YTHDC1

General Information

Gene Name : YTHDC1
Gene ID : ENSG00000083896.12
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: YTHDC1)

Not Available

Antibody Validation

View validation images for all YTHDC1 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	YTHDC1	ENSG00000083896.12	63.55	56.61	60.08	ENCSR000AEF
HepG2	YTHDC1	ENSG00000083896.12	38.93	51.09	45.01	ENCSR985KAT
K562	YTHDC1	ENSG00000083896.12	41.35	43.98	42.66	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
YTHDC1		81504S	1			Submitted, ENCORE2		BGKcLV46-111, Submitted, ENCORE2
YTHDC1		77422S	1			Submitted, ENCORE2		BGKcLV46-111, Submitted, ENCORE2

KD RNA-Seq

GeneName	Cell_Line	Method	Sample_reps	Control_reps	KD%	Status	Project
YTHDC1	K562	CRISPR	BGKcLV37-63,BGKcLV37-64	BGKcLV37-1,BGKcLV37-2	0.0,0.0	NotSatisfied	ENCORE2
YTHDC1	K562	CRISPR	BGKcLV44-89,BGKcLV44-90	BGKcLV44-1,BGKcLV44-2		NotSatisfied	ENCORE2
YTHDC1	K562	CRISPR	YTHDC1-BGKcLV46-111,YTHDC1-BGKcLV46-112	NT-BGKcLV46-1,NT-BGKcLV46-2	70.1,90.4	Submitting	ENCORE2
YTHDC1	HepG2	CRISPR	BGHcLV36-61,BGHcLV36-62	BGHcLV36-1,BGHcLV36-2	NO CLEAR BAND ON THE POSITION,	NotSatisfied	ENCORE2
YTHDC1	HepG2	CRISPR	BGHcLV45-83,BGHcLV45-84	BGHcLV45-1,BGHcLV45-2	no clear band on the position,	NotSatisfied	ENCORE2
YTHDC1	HepG2	CRISPR	BGHcLV45-85,BGHcLV45-86	BGHcLV45-1,BGHcLV45-2	no clear band on the position,	NotSatisfied	ENCORE2

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
YTHDC1	Product_ID: 77422S Lot_ID: 1 Source: Cell Signaling Technology Target Name: YTHDC1-human
YTHDC1	Product_ID: 81504S Lot_ID: 1 Source: Cell Signaling Technology Target Name: YTHDC1-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for YTHDC1 is not avaliable on ENCORE database.

Proteins bound to RNA

YTHDC1 RNA is bound by 30 proteins.

CanvasJS.com

eCLIP assay for YTHDC1 is not avaliable on ENCORE database.

30 proteins are bound to YTHDC1 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr4	69202744	69202834	-	CDS,intron-Distal,intron-Proximal	6.05270	45.99397	K562	UCHL5
chr4	69202834	69202898	-	CDS,intron-Distal	6.05354	40.37855	K562	UCHL5
chr4	69202796	69202897	-	CDS,intron-Distal	7.54822	37.53823	K562	ZNF622
chr4	69202957	69203097	-	CDS,intron-Distal	5.18910	34.45295	K562	TRA2A
chr4	69202839	69202957	-	CDS,intron-Distal	5.96865	29.90511	K562	TRA2A
chr4	69203289	69203369	-	CDS,intron-Distal,intron-Proximal	4.13953	27.48037	K562	UCHL5
chr4	69215255	69215361	-	intron-Distal	6.29411	24.13081	HepG2	EFTUD2
chr4	69203369	69203454	-	CDS,intron-Distal,intron-Proximal	3.41360	22.67401	K562	UCHL5
chr4	69202832	69202933	-	CDS,intron-Distal	4.69800	22.66961	K562	SRSF1
chr4	69203374	69203457	-	CDS,intron-Distal,intron-Proximal	3.58279	22.18013	K562	ZNF622
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 157 entries

eCLIP assay for YTHDC1 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for YTHDC1 is not available on ENCORE database.
48 RBPs can affect the levels of YTHDC1.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for YTHDC1 is not available on ENCORE database.

48 RBPs can affect the gene expression of YTHDC1 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
YTHDC1	ENSG00000083896.8	4193.68970	2427.00030	0.78890	14.14160	12.95580	K562	PUS1
YTHDC1	ENSG00000083896.8	3300.35840	2352.10750	0.48860	12.13750	11.04160	K562	AGGF1
YTHDC1	ENSG00000083896.8	4285.71780	2790.86480	0.61870	9.81250	8.81150	K562	AQR
YTHDC1	ENSG00000083896.8	3534.56210	2364.96050	0.57960	9.25470	8.19270	K562	RBM15
YTHDC1	ENSG00000083896.8	2980.20790	2255.14140	0.40210	8.86990	8.11280	HepG2	SRFBP1
YTHDC1	ENSG00000083896.8	2523.03060	1686.65930	0.58090	7.06430	6.07050	HepG2	U2AF1
YTHDC1	ENSG00000083896.8	2043.21190	2789.32510	-0.44910	5.66570	4.57980	K562	GRSF1
YTHDC1	ENSG00000083896.8	1926.10530	2335.67980	-0.27820	5.10580	4.13560	K562	NSUN2
YTHDC1	ENSG00000083896.8	1748.59320	1242.05230	0.49340	5.06690	4.05310	K562	PRPF8
YTHDC1	ENSG00000083896.8	3243.04800	2039.45990	0.66910	5.30170	3.94080	K562	NAA15
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 49 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for YTHDC1 is not available on ENCORE database.

8 RBPs can affect the splicing of YTHDC1 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
A3SS	YTHDC1	ENSG00000083896.8	chr4	-	69189856	69190079			69189856	69189941	69195719	69195872	0.23600	0.00000	longer	K562	AQR
A3SS	YTHDC1	ENSG00000083896.8	chr4	-	69185840	69185960			69185840	69185923	69188466	69188633	0.21600	0.00000	longer	K562	AQR
A3SS	YTHDC1	ENSG00000083896.8	chr4	-	69195919	69196139			69195919	69196028	69197820	69197977	0.10200	0.00000	longer	K562	AQR
A3SS	YTHDC1	ENSG00000083896.8	chr4	-	69184543	69184670			69184543	69184580	69185840	69185923	0.12400	0.00000	longer	K562	AQR
A3SS	YTHDC1	ENSG00000083896.8	chr4	-	69182009	69182208			69182009	69182166	69184236	69184299	0.05300	0.00004	longer	K562	AQR
RI	YTHDC1	ENSG00000083896.8	chr4	-	69184407	69184651			69184407	69184447	69184543	69184651	0.29100	0.00000	included	K562	AQR
MXE	YTHDC1	ENSG00000083896.8	chr4	-	69189856	69189941	69195719	69195837	69188466	69188633	69195919	69196028	-0.18500	0.00022	2included	K562	U2AF1
MXE	YTHDC1	ENSG00000083896.8	chr4	-	69195719	69195872	69195919	69196065	69189856	69189941	69197820	69197915	0.08600	0.00003	1included	K562	AQR
MXE	YTHDC1	ENSG00000083896.8	chr4	-	69195719	69195872	69195919	69196105	69189856	69189941	69197820	69197915	0.08300	0.00003	1included	K562	AQR
MXE	YTHDC1	ENSG00000083896.8	chr4	-	69195719	69195872	69195919	69196139	69189856	69189941	69197820	69197915	0.08800	0.00001	1included	K562	AQR

Showing 1 to 10 of 46 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

YTHDC1

General Information

Functions

Localization

Domains (AlphaFold: YTHDC1)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for YTHDC1 is not avaliable on ENCORE database.

30 proteins are bound to YTHDC1 RNA:

eCLIP assay for YTHDC1 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for YTHDC1 is not available on ENCORE database.

48 RBPs can affect the gene expression of YTHDC1 :

The Knockdown/knockout RNA-Seq assay for YTHDC1 is not available on ENCORE database.

8 RBPs can affect the splicing of YTHDC1 :

The Knockdown/knockout RNA-Seq assay for YTHDC1 is not avaliable on ENCORE database.