DNMT1

General Information

Gene Name : DNMT1
Gene ID : ENSG00000130816.15
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: DNMT1)

Not Available

Antibody Validation

Thermo Fisher: PA1-880

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	DNMT1	ENSG00000130816.15	83.18	93.05	88.12	ENCSR000AEF
HepG2	DNMT1	ENSG00000130816.15	73.48	71.18	72.33	ENCSR985KAT
K562	DNMT1	ENSG00000130816.15	117.96	121.56	119.76	ENCSR000AEO

Assays

1 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	DNMT1-BGKcLV13-K562	ENCSR600OWF	DNMT1	K562	Released		ENCSR712CQC	CRISPR	KD% = 85.6,78.0

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
DNMT1	ENCAB197TCQ	PA1-880	SH257771					BGKcLV13-19, Released, ENCODE4

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
DNMT1	K562	CRISPR	ENCSR600OWF	ENCSR712CQC	DNMT1-BGKcLV13-19,DNMT1-BGKcLV13-20	NT-BGKcLV13-1,NT-BGKcLV13-2	85.6,78.0	Released	ENCODE4
DNMT1	K562	CRISPR			BGKcLV13-21,BGKcLV13-22	BGKcLV13-1,BGKcLV13-2		NotSatisfied	ENCODE4
DNMT1	K562	CRISPR			BGKcLV13-23,BGKcLV13-24	BGKcLV13-1,BGKcLV13-2		NotSatisfied	ENCODE4
DNMT1	HepG2	CRISPR			BGHcLV14-19,BGHcLV14-20	BGHcLV14-1,BGHcLV14-2	no band on the position,	NotSatisfied	ENCODE4
DNMT1	HepG2	CRISPR			BGHcLV14-21,BGHcLV14-22	BGHcLV14-1,BGHcLV14-2	no band on the position,	NotSatisfied	ENCODE4
DNMT1	HepG2	CRISPR			BGHcLV14-23,BGHcLV14-24	BGHcLV14-1,BGHcLV14-2	no band on the position,	NotSatisfied	ENCODE4

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
DNMT1	Product_ID: PA1-880 Lot_ID: SH257771 Source: Thermo Fisher Target Name: DNMT1-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for DNMT1 is not avaliable on ENCORE database.

Proteins bound to RNA

DNMT1 RNA is bound by 36 proteins.

CanvasJS.com

eCLIP assay for DNMT1 is not avaliable on ENCORE database.

36 proteins are bound to DNMT1 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr19	10277182	10277275	-	5'-UTR,CDS,intron-Distal,intron-Proximal	6.10659	41.64569	K562	AQR
chr19	10254567	10254663	-	3'-UTR,CDS,intron-Distal,intron-Proximal	5.45589	34.23481	K562	LIN28B
chr19	10270519	10270599	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.90103	34.01825	K562	PUM1
chr19	10244218	10244279	-	3'-UTR,intron-Distal	7.46697	33.11451	HepG2	SUB1
chr19	10262068	10262170	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.61810	30.66434	K562	UCHL5
chr19	10244170	10244218	-	3'-UTR,intron-Distal,intron-Proximal	6.37619	30.21106	HepG2	SUB1
chr19	10292661	10292793	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.36089	25.85319	K562	AQR
chr19	10284538	10284582	-	3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal	3.22611	25.58867	K562	AQR
chr19	10273994	10274082	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.46506	21.96791	K562	AQR
chr19	10277367	10277434	-	intron-Distal,intron-Proximal	5.74327	21.68248	K562	SF3B4
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 317 entries

eCLIP assay for DNMT1 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for DNMT1 is not available on ENCORE database.
134 RBPs can affect the levels of DNMT1.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for DNMT1 is not available on ENCORE database.

134 RBPs can affect the gene expression of DNMT1 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
DNMT1	ENSG00000130816.10	1287.69850	3632.78150	-1.49630	102.41360	100.48080	HepG2	SRFBP1
DNMT1	ENSG00000130816.10	1287.36650	3216.43200	-1.32100	57.73270	55.97300	HepG2	RBM22
DNMT1	ENSG00000130816.10	1497.57500	2943.31000	-0.97480	51.79390	50.19780	HepG2	ZNF622
DNMT1	ENSG00000130816.10	1490.39870	3154.00970	-1.08150	51.71340	50.18030	HepG2	SSB
DNMT1	ENSG00000130816.10	982.43560	2887.59430	-1.55540	48.14500	46.14870	HepG2	RPLP0
DNMT1	ENSG00000130816.10	2546.30650	1247.01490	1.02980	41.67100	40.31330	HepG2	SRSF1
DNMT1	ENSG00000130816.10	1229.19720	3521.45230	-1.51850	41.09230	39.11120	HepG2	HNRNPLL
DNMT1	ENSG00000130816.10	1325.30360	3485.48460	-1.39500	39.60140	37.33200	HepG2	SF3B1
DNMT1	ENSG00000130816.10	3243.54670	7716.24310	-1.25030	36.76810	34.82950	K562	AQR
DNMT1	ENSG00000130816.10	1242.88460	2306.47640	-0.89200	36.50410	34.71790	HepG2	CKAP4
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 166 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for DNMT1 is not available on ENCORE database.

10 RBPs can affect the splicing of DNMT1 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	DNMT1	ENSG00000130816.10	chr19	-	10244892	10244983	10244215	10244377	10246411	10246528	-0.36700	0.00000	0.00000	excluded	HepG2	U2AF1
A3SS	DNMT1	ENSG00000130816.10	chr19	-	10250351	10250525	10250351	10250493	10250721	10250923	0.09900	0.00000	0.00104	longer	K562	EFTUD2
A3SS	DNMT1	ENSG00000130816.10	chr19	-	10286215	10286452	10286215	10286294	10287967	10288043	0.07800	0.00000	0.00011	longer	K562	U2AF2
A3SS	DNMT1	ENSG00000130816.10	chr19	-	10246796	10247034	10246796	10246963	10247760	10247956	0.14400	0.00000	0.00000	longer	K562	AQR
A3SS	DNMT1	ENSG00000130816.10	chr19	-	10244215	10244432	10244215	10244377	10244892	10244983	0.06100	0.00000	0.00000	longer	K562	AQR
A3SS	DNMT1	ENSG00000130816.10	chr19	-	10260528	10260721	10260528	10260644	10262073	10262373	0.05900	0.00003	0.00210	longer	K562	PUS1
SE	DNMT1	ENSG00000130816.10	chr19	-	10290862	10290910	10287967	10288043	10291025	10291245	0.17700	0.00005	0.00847	included	K562	XRCC6
SE	DNMT1	ENSG00000130816.10	chr19	-	10290862	10290910	10287967	10288043	10291025	10291245	0.18800	0.00013	0.00351	included	K562	HNRNPC
SE	DNMT1	ENSG00000130816.10	chr19	-	10290862	10290910	10287967	10288043	10291025	10291245	0.23100	0.00021	0.04945	included	HepG2	XRCC6
SE	DNMT1	ENSG00000130816.10	chr19	-	10290862	10290910	10287967	10288043	10291025	10291205	-0.12300	0.00035	0.01669	excluded	K562	HNRNPU

Showing 1 to 10 of 15 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

DNMT1

General Information

Functions

Localization

Domains (AlphaFold: DNMT1)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for DNMT1 is not avaliable on ENCORE database.

36 proteins are bound to DNMT1 RNA:

eCLIP assay for DNMT1 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for DNMT1 is not available on ENCORE database.

134 RBPs can affect the gene expression of DNMT1 :

The Knockdown/knockout RNA-Seq assay for DNMT1 is not available on ENCORE database.

10 RBPs can affect the splicing of DNMT1 :

The Knockdown/knockout RNA-Seq assay for DNMT1 is not avaliable on ENCORE database.