CD2BP2

General Information

Gene Name       : CD2BP2
Gene ID             : ENSG00000169217.8
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: CD2BP2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878CD2BP2ENSG00000169217.821.0318.2519.64ENCSR000AEF
HepG2CD2BP2ENSG00000169217.844.2035.8740.03ENCSR985KAT
K562CD2BP2ENSG00000169217.821.7422.0321.88ENCSR000AEO

Assays

1 Released experiments are available on ENCORE database.

Assay TypeExp_NameENCODE IDTarget labelBiosampleStatusLinked AntibodyControlsMethodNote
knockdown followed by RNA-seq CD2BP2-BGKcLV33-K562ENCSR383FCICD2BP2K562ReleasedENCSR271ZAB   CRISPRKD% = 12.2,18.2






  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
CD2BP2ENCAB273AEYA304-826A1Released, ENCODE4BGKcLV33-5, Experimented, ENCORE2


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
CD2BP2K562CRISPRENCSR383FCIENCSR271ZABCD2BP2-BGKcLV33-5,CD2BP2-BGKcLV33-6NT-BGKcLV33-1,NT-BGKcLV33-212.2,18.2ReleasedENCODE4
CD2BP2HepG2CRISPRBGHcLV27-57,BGHcLV27-58BGHcLV27-1,BGHcLV27-2NotSatisfiedENCODE4


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
CD2BP2Product_ID: A304-826A
Lot_ID: 1
Source: Bethyl Labs
Target Name: CD2BP2-human		 Bethyl_A304-826A_1_CD2BP2.png<br>Caption: IP-WB analysis of K562 whole cell lysate using the CD2BP2 specific antibody, A304-826A. Lanes 1 and 2 are 2.5% of five million whole cell lysate input and 50% of IP enrichment, respectively, using a normal IgG antibody. Lane 3 is 50% of IP enrichment from five million whole cell lysate using the CD2BP2-specific antibody, A304-826A. The same antibody was used to detect protein levels via Western blot. This antibody passes preliminary validation and will be further pursued for secondary validation. *NOTE* Protein sizes are taken from Genecards.org and are only estimates based on sequence. Actual protein size may differ based on protein characteristics and electrophoresis method used.
 CD2BP2-K562-CRISPR-A304-826A.png<br>Caption: Western blot following CRISPR against CD2BP2 in K562 whole cell lysate using CD2BP2 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against CD2BP2. CD2BP2 protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for CD2BP2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • CD2BP2 RNA is bound by 8 proteins.  







eCLIP assay for CD2BP2 is not avaliable on ENCORE database.





8 proteins are bound to CD2BP2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr163036364830363707-3'-UTR,intron-Distal4.752295.85041HepG2AKAP1
chr163036226330362356-3'-UTR,intron-Distal4.0075314.16954K562UPF1
chr163036400230364081-3'-UTR,intron-Distal,intron-Proximal3.552965.09017HepG2UPF1
chr163036294630363010-3'-UTR,intron-Distal4.2896312.03763K562UPF1
chr163036342930363546-3'-UTR,intron-Distal3.971296.42285HepG2AKAP1
chr163036385430363962-3'-UTR,intron-Distal3.556888.36335HepG2U2AF2
chr163036412130364181-3'-UTR,intron-Distal,intron-Proximal,polyA_site3.211803.40404K562CSTF2T
chr163036282530362887-3'-UTR,intron-Distal4.162548.99604K562UPF1
chr163036311130363167-3'-UTR,intron-Distal4.378668.27548K562UPF1
chr163036408130364181-3'-UTR,intron-Distal,intron-Proximal,polyA_site4.463694.49605HepG2UPF1
chr163036330930363382-3'-UTR,intron-Distal4.610065.71320HepG2AKAP1
chr163036329430363349-3'-UTR,intron-Distal3.837437.50442K562UPF1
chr163036270430362723-3'-UTR,intron-Distal4.530924.46422K562UPF1
chr163036364930363707-3'-UTR,intron-Distal5.8463912.83212K562UPF1
chr163036389930363945-3'-UTR,intron-Distal4.075863.92497HepG2UPF1
chr163036399530364090-3'-UTR,intron-Distal,intron-Proximal4.264338.75386HepG2AKAP1
chr163036263330362683-3'-UTR,intron-Distal3.837437.50442K562UPF1
chr163036385330363914-3'-UTR,intron-Distal3.380004.01829HepG2AKAP1
chr163036648830366539-5'-UTR,intron-Distal3.525965.90285HepG2PRPF8
chr163036450630364545-CDS,intron-Distal3.313733.59112HepG2PPIG
chr163036521930365229-CDS,intron-Distal,intron-Proximal4.217413.49905HepG2PPIG
chr163036506730365121-CDS,intron-Distal3.077365.47500HepG2PPIG
chr163036505430365121-CDS,intron-Distal3.805223.58172HepG2SRSF1
chr163036513730365176-intron-Distal,intron-Proximal4.176233.74254HepG2SF3B4
chr163036512430365173-intron-Distal,intron-Proximal4.811915.40008K562SF3B4
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for CD2BP2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for CD2BP2 is not available on ENCORE database.

  • 81 RBPs can affect the levels of CD2BP2.  








The Knockdown/knockout RNA-Seq assay for CD2BP2 is not available on ENCORE database.





81 RBPs can affect the gene expression of CD2BP2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
CD2BP2ENSG00000169217.41721.436201284.741500.422007.564006.65960HepG2ACO1
CD2BP2ENSG00000169217.42571.166901399.669400.8772011.0693010.07400HepG2AKAP1
CD2BP2ENSG00000169217.41528.130501290.726800.243502.521101.78530HepG2AKAP8L
CD2BP2ENSG00000169217.42312.728901889.142200.291804.085903.28170HepG2AUH
CD2BP2ENSG00000169217.4815.820201082.70250-0.408303.012302.07240HepG2BCLAF1
CD2BP2ENSG00000169217.41051.340401301.11350-0.307502.195601.65690HepG2BOP1
CD2BP2ENSG00000169217.41576.918501284.401200.295904.185903.40060HepG2CKAP4
CD2BP2ENSG00000169217.41458.758501071.910600.444502.204501.52720HepG2CNOT7
CD2BP2ENSG00000169217.4798.489101194.48910-0.581005.768804.80920HepG2CPSF6
CD2BP2ENSG00000169217.42012.266701593.896800.336204.693703.89590HepG2CELF1
CD2BP2ENSG00000169217.4708.84190923.73450-0.382002.304401.47970HepG2DDX24
CD2BP2ENSG00000169217.42037.080001225.276000.733305.629104.57370HepG2DDX55
CD2BP2ENSG00000169217.41515.593101151.671700.396102.623302.02190HepG2DDX6
CD2BP2ENSG00000169217.4590.50270955.61880-0.694508.060506.47700HepG2DHX30
CD2BP2ENSG00000169217.4989.996201229.13370-0.312103.350402.61510HepG2DKC1
CD2BP2ENSG00000169217.41552.858401191.339100.382202.042901.44720HepG2EIF4B
CD2BP2ENSG00000169217.41312.844801619.64250-0.303002.106801.38940HepG2EIF4G2
CD2BP2ENSG00000169217.41584.103401255.367800.335503.044202.16990HepG2EWSR1
CD2BP2ENSG00000169217.42091.374501534.996800.446103.548702.68400HepG2FIP1L1
CD2BP2ENSG00000169217.4643.26290917.23240-0.511904.951703.91290HepG2FUBP3
CD2BP2ENSG00000169217.41621.539401234.487300.393402.997002.27560HepG2FXR1
CD2BP2ENSG00000169217.4741.890901000.26720-0.431103.514602.79730HepG2HNRNPA1
CD2BP2ENSG00000169217.4698.765901292.18210-0.8869011.6493010.47090HepG2HNRNPLL
CD2BP2ENSG00000169217.41901.298801367.671600.475203.347501.98990HepG2HSPD1
CD2BP2ENSG00000169217.4962.168201174.37680-0.287503.437402.30000HepG2KIF1C
CD2BP2ENSG00000169217.4977.826301234.91740-0.336802.078601.50680HepG2MAGOH
CD2BP2ENSG00000169217.41523.141001242.601700.293602.539001.76230HepG2MSI2
CD2BP2ENSG00000169217.4884.163801317.88150-0.575803.534602.42950HepG2MTPAP
CD2BP2ENSG00000169217.42129.046501699.312300.325203.872002.96980HepG2NOL12
CD2BP2ENSG00000169217.4864.529201145.77450-0.406303.163902.36470HepG2NSUN2
CD2BP2ENSG00000169217.41314.801601094.006100.265102.404201.61050HepG2PARN
CD2BP2ENSG00000169217.41458.431101172.879000.314303.746803.06300HepG2PCBP1
CD2BP2ENSG00000169217.4794.43210985.81650-0.311402.770302.03310HepG2PPIL4
CD2BP2ENSG00000169217.4783.031001186.63060-0.5997010.137008.79000HepG2PRPF4
CD2BP2ENSG00000169217.41582.618601193.437000.407106.020605.27640HepG2PTBP1
CD2BP2ENSG00000169217.41168.198101622.17730-0.473605.109104.32950HepG2PUF60
CD2BP2ENSG00000169217.42282.918601722.053700.406609.771508.80170HepG2PUM1
CD2BP2ENSG00000169217.4927.978401292.54560-0.478103.204502.53880HepG2QKI
CD2BP2ENSG00000169217.41761.874101363.484500.369704.037203.02400HepG2RBM15
CD2BP2ENSG00000169217.42299.954401812.863700.343204.827104.19080HepG2RBM22
CD2BP2ENSG00000169217.41642.325301328.190100.306203.567102.96890HepG2NELFE
CD2BP2ENSG00000169217.41108.11980836.752700.405103.434402.75860HepG2RPS19
CD2BP2ENSG00000169217.42017.766201340.328500.590102.474001.83730HepG2SF3A3
CD2BP2ENSG00000169217.41038.634201278.99880-0.300302.063101.44840HepG2SF3B1
CD2BP2ENSG00000169217.41028.633601555.49900-0.5966013.3360011.99270HepG2SLBP
CD2BP2ENSG00000169217.41757.945901147.818300.6149016.8214015.43980HepG2SMN1
CD2BP2ENSG00000169217.41407.14400939.195800.583203.625402.51620HepG2SMNDC1
CD2BP2ENSG00000169217.43876.317802047.568100.9207043.7995042.43330HepG2SRFBP1
CD2BP2ENSG00000169217.41545.256401296.936700.252602.561002.10140HepG2SRSF1
CD2BP2ENSG00000169217.41411.523801055.120000.419706.512005.72920HepG2SRSF9
CD2BP2ENSG00000169217.41131.135101777.78310-0.6523015.4629014.45170HepG2SSB
CD2BP2ENSG00000169217.4581.97090859.27310-0.562203.033701.77040HepG2SUB1
CD2BP2ENSG00000169217.42273.915101821.546700.319903.641802.94660HepG2SUCLG1
CD2BP2ENSG00000169217.4761.329301036.73980-0.445504.268703.11260HepG2SUPT6H
CD2BP2ENSG00000169217.4914.777101165.71460-0.349703.757803.12080HepG2TAF15
CD2BP2ENSG00000169217.4805.375201259.50620-0.645107.219006.12320HepG2TARDBP
CD2BP2ENSG00000169217.42189.794401677.598800.384302.680301.85690HepG2UBE2L3
CD2BP2ENSG00000169217.4970.749001188.66710-0.292203.239102.49520HepG2UPF1
CD2BP2ENSG00000169217.41818.947101147.610300.6644015.6188014.36800HepG2UTP3
CD2BP2ENSG00000169217.4945.826501200.62430-0.344102.541301.84490HepG2XRN2
CD2BP2ENSG00000169217.41775.171501171.061100.6000014.9573013.59860HepG2ZC3H8
CD2BP2ENSG00000169217.41564.285401307.305300.258803.489602.89530HepG2ZNF622
CD2BP2ENSG00000169217.41365.475101178.017100.212901.894401.40760K562AGGF1
CD2BP2ENSG00000169217.43064.141501714.473600.8376014.5762013.37780K562AQR
CD2BP2ENSG00000169217.42025.282701479.875600.452507.951906.92420K562DDX47
CD2BP2ENSG00000169217.41594.276501093.492800.543904.215802.90230K562EIF3D
CD2BP2ENSG00000169217.4910.39990661.632700.460404.983303.93040K562EIF3G
CD2BP2ENSG00000169217.4858.53110687.890300.319602.168801.43810K562EIF4A3
CD2BP2ENSG00000169217.4531.42400781.04350-0.555504.163202.73820K562FKBP4
CD2BP2ENSG00000169217.41386.29830715.379600.9544023.0343021.40490K562FXR1
CD2BP2ENSG00000169217.4216.46640477.97330-1.142809.716308.23320K562G3BP2
CD2BP2ENSG00000169217.41171.58430899.973800.380403.330002.68320K562HNRNPC
CD2BP2ENSG00000169217.41642.805801337.314400.296702.475701.48170K562HNRNPL
CD2BP2ENSG00000169217.41427.302801055.560900.435203.233302.22130K562HNRNPM
CD2BP2ENSG00000169217.41110.76040756.629600.553804.956803.82390K562MAGOH
CD2BP2ENSG00000169217.42670.687002164.408300.303102.861401.34570K562NOL12
CD2BP2ENSG00000169217.4908.43690673.117200.432403.427802.33940K562PCBP2
CD2BP2ENSG00000169217.41499.52330993.858500.593306.310205.17840K562PRPF8
CD2BP2ENSG00000169217.41046.24450806.897200.374702.736301.83810K562PSIP1
CD2BP2ENSG00000169217.41233.54860735.152200.7466011.7002010.39050K562PTBP1
CD2BP2ENSG00000169217.42634.729602159.065100.287102.241001.50740K562PUF60
CD2BP2ENSG00000169217.41005.01050704.636600.512204.804803.66140K562RBM22
CD2BP2ENSG00000169217.41858.812201472.835000.335704.111603.12910K562SF3A3
CD2BP2ENSG00000169217.4796.22920496.993200.679903.183502.26500K562SF3B4
CD2BP2ENSG00000169217.41324.35040720.753200.8776015.3248013.65640K562SRSF1
CD2BP2ENSG00000169217.4528.43620682.49440-0.369102.722501.45860K562SSB
CD2BP2ENSG00000169217.4721.55260962.23480-0.415302.647401.65390K562SUPV3L1
CD2BP2ENSG00000169217.41373.90370729.322400.913609.999508.52210K562TARDBP
CD2BP2ENSG00000169217.4940.60510703.547100.418803.379202.46200K562TIA1
CD2BP2ENSG00000169217.41090.900401354.19720-0.311902.576001.72890K562WDR3
CD2BP2ENSG00000169217.41500.50880975.936300.620503.005901.34860K562XRCC6
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for CD2BP2 is not available on ENCORE database.





1 RBPs can affect the splicing of CD2BP2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSCD2BP2ENSG00000169217.4chr16-3036550430365747303655043036564330365924303661100.164000.000000.00000longerK562AQR
A3SSCD2BP2ENSG00000169217.4chr16-3036522130365401303652213036537930365504303657090.224000.000000.00000longerK562AQR
A3SSCD2BP2ENSG00000169217.4chr16-3036592430366110303659243036602830366532303666820.112000.000000.00000longerK562AQR
MXECD2BP2ENSG00000169217.4chr16-30365221303654013036550430365685303646883036512130365924303660280.076000.000000.000001includedK562AQR
MXECD2BP2ENSG00000169217.4chr16-30365221303654013036550430365709303646883036512130365924303660280.066000.000030.000371includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for CD2BP2 is not avaliable on ENCORE database.