SRSF2

General Information

Gene Name : SRSF2
Gene ID : ENSG00000161547.16
Essential Gene : Yes

Functions

Splicing regulation
RNA stability & decay
Viral RNA regulation

Localization

Not Available

Domains (AlphaFold: SRSF2)

RRM

Antibody Validation

Not Avaiable

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	SRSF2	ENSG00000161547.16	264.13	281.47	272.80	ENCSR000AEF
HepG2	SRSF2	ENSG00000161547.16	293.63	349.66	321.64	ENCSR985KAT
K562	SRSF2	ENSG00000161547.16	273.80	264.25	269.02	ENCSR000AEO

Assays

1 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
RNA Bind-n-Seq	RBNS: SRSF2	ENCSR275JFN	SRSF2	cell-free sample	Released

eCLIP

No eCLIP experiment available

Antibody Validation

No Antibody Primary Validation image or Secondary image available

KD RNA-Seq

No KD RNA-Seq experiment available

RNA Bind-n-Seqn

GeneName	gene_aliases	Status	Project	Note
SRSF2	SRSF2		Released	ENCODE3

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for SRSF2 is not avaliable on ENCORE database.

The binding motifs of SRSF2

Proteins bound to RNA

SRSF2 RNA is bound by 44 proteins.

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eCLIP assay for SRSF2 is not avaliable on ENCORE database.

44 proteins are bound to SRSF2 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr17	74732193	74732201	-	3'-UTR,intron-Distal,intron-Proximal	6.29331	400.00000	K562	AQR
chr17	74732836	74732881	-	intron-Distal	7.51431	114.51692	K562	AQR
chr17	74732201	74732232	-	3'-UTR,intron-Distal,intron-Proximal	5.51107	84.05168	K562	AQR
chr17	74732154	74732193	-	3'-UTR,intron-Distal,intron-Proximal	5.33839	83.68181	K562	AQR
chr17	74731258	74731284	-	3'-UTR,intron-Distal,intron-Proximal	5.37646	79.32926	HepG2	SF3A3
chr17	74731238	74731258	-	3'-UTR,intron-Distal,intron-Proximal	4.58924	78.54564	HepG2	SF3A3
chr17	74732198	74732257	-	3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal	3.56743	72.45796	HepG2	BUD13
chr17	74732232	74732235	-	3'-UTR,intron-Distal,intron-Proximal	5.21524	70.01400	K562	AQR
chr17	74732102	74732194	-	3'-UTR,intron-Distal,intron-Proximal	5.19373	69.86277	K562	EFTUD2
chr17	74731916	74731991	-	3'-UTR,5'-UTR,intron-Distal,intron-Proximal	4.58768	66.73154	HepG2	U2AF2
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 193 entries

eCLIP assay for SRSF2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for SRSF2 is not available on ENCORE database.
115 RBPs can affect the levels of SRSF2.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for SRSF2 is not available on ENCORE database.

115 RBPs can affect the gene expression of SRSF2 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
SRSF2	ENSG00000161547.10	14914.45840	3800.17210	1.97250	86.97050	83.89230	K562	PUS1
SRSF2	ENSG00000161547.10	8125.61440	3702.74860	1.13380	52.00580	49.30860	K562	RBM15
SRSF2	ENSG00000161547.10	6891.98380	3682.62140	0.90410	46.56590	44.29110	K562	AGGF1
SRSF2	ENSG00000161547.10	5593.74600	3023.93760	0.88730	41.67540	39.85220	HepG2	RECQL
SRSF2	ENSG00000161547.10	1812.64760	4502.12460	-1.31250	39.62250	37.74240	HepG2	RPLP0
SRSF2	ENSG00000161547.10	2865.47230	6253.50000	-1.12590	35.05630	33.22940	HepG2	PUF60
SRSF2	ENSG00000161547.10	2396.30100	4105.74540	-0.77680	29.65200	27.85840	HepG2	SRSF7
SRSF2	ENSG00000161547.10	2197.95000	4180.97070	-0.92770	23.68750	22.01660	K562	HNRNPC
SRSF2	ENSG00000161547.10	5038.70870	3246.80130	0.63390	20.67040	19.45840	HepG2	NELFE
SRSF2	ENSG00000161547.10	2401.28280	3640.56990	-0.60040	18.19440	16.74250	HepG2	HNRNPU
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 137 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for SRSF2 is not available on ENCORE database.

28 RBPs can affect the splicing of SRSF2 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	SRSF2	ENSG00000161547.10	chr17	-	74731853	74731957	74731142	74731240	74732235	74732546	-0.05200	0.00000	excluded	K562	SF3B4
SE	SRSF2	ENSG00000161547.10	chr17	-	74731853	74731957	74730228	74731240	74732235	74732637	0.18100	0.00000	included	HepG2	DHX30
SE	SRSF2	ENSG00000161547.10	chr17	-	74731853	74731957	74730228	74731240	74732235	74732637	0.10100	0.00001	included	HepG2	DDX59
SE	SRSF2	ENSG00000161547.10	chr17	-	74731853	74731957	74730228	74731240	74732235	74732637	-0.15500	0.00000	excluded	HepG2	AKAP1
SE	SRSF2	ENSG00000161547.10	chr17	-	74731853	74731957	74731142	74731240	74732235	74732546	0.27800	0.00000	included	K562	AQR
SE	SRSF2	ENSG00000161547.10	chr17	-	74730985	74731031	74730384	74730644	74731142	74731240	0.05300	0.00000	included	K562	AQR
SE	SRSF2	ENSG00000161547.10	chr17	-	74731853	74731957	74731161	74731240	74732235	74732637	0.06800	0.00050	included	HepG2	SRSF7
SE	SRSF2	ENSG00000161547.10	chr17	-	74731853	74731957	74730228	74731240	74732235	74732637	-0.16100	0.00000	excluded	HepG2	DDX3X
SE	SRSF2	ENSG00000161547.10	chr17	-	74731853	74731957	74731142	74731240	74732235	74732546	-0.05600	0.00000	excluded	K562	PUS1
SE	SRSF2	ENSG00000161547.10	chr17	-	74731853	74731957	74730228	74731240	74732235	74732637	-0.18800	0.00000	excluded	HepG2	NCBP2

Showing 1 to 10 of 50 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

SRSF2

General Information

Functions

Localization

Domains (AlphaFold: SRSF2)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for SRSF2 is not avaliable on ENCORE database.

44 proteins are bound to SRSF2 RNA:

eCLIP assay for SRSF2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for SRSF2 is not available on ENCORE database.

115 RBPs can affect the gene expression of SRSF2 :

The Knockdown/knockout RNA-Seq assay for SRSF2 is not available on ENCORE database.

28 RBPs can affect the splicing of SRSF2 :

The Knockdown/knockout RNA-Seq assay for SRSF2 is not avaliable on ENCORE database.