XRCC5

General Information

Gene Name : XRCC5
Gene ID : ENSG00000079246.15
Essential Gene : Yes

Functions

Novel RBP

Localization(RBPImage: XRCC5)

Nuclei
Nucleoplasm
Nuclear release mitosis

Domains (AlphaFold: XRCC5)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

View validation images for all XRCC5 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	XRCC5	ENSG00000079246.15	371.02	337.63	354.32	ENCSR000AEF
HepG2	XRCC5	ENSG00000079246.15	259.77	355.53	307.65	ENCSR985KAT
K562	XRCC5	ENSG00000079246.15	181.72	194.69	188.20	ENCSR000AEO

Assays

3 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Controls	Method	Note
knockdown followed by RNA-seq	XRCC5-BGKLV13-K562	ENCSR715XZS	XRCC5	K562	Released	ENCSR815CVQ	shRNA	KD% = 27.6,35.1
knockdown followed by RNA-seq	XRCC5-BGHLV14-HepG2	ENCSR732IYM	XRCC5	HepG2	Released	ENCSR491FOC	shRNA	KD% = 56.1,48.1
knockdown followed by RNA-seq	XRCC5-BGKcLV11-K562	ENCSR276GMG	XRCC5	K562	Released	ENCSR292PXV	CRISPR	KD% = 69.5,70.8

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
XRCC5	ENCAB457QLP	A302-627A	1	Released, ENCODE3	Released, ENCODE3	BGHLV14-67, Released, ENCODE3	BGKcLV11-111, Released, ENCODE4
XRCC5	ENCAB308AOH	201004	DD0729	Released, ENCODE3	Released, ENCODE3	BGHLV14-67, Released, ENCODE3
XRCC5		2180S	1	Released, ENCODE3	Submitted, ENCORE2	BGHLV14-67, Released, ENCODE3	BGKcLV11-107, Submitted, ENCORE2

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
XRCC5	K562	shRNA	ENCSR715XZS	ENCSR815CVQ	XRCC5_BGKLV13_35,XRCC5_BGKLV13_36	NT_BGKLV13_1,NT_BGKLV13_2	27.6,35.1	Released	ENCODE3
XRCC5	HepG2	shRNA	ENCSR732IYM	ENCSR491FOC	XRCC5_BGHLV14-67,XRCC5_BGHLV14-68	NT_BGHLV14-1,NT_BGHLV14-2	56.1,48.1	Released	ENCODE3
XRCC5	K562	CRISPR			BGKcLV06-43,BGKcLV06-44	BGKcLV06-1,BGKcLV06-2	no clear band,	NotSatisfied	ENCODE3
XRCC5	K562	CRISPR			BGKcLV11-107,BGKcLV11-108	BGKcLV11-1,BGKcLV11-2	39.0,49.5	NotSatisfied	ENCODE4
XRCC5	K562	CRISPR			BGKcLV11-109,BGKcLV11-110	BGKcLV11-1,BGKcLV11-2	0.0,0.0	NotSatisfied	ENCODE4
XRCC5	K562	CRISPR	ENCSR276GMG	ENCSR292PXV	XRCC5-BGKcLV11-111,XRCC5-BGKcLV11-112	NT-BGKcLV11-1,NT-BGKcLV11-2	69.5,70.8	Released	ENCODE4
XRCC5	HepG2	CRISPR			BGHcLV07-43,BGHcLV07-44	BGHcLV07-1,BGHcLV07-2	no clear band,	NotSatisfied	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

XRCC5: Click to RBP Image Database

Nuclei

Nucleoplasm

Nuclear release mitosis

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
XRCC5	Product_ID: A302-627A Lot_ID: 1 Source: Bethyl Labs Target Name: XRCC5-human
XRCC5	Product_ID: 201004 Lot_ID: DD0729 Source: Zen Bioscience Target Name: XRCC5-human
XRCC5	Product_ID: 2180S Lot_ID: 1 Source: Cell Signaling Technology Target Name: XRCC5-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for XRCC5 is not avaliable on ENCORE database.

Proteins bound to RNA

XRCC5 RNA is bound by 47 proteins.

CanvasJS.com

eCLIP assay for XRCC5 is not avaliable on ENCORE database.

47 proteins are bound to XRCC5 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr2	217069910	217069986	+	3'-UTR,CDS,intron-Proximal	4.53289	50.67664	K562	PABPC4
chr2	216974204	216974277	+	intron-Proximal	5.52148	47.56023	HepG2	EFTUD2
chr2	217070143	217070168	+	3'-UTR,polyA_site	4.96196	40.92581	K562	PABPC4
chr2	216974281	216974351	+	intron-Distal	5.21877	40.54322	HepG2	EFTUD2
chr2	217070317	217070368	+	3'-UTR	6.68424	38.33139	HepG2	SUB1
chr2	216995604	216995648	+	CDS	3.89905	38.20393	HepG2	BCLAF1
chr2	217017796	217017828	+	intron-Distal	7.19428	37.30088	HepG2	QKI
chr2	216992385	216992398	+	CDS,intron-Proximal	4.30062	36.19427	HepG2	BCLAF1
chr2	217017776	217017796	+	intron-Distal	7.12668	35.67161	HepG2	QKI
chr2	217070165	217070234	+	3'-UTR	7.56246	29.52619	HepG2	SUB1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 260 entries

eCLIP assay for XRCC5 is not avaliable on ENCORE database.

Diffrential Expression

1,538 differentially expressed genes after Knockdown/Knockout XRCC5 protein.

CanvasJS.com

119 RBPs can affect the levels of XRCC5.

CanvasJS.com

1,538 differentially expressed genes after Knockdown/Knockout XRCC5 protein :

Only display 100 entries as example. Please click "View All" button to see all 1,538 entries.

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
MTHFD2	ENSG00000065911.7	3178.99520	1531.31530	1.05370	12.12140	9.50810	HepG2	XRCC5
ASB4	ENSG00000005981.8	255.16900	73.64720	1.79270	11.85820	9.27480	HepG2	XRCC5
PPP2R5A	ENSG00000066027.7	1461.65250	675.95660	1.11250	11.66610	9.09690	HepG2	XRCC5
KITLG	ENSG00000049130.9	456.36180	172.90430	1.40010	11.26520	8.77870	HepG2	XRCC5
ACSM2B	ENSG00000066813.10	123.47610	403.54930	-1.70850	11.12700	8.65290	HepG2	XRCC5
CDH1	ENSG00000039068.14	442.23800	979.70600	-1.14750	11.10760	8.64910	HepG2	XRCC5
ITIH1	ENSG00000055957.6	129.18070	362.36020	-1.48800	10.53420	8.18820	HepG2	XRCC5
ELOVL5	ENSG00000012660.9	1278.18360	2487.94910	-0.96090	10.02310	7.73710	HepG2	XRCC5
PHLPP2	ENSG00000040199.14	1004.14950	517.18430	0.95710	8.21340	6.10220	HepG2	XRCC5
CYP24A1	ENSG00000019186.5	658.49330	327.98370	1.00540	7.76770	5.71150	HepG2	XRCC5
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

119 RBPs can affect the gene expression of XRCC5 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
XRCC5	ENSG00000079246.11	3931.01830	8724.39450	-1.15020	80.21360	77.10920	K562	MTPAP
XRCC5	ENSG00000079246.11	14035.02410	7338.69170	0.93530	64.32620	62.73200	HepG2	SRSF1
XRCC5	ENSG00000079246.11	4373.90770	9143.79850	-1.06390	41.07330	39.56760	HepG2	TIAL1
XRCC5	ENSG00000079246.11	3675.03220	9550.85360	-1.37790	39.83340	37.88190	HepG2	HNRNPLL
XRCC5	ENSG00000079246.11	5168.06650	8360.60560	-0.69400	39.52960	37.32070	HepG2	DNAJC2
XRCC5	ENSG00000079246.11	5380.78370	9225.22250	-0.77780	37.05590	35.29190	HepG2	TRIM56
XRCC5	ENSG00000079246.11	6562.85990	11273.10670	-0.78050	36.85650	34.91090	HepG2	SRSF7
XRCC5	ENSG00000079246.11	7040.33450	11474.37300	-0.70470	29.57100	27.62000	HepG2	HNRNPF
XRCC5	ENSG00000079246.11	8902.62850	13060.22910	-0.55290	28.22320	26.33320	HepG2	DAZAP1
XRCC5	ENSG00000079246.11	11387.20730	7515.58300	0.59940	23.08510	21.82280	HepG2	NELFE
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 154 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for XRCC5 is not available on ENCORE database.

5 RBPs can affect the splicing of XRCC5 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	XRCC5	ENSG00000079246.11	chr2	+	216975189	216975274			216974073	216974180	216977738	216977825	0.05800	0.00000	0.00000	included	K562	PRPF8
SE	XRCC5	ENSG00000079246.11	chr2	+	216975189	216975274			216974073	216974180	216977738	216977825	0.05600	0.00000	0.00000	included	K562	AQR
SE	XRCC5	ENSG00000079246.11	chr2	+	216975189	216975274			216974073	216974180	216977738	216977825	0.06500	0.00000	0.00000	included	K562	EFTUD2
SE	XRCC5	ENSG00000079246.11	chr2	+	216975189	216975274			216974073	216974180	216977738	216977852	0.08000	0.00000	0.00000	included	HepG2	SF3A3
A3SS	XRCC5	ENSG00000079246.11	chr2	+	216981360	216981565			216981381	216981565	216977687	216977852	0.05200	0.00000	0.00000	longer	K562	AQR
MXE	XRCC5	ENSG00000079246.11	chr2	+	216975189	216975274	216977738	216977825	216974041	216974180	216982463	216982517	0.09100	0.00000	0.00000	1included	HepG2	SF3A3
MXE	XRCC5	ENSG00000079246.11	chr2	+	217054947	217055057	217059641	217059709	217026701	217026771	217069044	217069119	-0.06700	0.02039	0.09388	2included	HepG2	U2AF2

Showing 1 to 7 of 7 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

XRCC5

General Information

Functions

Localization(RBPImage: XRCC5)

Domains (AlphaFold: XRCC5)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for XRCC5 is not avaliable on ENCORE database.

47 proteins are bound to XRCC5 RNA:

eCLIP assay for XRCC5 is not avaliable on ENCORE database.

Diffrential Expression

1,538 differentially expressed genes after Knockdown/Knockout XRCC5 protein :

119 RBPs can affect the gene expression of XRCC5 :

The Knockdown/knockout RNA-Seq assay for XRCC5 is not available on ENCORE database.

5 RBPs can affect the splicing of XRCC5 :

The Knockdown/knockout RNA-Seq assay for XRCC5 is not avaliable on ENCORE database.