EXOSC10

General Information

Gene Name : EXOSC10
Gene ID : ENSG00000171824.13
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: EXOSC10)

Not Available

Antibody Validation

Bethyl Labs: A303-987A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	EXOSC10	ENSG00000171824.13	47.72	53.70	50.71	ENCSR000AEF
HepG2	EXOSC10	ENSG00000171824.13	57.37	63.24	60.30	ENCSR985KAT
K562	EXOSC10	ENSG00000171824.13	87.59	98.22	92.91	ENCSR000AEO

Assays

3 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 4161	ENCSR521GON	EXOSC10	K562	Released	ENCAB270KRD	ENCSR481MVN
knockdown followed by RNA-seq	EXOSC10-BGKcLV21-K562	ENCSR299PRA	EXOSC10	K562	Released		ENCSR854OFV	CRISPR	KD% = 60.5,65.1389045
knockdown followed by RNA-seq	EXOSC10-BGHcLV22-HepG2	ENCSR455KXW	EXOSC10	HepG2	Released		ENCSR704VPL	CRISPR	KD% = 83.1,86.7

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
EXOSC10	4161	K562	ENCSR521GON	ENCSR481MVN	ENCAB270KRD	A303-987A	1	Released	ENCODE4

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
EXOSC10	ENCAB270KRD	A303-987A	1			Released, ENCODE4	BGHcLV22-23, Released, ENCODE4	BGKcLV21-21, Released, ENCODE4

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project	Note
EXOSC10	K562	CRISPR	ENCSR299PRA	ENCSR854OFV	EXOSC10-BGKcLV21-21,EXOSC10-BGKcLV21-22	NT-BGKcLV21-1,NT-BGKcLV21-2	60.5,65.1389045	Released	ENCODE4
EXOSC10	HepG2	CRISPR	ENCSR455KXW	ENCSR704VPL	EXOSC10-BGHcLV22-23,EXOSC10-BGHcLV22-24	NT-BGHcLV22-1,NT-BGHcLV22-2	83.1,86.7	Released	ENCODE4

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
EXOSC10	Product_ID: A303-987A Lot_ID: 1 Source: Bethyl Labs Target Name: EXOSC10-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for EXOSC10 is not avaliable on ENCORE database.

Proteins bound to RNA

EXOSC10 RNA is bound by 21 proteins.

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eCLIP assay for EXOSC10 is not avaliable on ENCORE database.

21 proteins are bound to EXOSC10 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr1	11151549	11151652	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.45869	29.81534	K562	DDX24
chr1	11151556	11151632	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.46513	25.42358	K562	ZNF622
chr1	11137652	11137750	-	CDS,intron-Distal,intron-Proximal	3.57172	21.61549	K562	EFTUD2
chr1	11137709	11137758	-	intron-Distal,intron-Proximal	3.94565	20.69951	K562	SF3B4
chr1	11140896	11140965	-	CDS,intron-Distal,intron-Proximal	3.69690	19.93487	K562	ZNF622
chr1	11140527	11140615	-	CDS,intron-Distal,intron-Proximal	3.36334	18.58147	K562	EFTUD2
chr1	11147502	11147552	-	CDS,intron-Distal,intron-Proximal	3.43971	17.69919	K562	ZNF622
chr1	11126702	11126760	-	3'-UTR,intron-Distal,intron-Proximal	6.40127	17.51182	K562	PUM2
chr1	11142345	11142463	-	intron-Distal	5.79144	16.01960	K562	TARDBP
chr1	11155814	11155865	-	CDS,intron-Distal,intron-Proximal	4.23044	15.15889	K562	ZNF622
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 90 entries

eCLIP assay for EXOSC10 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for EXOSC10 is not available on ENCORE database.
63 RBPs can affect the levels of EXOSC10.

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The Knockdown/knockout RNA-Seq assay for EXOSC10 is not available on ENCORE database.

63 RBPs can affect the gene expression of EXOSC10 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
EXOSC10	ENSG00000171824.9	1119.25880	2046.50850	-0.87060	15.13970	13.89480	HepG2	BOP1
EXOSC10	ENSG00000171824.9	3224.98830	2257.00630	0.51480	11.07510	9.95000	K562	FXR1
EXOSC10	ENSG00000171824.9	1027.76810	1493.70900	-0.53940	10.84810	9.76480	HepG2	PUS1
EXOSC10	ENSG00000171824.9	1757.31450	1244.75710	0.49740	9.33210	8.57870	HepG2	SRSF1
EXOSC10	ENSG00000171824.9	906.00700	1277.38480	-0.49560	9.37940	8.26400	HepG2	DNAJC2
EXOSC10	ENSG00000171824.9	1366.13670	1875.53270	-0.45720	8.81400	7.68650	HepG2	UPF1
EXOSC10	ENSG00000171824.9	1733.16620	1080.88340	0.68110	8.64520	7.46340	HepG2	HNRNPK
EXOSC10	ENSG00000171824.9	3640.53760	5218.23380	-0.51940	8.32270	6.99960	K562	GRSF1
EXOSC10	ENSG00000171824.9	1316.92270	1977.72630	-0.58670	7.78560	6.71570	HepG2	SRSF7
EXOSC10	ENSG00000171824.9	1294.94880	1981.07960	-0.61340	7.78070	6.64440	HepG2	TARDBP
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 72 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for EXOSC10 is not available on ENCORE database.

20 RBPs can affect the splicing of EXOSC10 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	EXOSC10	ENSG00000171824.9	chr1	-	11142744	11142935	11141138	11141295	11147504	11147648	-0.21600	0.00000	excluded	K562	AKAP8L
SE	EXOSC10	ENSG00000171824.9	chr1	-	11137421	11137500	11136898	11137005	11137657	11137708	-0.10500	0.00012	excluded	K562	PUS1
SE	EXOSC10	ENSG00000171824.9	chr1	-	11142744	11142935	11141138	11141295	11147504	11147648	-0.25400	0.00000	excluded	K562	PUS1
SE	EXOSC10	ENSG00000171824.9	chr1	-	11142744	11142935	11141138	11141295	11147504	11147648	-0.15600	0.01241	excluded	K562	DDX6
SE	EXOSC10	ENSG00000171824.9	chr1	-	11142744	11142935	11141138	11141295	11147504	11147648	-0.24600	0.00000	excluded	K562	UTP18
SE	EXOSC10	ENSG00000171824.9	chr1	-	11142744	11142935	11141138	11141295	11147504	11147648	-0.28600	0.00000	excluded	K562	RBM15
SE	EXOSC10	ENSG00000171824.9	chr1	-	11142744	11142935	11141138	11141295	11147504	11147648	-0.30600	0.00000	excluded	K562	AGGF1
A3SS	EXOSC10	ENSG00000171824.9	chr1	-	11133990	11134110	11133990	11134065	11134287	11134383	0.18600	0.00005	longer	HepG2	U2AF2
A3SS	EXOSC10	ENSG00000171824.9	chr1	-	11130956	11131112	11130956	11131030	11132143	11132286	0.13900	0.00000	longer	K562	AQR
A3SS	EXOSC10	ENSG00000171824.9	chr1	-	11126677	11126884	11126677	11126805	11128064	11128208	0.05500	0.00000	longer	K562	AQR

Showing 1 to 10 of 49 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

EXOSC10

General Information

Functions

Localization

Domains (AlphaFold: EXOSC10)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for EXOSC10 is not avaliable on ENCORE database.

21 proteins are bound to EXOSC10 RNA:

eCLIP assay for EXOSC10 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for EXOSC10 is not available on ENCORE database.

63 RBPs can affect the gene expression of EXOSC10 :

The Knockdown/knockout RNA-Seq assay for EXOSC10 is not available on ENCORE database.

20 RBPs can affect the splicing of EXOSC10 :

The Knockdown/knockout RNA-Seq assay for EXOSC10 is not avaliable on ENCORE database.