DYNC1LI1

General Information

Gene Name       : DYNC1LI1
Gene ID             : ENSG00000144635.8
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: DYNC1LI1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878DYNC1LI1ENSG00000144635.825.7321.7723.75ENCSR000AEF
HepG2DYNC1LI1ENSG00000144635.817.3627.6822.52ENCSR985KAT
K562DYNC1LI1ENSG00000144635.848.3240.8244.57ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
DYNC1LI1A304-209A1BGKcLV38-25, Submitted, ENCORE2


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
DYNC1LI1K562CRISPRDYNC1LI1-BGKcLV38-25,DYNC1LI1-BGKcLV38-26NT-BGKcLV38-1,NT-BGKcLV38-260.9,63.4SubmittingENCORE2
DYNC1LI1HepG2CRISPRBGHcLV39-33,BGHcLV39-34BGHcLV39-1,BGHcLV39-20.0,0.0NotSatisfiedENCORE2
DYNC1LI1HepG2CRISPRBGHcLV41-17,BGHcLV41-18BGHcLV41-1,BGHcLV41-20.0,0.0NotSatisfiedENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
DYNC1LI1Product_ID: A304-209A
Lot_ID: 1
Source: Bethyl Labs
Target Name: DYNC1LI1-human		 DYNC1LI1-K562-CRISPR-A304-209A.png<br>Caption: Western blot following CRISPR against DYNC1LI1 in K562 whole cell lysate using DYNC1LI1 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against DYNC1LI1. DYNC1LI1 protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for DYNC1LI1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • DYNC1LI1 RNA is bound by 10 proteins.  







eCLIP assay for DYNC1LI1 is not avaliable on ENCORE database.





10 proteins are bound to DYNC1LI1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr33261213832612303-5'-UTR,CDS,intron-Distal,intron-Proximal3.0963610.82212K562DDX3X
chr33261212332612265-5'-UTR,CDS,intron-Distal,intron-Proximal3.872793.31827HepG2GRWD1
chr33257103132571052-CDS,intron-Distal,intron-Proximal3.486747.18470K562YBX3
chr33256835332568413-CDS,intron-Distal5.5175810.47074K562U2AF2
chr33256835932568411-CDS,intron-Distal5.248278.29657K562U2AF1
chr33257177032571828-CDS,intron-Distal,intron-Proximal3.6528913.28567K562BUD13
chr33257176932571829-CDS,intron-Distal,intron-Proximal3.288086.36450HepG2U2AF2
chr33257195432572013-CDS,intron-Distal,intron-Proximal3.969143.02457HepG2BCLAF1
chr33257175832571827-CDS,intron-Distal,intron-Proximal3.340586.70555K562U2AF1
chr33257105332571108-CDS,intron-Distal,intron-Proximal3.6651811.30069K562YBX3
chr33257113532571152-CDS,intron-Distal3.342143.46769K562YBX3
chr33258733732587424-CDS,intron-Distal,intron-Proximal3.755566.84505K562ZNF622
chr33257176332571830-CDS,intron-Distal,intron-Proximal3.843729.64873K562U2AF2
chr33258734032587371-CDS,intron-Distal,intron-Proximal3.165074.86973K562UCHL5
chr33257576932575821-intron-Distal4.051463.00614K562U2AF2
chr33261049832610644-intron-Distal4.025557.05443K562KHSRP
chr33257575232575837-intron-Distal4.447863.77802HepG2U2AF2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for DYNC1LI1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for DYNC1LI1 is not available on ENCORE database.

  • 76 RBPs can affect the levels of DYNC1LI1.  








The Knockdown/knockout RNA-Seq assay for DYNC1LI1 is not available on ENCORE database.





76 RBPs can affect the gene expression of DYNC1LI1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
DYNC1LI1ENSG00000144635.4742.44220497.505300.577507.691706.78010HepG2ACO1
DYNC1LI1ENSG00000144635.41641.06120717.240301.1940017.0640015.85760HepG2AKAP1
DYNC1LI1ENSG00000144635.4627.27600499.879000.327402.540901.80260HepG2AKAP8L
DYNC1LI1ENSG00000144635.4369.50730519.17640-0.490602.691201.80360HepG2BCLAF1
DYNC1LI1ENSG00000144635.4671.84200510.628700.395702.963502.16730HepG2CALR
DYNC1LI1ENSG00000144635.4885.10840667.214900.407603.794503.06350HepG2CELF1
DYNC1LI1ENSG00000144635.4507.54400717.58920-0.499605.059204.10090HepG2DAZAP1
DYNC1LI1ENSG00000144635.4873.97910687.075400.347001.958301.42340HepG2DDX3X
DYNC1LI1ENSG00000144635.4639.85650475.989000.426703.767903.00090HepG2DKC1
DYNC1LI1ENSG00000144635.4310.37900448.25250-0.530304.992904.15750HepG2DNAJC2
DYNC1LI1ENSG00000144635.4538.39020336.078800.679804.796203.61230HepG2EEF2
DYNC1LI1ENSG00000144635.4449.61700272.833400.720604.749903.58980HepG2EIF3D
DYNC1LI1ENSG00000144635.4949.94780707.799900.424404.210803.21950HepG2EIF4G1
DYNC1LI1ENSG00000144635.4614.68470486.190300.338202.126301.39570HepG2EWSR1
DYNC1LI1ENSG00000144635.4818.61440614.457300.413802.449001.72110HepG2FIP1L1
DYNC1LI1ENSG00000144635.4245.61770332.70310-0.437802.106501.41270HepG2FUBP3
DYNC1LI1ENSG00000144635.4428.12750242.926600.817406.131804.79840HepG2GEMIN5
DYNC1LI1ENSG00000144635.4509.00860693.58830-0.446404.363203.48510HepG2HNRNPF
DYNC1LI1ENSG00000144635.4478.33020636.72430-0.412702.391701.80110HepG2HNRNPLL
DYNC1LI1ENSG00000144635.4541.16650424.020600.351802.226701.37300HepG2HNRNPM
DYNC1LI1ENSG00000144635.4552.85930682.98820-0.304901.942701.32780HepG2IGF2BP1
DYNC1LI1ENSG00000144635.4853.05350596.546100.515903.864603.07910HepG2IGF2BP2
DYNC1LI1ENSG00000144635.4571.42830437.829700.384102.550601.46270HepG2LARP7
DYNC1LI1ENSG00000144635.4467.81040285.553500.712103.355702.20080HepG2METAP2
DYNC1LI1ENSG00000144635.4394.03640564.57550-0.518803.435002.60090HepG2NSUN2
DYNC1LI1ENSG00000144635.4393.83510499.37280-0.342502.302801.52400HepG2PARN
DYNC1LI1ENSG00000144635.4762.03290585.582000.379903.509802.90940HepG2PTBP1
DYNC1LI1ENSG00000144635.4961.82150720.443400.416803.467002.72040HepG2PUM2
DYNC1LI1ENSG00000144635.4653.98130506.747800.367903.282702.62570HepG2PUS1
DYNC1LI1ENSG00000144635.4811.23380474.199400.774504.343603.47060HepG2RAVER1
DYNC1LI1ENSG00000144635.41357.89590866.302300.6483011.1819010.29150HepG2RBM22
DYNC1LI1ENSG00000144635.4787.02980575.583100.451303.692702.92090HepG2RBM25
DYNC1LI1ENSG00000144635.4817.60020651.701000.327102.690002.15480HepG2NELFE
DYNC1LI1ENSG00000144635.4446.50780265.467900.750006.165605.28930HepG2RPS19
DYNC1LI1ENSG00000144635.4502.08080343.547400.547302.801801.99730HepG2RPS3A
DYNC1LI1ENSG00000144635.4634.10050448.288000.500202.934802.12770HepG2RRP9
DYNC1LI1ENSG00000144635.4280.01820449.28300-0.682106.895705.94590HepG2SAFB2
DYNC1LI1ENSG00000144635.41007.29180594.984600.759506.330605.28710HepG2SF3A3
DYNC1LI1ENSG00000144635.41007.90250701.244300.523302.768001.98670HepG2SNRNP70
DYNC1LI1ENSG00000144635.41482.78370978.465300.5996012.2973011.44200HepG2SRFBP1
DYNC1LI1ENSG00000144635.41239.65710636.365900.9619022.9852021.90870HepG2SRSF1
DYNC1LI1ENSG00000144635.4875.35530670.535900.384503.431702.74790HepG2SRSF5
DYNC1LI1ENSG00000144635.4913.91120762.640500.261001.927101.39030HepG2SUCLG1
DYNC1LI1ENSG00000144635.4362.65200620.60040-0.775107.128306.04010HepG2TARDBP
DYNC1LI1ENSG00000144635.4273.02860494.60130-0.8572011.0969010.07960HepG2TRIM56
DYNC1LI1ENSG00000144635.4992.92570525.692900.9174011.4905010.18310HepG2U2AF1
DYNC1LI1ENSG00000144635.4673.16350509.435600.402003.553402.89040HepG2UTP3
DYNC1LI1ENSG00000144635.4730.22090521.445000.485702.505601.50020HepG2XRCC6
DYNC1LI1ENSG00000144635.4441.03730575.68120-0.384401.918001.30720HepG2XRN2
DYNC1LI1ENSG00000144635.4749.10810580.325600.368203.899703.28020HepG2ZNF622
DYNC1LI1ENSG00000144635.41552.436301130.227200.457804.256002.75650K562AARS
DYNC1LI1ENSG00000144635.43118.104701933.934700.6890022.0725020.57690K562AGGF1
DYNC1LI1ENSG00000144635.42852.256802125.220100.424405.018203.59780K562AKAP8
DYNC1LI1ENSG00000144635.42856.413602012.375800.505206.767405.70960K562AKAP8L
DYNC1LI1ENSG00000144635.41292.972701972.87550-0.609603.523102.29840K562CNOT7
DYNC1LI1ENSG00000144635.41737.433402107.78270-0.278803.035101.87150K562CPEB4
DYNC1LI1ENSG00000144635.41422.762301179.444700.270502.880401.53240K562DDX27
DYNC1LI1ENSG00000144635.43239.146002180.891100.5706014.7835013.39160K562DDX47
DYNC1LI1ENSG00000144635.42702.433302165.278200.319604.703403.51190K562DKC1
DYNC1LI1ENSG00000144635.41486.441201938.69980-0.383204.065003.21850K562EIF2S2
DYNC1LI1ENSG00000144635.41500.596401193.805900.329902.700001.91270K562EIF3G
DYNC1LI1ENSG00000144635.42457.161003095.07820-0.333004.772803.55450K562EIF4G2
DYNC1LI1ENSG00000144635.4895.239201268.04520-0.502303.272502.33730K562FMR1
DYNC1LI1ENSG00000144635.41887.950501459.086500.371705.262804.46600K562FXR1
DYNC1LI1ENSG00000144635.41895.045401384.803500.452502.971002.23590K562G3BP2
DYNC1LI1ENSG00000144635.4870.485201236.81300-0.506705.363604.55800K562HNRNPC
DYNC1LI1ENSG00000144635.4840.638701104.42380-0.393703.380802.11210K562HNRNPF
DYNC1LI1ENSG00000144635.42935.102502135.531800.458705.564604.30380K562KIF1C
DYNC1LI1ENSG00000144635.42888.482602392.349300.271802.352701.52390K562MBNL1
DYNC1LI1ENSG00000144635.4733.902501161.60370-0.662504.601603.45170K562METAP2
DYNC1LI1ENSG00000144635.42554.690501676.872500.607302.699701.82930K562NAA15
DYNC1LI1ENSG00000144635.41602.702501804.41070-0.171002.061001.40590K562NSUN2
DYNC1LI1ENSG00000144635.42039.626401194.882600.7713011.363509.83570K562PRPF8
DYNC1LI1ENSG00000144635.4794.107501108.91800-0.481704.178403.03350K562PSIP1
DYNC1LI1ENSG00000144635.42043.295701604.310400.348803.642302.89150K562PTBP1
DYNC1LI1ENSG00000144635.42854.720403519.39750-0.302004.065002.89610K562PUM2
DYNC1LI1ENSG00000144635.44210.312001995.516901.0771024.8510023.22730K562PUS1
DYNC1LI1ENSG00000144635.43107.688601944.502700.6763016.4372014.97700K562RBM15
DYNC1LI1ENSG00000144635.4810.906701011.67460-0.319102.402501.48280K562RCC2
DYNC1LI1ENSG00000144635.41848.730401217.265200.602805.883504.68760K562RPS19
DYNC1LI1ENSG00000144635.41734.476001221.873000.505303.595102.06510K562RRP9
DYNC1LI1ENSG00000144635.41424.258801780.45100-0.322003.949302.98440K562SF3A3
DYNC1LI1ENSG00000144635.4762.04730959.04770-0.331702.205901.31090K562SRFBP1
DYNC1LI1ENSG00000144635.4933.965901156.70760-0.308602.263901.32990K562SRSF4
DYNC1LI1ENSG00000144635.41437.258101203.912400.255502.095101.38000K562SYNCRIP
DYNC1LI1ENSG00000144635.4825.074701066.60210-0.370402.374801.51290K562TIAL1
DYNC1LI1ENSG00000144635.4882.636301133.04930-0.360302.614201.70050K562TRIM56
DYNC1LI1ENSG00000144635.43022.851203807.39160-0.332903.580201.96830K562UBE2L3
DYNC1LI1ENSG00000144635.41312.018901913.25270-0.5442011.9145010.55290K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for DYNC1LI1 is not available on ENCORE database.





4 RBPs can affect the splicing of DYNC1LI1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEDYNC1LI1ENSG00000144635.4chr3-325744773257458932571952325720123257600232576138-0.053000.000000.00004excludedK562AQR
SEDYNC1LI1ENSG00000144635.4chr3-325719523257201232571775325718203257447732574581-0.107000.000000.00001excludedK562U2AF1
SEDYNC1LI1ENSG00000144635.4chr3-325719523257201232571775325718203257447732574581-0.095000.000000.00004excludedK562U2AF2
MXEDYNC1LI1ENSG00000144635.4chr3-32571952325720123257447732574581325717753257182032576002325761380.068000.000010.000431includedK562U2AF2
MXEDYNC1LI1ENSG00000144635.4chr3-3257195232572012325744773257458932571775325718203257600232576138-0.157000.000230.048552includedK562NCBP2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for DYNC1LI1 is not avaliable on ENCORE database.