CRKL

General Information

Gene Name : CRKL
Gene ID : ENSG00000099942.12
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: CRKL)

Not Available

Antibody Validation

Cell Signaling Technology: 38710S

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	CRKL	ENSG00000099942.12	23.66	25.01	24.34	ENCSR000AEF
HepG2	CRKL	ENSG00000099942.12	29.55	31.47	30.51	ENCSR985KAT
K562	CRKL	ENSG00000099942.12	104.10	105.07	104.58	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
CRKL		38710S	1			Submitted, ENCORE2	BGHcLV43-11, Submitted, ENCORE2	BGKcLV42-19, Submitted, ENCORE2

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project	Note
CRKL	K562	CRISPR			CRKL-BGKcLV42-19,CRKL-BGKcLV42-20	NT-BGKcLV42-1,NT-BGKcLV42-2	87.2,84.8	Submitting	ENCORE2
CRKL	HepG2	CRISPR			CRKL-BGHcLV43-11,CRKL-BGHcLV43-12	NT-BGHcLV43-1,NT-BGHcLV43-2	87.5,89.4	Submitting	ENCORE2

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
CRKL	Product_ID: 38710S Lot_ID: 1 Source: Cell Signaling Technology Target Name: CRKL-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for CRKL is not avaliable on ENCORE database.

Proteins bound to RNA

CRKL RNA is bound by 34 proteins.

CanvasJS.com

eCLIP assay for CRKL is not avaliable on ENCORE database.

34 proteins are bound to CRKL RNA:

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Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr22	21306434	21306524	+	3'-UTR,intron-Distal	3.83779	400.00000	K562	UPF1
chr22	21304302	21304389	+	3'-UTR,intron-Distal,intron-Proximal	4.03844	400.00000	K562	PUM2
chr22	21306025	21306130	+	3'-UTR,intron-Distal	3.95277	400.00000	K562	UPF1
chr22	21307068	21307129	+	3'-UTR,intron-Distal	4.41925	400.00000	K562	UPF1
chr22	21305301	21305329	+	3'-UTR,intron-Distal	5.18593	87.79923	K562	UPF1
chr22	21305254	21305301	+	3'-UTR,intron-Distal	5.32587	82.22233	K562	UPF1
chr22	21306997	21307033	+	3'-UTR,intron-Distal	4.95495	78.54519	K562	UPF1
chr22	21288406	21288474	+	CDS	5.19098	76.00834	K562	IGF2BP2
chr22	21307941	21308024	+	3'-UTR	3.92117	73.52516	K562	PUM2
chr22	21306863	21306912	+	3'-UTR,intron-Distal	3.43113	72.05828	K562	UPF1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 188 entries

eCLIP assay for CRKL is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for CRKL is not available on ENCORE database.
142 RBPs can affect the levels of CRKL.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for CRKL is not available on ENCORE database.

142 RBPs can affect the gene expression of CRKL :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
CRKL	ENSG00000099942.8	1502.02070	3596.32600	-1.25960	85.17540	82.77180	HepG2	CKAP4
CRKL	ENSG00000099942.8	2092.14480	4168.13690	-0.99440	62.22800	60.19940	HepG2	PUM1
CRKL	ENSG00000099942.8	57519.06260	20769.52480	1.46950	58.19020	55.84460	K562	AQR
CRKL	ENSG00000099942.8	567.28900	1992.10580	-1.81210	45.45320	42.83430	HepG2	PRPF8
CRKL	ENSG00000099942.8	1217.16390	2356.16780	-0.95290	40.00200	38.05840	HepG2	ZC3H8
CRKL	ENSG00000099942.8	1763.68620	3088.03040	-0.80810	38.71930	36.81230	HepG2	SMN1
CRKL	ENSG00000099942.8	2602.38320	4384.62850	-0.75260	30.29970	29.10540	HepG2	SRSF1
CRKL	ENSG00000099942.8	1475.87330	2889.36800	-0.96920	27.77460	26.49500	HepG2	TIAL1
CRKL	ENSG00000099942.8	1733.85700	2973.41800	-0.77810	27.09930	25.36200	HepG2	HNRNPU
CRKL	ENSG00000099942.8	985.81350	2570.54400	-1.38270	27.07290	25.35510	HepG2	SUPV3L1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 170 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for CRKL is not available on ENCORE database.

2 RBPs can affect the splicing of CRKL :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	CRKL	ENSG00000099942.8	chr22	+	21288410	21288532			21271721	21272533	21303998	21304215	-0.06500	0.00000	0.00000	excluded	K562	AQR
A3SS	CRKL	ENSG00000099942.8	chr22	+	21288043	21288194			21288066	21288194	21271721	21272533	0.05600	0.00000	0.00000	longer	K562	AQR
MXE	CRKL	ENSG00000099942.8	chr22	+	21288043	21288194	21288410	21288532	21271721	21272533	21303998	21308037	0.06100	0.00000	0.00000	1included	K562	AQR
MXE	CRKL	ENSG00000099942.8	chr22	+	21288066	21288532	21303998	21304215	21271721	21272533	21307493	21308035	-0.05700	0.00000	0.00000	2included	K562	AQR
MXE	CRKL	ENSG00000099942.8	chr22	+	21303998	21304215	21305428	21305553	21288410	21288532	21307493	21308035	-0.10900	0.00000	0.00000	2included	K562	AQR
MXE	CRKL	ENSG00000099942.8	chr22	+	21303998	21304215	21305473	21305553	21288410	21288532	21307493	21308035	-0.11200	0.00000	0.00000	2included	K562	AQR
SE	CRKL	ENSG00000099942.8	chr22	+	21288066	21288194			21271721	21272533	21303998	21308037	-0.05100	0.00050	0.01199	excluded	K562	SF3B4

Showing 1 to 7 of 7 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

CRKL

General Information

Functions

Localization

Domains (AlphaFold: CRKL)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for CRKL is not avaliable on ENCORE database.

34 proteins are bound to CRKL RNA:

eCLIP assay for CRKL is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for CRKL is not available on ENCORE database.

142 RBPs can affect the gene expression of CRKL :

The Knockdown/knockout RNA-Seq assay for CRKL is not available on ENCORE database.

2 RBPs can affect the splicing of CRKL :

The Knockdown/knockout RNA-Seq assay for CRKL is not avaliable on ENCORE database.