POLR2B

General Information

Gene Name       : POLR2B
Gene ID             : ENSG00000047315.15
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: POLR2B)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878POLR2BENSG00000047315.1590.7576.6783.71ENCSR000AEF
HepG2POLR2BENSG00000047315.1560.8477.9669.40ENCSR985KAT
K562POLR2BENSG00000047315.1597.9593.8795.91ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for POLR2B is not avaliable on ENCORE database.



Proteins bound to RNA
  • POLR2B RNA is bound by 26 proteins.  







eCLIP assay for POLR2B is not avaliable on ENCORE database.





26 proteins are bound to POLR2B RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr45789717757897202+3'-UTR3.114095.01170K562KHSRP
chr45789718457897301+3'-UTR5.516689.76393HepG2SUB1
chr45789706457897184+3'-UTR,CDS,intron-Proximal4.251995.46178K562ZC3H11A
chr45789719657897255+3'-UTR3.850194.49052K562DDX6
chr45789720257897262+3'-UTR3.262518.86655K562KHSRP
chr45789720557897302+3'-UTR3.846624.13343HepG2FUBP3
chr45789710057897194+3'-UTR,CDS3.808574.59124HepG2FUBP3
chr45785251857852592+3'-UTR,5'-UTR,CDS,intron-Proximal4.802387.41350HepG2GRWD1
chr45784516257845191+5'-UTR,CDS,intron-Proximal3.775635.70278K562AQR
chr45785256357852583+5'-UTR,CDS3.837625.06180HepG2BCLAF1
chr45788388057883892+CDS3.061404.33023K562ZNF622
chr45787662657876671+CDS,intron-Proximal3.542166.70085HepG2PPIG
chr45788332457883408+CDS,intron-Proximal3.0536811.94287K562DDX24
chr45787725257877267+CDS,intron-Proximal3.654284.14015K562DDX24
chr45787300957873084+CDS3.351493.86151K562SRSF1
chr45787696057876997+CDS3.740165.56491HepG2BCLAF1
chr45786591857865942+CDS4.070616.22576HepG2BCLAF1
chr45786152857861571+CDS3.327426.97987K562ZNF622
chr45786092457860975+CDS3.055643.13141K562RBM15
chr45786090557860986+CDS3.299283.69775K562YBX3
chr45788325857883340+CDS3.952946.49445HepG2G3BP1
chr45788327557883343+CDS4.576523.43975HepG2LIN28B
chr45788324957883327+CDS3.3167110.35084HepG2BCLAF1
chr45787694157876976+CDS3.264095.75243K562ZNF622
chr45787141157871422+CDS,intron-Proximal3.872825.35703HepG2BCLAF1
chr45787145457871486+CDS3.042295.39278K562ZNF622
chr45787715257877210+CDS,intron-Proximal4.053615.79938K562LIN28B
chr45785691957856957+CDS,intron-Distal3.675416.06436HepG2BCLAF1
chr45787691357876933+CDS,intron-Proximal3.223453.32039HepG2PPIG
chr45786059157860652+CDS3.239359.04720K562ZNF622
chr45786076357860825+CDS,intron-Proximal3.729085.83621K562AQR
chr45787691457876960+CDS3.916003.86058K562GRWD1
chr45788837457888413+CDS,intron-Proximal4.293864.15208K562RBM15
chr45788167157881713+CDS4.074598.94445HepG2BCLAF1
chr45787663157876672+CDS,intron-Proximal3.292644.27260K562FXR2
chr45786082457860931+CDS3.113875.33987HepG2GRWD1
chr45785691857856955+CDS,intron-Distal3.041145.11643K562ZNF622
chr45786591957865948+CDS,intron-Proximal3.281203.54718K562PRPF8
chr45787299557873037+CDS3.884188.19556HepG2BCLAF1
chr45788321657883269+CDS3.821143.91115K562LIN28B
chr45788321557883280+CDS3.586588.56897K562DDX24
chr45787307857873138+CDS3.210353.60157HepG2GRWD1
chr45786139457861444+CDS,intron-Proximal4.513146.08688K562GPKOW
chr45786153357861573+CDS4.091524.51739HepG2BCLAF1
chr45787691457876924+CDS3.579164.74755K562ZNF622
chr45788329157883381+CDS4.5932716.02911K562LIN28B
chr45786574157865817+CDS,intron-Proximal3.746025.47851K562SF3B4
chr45788334057883408+CDS,intron-Proximal3.346484.96885HepG2G3BP1
chr45788370657883763+CDS,intron-Proximal3.569205.47851K562SF3B4
chr45786140257861451+CDS,intron-Proximal3.029183.49653K562PRPF8
chr45786080557860868+CDS,intron-Proximal3.373664.98422K562PRPF8
chr45789158857891630+CDS3.790956.42513K562YBX3
chr45786137557861460+CDS,intron-Proximal3.564918.81658K562BUD13
chr45788326957883291+CDS4.721874.78556K562LIN28B
chr45787302857873156+CDS3.915604.30147K562FXR1
chr45789017757890226+CDS4.266954.25741HepG2G3BP1
chr45787652657876625+CDS,intron-Proximal3.399894.65237HepG2U2AF2
chr45787716657877229+CDS3.427923.50786HepG2G3BP1
chr45788952957889585+CDS3.719843.02919K562GRWD1
chr45786135957861438+CDS,intron-Proximal3.642797.90194K562SF3B4
chr45788340657883416+CDS,intron-Proximal3.316577.02925K562AQR
chr45787305157873110+CDS3.962553.84295K562GRWD1
chr45787625157876340+intron-Distal3.775066.41553K562KHSRP
chr45784535557845408+intron-Distal3.829293.51089HepG2DGCR8
chr45784818857848249+intron-Distal4.209224.69074K562PTBP1
chr45784818057848254+intron-Distal3.935103.41738HepG2PTBP1
chr45787483057874958+intron-Distal4.303784.07830K562SRSF1
chr45786120457861347+intron-Distal,intron-Proximal4.7162317.49466K562KHSRP
chr45789118657891288+intron-Distal,intron-Proximal4.722177.17304K562KHSRP
chr45787608457876136+intron-Distal3.085543.49021K562U2AF2
chr45784535857845443+intron-Distal5.102845.67221K562DGCR8
chr45787636257876473+intron-Distal,intron-Proximal3.264243.81210HepG2KHSRP
chr45787190657871995+intron-Distal,intron-Proximal3.694065.95946K562KHSRP
chr45787710257877150+intron-Proximal4.820454.40745K562SF3B4
chr45784519157845207+intron-Proximal5.077075.26064K562AQR
chr45788701857887062+intron-Proximal4.861685.40008K562SF3B4
chr45787644957876500+intron-Proximal3.052685.42536K562KHSRP
chr45788341657883435+intron-Proximal4.8533410.08262K562AQR
chr45788977257889821+intron-Proximal4.658314.75425K562EFTUD2
chr45788343557883469+intron-Proximal4.9455611.65116K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for POLR2B is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for POLR2B is not available on ENCORE database.

  • 72 RBPs can affect the levels of POLR2B.  








The Knockdown/knockout RNA-Seq assay for POLR2B is not available on ENCORE database.





72 RBPs can affect the gene expression of POLR2B :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
POLR2BENSG00000047315.103019.201602561.199400.237203.586602.91050HepG2ACO1
POLR2BENSG00000047315.105380.226303420.112200.653507.277206.45900HepG2AKAP1
POLR2BENSG00000047315.103532.172204127.20700-0.224603.236602.50360HepG2AUH
POLR2BENSG00000047315.101817.961302343.18140-0.366102.461301.61440HepG2BCLAF1
POLR2BENSG00000047315.103263.723002688.596100.279602.031101.36230HepG2CIRBP
POLR2BENSG00000047315.101939.552802633.34970-0.441204.390003.54100HepG2CPSF6
POLR2BENSG00000047315.103039.870103734.22620-0.296806.467005.40100HepG2DAZAP1
POLR2BENSG00000047315.102016.177002328.34300-0.207702.047501.43210HepG2DNAJC21
POLR2BENSG00000047315.101762.203102307.66890-0.389108.514507.44630HepG2DNAJC2
POLR2BENSG00000047315.102133.799102705.60280-0.342502.537001.96910HepG2EIF2S1
POLR2BENSG00000047315.103981.627202911.054800.451703.027102.31050HepG2EIF4B
POLR2BENSG00000047315.104055.619004738.53170-0.224503.214002.57430HepG2ETF1
POLR2BENSG00000047315.103673.714302807.882400.387703.096702.28680HepG2FIP1L1
POLR2BENSG00000047315.102131.828802985.20110-0.485704.368403.57580HepG2GPKOW
POLR2BENSG00000047315.101834.872902614.62330-0.510906.474205.44960HepG2HNRNPC
POLR2BENSG00000047315.102332.399003167.47990-0.441509.450008.22290HepG2HNRNPF
POLR2BENSG00000047315.102968.219803401.63360-0.196603.159702.44260HepG2HNRNPL
POLR2BENSG00000047315.102101.570702597.33980-0.305604.810204.02900HepG2HNRNPU
POLR2BENSG00000047315.102294.806903119.05380-0.442706.527005.45790HepG2IGF2BP1
POLR2BENSG00000047315.103923.711602844.675000.463904.666903.80980HepG2IGF2BP2
POLR2BENSG00000047315.102098.691002653.10310-0.338207.528606.38310HepG2ILF2
POLR2BENSG00000047315.102047.051002905.22460-0.505103.189802.14330HepG2MTPAP
POLR2BENSG00000047315.102061.380402525.95900-0.293202.397101.69900HepG2NSUN2
POLR2BENSG00000047315.103131.708102747.027700.189002.228201.67260HepG2PCBP1
POLR2BENSG00000047315.101606.914902316.62620-0.527709.830008.48580HepG2PPIL4
POLR2BENSG00000047315.104428.166403752.147400.238904.734204.00200HepG2PUM1
POLR2BENSG00000047315.103469.486102601.656700.415201.943401.34230HepG2RAVER1
POLR2BENSG00000047315.104860.752503960.547000.295404.469103.85210HepG2RBM22
POLR2BENSG00000047315.102563.548103412.29710-0.412604.755403.89170HepG2RPLP0
POLR2BENSG00000047315.101759.391302313.06830-0.394707.977306.96910HepG2SAFB2
POLR2BENSG00000047315.104039.018502994.843900.431402.794802.11760HepG2SF3A3
POLR2BENSG00000047315.103770.871002910.142200.373707.473606.57940HepG2SF3B4
POLR2BENSG00000047315.102794.556803389.09380-0.278305.469504.53980HepG2SLBP
POLR2BENSG00000047315.105614.922704473.312100.327807.800207.07700HepG2SRFBP1
POLR2BENSG00000047315.106047.978803037.583000.9934057.4506055.91650HepG2SRSF1
POLR2BENSG00000047315.103942.491703489.903700.175801.995801.45310HepG2SRSF5
POLR2BENSG00000047315.102381.428203111.97790-0.386007.602806.54240HepG2SRSF7
POLR2BENSG00000047315.102799.250302471.256800.179702.139601.64160HepG2SRSF9
POLR2BENSG00000047315.102113.707002776.47200-0.393503.787102.95430HepG2TARDBP
POLR2BENSG00000047315.101300.432102523.94300-0.9567025.8922024.65330HepG2TIAL1
POLR2BENSG00000047315.101704.411202546.35270-0.5792015.0305013.86620HepG2TRIM56
POLR2BENSG00000047315.103283.629302402.189200.450804.976104.14740HepG2U2AF1
POLR2BENSG00000047315.102887.518602564.231400.171201.842901.33220HepG2UTP3
POLR2BENSG00000047315.101931.521202598.13660-0.427703.564502.74990HepG2XRN2
POLR2BENSG00000047315.105451.026004711.312300.210303.275602.66740K562AGGF1
POLR2BENSG00000047315.105712.122604902.360800.220501.851001.31190K562AKAP8L
POLR2BENSG00000047315.108980.008907443.324300.270702.371501.82160K562AQR
POLR2BENSG00000047315.103744.780704486.46620-0.260704.254103.04630K562BCLAF1
POLR2BENSG00000047315.101369.899801929.92350-0.494504.993203.48130K562CCAR1
POLR2BENSG00000047315.103710.727604357.79860-0.231902.248301.53410K562CPSF6
POLR2BENSG00000047315.102837.201003403.65240-0.262603.211202.06150K562CSTF2
POLR2BENSG00000047315.101666.853602160.43890-0.374203.100401.69040K562DHX30
POLR2BENSG00000047315.106559.099905275.123200.314205.399904.12230K562DKC1
POLR2BENSG00000047315.103373.333604000.53420-0.246003.414202.05720K562EIF2S1
POLR2BENSG00000047315.104932.744705738.17400-0.218202.779702.05900K562EIF2S2
POLR2BENSG00000047315.102870.323303805.08990-0.406704.593703.53680K562EIF4A3
POLR2BENSG00000047315.107956.328609314.23310-0.227302.948101.97960K562EIF4G2
POLR2BENSG00000047315.104006.674905109.18820-0.350703.564902.59280K562FIP1L1
POLR2BENSG00000047315.105081.773103957.134200.360806.639905.75980K562FXR1
POLR2BENSG00000047315.106075.010004471.758400.441903.173002.40740K562G3BP2
POLR2BENSG00000047315.103423.205904160.65640-0.281502.562601.79680K562GPKOW
POLR2BENSG00000047315.105336.355907646.66000-0.519008.795907.42930K562GRSF1
POLR2BENSG00000047315.104245.180805035.20780-0.246202.401701.40420K562HNRNPA1
POLR2BENSG00000047315.102296.688003650.15660-0.668408.968507.94500K562HNRNPC
POLR2BENSG00000047315.102639.543503259.11970-0.304202.509501.43240K562HNRNPF
POLR2BENSG00000047315.104800.961505575.97820-0.215902.443201.60330K562HNRNPU
POLR2BENSG00000047315.106422.364005202.536100.303803.222002.32580K562KIF1C
POLR2BENSG00000047315.104550.751705388.06480-0.243702.283401.45230K562MATR3
POLR2BENSG00000047315.104012.221804761.38610-0.247004.197203.21890K562MTPAP
POLR2BENSG00000047315.106012.813804085.131700.557602.797001.90790K562NAA15
POLR2BENSG00000047315.104385.102205290.31360-0.270707.552006.40380K562NSUN2
POLR2BENSG00000047315.104665.334105800.10810-0.314102.839402.00710K562PPIG
POLR2BENSG00000047315.104907.457303733.530100.394304.262303.33320K562PRPF8
POLR2BENSG00000047315.102359.576603272.61570-0.471903.261502.26740K562PSIP1
POLR2BENSG00000047315.108998.8282010591.26110-0.235103.113802.09800K562PUM2
POLR2BENSG00000047315.108411.394604861.605300.7908015.0796013.85290K562PUS1
POLR2BENSG00000047315.106178.761904737.060600.383206.870605.96400K562RBM15
POLR2BENSG00000047315.102452.148502985.20140-0.283802.758401.77060K562RCC2
POLR2BENSG00000047315.105749.888004650.360300.306103.847002.83330K562SF3B4
POLR2BENSG00000047315.102235.205902829.95710-0.340403.086901.98960K562SRFBP1
POLR2BENSG00000047315.107446.864605141.781200.534309.904608.58270K562SRSF1
POLR2BENSG00000047315.102571.700603397.62500-0.401804.991903.50710K562SRSF4
POLR2BENSG00000047315.104024.334004855.56960-0.270902.257801.32770K562SRSF5
POLR2BENSG00000047315.104240.293503436.551300.303103.632602.69270K562SYNCRIP
POLR2BENSG00000047315.103870.848605019.94840-0.375004.935103.79400K562TIA1
POLR2BENSG00000047315.102115.257303147.78610-0.573506.385804.90600K562TIAL1
POLR2BENSG00000047315.102530.637403343.40560-0.401804.361603.11250K562TRIM56
POLR2BENSG00000047315.105525.252804335.169800.349902.412601.40220K562U2AF1
POLR2BENSG00000047315.104796.503805609.43280-0.225903.803502.97390K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for POLR2B is not available on ENCORE database.





4 RBPs can affect the splicing of POLR2B :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPOLR2BENSG00000047315.10chr4+5787477257874956578729815787316857876526578766700.087000.000000.00000includedK562AQR
SEPOLR2BENSG00000047315.10chr4+578762095787636657874818578749565787652657876670-0.742000.000000.00007excludedK562AQR
SEPOLR2BENSG00000047315.10chr4+578883175788841257886992578871615788949557889746-0.060000.000000.00000excludedK562AQR
SEPOLR2BENSG00000047315.10chr4+578901705789019257889827578899175789105157891165-0.106000.001580.01795excludedK562AQR
SEPOLR2BENSG00000047315.10chr4+578514455785162357845034578451705785251957852592-0.085000.000300.06094excludedK562FXR2
SEPOLR2BENSG00000047315.10chr4+5785142557851623578450615784517057852519578525920.071000.000000.00002includedK562HNRNPC
A3SSPOLR2BENSG00000047315.10chr4+5786137057861575578614165786157557860812578610320.058000.000000.00000longerK562AQR
A3SSPOLR2BENSG00000047315.10chr4+5789151157891703578915425789170357891031578911650.083000.000000.00000longerK562AQR
MXEPOLR2BENSG00000047315.10chr4+57874772578749565787622057876366578729815787316857876526578766700.659000.000010.000091includedK562AQR
MXEPOLR2BENSG00000047315.10chr4+57889495578897465788982757889917578870645788716157890170578902780.058000.000000.000001includedK562AQR
MXEPOLR2BENSG00000047315.10chr4+57872981578731685787715457877266578717655787188557881667578818220.090000.004470.032631includedK562AQR
MXEPOLR2BENSG00000047315.10chr4+5787294257873168578748185787495657871765578718855787652657876670-0.146000.000000.000002includedK562AQR
MXEPOLR2BENSG00000047315.10chr4+5787298157873168578748185787495657871765578718855787652657876670-0.074000.000000.000002includedK562AQR
MXEPOLR2BENSG00000047315.10chr4+5785251957852592578569135785706457845108578451705786056957860682-0.143000.000000.000232includedHepG2SF3A3

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for POLR2B is not avaliable on ENCORE database.