METTL6

General Information

Gene Name : METTL6
Gene ID : ENSG00000206562.11
Essential Gene : No

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: METTL6)

Not Available

Antibody Validation

Not Avaiable

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	METTL6	ENSG00000206562.11	18.52	14.66	16.59	ENCSR000AEF
HepG2	METTL6	ENSG00000206562.11	13.00	20.75	16.88	ENCSR985KAT
K562	METTL6	ENSG00000206562.11	19.35	23.23	21.29	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

No Antibody Primary Validation image or Secondary image available

KD RNA-Seq

No KD RNA-Seq experiment available

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for METTL6 is not avaliable on ENCORE database.

Proteins bound to RNA

METTL6 RNA is bound by 2 proteins.

eCLIP assay for METTL6 is not avaliable on ENCORE database.

2 proteins are bound to METTL6 RNA:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr3	15452462	15452544	-	3'-UTR,intron-Distal,intron-Proximal	4.29697	4.93188	HepG2	UPF1
chr3	15466460	15466595	-	CDS,intron-Distal,intron-Proximal	3.46412	3.94979	HepG2	BCLAF1
chr3	15452312	15452371	-	intron-Distal	4.51345	4.93188	HepG2	UPF1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

eCLIP assay for METTL6 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for METTL6 is not available on ENCORE database.
22 RBPs can affect the levels of METTL6.

The Knockdown/knockout RNA-Seq assay for METTL6 is not available on ENCORE database.

22 RBPs can affect the gene expression of METTL6 :

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
METTL6	ENSG00000206562.7	483.75660	343.89110	0.49220	2.37960	1.88180	HepG2	AKAP1
METTL6	ENSG00000206562.7	296.72120	185.98500	0.67380	3.73620	3.05140	HepG2	BOP1
METTL6	ENSG00000206562.7	148.18230	222.83770	-0.58860	2.98150	2.25630	HepG2	DNAJC21
METTL6	ENSG00000206562.7	159.84830	220.86770	-0.46650	2.26280	1.66020	HepG2	DNAJC2
METTL6	ENSG00000206562.7	194.18080	281.38340	-0.53510	2.35380	1.73710	HepG2	G3BP1
METTL6	ENSG00000206562.7	173.77430	248.58520	-0.51650	2.78380	2.17420	HepG2	HNRNPU
METTL6	ENSG00000206562.7	197.61370	278.15420	-0.49320	2.08590	1.45090	HepG2	PABPC4
METTL6	ENSG00000206562.7	158.87390	221.71830	-0.48080	2.22350	1.55570	HepG2	PPIL4
METTL6	ENSG00000206562.7	206.87990	280.90020	-0.44130	1.92370	1.35250	HepG2	RBM25
METTL6	ENSG00000206562.7	358.35340	264.41050	0.43850	1.91250	1.34930	HepG2	SF3A3
METTL6	ENSG00000206562.7	438.53140	310.56610	0.49770	3.64770	3.12350	HepG2	SRSF1
METTL6	ENSG00000206562.7	299.62970	196.71780	0.60700	2.53110	1.57700	HepG2	SRSF3
METTL6	ENSG00000206562.7	180.58870	243.70610	-0.43240	2.11310	1.60790	HepG2	TRIM56
METTL6	ENSG00000206562.7	364.50260	221.15890	0.72070	4.27380	3.50230	HepG2	U2AF1
METTL6	ENSG00000206562.7	694.39780	431.44730	0.68650	7.81070	6.79210	K562	DDX47
METTL6	ENSG00000206562.7	375.46000	199.98780	0.90860	8.55750	7.56420	K562	FXR1
METTL6	ENSG00000206562.7	411.61850	276.66530	0.57310	3.25160	2.23560	K562	HNRNPM
METTL6	ENSG00000206562.7	740.99930	455.94920	0.70050	6.73960	5.50720	K562	HSPD1
METTL6	ENSG00000206562.7	1012.26570	622.02520	0.70240	8.10060	6.69970	K562	PUF60
METTL6	ENSG00000206562.7	415.86950	236.90020	0.81180	3.95030	2.97110	K562	RPS19
METTL6	ENSG00000206562.7	357.79540	238.85810	0.58290	3.86550	2.89310	K562	SYNCRIP
METTL6	ENSG00000206562.7	399.10430	314.78820	0.34230	2.22740	1.46110	K562	WDR43
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for METTL6 is not available on ENCORE database.

18 RBPs can affect the splicing of METTL6 :

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	METTL6	ENSG00000206562.7	chr3	-	15457004	15457090			15455527	15455669	15457278	15457449	-0.10900	0.00376	0.06046	excluded	HepG2	U2AF1
SE	METTL6	ENSG00000206562.7	chr3	-	15457004	15457090			15455527	15455669	15457278	15457449	0.41600	0.00008	0.02700	included	K562	PCBP1
SE	METTL6	ENSG00000206562.7	chr3	-	15457004	15457090			15455527	15455669	15457278	15457449	-0.17400	0.00304	0.03550	excluded	HepG2	U2AF2
SE	METTL6	ENSG00000206562.7	chr3	-	15457004	15457090			15455527	15455669	15457278	15457449	-0.24800	0.00215	0.07017	excluded	K562	FXR1
SE	METTL6	ENSG00000206562.7	chr3	-	15457004	15457090			15455527	15455669	15457278	15457449	0.43500	0.00003	0.00081	included	K562	PUS1
SE	METTL6	ENSG00000206562.7	chr3	-	15457004	15457090			15455527	15455669	15457278	15457449	0.36100	0.00009	0.01346	included	HepG2	DDX6
SE	METTL6	ENSG00000206562.7	chr3	-	15457004	15457090			15455527	15455669	15457278	15457449	-0.24600	0.00000	0.00015	excluded	HepG2	SRSF1
SE	METTL6	ENSG00000206562.7	chr3	-	15457004	15457090			15455527	15455669	15457278	15457449	-0.26000	0.00001	0.00046	excluded	HepG2	SF3A3
SE	METTL6	ENSG00000206562.7	chr3	-	15457004	15457090			15455527	15455669	15457278	15457449	0.28800	0.00034	0.01185	included	K562	AGGF1
SE	METTL6	ENSG00000206562.7	chr3	-	15456236	15456421			15455527	15455669	15457004	15457164	0.55400	0.00312	0.09142	included	HepG2	HNRNPC
A3SS	METTL6	ENSG00000206562.7	chr3	-	15455527	15455709			15455527	15455669	15457278	15457449	0.19000	0.00024	0.00194	longer	K562	AQR
A3SS	METTL6	ENSG00000206562.7	chr3	-	15452751	15452976			15452751	15452944	15455527	15455709	0.09600	0.00915	0.04900	longer	K562	AQR
MXE	METTL6	ENSG00000206562.7	chr3	-	15455527	15455669	15457004	15457090	15452836	15452944	15457278	15457449	-0.17500	0.00010	0.00342	2included	HepG2	SRSF1
MXE	METTL6	ENSG00000206562.7	chr3	-	15455527	15455687	15457004	15457164	15452836	15452944	15457278	15457449	0.11200	0.00327	0.05069	1included	K562	PUS1
MXE	METTL6	ENSG00000206562.7	chr3	-	15455527	15455687	15457004	15457090	15452836	15452944	15457278	15457449	0.47300	0.00000	0.00001	1included	K562	PUS1
MXE	METTL6	ENSG00000206562.7	chr3	-	15455527	15455669	15457004	15457164	15452836	15452944	15457278	15457449	0.09700	0.00243	0.04037	1included	K562	PUS1
MXE	METTL6	ENSG00000206562.7	chr3	-	15455527	15455669	15457004	15457090	15452836	15452944	15457278	15457449	0.41000	0.00000	0.00000	1included	K562	PUS1
MXE	METTL6	ENSG00000206562.7	chr3	-	15455527	15455687	15457004	15457090	15452836	15452944	15457278	15457449	0.46000	0.00000	0.00000	1included	K562	AGGF1
MXE	METTL6	ENSG00000206562.7	chr3	-	15455527	15455669	15457004	15457090	15452836	15452944	15457278	15457449	0.35900	0.00000	0.00000	1included	K562	AGGF1
MXE	METTL6	ENSG00000206562.7	chr3	-	15455321	15455452	15455527	15455669	15452523	15452944	15457278	15457449	-0.09600	0.00030	0.01528	2included	K562	AGGF1
MXE	METTL6	ENSG00000206562.7	chr3	-	15455321	15455452	15455527	15455687	15452523	15452944	15457278	15457449	-0.16400	0.00011	0.00687	2included	K562	AGGF1
MXE	METTL6	ENSG00000206562.7	chr3	-	15455527	15455687	15457004	15457090	15452836	15452944	15457278	15457449	0.22500	0.00135	0.06440	1included	K562	UTP18
MXE	METTL6	ENSG00000206562.7	chr3	-	15455527	15455669	15457004	15457090	15452836	15452944	15457278	15457449	0.18600	0.00092	0.05162	1included	K562	UTP18
MXE	METTL6	ENSG00000206562.7	chr3	-	15455527	15455669	15457004	15457090	15452836	15452944	15457278	15457449	-0.15400	0.00057	0.02422	2included	HepG2	SF3A3
MXE	METTL6	ENSG00000206562.7	chr3	-	15455527	15455669	15457004	15457090	15452836	15452944	15457278	15457449	0.31600	0.00003	0.01054	1included	K562	PCBP1
MXE	METTL6	ENSG00000206562.7	chr3	-	15455527	15455669	15457004	15457090	15452836	15452944	15457278	15457449	0.11800	0.00043	0.00995	1included	HepG2	HNRNPUL1
MXE	METTL6	ENSG00000206562.7	chr3	-	15455321	15455452	15455527	15455604	15452523	15452944	15457004	15457090	0.13200	0.00125	0.03551	1included	K562	PPIL4
MXE	METTL6	ENSG00000206562.7	chr3	-	15455527	15455669	15457004	15457090	15452836	15452944	15457278	15457449	-0.08300	0.00465	0.08055	2included	K562	PPIL4
MXE	METTL6	ENSG00000206562.7	chr3	-	15455527	15455669	15457004	15457090	15452836	15452944	15457278	15457449	0.22900	0.00122	0.03155	1included	HepG2	HNRNPK
MXE	METTL6	ENSG00000206562.7	chr3	-	15455527	15455669	15457004	15457090	15452836	15452944	15457278	15457449	0.21600	0.00241	0.08903	1included	K562	IGF2BP2
MXE	METTL6	ENSG00000206562.7	chr3	-	15455527	15455669	15457004	15457090	15452836	15452944	15457278	15457449	0.23000	0.00161	0.07172	1included	HepG2	DDX6
MXE	METTL6	ENSG00000206562.7	chr3	-	15455527	15455669	15457004	15457090	15452836	15452944	15457278	15457449	-0.24400	0.00197	0.04466	2included	K562	FXR2
MXE	METTL6	ENSG00000206562.7	chr3	-	15455527	15455687	15457004	15457090	15452836	15452944	15457278	15457449	0.26900	0.00039	0.02070	1included	K562	AKAP8L
MXE	METTL6	ENSG00000206562.7	chr3	-	15455527	15455669	15457004	15457090	15452836	15452944	15457278	15457449	0.16500	0.00305	0.08990	1included	K562	AKAP8L

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

METTL6

General Information

Functions

Localization

Domains (AlphaFold: METTL6)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for METTL6 is not avaliable on ENCORE database.

2 proteins are bound to METTL6 RNA:

eCLIP assay for METTL6 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for METTL6 is not available on ENCORE database.

22 RBPs can affect the gene expression of METTL6 :

The Knockdown/knockout RNA-Seq assay for METTL6 is not available on ENCORE database.

18 RBPs can affect the splicing of METTL6 :

The Knockdown/knockout RNA-Seq assay for METTL6 is not avaliable on ENCORE database.