	4186.82590	5131.64170	-0.29360	3.78170	2.23680	K562	EWSR1
TOP2B	ENSG00000077097.9	5494.31860	7930.78320	-0.52950	7.71240	6.22770	K562	FIP1L1
TOP2B	ENSG00000077097.9	5012.81370	6359.22280	-0.34320	3.31340	2.37280	K562	FMR1
TOP2B	ENSG00000077097.9	4158.33620	5390.03840	-0.37430	3.35160	2.33850	K562	FTO
TOP2B	ENSG00000077097.9	8737.35030	6429.58220	0.44240	3.26310	2.48400	K562	G3BP2
TOP2B	ENSG00000077097.9	3861.41010	5354.65820	-0.47170	4.67200	2.79610	K562	GEMIN5
TOP2B	ENSG00000077097.9	4524.61980	7852.95300	-0.79540	26.87360	24.04920	K562	GLRX3
TOP2B	ENSG00000077097.9	4278.20950	5967.13520	-0.48000	6.83550	5.58910	K562	GPKOW
TOP2B	ENSG00000077097.9	5060.72150	9990.48170	-0.98120	29.35660	26.80170	K562	GRSF1
TOP2B	ENSG00000077097.9	2778.85040	5490.47370	-0.98240	16.49740	15.11850	K562	HNRNPC
TOP2B	ENSG00000077097.9	4075.13360	4902.31920	-0.26660	2.34200	1.30620	K562	HNRNPF
TOP2B	ENSG00000077097.9	4711.39120	6523.04200	-0.46940	4.60240	3.37610	K562	HNRNPM
TOP2B	ENSG00000077097.9	5863.55000	7811.68570	-0.41390	7.92500	6.41920	K562	HNRNPU
TOP2B	ENSG00000077097.9	8175.95220	10752.65500	-0.39520	4.62790	3.60470	K562	HSPD1
TOP2B	ENSG00000077097.9	5145.38270	10613.90530	-1.04460	9.45300	6.84610	K562	ILF2
TOP2B	ENSG00000077097.9	5857.32590	8562.46890	-0.54780	9.25400	7.65850	K562	MAGOH
TOP2B	ENSG00000077097.9	6538.63610	8545.38970	-0.38620	5.24970	3.92780	K562	MATR3
TOP2B	ENSG00000077097.9	4168.89430	5824.59930	-0.48250	7.13800	5.69650	K562	METAP2
TOP2B	ENSG00000077097.9	11703.11110	14489.52240	-0.30810	2.74770	1.62350	K562	MSI2
TOP2B	ENSG00000077097.9	5127.06250	8256.35920	-0.68740	30.75350	28.53840	K562	MTPAP
TOP2B	ENSG00000077097.9	7028.09460	9173.53830	-0.38430	17.94870	16.27380	K562	NSUN2
TOP2B	ENSG00000077097.9	4238.03440	5817.75530	-0.45710	4.57100	3.50400	K562	PCBP3
TOP2B	ENSG00000077097.9	3473.60790	4462.45360	-0.36140	4.65910	3.61940	K562	POLR2G
TOP2B	ENSG00000077097.9	5547.87590	9002.80520	-0.69840	12.02900	9.96000	K562	PPIG
TOP2B	ENSG00000077097.9	5859.39110	9146.05320	-0.64240	2.71800	1.30420	K562	PPP1R8
TOP2B	ENSG00000077097.9	4139.91260	5197.41950	-0.32820	2.76990	2.02060	K562	PRPF8
TOP2B	ENSG00000077097.9	3613.34320	4922.59540	-0.44610	3.72230	2.65290	K562	PSIP1
TOP2B	ENSG00000077097.9	12664.11670	15457.24620	-0.28750	4.65100	3.39660	K562	PUM2
TOP2B	ENSG00000077097.9	6693.42870	7977.81290	-0.25320	2.12060	1.38930	K562	RBM22
TOP2B	ENSG00000077097.9	3356.86320	4490.31800	-0.41970	5.50700	4.10150	K562	RCC2
TOP2B	ENSG00000077097.9	6562.62930	9051.96840	-0.46400	11.13660	9.58090	K562	SF3A3
TOP2B	ENSG00000077097.9	4857.85100	6689.35530	-0.46150	5.88760	4.60700	K562	SF3B4
TOP2B	ENSG00000077097.9	5170.33850	8578.38990	-0.73040	3.47980	1.95800	K562	SFPQ
TOP2B	ENSG00000077097.9	3128.16280	4256.79590	-0.44450	5.43230	3.85090	K562	SRFBP1
TOP2B	ENSG00000077097.9	8307.17320	9273.93950	-0.15880	2.72570	1.79540	K562	SRPK2
TOP2B	ENSG00000077097.9	2964.14750	4029.18850	-0.44290	6.15620	4.47680	K562	SRSF4
TOP2B	ENSG00000077097.9	5910.06290	7701.26350	-0.38190	4.13950	2.81360	K562	SRSF5
TOP2B	ENSG00000077097.9	4929.46170	5695.15990	-0.20830	2.55690	1.43430	K562	SRSF7
TOP2B	ENSG00000077097.9	3701.97520	5033.30270	-0.44320	3.09040	2.01590	K562	SUPV3L1
TOP2B	ENSG00000077097.9	5425.77880	4475.90620	0.27760	3.24260	2.35410	K562	SYNCRIP
TOP2B	ENSG00000077097.9	5608.74760	8253.86910	-0.55740	6.79390	5.64240	K562	TARDBP
TOP2B	ENSG00000077097.9	6657.34210	7961.66700	-0.25810	2.73170	1.92030	K562	TIA1
TOP2B	ENSG00000077097.9	3167.12990	4734.82420	-0.58010	6.78980	5.26860	K562	TIAL1
TOP2B	ENSG00000077097.9	3315.97540	5029.12010	-0.60090	9.02470	7.09840	K562	TRIM56
TOP2B	ENSG00000077097.9	3541.17980	6236.53890	-0.81650	11.70130	9.26290	K562	U2AF1
TOP2B	ENSG00000077097.9	3652.27200	6439.61830	-0.81820	15.86330	13.90750	K562	U2AF2
TOP2B	ENSG00000077097.9	7642.09290	9726.89860	-0.34800	8.85890	7.66180	K562	UPF1
TOP2B	ENSG00000077097.9	5788.43420	8322.99760	-0.52390	9.15480	7.52360	K562	WDR3
TOP2B	ENSG00000077097.9	7232.26840	8654.96800	-0.25910	5.63830	4.47370	K562	WDR43
TOP2B	ENSG00000077097.9	8936.51400	11419.97140	-0.35380	4.02630	2.95190	K562	ZC3H8
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for TOP2B is not available on ENCORE database.

13 RBPs can affect the splicing of TOP2B :

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	TOP2B	ENSG00000077097.9	chr3	-	25646250	25646361			25642590	25642716	25647533	25647613	-0.06500	0.00001	0.00031	excluded	K562	SF3B4
SE	TOP2B	ENSG00000077097.9	chr3	-	25659908	25660000			25656963	25657077	25660144	25660340	-0.09500	0.00000	0.00000	excluded	K562	SF3B4
SE	TOP2B	ENSG00000077097.9	chr3	-	25659908	25660000			25656963	25657077	25660144	25660340	-0.08800	0.00042	0.00987	excluded	HepG2	U2AF1
SE	TOP2B	ENSG00000077097.9	chr3	-	25659908	25660000			25656963	25657077	25660144	25660358	-0.06400	0.00000	0.00000	excluded	K562	AKAP8L
SE	TOP2B	ENSG00000077097.9	chr3	-	25659908	25660000			25656963	25657077	25660144	25660340	-0.13400	0.00000	0.00000	excluded	HepG2	U2AF2
SE	TOP2B	ENSG00000077097.9	chr3	-	25683812	25683970			25679655	25679801	25685184	25685275	-0.09200	0.00001	0.00016	excluded	K562	AQR
SE	TOP2B	ENSG00000077097.9	chr3	-	25659908	25660000			25656921	25657094	25660144	25660340	-0.15800	0.00000	0.00000	excluded	K562	AQR
SE	TOP2B	ENSG00000077097.9	chr3	-	25659908	25660000			25656963	25657077	25660144	25660340	-0.09700	0.00000	0.00000	excluded	K562	PUS1
SE	TOP2B	ENSG00000077097.9	chr3	-	25659908	25660000			25656963	25657077	25660144	25660340	-0.17700	0.00000	0.00000	excluded	K562	U2AF1
SE	TOP2B	ENSG00000077097.9	chr3	-	25647533	25647613			25642590	25642716	25648661	25648866	-0.32100	0.00001	0.00025	excluded	K562	U2AF1
SE	TOP2B	ENSG00000077097.9	chr3	-	25659908	25660000			25656963	25657077	25660144	25660340	-0.07300	0.00007	0.00376	excluded	HepG2	SF3A3
SE	TOP2B	ENSG00000077097.9	chr3	-	25659908	25660000			25656963	25657077	25660144	25660340	0.06300	0.00063	0.08816	included	K562	FXR2
SE	TOP2B	ENSG00000077097.9	chr3	-	25659908	25660000			25656963	25657077	25660144	25660340	-0.06000	0.00000	0.00001	excluded	K562	UTP18
SE	TOP2B	ENSG00000077097.9	chr3	-	25659908	25660000			25656963	25657077	25660144	25660340	-0.14500	0.00000	0.00000	excluded	K562	U2AF2
SE	TOP2B	ENSG00000077097.9	chr3	-	25659908	25660000			25656963	25657077	25660144	25660340	-0.08800	0.00000	0.00000	excluded	K562	RBM15
SE	TOP2B	ENSG00000077097.9	chr3	-	25659908	25660000			25656963	25657077	25660144	25660340	-0.06900	0.00000	0.00000	excluded	K562	AGGF1
A3SS	TOP2B	ENSG00000077097.9	chr3	-	25674183	25674318			25674183	25674285	25675331	25675505	0.08300	0.00000	0.00000	longer	K562	AQR
A3SS	TOP2B	ENSG00000077097.9	chr3	-	25640925	25641146			25640925	25641020	25642590	25642701	0.10200	0.00000	0.00000	longer	K562	AQR
A3SS	TOP2B	ENSG00000077097.9	chr3	-	25656921	25657094			25656921	25657077	25660144	25660358	0.69700	0.00000	0.00000	longer	K562	AQR
A3SS	TOP2B	ENSG00000077097.9	chr3	-	25666172	25666325			25666172	25666294	25668050	25668165	0.08300	0.00000	0.00000	longer	K562	AQR
MXE	TOP2B	ENSG00000077097.9	chr3	-	25660144	25660340	25661352	25661553	25656921	25657077	25662172	25662307	-0.10100	0.00000	0.00000	2included	K562	RBM15
MXE	TOP2B	ENSG00000077097.9	chr3	-	25660144	25660340	25661352	25661553	25656921	25657077	25662172	25662307	-0.13500	0.00000	0.00000	2included	K562	U2AF1
MXE	TOP2B	ENSG00000077097.9	chr3	-	25661352	25661553	25662172	25662307	25660144	25660340	25665005	25665237	0.13700	0.00063	0.02387	1included	K562	XRN2
MXE	TOP2B	ENSG00000077097.9	chr3	-	25679655	25679701	25679740	25679801	25678705	25678803	25685184	25685275	0.05200	0.00005	0.00062	1included	K562	AQR
MXE	TOP2B	ENSG00000077097.9	chr3	-	25659908	25660000	25660144	25660358	25656921	25657077	25661352	25661553	0.05100	0.00018	0.00207	1included	K562	AQR
MXE	TOP2B	ENSG00000077097.9	chr3	-	25660144	25660340	25661352	25661553	25656921	25657077	25662172	25662307	-0.06300	0.00000	0.00021	2included	K562	UTP18
MXE	TOP2B	ENSG00000077097.9	chr3	-	25660144	25660340	25661352	25661553	25656921	25657077	25662172	25662307	-0.05700	0.00029	0.01465	2included	HepG2	SF3A3
MXE	TOP2B	ENSG00000077097.9	chr3	-	25660144	25660340	25661352	25661553	25656921	25657077	25662172	25662307	-0.09900	0.00000	0.00000	2included	HepG2	U2AF2
MXE	TOP2B	ENSG00000077097.9	chr3	-	25642590	25642716	25646250	25646361	25640925	25641020	25647533	25647613	0.10700	0.00004	0.00297	1included	K562	FXR2
MXE	TOP2B	ENSG00000077097.9	chr3	-	25642590	25642716	25646250	25646361	25640925	25641020	25647533	25647613	-0.11500	0.00008	0.00411	2included	K562	HNRNPUL1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

TOP2B

General Information

Functions

Localization

Domains (AlphaFold: TOP2B)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for TOP2B is not avaliable on ENCORE database.

45 proteins are bound to TOP2B RNA:

eCLIP assay for TOP2B is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for TOP2B is not available on ENCORE database.

110 RBPs can affect the gene expression of TOP2B :

The Knockdown/knockout RNA-Seq assay for TOP2B is not available on ENCORE database.

13 RBPs can affect the splicing of TOP2B :

The Knockdown/knockout RNA-Seq assay for TOP2B is not avaliable on ENCORE database.