TSC2

General Information

Gene Name : TSC2
Gene ID : ENSG00000103197.17
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: TSC2)

Not Available

Antibody Validation

Not Avaiable

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	TSC2	ENSG00000103197.17	3.08	15.47	9.28	ENCSR000AEF
HepG2	TSC2	ENSG00000103197.17	49.69	22.09	35.89	ENCSR985KAT
K562	TSC2	ENSG00000103197.17	25.86	18.67	22.27	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

No Antibody Primary Validation image or Secondary image available

KD RNA-Seq

No KD RNA-Seq experiment available

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for TSC2 is not avaliable on ENCORE database.

Proteins bound to RNA

TSC2 RNA is bound by 36 proteins.

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eCLIP assay for TSC2 is not avaliable on ENCORE database.

36 proteins are bound to TSC2 RNA:

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Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr16	2127822	2127898	+	intron-Distal,intron-Proximal	6.96369	71.50072	HepG2	RBFOX2
chr16	2127782	2127822	+	intron-Distal,intron-Proximal	5.57571	51.51257	HepG2	RBFOX2
chr16	2128136	2128228	+	intron-Distal	5.01957	35.66154	HepG2	RBFOX2
chr16	2114054	2114136	+	intron-Distal	4.69753	28.72628	HepG2	DKC1
chr16	2128968	2129027	+	intron-Proximal	5.45325	23.50044	HepG2	SF3B4
chr16	2108091	2108291	+	intron-Distal	4.53920	21.88020	HepG2	RBFOX2
chr16	2127727	2127782	+	intron-Distal,intron-Proximal	4.35146	20.15917	HepG2	RBFOX2
chr16	2128131	2128240	+	intron-Distal	5.15884	20.06228	HepG2	PRPF4
chr16	2124360	2124432	+	3'-UTR,CDS,intron-Proximal	4.44369	19.76015	HepG2	PRPF8
chr16	2131541	2131613	+	3'-UTR,CDS,intron-Proximal	6.61716	18.74766	K562	SF3B4
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 196 entries

eCLIP assay for TSC2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for TSC2 is not available on ENCORE database.
94 RBPs can affect the levels of TSC2.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for TSC2 is not available on ENCORE database.

94 RBPs can affect the gene expression of TSC2 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
TSC2	ENSG00000103197.12	1592.22980	758.32020	1.07010	30.96980	29.12530	HepG2	HNRNPU
TSC2	ENSG00000103197.12	1619.65150	736.70540	1.13640	29.18670	27.87810	HepG2	TIAL1
TSC2	ENSG00000103197.12	1928.92850	1013.60460	0.92820	29.40100	27.65960	HepG2	SRSF5
TSC2	ENSG00000103197.12	1313.22670	743.44600	0.82070	19.97230	18.63200	HepG2	TRIM56
TSC2	ENSG00000103197.12	1191.00620	675.29500	0.81850	19.70450	18.20680	HepG2	SAFB2
TSC2	ENSG00000103197.12	1601.48230	984.34080	0.70210	18.99620	17.46770	HepG2	SLBP
TSC2	ENSG00000103197.12	2018.59130	1026.58060	0.97540	18.13190	16.78680	HepG2	PUF60
TSC2	ENSG00000103197.12	1820.75550	1152.74270	0.65940	17.46620	16.12060	HepG2	SUCLG1
TSC2	ENSG00000103197.12	1642.18050	1089.76550	0.59150	15.08450	13.92810	HepG2	PUM1
TSC2	ENSG00000103197.12	2752.01570	1821.33550	0.59540	14.02900	12.69360	HepG2	AUH
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 103 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for TSC2 is not available on ENCORE database.

5 RBPs can affect the splicing of TSC2 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	TSC2	ENSG00000103197.12	chr16	+	2127598	2127727	2126491	2126586	2129032	2129197	0.70300	0.00000	0.00003	included	HepG2	U2AF1
SE	TSC2	ENSG00000103197.12	chr16	+	2127598	2127727	2126491	2126586	2129032	2129197	0.70000	0.00000	0.00002	included	HepG2	U2AF2
SE	TSC2	ENSG00000103197.12	chr16	+	2127598	2127727	2126491	2126586	2129032	2129197	-0.22200	0.00000	0.00037	excluded	HepG2	DDX55
A3SS	TSC2	ENSG00000103197.12	chr16	+	2136732	2136872	2136767	2136872	2136240	2136380	-0.25400	0.00001	0.00075	shorter	HepG2	U2AF2
SE	TSC2	ENSG00000103197.12	chr16	+	2127598	2127727	2126491	2126586	2129032	2129197	0.24000	0.00026	0.05814	included	HepG2	PRPF4
SE	TSC2	ENSG00000103197.12	chr16	+	2127598	2127727	2126491	2126586	2129032	2129197	0.40000	0.00028	0.00685	included	K562	U2AF2
A3SS	TSC2	ENSG00000103197.12	chr16	+	2136732	2136872	2136767	2136872	2136193	2136380	-0.19500	0.00122	0.04714	shorter	HepG2	U2AF1
SE	TSC2	ENSG00000103197.12	chr16	+	2110953	2111040	2110670	2110814	2111871	2112009	-0.09100	0.00131	0.04598	excluded	K562	HNRNPU

Showing 1 to 8 of 8 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

TSC2

General Information

Functions

Localization

Domains (AlphaFold: TSC2)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for TSC2 is not avaliable on ENCORE database.

36 proteins are bound to TSC2 RNA:

eCLIP assay for TSC2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for TSC2 is not available on ENCORE database.

94 RBPs can affect the gene expression of TSC2 :

The Knockdown/knockout RNA-Seq assay for TSC2 is not available on ENCORE database.

5 RBPs can affect the splicing of TSC2 :

The Knockdown/knockout RNA-Seq assay for TSC2 is not avaliable on ENCORE database.