PPP2R2A

General Information

Gene Name       : PPP2R2A
Gene ID             : ENSG00000221914.9
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: PPP2R2A)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PPP2R2AENSG00000221914.953.6545.0249.34ENCSR000AEF
HepG2PPP2R2AENSG00000221914.915.2231.3623.29ENCSR985KAT
K562PPP2R2AENSG00000221914.942.1249.6245.87ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PPP2R2A is not avaliable on ENCORE database.



Proteins bound to RNA
  • PPP2R2A RNA is bound by 37 proteins.  







eCLIP assay for PPP2R2A is not avaliable on ENCORE database.





37 proteins are bound to PPP2R2A RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr82622819626228280+3'-UTR3.649304.29472K562IGF2BP1
chr82622851026228598+3'-UTR3.523415.35486K562UPF1
chr82622851926228574+3'-UTR4.293605.42839K562PABPC4
chr82622798326228072+3'-UTR5.0524510.95701HepG2SUB1
chr82622792126227981+3'-UTR,CDS4.276734.24698K562IGF2BP1
chr82622834626228429+3'-UTR3.076515.57830K562TIA1
chr82622815826228219+3'-UTR3.247143.26079K562UPF1
chr82622786926227958+3'-UTR,CDS3.6380713.17743K562PUM2
chr82622801426228056+3'-UTR3.379124.51400K562ZC3H11A
chr82614905826149143+5'-UTR3.3036910.35530K562ZNF622
chr82614904226149084+5'-UTR3.904453.02919K562GRWD1
chr82614916426149262+5'-UTR,intron-Proximal4.461235.13929K562PCBP1
chr82615112826151237+5'-UTR,CDS,intron-Distal,intron-Proximal3.3863813.75848K562SF3B4
chr82614922426149351+5'-UTR,CDS,intron-Distal,intron-Proximal3.536688.43531K562ZNF622
chr82614947126149537+5'-UTR,intron-Distal,intron-Proximal4.224724.11564K562U2AF2
chr82614904126149147+5'-UTR4.197878.13071HepG2NCBP2
chr82614947526149544+5'-UTR,intron-Distal,intron-Proximal4.0711312.89733K562EFTUD2
chr82614948126149543+5'-UTR,intron-Distal,intron-Proximal3.722315.36788K562U2AF1
chr82615117126151246+5'-UTR,CDS,intron-Distal,intron-Proximal3.951939.72693K562U2AF2
chr82614904026149150+5'-UTR4.8526713.04528K562DDX3X
chr82614946726149535+5'-UTR,intron-Distal,intron-Proximal3.886683.15816HepG2PRPF4
chr82615117626151272+5'-UTR,CDS,intron-Distal,intron-Proximal4.377004.90586K562SRSF1
chr82622026026220311+CDS3.133594.44630K562ZNF622
chr82622027726220297+CDS3.746816.76362K562YBX3
chr82622118726221261+CDS,intron-Proximal4.152283.25089HepG2AQR
chr82622036226220454+CDS,intron-Proximal5.7286320.15911K562AQR
chr82617215226172202+intron-Distal4.614795.01910HepG2MATR3
chr82616743726167535+intron-Distal3.130163.38830K562ILF3
chr82617244226172479+intron-Distal3.456076.31916HepG2SUGP2
chr82617592226176051+intron-Distal3.2941910.25162K562KHSRP
chr82618315026183246+intron-Distal3.9331812.83520K562KHSRP
chr82615168526151762+intron-Distal4.2876518.23076K562EXOSC5
chr82617651526176578+intron-Distal3.442834.23286HepG2QKI
chr82615229826152358+intron-Distal4.0359315.32462K562EXOSC5
chr82617170826171756+intron-Distal4.272247.80398HepG2SUGP2
chr82615198126152028+intron-Distal4.861835.37406HepG2HNRNPM
chr82617747226177544+intron-Distal3.706984.61282K562EXOSC5
chr82617285926172942+intron-Distal5.2631717.30891HepG2SUGP2
chr82617332726173372+intron-Distal3.040273.86754HepG2SUGP2
chr82619630026196376+intron-Distal,intron-Proximal3.396876.26686K562SF3B4
chr82615223526152292+intron-Distal3.7470910.63003HepG2HNRNPM
chr82615171726151752+intron-Distal3.380343.68481HepG2HNRNPM
chr82617180326171877+intron-Distal3.190746.97013HepG2SUGP2
chr82615145226151504+intron-Distal,intron-Proximal3.591629.44666K562EXOSC5
chr82617202026172093+intron-Distal4.991317.51321HepG2MATR3
chr82618382526183920+intron-Distal3.6573011.27125K562RBFOX2
chr82614961626149676+intron-Distal,intron-Proximal3.821664.95247K562PRPF8
chr82615357526153660+intron-Distal4.7431912.98973K562MATR3
chr82615196726152027+intron-Distal3.5057112.47579K562EXOSC5
chr82618246926182558+intron-Distal4.503164.67790K562CPSF6
chr82618830926188436+intron-Distal4.462094.66899HepG2HNRNPM
chr82620642526206507+intron-Distal3.622136.04886K562KHSRP
chr82618300626183063+intron-Distal3.6701610.31216K562KHSRP
chr82617299526173040+intron-Distal4.559775.51760K562MATR3
chr82617276026172831+intron-Distal5.0410316.03244HepG2SUGP2
chr82617312326173170+intron-Distal3.294368.11449HepG2SUGP2
chr82618201326182055+intron-Distal4.944454.82934K562RBM15
chr82617200026172051+intron-Distal3.081068.05918HepG2SUGP2
chr82620635726206426+intron-Distal4.413265.30489K562TARDBP
chr82615392726153989+intron-Distal3.229315.42089K562MATR3
chr82616316126163221+intron-Distal3.334394.43202K562HNRNPL
chr82615143126151520+intron-Distal,intron-Proximal3.282283.37074K562TIA1
chr82617180026171848+intron-Distal3.896756.46365K562MATR3
chr82617261226172681+intron-Distal3.974819.86758K562MATR3
chr82615341326153529+intron-Distal3.354393.84494HepG2QKI
chr82622156326221664+intron-Distal3.896146.19377K562KHSRP
chr82617205126172102+intron-Distal3.677509.95310HepG2SUGP2
chr82617263526172752+intron-Distal3.265748.49983HepG2MATR3
chr82618298826183038+intron-Distal3.966143.31110K562TIA1
chr82618221526182265+intron-Distal4.229047.36824K562RBM15
chr82619775726197847+intron-Distal5.025976.64929HepG2QKI
chr82617286026172925+intron-Distal4.536029.76733HepG2MATR3
chr82618336426183421+intron-Distal3.291733.63916HepG2HNRNPC
chr82615178126151822+intron-Distal4.4704914.87928K562EXOSC5
chr82619775726197878+intron-Distal4.028899.64911K562QKI
chr82615250226152564+intron-Distal3.309693.86744K562HNRNPM
chr82622050326220577+intron-Distal5.646998.79654HepG2XPO5
chr82615217726152222+intron-Distal4.8688611.57958K562EXOSC5
chr82615185326151903+intron-Distal3.960118.17180K562EXOSC5
chr82617242126172487+intron-Distal3.512835.96782K562MATR3
chr82619653226196582+intron-Distal,intron-Proximal4.621076.16999K562TIA1
chr82615204226152110+intron-Distal3.269346.92889K562KHSRP
chr82617213926172222+intron-Distal5.455489.85433K562MATR3
chr82617267726172760+intron-Distal4.6190917.10139HepG2SUGP2
chr82617307526173129+intron-Distal3.712884.72029K562MATR3
chr82615913826159220+intron-Distal4.4431114.32814K562TARDBP
chr82615219626152235+intron-Distal4.801126.79824HepG2HNRNPM
chr82615198026152036+intron-Distal3.9468810.89863K562HNRNPM
chr82615160526151650+intron-Distal3.325736.64660K562EXOSC5
chr82617190626171973+intron-Distal5.152239.10501K562MATR3
chr82614972126149775+intron-Distal3.745334.75435K562EFTUD2
chr82617233626172365+intron-Distal3.233485.35016HepG2SUGP2
chr82615205226152116+intron-Distal5.4181020.06847K562EXOSC5
chr82615223226152297+intron-Distal3.647378.67975K562HNRNPM
chr82619728726197368+intron-Distal,intron-Proximal3.646983.06411K562KHDRBS1
chr82620939826209478+intron-Distal4.359805.30489K562TARDBP
chr82615323926153295+intron-Distal3.264035.78064K562KHSRP
chr82619667426196735+intron-Distal4.436974.92524K562TARDBP
chr82617270526172784+intron-Distal3.6881510.55947K562MATR3
chr82615223626152298+intron-Distal3.7056420.27412K562EXOSC5
chr82617284926172928+intron-Distal3.445618.41272K562MATR3
chr82616904426169167+intron-Distal3.159613.62066K562ILF3
chr82617230626172373+intron-Distal3.673027.67347K562MATR3
chr82615247926152555+intron-Distal3.5945512.24315K562EXOSC5
chr82616926426169371+intron-Distal3.219103.00914HepG2PTBP1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PPP2R2A is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PPP2R2A is not available on ENCORE database.

  • 92 RBPs can affect the levels of PPP2R2A.  








The Knockdown/knockout RNA-Seq assay for PPP2R2A is not available on ENCORE database.





92 RBPs can affect the gene expression of PPP2R2A :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PPP2R2AENSG00000221914.4641.34970899.71300-0.488403.096502.09810HepG2ABCF1
PPP2R2AENSG00000221914.41210.44110731.588500.7263015.8694014.66830HepG2ACO1
PPP2R2AENSG00000221914.41467.861901053.170200.478903.380902.80120HepG2AKAP1
PPP2R2AENSG00000221914.4908.02000735.053700.304802.364001.64910HepG2AKAP8L
PPP2R2AENSG00000221914.4453.97380685.82510-0.595203.646902.62530HepG2BCLAF1
PPP2R2AENSG00000221914.4632.35040832.88940-0.397402.644401.97060HepG2CPSF6
PPP2R2AENSG00000221914.41370.704001076.557700.348403.870403.13290HepG2CELF1
PPP2R2AENSG00000221914.4796.644101157.68440-0.539209.934508.66990HepG2DAZAP1
PPP2R2AENSG00000221914.41264.79500866.665700.545304.106303.36510HepG2DDX6
PPP2R2AENSG00000221914.4561.77660699.94060-0.317202.475101.82890HepG2DKC1
PPP2R2AENSG00000221914.4529.81630651.46240-0.298202.540601.91080HepG2DNAJC2
PPP2R2AENSG00000221914.4697.22700522.585900.415902.587901.71050HepG2EIF3D
PPP2R2AENSG00000221914.4707.85650920.63490-0.379202.138201.57350HepG2EIF4A3
PPP2R2AENSG00000221914.41187.12430896.419700.405102.090401.48840HepG2EIF4B
PPP2R2AENSG00000221914.4723.303101094.00340-0.596906.211305.01440HepG2EIF4G2
PPP2R2AENSG00000221914.4392.54070645.86670-0.718404.672703.05770HepG2FKBP4
PPP2R2AENSG00000221914.4601.68660861.70770-0.518203.680402.91690HepG2G3BP1
PPP2R2AENSG00000221914.4659.64230944.17320-0.517403.685002.95490HepG2GPKOW
PPP2R2AENSG00000221914.4624.16910863.38310-0.468105.539604.56770HepG2HNRNPF
PPP2R2AENSG00000221914.4859.609701054.59850-0.294903.539602.78440HepG2HNRNPL
PPP2R2AENSG00000221914.4481.41970733.21730-0.606908.023807.03200HepG2HNRNPU
PPP2R2AENSG00000221914.4599.81270850.18470-0.503305.127304.17150HepG2IGF2BP1
PPP2R2AENSG00000221914.4674.50910929.28980-0.462303.220002.51310HepG2MAGOH
PPP2R2AENSG00000221914.4892.840801147.95100-0.362603.739802.85080HepG2NOL12
PPP2R2AENSG00000221914.41486.60570818.734800.860504.781603.59100HepG2PABPC1
PPP2R2AENSG00000221914.4304.15980432.16710-0.506803.510502.12410HepG2PKM
PPP2R2AENSG00000221914.4516.09960653.97160-0.341602.613701.89610HepG2PPIL4
PPP2R2AENSG00000221914.41029.80920864.673600.252002.287001.77990HepG2PTBP1
PPP2R2AENSG00000221914.4744.446401095.78620-0.557706.209405.36390HepG2PUF60
PPP2R2AENSG00000221914.41398.77480782.141800.838605.665604.67890HepG2RAVER1
PPP2R2AENSG00000221914.41946.425801018.601200.9341025.4585024.20690HepG2RBM22
PPP2R2AENSG00000221914.41149.81800849.874600.436004.227103.40870HepG2RBM25
PPP2R2AENSG00000221914.4744.63570930.09320-0.320802.305601.67350HepG2RPLP0
PPP2R2AENSG00000221914.4557.57280768.13790-0.462202.244601.39160HepG2RPS10
PPP2R2AENSG00000221914.4626.70590899.54800-0.521403.137602.28780HepG2RPS3A
PPP2R2AENSG00000221914.4823.49610592.333100.475303.390702.53260HepG2RRP9
PPP2R2AENSG00000221914.4463.64350652.96380-0.494005.397704.55070HepG2SAFB2
PPP2R2AENSG00000221914.41035.29740804.079200.364501.925401.36030HepG2SF3A3
PPP2R2AENSG00000221914.4756.929301050.60760-0.473007.320506.26400HepG2SLBP
PPP2R2AENSG00000221914.42316.95910992.352801.223204.687303.65870HepG2SNRNP70
PPP2R2AENSG00000221914.42529.319201150.497001.1364052.4030050.93910HepG2SRFBP1
PPP2R2AENSG00000221914.41510.24420939.626400.6845014.7141013.80780HepG2SRSF1
PPP2R2AENSG00000221914.4913.881901081.88230-0.243502.317601.73850HepG2SRSF5
PPP2R2AENSG00000221914.4646.91090848.24950-0.390904.163003.33590HepG2SRSF7
PPP2R2AENSG00000221914.41056.69950764.450500.467006.806506.00940HepG2SRSF9
PPP2R2AENSG00000221914.4781.27470998.94630-0.354603.743103.16680HepG2SSB
PPP2R2AENSG00000221914.41011.397901230.43850-0.282803.499902.81540HepG2SUCLG1
PPP2R2AENSG00000221914.4566.68320878.15970-0.631906.003604.99240HepG2TARDBP
PPP2R2AENSG00000221914.4433.51350712.46650-0.716708.801107.99970HepG2TIAL1
PPP2R2AENSG00000221914.4574.48260718.82580-0.323402.889102.31600HepG2TRIM56
PPP2R2AENSG00000221914.41190.78190777.348600.615204.525503.73200HepG2U2AF1
PPP2R2AENSG00000221914.4948.67330688.465000.462405.722304.91200HepG2UTP3
PPP2R2AENSG00000221914.4565.90650760.39650-0.426202.091501.45320HepG2XRN2
PPP2R2AENSG00000221914.4952.14920784.268000.279702.930902.37290HepG2ZNF622
PPP2R2AENSG00000221914.42066.041201401.875900.559403.150601.88280K562AARS
PPP2R2AENSG00000221914.43507.359801871.121000.9064036.9984034.97950K562AGGF1
PPP2R2AENSG00000221914.42770.363002056.086300.430104.865103.47420K562AKAP8
PPP2R2AENSG00000221914.43656.132001946.988000.9090019.7071017.64950K562AKAP8L
PPP2R2AENSG00000221914.44434.984202951.850800.587208.362207.43070K562AQR
PPP2R2AENSG00000221914.42894.514602042.862400.502609.437507.62340K562ATP5C1
PPP2R2AENSG00000221914.42991.875102236.086600.420004.881203.27420K562CCDC124
PPP2R2AENSG00000221914.41494.686301975.59510-0.402403.506702.62280K562CPSF6
PPP2R2AENSG00000221914.41691.445401381.874900.291503.474801.97610K562DDX27
PPP2R2AENSG00000221914.44319.997602804.856200.6230019.3486017.77600K562DDX47
PPP2R2AENSG00000221914.43169.297302095.087500.5971014.1024011.79720K562DKC1
PPP2R2AENSG00000221914.41653.162902094.94350-0.341704.499003.60850K562EIF2S2
PPP2R2AENSG00000221914.42140.189401483.758800.528404.710003.31530K562EIF3D
PPP2R2AENSG00000221914.41807.013801394.516000.373702.635201.85650K562EIF3G
PPP2R2AENSG00000221914.43001.978403487.35470-0.216202.341101.47250K562EIF4G2
PPP2R2AENSG00000221914.41511.717901232.853900.294102.777501.43470K562FUS
PPP2R2AENSG00000221914.42736.527101915.129800.514803.855702.98930K562G3BP2
PPP2R2AENSG00000221914.41338.734201886.26730-0.494703.778002.85620K562GPKOW
PPP2R2AENSG00000221914.42888.706301911.717500.595502.497801.35660K562HNRNPA2B1
PPP2R2AENSG00000221914.41094.871801533.90430-0.486405.486604.67420K562HNRNPC
PPP2R2AENSG00000221914.41632.092602028.43040-0.313603.691002.65950K562HNRNPU
PPP2R2AENSG00000221914.43480.842702066.234700.752308.273006.65030K562KIF1C
PPP2R2AENSG00000221914.42740.782501977.900100.470502.259501.32010K562MAK16
PPP2R2AENSG00000221914.41687.661602150.58750-0.349702.885301.94170K562MATR3
PPP2R2AENSG00000221914.43420.609702314.705700.563309.053807.21820K562MBNL1
PPP2R2AENSG00000221914.43137.479701622.441600.951304.983403.68530K562NAA15
PPP2R2AENSG00000221914.41892.648202140.76630-0.177702.351401.65910K562NSUN2
PPP2R2AENSG00000221914.42543.289201917.424000.407403.634502.51600K562PCBP2
PPP2R2AENSG00000221914.41474.875801826.05650-0.308102.044401.33000K562PCBP3
PPP2R2AENSG00000221914.41130.070501400.64180-0.309702.631801.85400K562POLR2G
PPP2R2AENSG00000221914.42077.543901348.342200.623607.872406.59940K562PRPF8
PPP2R2AENSG00000221914.4956.709601375.30950-0.523605.476904.14360K562PSIP1
PPP2R2AENSG00000221914.43378.992503965.42500-0.230902.736301.78210K562PUM2
PPP2R2AENSG00000221914.45089.778301930.865501.3983040.6894038.55140K562PUS1
PPP2R2AENSG00000221914.43875.501201881.347801.0425030.7931028.72940K562RBM15
PPP2R2AENSG00000221914.42102.421901373.584900.614006.295205.05330K562RPS19
PPP2R2AENSG00000221914.42422.204201991.277300.282502.835001.97000K562SF3B4
PPP2R2AENSG00000221914.4904.986201189.52370-0.394403.179902.06200K562SRFBP1
PPP2R2AENSG00000221914.42466.852702164.086700.188802.356901.48390K562SRPK2
PPP2R2AENSG00000221914.42749.049602052.193700.421705.426504.44300K562SRSF1
PPP2R2AENSG00000221914.41071.752801523.00560-0.506904.998903.51070K562SRSF4
PPP2R2AENSG00000221914.41449.286402077.17970-0.519305.194904.20840K562TARDBP
PPP2R2AENSG00000221914.41503.858902003.61510-0.413903.642702.68390K562TIA1
PPP2R2AENSG00000221914.4906.342801322.81560-0.545504.878003.60380K562TIAL1
PPP2R2AENSG00000221914.41099.622501405.33990-0.353902.818201.86170K562TRIM56
PPP2R2AENSG00000221914.43045.882701917.143900.6678013.5964011.79930K562U2AF2
PPP2R2AENSG00000221914.41843.463202269.89500-0.300204.672503.76380K562UPF1
PPP2R2AENSG00000221914.43654.507001957.708900.900405.415303.42110K562UTP18
PPP2R2AENSG00000221914.42694.034102019.696700.415509.130707.68770K562WDR43
PPP2R2AENSG00000221914.42762.359703325.16360-0.267502.216501.45520K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PPP2R2A is not available on ENCORE database.





10 RBPs can affect the splicing of PPP2R2A :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPPP2R2AENSG00000221914.4chr8+261974182619748926196405261965032621198326212149-0.108000.000000.00016excludedHepG2U2AF1
SEPPP2R2AENSG00000221914.4chr8+2619741826197489261964052619650326211983262121490.073000.000000.00024includedK562FMR1
SEPPP2R2AENSG00000221914.4chr8+2619741826197489261964052619650326211983262121490.051000.000170.04518includedK562GPKOW
SEPPP2R2AENSG00000221914.4chr8+2619741826197489261964052619650326211983262121490.070000.000060.00413includedK562TARDBP
SEPPP2R2AENSG00000221914.4chr8+2619741826197489261964052619650326211983262121490.057000.000120.02043includedK562CPSF6
SEPPP2R2AENSG00000221914.4chr8+2619741826197489261964052619650326211983262121490.097000.000030.00093includedK562HNRNPC
A3SSPPP2R2AENSG00000221914.4chr8+2622380326223922262238302622392226221236262214060.182000.000000.00000longerK562AQR
A5SSPPP2R2AENSG00000221914.4chr8+2621848926218704262184892621866726220199262203640.080000.000790.06105longerHepG2SF3B4
RIPPP2R2AENSG00000221914.4chr8+2622019926221406262201992622036426221236262214060.059000.008640.07707includedHepG2NCBP2
RIPPP2R2AENSG00000221914.4chr8+2622019926221406262201992622036426221236262214060.051000.001290.01539includedHepG2RBM22
MXEPPP2R2AENSG00000221914.4chr8+26217651262177972622123626221406262119832621214926223830262239220.067000.000000.000001includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PPP2R2A is not avaliable on ENCORE database.