PPIL4

General Information

Gene Name : PPIL4
Gene ID : ENSG00000131013.3
Essential Gene : No

Functions

Novel RBP

Localization(RBPImage: PPIL4)

Nuclei
Mutually Exclusive from Nucleolus
Speckles
Cytoplasm
Cytosolic
Nuclear release mitosis

Domains (AlphaFold: PPIL4)

RRM

Antibody Validation

GeneTex: GTX117014

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	PPIL4	ENSG00000131013.3	22.01	17.20	19.61	ENCSR000AEF
HepG2	PPIL4	ENSG00000131013.3	21.44	44.16	32.80	ENCSR985KAT
K562	PPIL4	ENSG00000131013.3	25.22	30.89	28.05	ENCSR000AEO

Assays

3 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 414	ENCSR197INS	PPIL4	K562	Released	ENCAB535ZKU	ENCSR346IHS
knockdown followed by RNA-seq	PPIL4-BGKLV24-K562	ENCSR556FNN	PPIL4	K562	Released		ENCSR419JMU	shRNA	KD% = 87.2,88.6
knockdown followed by RNA-seq	PPIL4-BGHLV20-HepG2	ENCSR851KEX	PPIL4	HepG2	Released		ENCSR305XWT	shRNA	KD% = 79.1,79.7

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
PPIL4	414	K562	ENCSR197INS	ENCSR346IHS	ENCAB535ZKU	GTX117014	40555	Released	ENCODE3

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
PPIL4	ENCAB535ZKU	GTX117014	40555			Released, ENCODE3	BGHLV20-51, Released, ENCODE3	BGKLV24-45, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
PPIL4	K562	shRNA	ENCSR556FNN	ENCSR419JMU	PPIL4_BGKLV24_45B,PPIL4_BGKLV24_46B	non-target_BGKLV24_1B,non-target_BGKLV24_2B	87.2,88.6	Released	ENCODE3
PPIL4	K562	shRNA			BGKLV40-11,BGKLV40-12	BGKLV40-1,BGKLV40-2	59.0,73.0	Others	ENCODE4
PPIL4	HepG2	shRNA	ENCSR851KEX	ENCSR305XWT	PPIL4-BGHLV20-51_17732,PPIL4-BGHLV20-52_17733	non-target-BGHLV20-1_17706,non-target-BGHLV20-2_17707	79.1,79.7	Released	ENCODE3
PPIL4	HepG2	shRNA			BGHLV39-11,BGHLV39-12	BGHLV39-1,BGHLV39-2	58.0,64.0	Others	ENCODE4

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

PPIL4: Click to RBP Image Database

Nuclei

Mutually Exclusive from Nucleolus

Speckles

Cytoplasm

Cytosolic

Nuclear release mitosis

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
PPIL4	Product_ID: GTX117014 Lot_ID: 40555 Source: GeneTex Target Name: PPIL4-human

RNA Targets

PPIL4 protein binds to 511 RNA regions.

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Proteins bound to RNA

PPIL4 RNA is bound by 20 proteins.

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PPIL4 protein has 511 RNA targets:

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
PPIL4	chr4	174253189	174253220	-	3.13528	25.48213	K562	HMGB2	3'-UTR,intron-Distal
PPIL4	chr7	120887653	120887789	+	5.66111	14.87763	K562	CPED1	intron-Distal
PPIL4	chr18	75689364	75689494	-	4.90486	13.23387	K562	LINC01029	intron-Distal
PPIL4	chr7	119434094	119434171	-	3.78486	12.30035	K562	RP11-328J2.1	intron-Distal
PPIL4	chr9	134079683	134079806	+	3.69459	11.88593	K562	NUP214	intron-Distal
PPIL4	chr7	119435635	119435722	-	3.80810	11.63547	K562	RP11-328J2.1	intron-Distal
PPIL4	chr7	119435562	119435624	-	3.72575	9.37187	K562	RP11-328J2.1	intron-Distal
PPIL4	chr7	120888076	120888183	+	3.09632	8.39392	K562	CPED1	intron-Distal
PPIL4	chr11	62290627	62290700	-	3.21990	8.31722	K562	AHNAK	CDS,intron-Distal
PPIL4	chr3	6616933	6616989	+	3.95284	7.97676	K562	AC069277.2	intron-Distal

Showing 1 to 10 of 100 entries

20 proteins are bound to PPIL4 RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr6	149838111	149838162	-	intron-Distal	7.92803	32.28370	K562	LSM11
chr6	149866541	149866670	-	intron-Distal	5.34926	27.43407	K562	HNRNPM
chr6	149866813	149866866	-	intron-Distal	4.75874	26.14663	K562	HNRNPM
chr6	149866187	149866285	-	intron-Distal	4.72046	25.77435	K562	EXOSC5
chr6	149866813	149866892	-	intron-Distal	5.67881	25.27817	HepG2	HNRNPM
chr6	149866757	149866813	-	intron-Distal	4.82536	22.24161	K562	HNRNPM
chr6	149866555	149866675	-	intron-Distal	4.81178	20.30836	HepG2	HNRNPM
chr6	149854592	149854627	-	CDS,intron-Distal,intron-Proximal	5.29347	17.23395	HepG2	BCLAF1
chr6	149866565	149866635	-	intron-Distal	4.13140	15.09791	K562	EXOSC5
chr6	149838106	149838160	-	intron-Distal	4.78009	14.21295	K562	TIA1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 79 entries

No autoregularoty interactions between protein PPIL4 and its RNA.

Diffrential Expression

5,718 differentially expressed genes after Knockdown/Knockout PPIL4 protein.

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75 RBPs can affect the levels of PPIL4.

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5,718 differentially expressed genes after Knockdown/Knockout PPIL4 protein :

Only display 100 entries as example. Please click "View All" button to see all 5,718 entries.

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
PKD1	ENSG00000008710.13	842.40800	277.81760	1.60030	40.99610	38.36980	HepG2	PPIL4
MLXIPL	ENSG00000009950.11	3243.31530	1168.80880	1.47230	37.99300	35.53190	HepG2	PPIL4
WIZ	ENSG00000011451.13	664.86620	266.44280	1.31910	25.55510	23.48200	HepG2	PPIL4
ARHGAP33	ENSG00000004777.14	379.60700	116.55890	1.70330	25.07450	23.03600	HepG2	PPIL4
TMEM132A	ENSG00000006118.10	837.07020	376.75280	1.15160	23.73210	21.74450	HepG2	PPIL4
ASB4	ENSG00000005981.8	34.12380	192.62860	-2.49700	23.40680	21.43370	HepG2	PPIL4
PLEKHG6	ENSG00000008323.11	378.02280	162.88120	1.21460	14.76200	13.13560	HepG2	PPIL4
CRLF1	ENSG00000006016.6	4518.70180	2761.93480	0.71010	14.65120	13.03040	HepG2	PPIL4
RECQL	ENSG00000004700.11	349.21020	653.43930	-0.90400	13.29270	11.74820	HepG2	PPIL4
CX3CL1	ENSG00000006210.6	2163.11500	1217.02860	0.82960	12.62140	11.11210	HepG2	PPIL4
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

75 RBPs can affect the gene expression of PPIL4 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
PPIL4	ENSG00000131013.3	329.49440	825.29010	-1.32460	29.22950	27.04980	HepG2	PPIL4
PPIL4	ENSG00000131013.3	553.92060	1382.67510	-1.31970	20.60810	18.95120	HepG2	CPSF6
PPIL4	ENSG00000131013.3	916.38610	1522.90580	-0.73280	17.57260	15.78310	K562	MTPAP
PPIL4	ENSG00000131013.3	864.72520	2195.10290	-1.34400	18.01240	13.91920	K562	PPIL4
PPIL4	ENSG00000131013.3	3047.84190	1713.57320	0.83070	13.77380	12.60690	K562	PUS1
PPIL4	ENSG00000131013.3	2262.25050	1550.87990	0.54460	13.15390	12.27750	HepG2	SRFBP1
PPIL4	ENSG00000131013.3	491.01530	1012.52580	-1.04410	13.63220	11.44490	K562	TIAL1
PPIL4	ENSG00000131013.3	867.23160	1373.12440	-0.66300	11.39260	10.49380	HepG2	RBM22
PPIL4	ENSG00000131013.3	844.82740	1239.83750	-0.55340	9.79720	8.62130	HepG2	UPF1
PPIL4	ENSG00000131013.3	2295.06950	1660.59870	0.46670	9.41660	8.44880	K562	AGGF1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 89 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

659 alternative splicing events after Knockdown/Knockout PPIL4 protein :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	SREK1	ENSG00000153914.11	chr5	+	65454636	65454760	65449290	65449424	65455046	65455162	0.12600	0.00170	included	K562	PPIL4
SE	YME1L1	ENSG00000136758.14	chr10	-	27431315	27431414	27425204	27425314	27434356	27434519	0.09600	0.00266	included	K562	PPIL4
SE	ACIN1	ENSG00000100813.10	chr14	-	23559190	23559310	23550956	23551045	23559730	23559842	0.17500	0.00342	included	K562	PPIL4
SE	HNRNPD	ENSG00000138668.14	chr4	-	83276047	83276154	83274986	83275307	83276456	83276554	0.09500	0.00000	included	K562	PPIL4
SE	CLK1	ENSG00000013441.11	chr2	-	201724847	201724938	201724402	201724469	201725960	201726189	0.22900	0.00198	included	K562	PPIL4
SE	ZFAND6	ENSG00000086666.14	chr15	+	80390757	80390920	80351909	80352151	80412669	80412840	0.29800	0.00005	included	K562	PPIL4
SE	NUP62	ENSG00000213024.6	chr19	-	50430950	50431072	50412230	50413141	50432582	50432761	0.22300	0.00000	included	K562	PPIL4
SE	HNRNPC	ENSG00000092199.13	chr14	-	21731825	21731988	21731469	21731495	21737456	21737584	0.19100	0.00000	included	K562	PPIL4
SE	BRD8	ENSG00000112983.13	chr5	-	137499775	137499822	137498818	137499033	137500008	137500102	0.09600	0.00000	included	K562	PPIL4
SE	DTWD1	ENSG00000104047.10	chr15	+	49923152	49923255	49917309	49917628	49924355	49924499	0.13200	0.00483	included	K562	PPIL4

Showing 1 to 10 of 100 entries

6 RBPs can affect the splicing of PPIL4 :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
A3SS	PPIL4	ENSG00000131013.3	chr6	-	149846278	149846369			149846278	149846345	149847787	149847947	0.14500	0.00000	0.00000	longer	K562	AQR
SE	PPIL4	ENSG00000131013.3	chr6	-	149863214	149863290			149862654	149862722	149867071	149867174	0.05200	0.00003	0.03838	included	K562	ZRANB2
MXE	PPIL4	ENSG00000131013.3	chr6	-	149862502	149862567	149862654	149862722	149862077	149862195	149867071	149867174	-0.12400	0.00025	0.00270	2included	K562	AQR
MXE	PPIL4	ENSG00000131013.3	chr6	-	149838177	149838220	149838489	149838630	149833206	149833438	149842195	149842307	-0.05200	0.00032	0.00339	2included	K562	AQR
SE	PPIL4	ENSG00000131013.3	chr6	-	149863214	149863253			149862654	149862722	149867071	149867174	0.07700	0.00077	0.01827	included	K562	U2AF1
SE	PPIL4	ENSG00000131013.3	chr6	-	149862654	149862722			149862502	149862567	149867071	149867174	-0.07200	0.00132	0.02807	excluded	K562	U2AF1
MXE	PPIL4	ENSG00000131013.3	chr6	-	149833290	149833415	149842195	149842307	149825868	149826840	149846278	149846345	-0.19300	0.00166	0.04426	2included	HepG2	TIAL1
MXE	PPIL4	ENSG00000131013.3	chr6	-	149833290	149833415	149842195	149842307	149825868	149826840	149846278	149846345	-0.10600	0.00342	0.02227	2included	HepG2	U2AF2
MXE	PPIL4	ENSG00000131013.3	chr6	-	149833290	149833415	149842195	149842307	149825868	149826840	149846278	149846345	-0.08500	0.00865	0.07201	2included	HepG2	SFPQ

Showing 1 to 9 of 9 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

PPIL4

General Information

Functions

Localization(RBPImage: PPIL4)

Domains (AlphaFold: PPIL4)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

PPIL4 protein has 511 RNA targets:

20 proteins are bound to PPIL4 RNA:

No autoregularoty interactions between protein PPIL4 and its RNA.

Diffrential Expression

5,718 differentially expressed genes after Knockdown/Knockout PPIL4 protein :

75 RBPs can affect the gene expression of PPIL4 :

659 alternative splicing events after Knockdown/Knockout PPIL4 protein :

6 RBPs can affect the splicing of PPIL4 :

No autoregularoty alternative splicing events between protein PPIL4 and its RNA.