CCT4

General Information

Gene Name : CCT4
Gene ID : ENSG00000115484.14
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: CCT4)

Not Available

Antibody Validation

View validation images for all CCT4 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	CCT4	ENSG00000115484.14	143.60	135.34	139.47	ENCSR000AEF
HepG2	CCT4	ENSG00000115484.14	157.72	239.74	198.73	ENCSR985KAT
K562	CCT4	ENSG00000115484.14	220.60	203.59	212.09	ENCSR000AEO

Assays

1 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	CCT4-BGKcLV28-K562	ENCSR995XEP	CCT4	K562	Released		ENCSR220DTX	CRISPR	KD% = 60.9,59.4

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
CCT4	ENCAB174YJK	A304-725A	1			Released, ENCODE4		BGKcLV28-7, Released, ENCODE4
CCT4	ENCAB744IBM	A304-726A	1			Released, ENCODE4

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
CCT4	K562	CRISPR	ENCSR995XEP	ENCSR220DTX	CCT4-BGKcLV28-7,CCT4-BGKcLV28-8	NT-BGKcLV28-1,NT-BGKcLV28-2	60.9,59.4	Released	ENCODE4
CCT4	HepG2	CRISPR			BGHcLV27-55,BGHcLV27-56	BGHcLV27-1,BGHcLV27-2	32.5,34.3	NotSatisfied	ENCODE4
CCT4	HepG2	CRISPR			BGHcLV36-9,BGHcLV36-10	BGHcLV36-1,BGHcLV36-2	0.0,0.0	NotSatisfied	ENCORE2

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
CCT4	Product_ID: A304-725A Lot_ID: 1 Source: Bethyl Labs Target Name: CCT4-human
CCT4	Product_ID: A304-726A Lot_ID: 1 Source: Bethyl Labs Target Name: CCT4-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for CCT4 is not avaliable on ENCORE database.

Proteins bound to RNA

CCT4 RNA is bound by 29 proteins.

CanvasJS.com

eCLIP assay for CCT4 is not avaliable on ENCORE database.

29 proteins are bound to CCT4 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr2	62107487	62107496	-	CDS,intron-Distal	6.83561	92.05287	K562	LIN28B
chr2	62115674	62115680	-	5'-UTR,intron-Distal,intron-Proximal	4.47478	87.32918	K562	YBX3
chr2	62115701	62115717	-	5'-UTR,intron-Distal,intron-Proximal	4.65269	86.33672	K562	YBX3
chr2	62095611	62095655	-	3'-UTR,intron-Distal,intron-Proximal	5.56977	82.96920	K562	PABPC4
chr2	62095665	62095740	-	3'-UTR,intron-Distal,intron-Proximal	6.70593	72.68942	HepG2	SUB1
chr2	62095782	62095831	-	3'-UTR,CDS,intron-Distal	4.76442	67.52863	K562	PABPC4
chr2	62107464	62107487	-	CDS,intron-Distal	6.20719	67.10975	K562	LIN28B
chr2	62107496	62107504	-	CDS,intron-Distal	6.77552	60.55832	K562	LIN28B
chr2	62115670	62115674	-	5'-UTR,intron-Distal,intron-Proximal	3.97398	55.19412	K562	YBX3
chr2	62115635	62115692	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.50336	41.06530	K562	DDX3X
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 107 entries

eCLIP assay for CCT4 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for CCT4 is not available on ENCORE database.
107 RBPs can affect the levels of CCT4.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for CCT4 is not available on ENCORE database.

107 RBPs can affect the gene expression of CCT4 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
CCT4	ENSG00000115484.10	2413.29230	5064.89240	-1.06950	38.18430	36.72140	HepG2	TIAL1
CCT4	ENSG00000115484.10	2004.25650	4717.29030	-1.23490	37.75980	35.91470	HepG2	HNRNPA1
CCT4	ENSG00000115484.10	5149.69670	7854.45810	-0.60900	30.32710	28.37290	HepG2	DAZAP1
CCT4	ENSG00000115484.10	5186.00730	7926.95870	-0.61210	24.41650	23.22960	HepG2	SSB
CCT4	ENSG00000115484.10	2903.91310	5247.09580	-0.85350	18.81410	17.17260	HepG2	HNRNPC
CCT4	ENSG00000115484.10	5555.84610	8000.30800	-0.52600	17.53440	16.19970	HepG2	RECQL
CCT4	ENSG00000115484.10	5352.87880	7718.43770	-0.52800	16.95980	15.82620	HepG2	PTBP1
CCT4	ENSG00000115484.10	4311.21720	7215.14870	-0.74290	17.23210	15.82230	K562	HNRNPC
CCT4	ENSG00000115484.10	3069.68960	5552.92530	-0.85520	16.67790	15.15710	HepG2	CPSF6
CCT4	ENSG00000115484.10	5483.57480	8359.25250	-0.60830	15.89980	14.57970	HepG2	QKI
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 129 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for CCT4 is not available on ENCORE database.

21 RBPs can affect the splicing of CCT4 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	CCT4	ENSG00000115484.10	chr2	-	62115158	62115392	62112154	62112207	62115515	62115748	0.07600	0.00000	0.00006	included	K562	AKAP8L
SE	CCT4	ENSG00000115484.10	chr2	-	62103229	62103444	62100336	62100428	62104054	62104187	-0.05200	0.00000	0.00000	excluded	K562	AQR
SE	CCT4	ENSG00000115484.10	chr2	-	62115158	62115392	62112154	62112207	62115515	62115748	0.14900	0.00000	0.00044	included	HepG2	SRSF7
SE	CCT4	ENSG00000115484.10	chr2	-	62115158	62115392	62112154	62112207	62115515	62115748	0.12300	0.00000	0.00000	included	K562	PUS1
SE	CCT4	ENSG00000115484.10	chr2	-	62115158	62115392	62112154	62112207	62115515	62115748	-0.53200	0.00000	0.00000	excluded	HepG2	SFPQ
SE	CCT4	ENSG00000115484.10	chr2	-	62115158	62115392	62112154	62112207	62115515	62115748	0.11100	0.00000	0.00016	included	K562	HNRNPL
SE	CCT4	ENSG00000115484.10	chr2	-	62115158	62115392	62112154	62112207	62115515	62115748	0.07300	0.00000	0.00018	included	K562	UTP18
SE	CCT4	ENSG00000115484.10	chr2	-	62115158	62115392	62112154	62112207	62115515	62115748	0.11400	0.00000	0.00000	included	K562	RBM15
SE	CCT4	ENSG00000115484.10	chr2	-	62115158	62115392	62112154	62112207	62115515	62115748	0.10700	0.00000	0.00000	included	K562	AGGF1
SE	CCT4	ENSG00000115484.10	chr2	-	62115158	62115392	62112154	62112207	62115515	62115748	-0.05200	0.00001	0.00048	excluded	HepG2	SRSF1

Showing 1 to 10 of 28 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

CCT4

General Information

Functions

Localization

Domains (AlphaFold: CCT4)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for CCT4 is not avaliable on ENCORE database.

29 proteins are bound to CCT4 RNA:

eCLIP assay for CCT4 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for CCT4 is not available on ENCORE database.

107 RBPs can affect the gene expression of CCT4 :

The Knockdown/knockout RNA-Seq assay for CCT4 is not available on ENCORE database.

21 RBPs can affect the splicing of CCT4 :

The Knockdown/knockout RNA-Seq assay for CCT4 is not avaliable on ENCORE database.