SOS1

General Information

Gene Name : SOS1
Gene ID : ENSG00000115904.12
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: SOS1)

Not Available

Antibody Validation

Not Avaiable

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	SOS1	ENSG00000115904.12	14.91	11.17	13.04	ENCSR000AEF
HepG2	SOS1	ENSG00000115904.12	14.88	25.83	20.36	ENCSR985KAT
K562	SOS1	ENSG00000115904.12	17.67	18.04	17.86	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

No Antibody Primary Validation image or Secondary image available

KD RNA-Seq

No KD RNA-Seq experiment available

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for SOS1 is not avaliable on ENCORE database.

Proteins bound to RNA

SOS1 RNA is bound by 41 proteins.

CanvasJS.com

eCLIP assay for SOS1 is not avaliable on ENCORE database.

41 proteins are bound to SOS1 RNA:

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Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr2	39250181	39250296	-	3'-UTR,CDS,intron-Distal,intron-Proximal	6.00577	76.29687	HepG2	BCLAF1
chr2	39281660	39281748	-	intron-Distal,intron-Proximal	5.07809	35.22016	K562	KHSRP
chr2	39251215	39251279	-	3'-UTR,CDS,intron-Distal,intron-Proximal	6.29295	33.68898	HepG2	BCLAF1
chr2	39251150	39251215	-	3'-UTR,CDS,intron-Distal,intron-Proximal	6.14036	30.69011	HepG2	BCLAF1
chr2	39233552	39233586	-	CDS,intron-Distal,intron-Proximal	4.81043	26.88857	HepG2	BCLAF1
chr2	39272315	39272407	-	intron-Distal	5.03431	25.93296	HepG2	HNRNPL
chr2	39249897	39249943	-	CDS,intron-Distal,intron-Proximal	4.82955	24.03603	HepG2	BCLAF1
chr2	39240652	39240704	-	CDS,intron-Distal	4.52505	23.50934	HepG2	BCLAF1
chr2	39337177	39337267	-	intron-Distal	3.38393	23.46218	HepG2	HNRNPL
chr2	39241006	39241046	-	CDS,intron-Distal,intron-Proximal	4.59311	22.71888	HepG2	BCLAF1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 172 entries

eCLIP assay for SOS1 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for SOS1 is not available on ENCORE database.
102 RBPs can affect the levels of SOS1.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for SOS1 is not available on ENCORE database.

102 RBPs can affect the gene expression of SOS1 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
SOS1	ENSG00000115904.8	1688.14720	3609.67460	-1.09640	54.74540	52.61230	HepG2	UTP3
SOS1	ENSG00000115904.8	1359.39740	2906.48370	-1.09630	46.90670	44.62850	K562	AGGF1
SOS1	ENSG00000115904.8	1347.99370	2922.37140	-1.11630	38.26560	35.97320	K562	RBM15
SOS1	ENSG00000115904.8	1358.23690	2999.46090	-1.14300	26.26510	24.58650	K562	PUS1
SOS1	ENSG00000115904.8	1494.61790	3024.30250	-1.01680	21.26920	19.12640	K562	AKAP8L
SOS1	ENSG00000115904.8	1768.39370	3934.71930	-1.15380	19.55410	18.27430	HepG2	AKAP1
SOS1	ENSG00000115904.8	1928.77580	2840.99290	-0.55870	18.91500	17.46510	HepG2	SMN1
SOS1	ENSG00000115904.8	1731.30300	2681.86650	-0.63140	17.74630	16.47820	HepG2	TRIM56
SOS1	ENSG00000115904.8	3108.53530	2102.70640	0.56390	17.71470	15.63950	K562	SRPK2
SOS1	ENSG00000115904.8	1947.61250	2980.65590	-0.61390	15.62840	14.34560	HepG2	CELF1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 124 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for SOS1 is not available on ENCORE database.

24 RBPs can affect the splicing of SOS1 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	SOS1	ENSG00000115904.8	chr2	-	39216410	39216455			39214613	39214732	39222263	39222528	0.23300	0.00000	0.00155	included	K562	TROVE2
SE	SOS1	ENSG00000115904.8	chr2	-	39216410	39216455			39214613	39214732	39222263	39222528	0.20200	0.00000	0.00004	included	K562	FMR1
SE	SOS1	ENSG00000115904.8	chr2	-	39216410	39216455			39214613	39214732	39222263	39222528	0.21700	0.00000	0.00029	included	HepG2	SUGP2
SE	SOS1	ENSG00000115904.8	chr2	-	39216410	39216455			39214613	39214732	39222263	39222528	0.16800	0.00000	0.00153	included	HepG2	RBM15
SE	SOS1	ENSG00000115904.8	chr2	-	39216410	39216455			39214613	39214732	39222263	39222528	0.30300	0.00000	0.00003	included	HepG2	SUPV3L1
SE	SOS1	ENSG00000115904.8	chr2	-	39216410	39216455			39214613	39214732	39222263	39222528	0.23300	0.00000	0.00322	included	HepG2	DROSHA
A3SS	SOS1	ENSG00000115904.8	chr2	-	39234171	39234356			39234171	39234334	39237724	39237885	0.23100	0.00000	0.00001	longer	K562	AQR
MXE	SOS1	ENSG00000115904.8	chr2	-	39216410	39216455	39222263	39222528	39214613	39214732	39224062	39224179	-0.38500	0.00000	0.00000	2included	HepG2	U2AF2
MXE	SOS1	ENSG00000115904.8	chr2	-	39216410	39216455	39222263	39222528	39214613	39214732	39224062	39224179	-0.32600	0.00000	0.00000	2included	HepG2	HNRNPUL1
SE	SOS1	ENSG00000115904.8	chr2	-	39216410	39216455			39214613	39214732	39222263	39222528	-0.28100	0.00001	0.00086	excluded	HepG2	PTBP1

Showing 1 to 10 of 30 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

SOS1

General Information

Functions

Localization

Domains (AlphaFold: SOS1)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for SOS1 is not avaliable on ENCORE database.

41 proteins are bound to SOS1 RNA:

eCLIP assay for SOS1 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for SOS1 is not available on ENCORE database.

102 RBPs can affect the gene expression of SOS1 :

The Knockdown/knockout RNA-Seq assay for SOS1 is not available on ENCORE database.

24 RBPs can affect the splicing of SOS1 :

The Knockdown/knockout RNA-Seq assay for SOS1 is not avaliable on ENCORE database.