IKBKB

General Information

Gene Name       : IKBKB
Gene ID             : ENSG00000104365.14
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: IKBKB)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878IKBKBENSG00000104365.1419.5826.5223.05ENCSR000AEF
HepG2IKBKBENSG00000104365.1414.1012.6213.36ENCSR985KAT
K562IKBKBENSG00000104365.1417.4824.1820.83ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for IKBKB is not avaliable on ENCORE database.



Proteins bound to RNA
  • IKBKB RNA is bound by 21 proteins.  







eCLIP assay for IKBKB is not avaliable on ENCORE database.





21 proteins are bound to IKBKB RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr84218842942188492+3'-UTR,CDS,intron-Distal,intron-Proximal3.035545.77687HepG2PPIG
chr84217372842173784+3'-UTR,CDS,intron-Distal3.906353.12746HepG2GRWD1
chr84218347442183519+3'-UTR,CDS,intron-Distal,intron-Proximal3.777343.62357HepG2U2AF2
chr84218348642183546+3'-UTR,CDS,intron-Distal,intron-Proximal3.939936.36347HepG2PPIG
chr84217607542176172+3'-UTR,CDS,intron-Distal3.413315.04943K562ZNF622
chr84214767342147788+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.153479.02617HepG2PPIG
chr84216273542162790+3'-UTR,CDS,intron-Distal4.214554.16170K562UCHL5
chr84218665442186724+3'-UTR,CDS,intron-Distal4.040583.36385K562UCHL5
chr84217987042180014+3'-UTR,CDS,intron-Distal,intron-Proximal4.6621415.99366HepG2PPIG
chr84217827342178371+3'-UTR,CDS,intron-Distal,intron-Proximal3.202603.28147K562GRWD1
chr84217826742178372+3'-UTR,CDS,intron-Distal,intron-Proximal3.635395.94029HepG2SRSF1
chr84217831942178365+3'-UTR,CDS,intron-Distal,intron-Proximal3.436843.66187K562ZNF622
chr84217607642176148+3'-UTR,CDS,intron-Distal3.386094.88141HepG2GRWD1
chr84217521142175285+3'-UTR,CDS,intron-Distal,intron-Proximal4.175934.69071HepG2GRWD1
chr84217943542179464+3'-UTR,CDS,intron-Distal,intron-Proximal3.368204.24993HepG2PPIG
chr84217990942179995+3'-UTR,CDS,intron-Distal3.165283.39306HepG2GRWD1
chr84215095842151030+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.5269711.59798HepG2PPIG
chr84218670342186774+3'-UTR,CDS,intron-Distal,intron-Proximal5.567998.38577HepG2PRPF8
chr84217993142180007+3'-UTR,CDS,intron-Distal4.042296.94741K562ZNF622
chr84217957042179675+3'-UTR,CDS,intron-Distal,intron-Proximal3.375534.14618K562ZNF622
chr84217710042177146+3'-UTR,CDS,intron-Distal,intron-Proximal3.366173.54718K562PRPF8
chr84217606742176186+3'-UTR,CDS,intron-Distal,intron-Proximal3.339784.42661HepG2PPIG
chr84216641842166466+3'-UTR,CDS,intron-Distal,intron-Proximal4.946774.48364K562DDX24
chr84216388742163952+3'-UTR,CDS,intron-Distal,intron-Proximal3.463303.17151K562UCHL5
chr84217380742173831+3'-UTR,CDS,intron-Distal4.043453.16051HepG2PPIG
chr84216270342162730+3'-UTR,CDS,intron-Distal,intron-Proximal5.078284.17466K562DDX24
chr84217372642173804+3'-UTR,CDS,intron-Distal,intron-Proximal3.448824.85828HepG2BCLAF1
chr84217687642176934+3'-UTR,CDS,intron-Distal4.255564.21675K562ZNF622
chr84217375242173822+3'-UTR,CDS,intron-Distal4.264314.16170K562UCHL5
chr84217957042179663+3'-UTR,CDS,intron-Distal,intron-Proximal3.852459.02617HepG2PPIG
chr84216641642166438+3'-UTR,CDS,intron-Distal,intron-Proximal4.152333.87582K562ZNF622
chr84218349042183625+3'-UTR,CDS,intron-Distal,intron-Proximal3.518593.99908K562BUD13
chr84215096042151026+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.539706.85891K562DDX24
chr84217372742173785+3'-UTR,CDS,intron-Distal,intron-Proximal3.491475.86107HepG2PPIG
chr84218843442188490+3'-UTR,CDS,intron-Distal4.480334.37348HepG2BCLAF1
chr84217685542176920+3'-UTR,CDS,intron-Distal4.416744.78571K562UCHL5
chr84217710542177180+3'-UTR,CDS,intron-Distal,intron-Proximal3.198363.68325HepG2U2AF1
chr84217707142177178+3'-UTR,CDS,intron-Distal,intron-Proximal5.7235322.76949HepG2U2AF2
chr84217689442176938+3'-UTR,CDS,intron-Distal4.215044.45558HepG2GRWD1
chr84216391842163951+3'-UTR,CDS,intron-Distal,intron-Proximal4.128153.20027K562ZNF622
chr84217679342176876+3'-UTR,CDS,intron-Distal3.387073.36945K562ZNF622
chr84217994942180020+3'-UTR,CDS,intron-Distal,intron-Proximal3.101086.72164K562UCHL5
chr84212966142129723+5'-UTR,CDS,intron-Distal4.077366.13978HepG2PPIG
chr84214761042147677+CDS,intron-Distal,intron-Proximal3.8035112.76465HepG2SF3B4
chr84214762442147680+CDS,intron-Distal,intron-Proximal6.0586010.47189K562SF3B4
chr84214615742146249+CDS,intron-Distal,intron-Proximal4.323109.56105HepG2PPIG
chr84217623142176283+intron-Distal,intron-Proximal3.814063.07706HepG2TIAL1
chr84214474742144818+intron-Distal5.012995.79813HepG2LIN28B
chr84217717842177225+intron-Distal,intron-Proximal4.591954.53454K562PRPF8
chr84217904742179089+intron-Distal3.408863.62357HepG2U2AF2
chr84218391742184066+intron-Distal3.900643.06617K562HNRNPK
chr84217723442177312+intron-Distal,intron-Proximal3.723463.20886K562PRPF8
chr84217623142176287+intron-Distal,intron-Proximal3.894133.84732HepG2TIA1
chr84217633342176421+intron-Distal,intron-Proximal3.540325.15405HepG2PRPF4
chr84213520442135293+intron-Distal4.069963.57432K562NONO
chr84218396142184098+intron-Distal4.365805.08471HepG2HNRNPK
chr84214478142144828+intron-Distal4.7798210.06502K562LIN28B
chr84213192842132023+intron-Distal4.732044.55788HepG2QKI
chr84213189842131986+intron-Distal4.302665.50753K562QKI
chr84214377542143874+intron-Distal4.238364.31871HepG2HNRNPM
chr84217623642176302+intron-Distal,intron-Proximal3.521104.71867K562TIA1
chr84217632642176432+intron-Distal,intron-Proximal4.096414.00100K562TIA1
chr84217922042179249+intron-Distal4.453363.83114K562DGCR8
chr84214476442144781+intron-Distal5.562349.55253K562LIN28B
chr84218380442183876+intron-Distal5.148719.03229HepG2QKI
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for IKBKB is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for IKBKB is not available on ENCORE database.

  • 69 RBPs can affect the levels of IKBKB.  








The Knockdown/knockout RNA-Seq assay for IKBKB is not available on ENCORE database.





69 RBPs can affect the gene expression of IKBKB :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
IKBKBENSG00000104365.9799.32920671.728100.250802.044301.50690HepG2ACO1
IKBKBENSG00000104365.9893.88510565.267300.661105.012704.32280HepG2AKAP1
IKBKBENSG00000104365.9819.04240674.894200.279202.296501.59080HepG2AKAP8L
IKBKBENSG00000104365.9802.41130415.590200.9491011.9945010.86600HepG2BOP1
IKBKBENSG00000104365.9626.92770444.364100.496503.265702.42950HepG2CIRBP
IKBKBENSG00000104365.91063.69490671.594300.6633013.1094011.88000HepG2CKAP4
IKBKBENSG00000104365.9767.75570621.257900.305402.948702.08960HepG2DDX19B
IKBKBENSG00000104365.9776.23310598.312800.375502.532001.88030HepG2DDX21
IKBKBENSG00000104365.9610.14870854.13070-0.485303.945902.41570HepG2DDX47
IKBKBENSG00000104365.9675.56160465.113800.538403.344302.67220HepG2DDX6
IKBKBENSG00000104365.9804.50930447.174600.847208.513407.51030HepG2EIF2S1
IKBKBENSG00000104365.9928.88140494.204400.910309.441908.26910HepG2EIF4A3
IKBKBENSG00000104365.9886.82660481.131700.882107.104106.02990HepG2EIF4B
IKBKBENSG00000104365.91271.205801025.695000.309503.288202.64180HepG2ETF1
IKBKBENSG00000104365.9902.92590646.003300.483002.869002.08470HepG2FIP1L1
IKBKBENSG00000104365.9505.63770316.090800.677705.505004.40620HepG2FUBP3
IKBKBENSG00000104365.9735.77260498.559200.561404.212703.37200HepG2FXR1
IKBKBENSG00000104365.9730.45540462.524800.659205.274104.36790HepG2G3BP1
IKBKBENSG00000104365.9712.81660490.979600.537803.905802.83590HepG2G3BP2
IKBKBENSG00000104365.9565.28850432.459100.386301.859001.32740HepG2GPKOW
IKBKBENSG00000104365.9676.12830520.745700.376602.411701.80510HepG2HNRNPA1
IKBKBENSG00000104365.9779.51030468.259400.735207.170306.08540HepG2HNRNPK
IKBKBENSG00000104365.9718.22020470.159900.611204.862503.99050HepG2IGF2BP2
IKBKBENSG00000104365.9748.69910441.170200.763002.503601.57320HepG2IGF2BP3
IKBKBENSG00000104365.9741.05420587.767200.334203.394302.58830HepG2ILF2
IKBKBENSG00000104365.9729.89600501.536000.541203.496202.79430HepG2MATR3
IKBKBENSG00000104365.9728.89480513.359600.505603.314402.62390HepG2NCBP2
IKBKBENSG00000104365.91191.35430923.405200.367503.941903.03090HepG2NOL12
IKBKBENSG00000104365.9593.87470457.224100.377201.996501.37450HepG2PABPC4
IKBKBENSG00000104365.9733.48840466.556000.652608.601407.62910HepG2PCBP1
IKBKBENSG00000104365.9630.80460422.106600.579504.192103.22210HepG2PRPF8
IKBKBENSG00000104365.9688.31760474.722200.535905.854005.11770HepG2PTBP1
IKBKBENSG00000104365.9556.81440881.50500-0.662806.998006.10630HepG2PUF60
IKBKBENSG00000104365.9716.75000514.169900.479104.111103.37010HepG2QKI
IKBKBENSG00000104365.91095.21810605.617300.854605.497304.52440HepG2RAVER1
IKBKBENSG00000104365.91528.25650857.289000.8339018.1664017.07320HepG2RBM22
IKBKBENSG00000104365.9807.34580528.333500.611607.427106.61630HepG2NELFE
IKBKBENSG00000104365.9759.44480492.046800.626007.713506.76130HepG2RECQL
IKBKBENSG00000104365.9726.27200417.557700.798406.895005.71670HepG2RRP9
IKBKBENSG00000104365.9768.52000494.275800.636707.949607.02880HepG2SF3B4
IKBKBENSG00000104365.9639.74820454.513000.493102.237601.53830HepG2SNRNP70
IKBKBENSG00000104365.91333.00760968.272300.461107.130906.42980HepG2SRFBP1
IKBKBENSG00000104365.9655.37970515.905200.345102.109001.68020HepG2SRSF1
IKBKBENSG00000104365.91021.98250870.405300.231502.090401.53710HepG2SRSF5
IKBKBENSG00000104365.9543.31720419.706300.372302.882902.32220HepG2SRSF9
IKBKBENSG00000104365.9843.28400463.683300.8628013.7751012.66520HepG2TAF15
IKBKBENSG00000104365.9599.12590426.096200.491603.914302.92860HepG2TIA1
IKBKBENSG00000104365.9826.84470559.070300.564506.328705.62840HepG2TIAL1
IKBKBENSG00000104365.9530.07970321.750200.720205.993504.86570HepG2UCHL5
IKBKBENSG00000104365.9889.98620690.315200.366404.367103.72120HepG2ZNF622
IKBKBENSG00000104365.9754.72750918.16920-0.282802.436301.89840K562AGGF1
IKBKBENSG00000104365.9736.417101008.87460-0.454203.895502.68710K562AKAP8
IKBKBENSG00000104365.9690.94130955.38330-0.467504.143703.34130K562AKAP8L
IKBKBENSG00000104365.9788.349701002.40160-0.346603.320302.31240K562ATP5C1
IKBKBENSG00000104365.91279.739201037.959700.302003.290902.59030K562DDX47
IKBKBENSG00000104365.9746.144101028.14500-0.462505.708404.39440K562DKC1
IKBKBENSG00000104365.91057.60040721.325400.552004.962503.72340K562EFTUD2
IKBKBENSG00000104365.91277.440701089.356400.229702.004101.37500K562EIF2S2
IKBKBENSG00000104365.9888.23850603.263500.558106.708405.82550K562FXR1
IKBKBENSG00000104365.9292.51220491.77840-0.749504.838403.84300K562G3BP2
IKBKBENSG00000104365.9634.07160788.88530-0.315202.441301.37500K562GLRX3
IKBKBENSG00000104365.9546.63740953.39730-0.802502.642201.46030K562HNRNPA2B1
IKBKBENSG00000104365.9740.758101013.94750-0.452904.549103.44980K562KIF1C
IKBKBENSG00000104365.9693.83430970.55910-0.484204.291202.86590K562MAK16
IKBKBENSG00000104365.9896.500801135.87070-0.341402.690301.79740K562MBNL1
IKBKBENSG00000104365.9586.33590796.15900-0.441302.358001.55870K562NAA15
IKBKBENSG00000104365.9498.06280834.47470-0.744502.165501.31090K562PABPN1
IKBKBENSG00000104365.91003.05310661.952900.599506.317704.82420K562PCBP2
IKBKBENSG00000104365.91298.949501724.02680-0.408403.077802.21830K562PUF60
IKBKBENSG00000104365.9703.90940947.57420-0.428803.107402.53780K562PUS1
IKBKBENSG00000104365.9597.22870923.18860-0.628308.127907.14080K562RBM15
IKBKBENSG00000104365.91170.18290977.130200.260002.542901.85270K562UPF1
IKBKBENSG00000104365.9628.25070960.64420-0.612702.898101.56660K562UTP18
IKBKBENSG00000104365.91148.267901471.06450-0.357402.287301.51450K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for IKBKB is not available on ENCORE database.





7 RBPs can affect the splicing of IKBKB :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEIKBKBENSG00000104365.9chr8+421771024217716442176731421769394217825242178362-0.190000.001940.06101excludedK562PRPF8
SEIKBKBENSG00000104365.9chr8+421866414218673242183487421836154218843142189428-0.192000.007680.07409excludedHepG2U2AF2
SEIKBKBENSG00000104365.9chr8+421866414218673242183487421836154218843142189127-0.118000.001850.02055excludedK562AQR
SEIKBKBENSG00000104365.9chr8+421461514214624642129600421297234214767342147791-0.280000.001880.08052excludedK562EFTUD2
SEIKBKBENSG00000104365.9chr8+421461584214624642129600421297234214767342147791-0.616000.004920.08723excludedHepG2SRSF1
SEIKBKBENSG00000104365.9chr8+421461514214624642129600421297234214767342147791-0.331000.001230.04417excludedK562HNRNPU
SEIKBKBENSG00000104365.9chr8+421664184216654342163860421639504217183942171947-0.261000.000220.00539excludedK562HNRNPC
A3SSIKBKBENSG00000104365.9chr8+4217673142176939421767874217693942176069421761930.283000.000950.03595longerK562U2AF2
A5SSIKBKBENSG00000104365.9chr8+4217993542180167421799354218001242183487421836920.082000.000440.00941longerK562AQR
A5SSIKBKBENSG00000104365.9chr8+4217957142179719421795714217967142179864421800120.079000.000020.00050longerK562AQR
RIIKBKBENSG00000104365.9chr8+421767874217836242176787421769394217825242178362-0.469000.004320.04821excludedK562PRPF8

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for IKBKB is not avaliable on ENCORE database.