SRPRB

General Information

Gene Name       : SRPRB
Gene ID             : ENSG00000144867.11
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: SRPRB)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SRPRBENSG00000144867.1126.7531.5129.13ENCSR000AEF
HepG2SRPRBENSG00000144867.1136.2748.5442.41ENCSR985KAT
K562SRPRBENSG00000144867.1131.6734.3433.01ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
SRPRBA305-440A1BGHcLV36-41, Submitted, ENCORE2BGKcLV37-43, Submitted, ENCORE2


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
SRPRBK562CRISPRSRPRB-BGKcLV37-43,SRPRB-BGKcLV37-44NT-BGKcLV37-1,NT-BGKcLV37-261.8,65.2SubmittingENCORE2
SRPRBHepG2CRISPRSRPRB-BGHcLV36-41,SRPRB-BGHcLV36-42NT-BGHcLV36-1,NT-BGHcLV36-274.7,64.9SubmittingENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
SRPRBProduct_ID: A305-440A
Lot_ID: 1
Source: Bethyl Labs
Target Name: SRPRB-human		 SRPRB-HEPG2-CRISPR-A305-440A.png<br>Caption: Western blot following CRISPR against SRPRB in HepG2 whole cell lysate using SRPRB specific antibody. Lane 1 is a ladder, lane 2 is HepG2 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against SRPRB. SRPRB protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.
 SRPRB-K562-CRISPR-A305-440A.png<br>Caption: Western blot following CRISPR against SRPRB in K562 whole cell lysate using SRPRB specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against SRPRB. SRPRB protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for SRPRB is not avaliable on ENCORE database.



Proteins bound to RNA
  • SRPRB RNA is bound by 12 proteins.  







eCLIP assay for SRPRB is not avaliable on ENCORE database.





12 proteins are bound to SRPRB RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr3133538499133538623+3'-UTR,CDS4.1291010.11508HepG2RPS3
chr3133538784133538830+3'-UTR,intron-Distal4.413553.61011HepG2AKAP1
chr3133539299133539393+3'-UTR,intron-Distal5.7407410.75082HepG2UPF1
chr3133539290133539397+3'-UTR,intron-Distal4.021624.17280HepG2AKAP1
chr3133538830133538913+3'-UTR,intron-Distal4.633715.71320HepG2AKAP1
chr3133539189133539254+3'-UTR,intron-Distal3.589453.97153HepG2UPF1
chr3133539330133539410+3'-UTR,intron-Distal5.477918.76530K562UPF1
chr3133524668133524824+3'-UTR,5'-UTR,CDS4.1410211.42614K562DDX3X
chr3133539101133539152+3'-UTR,intron-Distal4.295123.54095K562FAM120A
chr3133538869133538915+3'-UTR,intron-Distal4.171203.70195HepG2UPF1
chr3133539202133539254+3'-UTR,intron-Distal3.349044.70209K562YBX3
chr3133538782133538840+3'-UTR,intron-Distal3.015923.71381K562UPF1
chr3133539091133539135+3'-UTR,intron-Distal4.030925.15345K562UPF1
chr3133538597133538634+3'-UTR,CDS4.184774.03377HepG2LARP4
chr3133538785133538861+3'-UTR,intron-Distal3.417183.77680K562TIA1
chr3133539085133539159+3'-UTR,intron-Distal4.962546.96152HepG2UPF1
chr3133538787133538835+3'-UTR,intron-Distal4.415143.45012HepG2UPF1
chr3133524665133524794+3'-UTR,5'-UTR,CDS5.6104221.71690HepG2DDX3X
chr3133539168133539242+3'-UTR,intron-Distal3.645035.05294K562UPF1
chr3133538858133538908+3'-UTR,intron-Distal3.849213.95400K562UPF1
chr3133524696133524823+CDS4.5441410.82619HepG2RPS3
chr3133534432133534491+CDS,intron-Proximal4.786195.84094HepG2SND1
chr3133538403133538471+CDS3.643163.49838K562SND1
chr3133526599133526668+CDS,intron-Proximal3.750224.38503K562SND1
chr3133538514133538587+CDS4.285189.64451HepG2SND1
chr3133538383133538454+CDS,intron-Proximal3.206663.21151HepG2U2AF2
chr3133535721133535748+CDS,intron-Proximal3.666813.49838K562SND1
chr3133534485133534539+CDS3.774683.49838K562SND1
chr3133534539133534571+CDS,intron-Proximal5.110375.87535K562SND1
chr3133529960133530011+CDS,intron-Proximal4.927736.43734HepG2SND1
chr3133538400133538494+CDS4.3555816.94123HepG2SND1
chr3133530247133530343+intron-Distal4.278534.07352K562KHSRP
chr3133531856133531939+intron-Distal4.707256.32237HepG2SUGP2
chr3133533841133533943+intron-Distal4.329814.53347HepG2SUGP2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SRPRB is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SRPRB is not available on ENCORE database.

  • 100 RBPs can affect the levels of SRPRB.  








The Knockdown/knockout RNA-Seq assay for SRPRB is not available on ENCORE database.





100 RBPs can affect the gene expression of SRPRB :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SRPRBENSG00000144867.71000.37990754.105600.407602.461001.57180HepG2ABCF1
SRPRBENSG00000144867.7978.71340795.852200.298303.042802.41010HepG2ACO1
SRPRBENSG00000144867.72633.926901134.463901.2151019.8886018.59780HepG2AKAP1
SRPRBENSG00000144867.71798.198901378.429200.383405.920304.97770HepG2AUH
SRPRBENSG00000144867.71262.21930995.213400.342802.656602.06910HepG2BOP1
SRPRBENSG00000144867.71085.18320580.656900.902106.439905.32620HepG2CALR
SRPRBENSG00000144867.71202.42890891.807500.431003.314202.47240HepG2CIRBP
SRPRBENSG00000144867.71196.34690795.679900.5883011.5407010.37060HepG2CKAP4
SRPRBENSG00000144867.7990.69340686.098800.529902.711601.95540HepG2CNOT7
SRPRBENSG00000144867.71636.24460996.331500.7156012.7876011.60240HepG2CELF1
SRPRBENSG00000144867.71226.330501071.148200.195102.087801.43090HepG2DAZAP1
SRPRBENSG00000144867.7737.76950559.057600.400103.398002.11190HepG2DDX1
SRPRBENSG00000144867.7889.43680617.480500.526405.251403.98550HepG2DDX24
SRPRBENSG00000144867.72513.594601086.740801.2096022.7451021.13010HepG2DDX3X
SRPRBENSG00000144867.7949.52270632.174700.586805.485404.10870HepG2DDX5
SRPRBENSG00000144867.7631.70370390.373900.694305.868304.24950HepG2EFTUD2
SRPRBENSG00000144867.7847.33770581.027500.544203.543002.27980HepG2AGO1
SRPRBENSG00000144867.71159.93520897.428500.370102.347301.79840HepG2EIF2S1
SRPRBENSG00000144867.71462.72320991.775500.560504.589203.76890HepG2EIF4A3
SRPRBENSG00000144867.71499.95510965.610600.635304.678603.79830HepG2EIF4B
SRPRBENSG00000144867.71273.979801012.404600.331502.534801.75290HepG2EIF4G2
SRPRBENSG00000144867.71328.766701582.53200-0.252102.559301.97720HepG2ETF1
SRPRBENSG00000144867.71017.85490777.690400.388203.328802.41360HepG2EWSR1
SRPRBENSG00000144867.7805.53470601.182100.422003.372902.12920HepG2FASTKD2
SRPRBENSG00000144867.71344.195601002.240600.423403.193201.41980HepG2FMR1
SRPRBENSG00000144867.7806.444001035.78770-0.361102.065901.50820HepG2GPKOW
SRPRBENSG00000144867.7345.83380553.45320-0.678405.580604.70690HepG2HNRNPA1
SRPRBENSG00000144867.71272.94730984.489600.370604.699803.53330HepG2HNRNPA2B1
SRPRBENSG00000144867.7785.023101003.71900-0.354503.611402.80060HepG2HNRNPF
SRPRBENSG00000144867.71267.24940939.889000.431003.565302.77810HepG2HNRNPK
SRPRBENSG00000144867.7689.72350988.46600-0.519204.132203.37820HepG2HNRNPLL
SRPRBENSG00000144867.7682.42940525.383700.377202.453701.55650HepG2HNRNPM
SRPRBENSG00000144867.7932.41450661.434600.495303.023401.73190HepG2HSPD1
SRPRBENSG00000144867.7753.74040988.37990-0.391003.343602.55440HepG2IGF2BP1
SRPRBENSG00000144867.71384.81770943.547100.553405.223504.32210HepG2IGF2BP2
SRPRBENSG00000144867.7577.76900727.50910-0.332503.200602.10590HepG2KIF1C
SRPRBENSG00000144867.71324.47480902.841500.552803.880702.89390HepG2LARP4
SRPRBENSG00000144867.7864.13430610.483900.501204.070202.68410HepG2LARP7
SRPRBENSG00000144867.71678.453201000.974200.745608.825607.66770HepG2MAGOH
SRPRBENSG00000144867.72282.881901006.582201.1813019.2521017.70670HepG2MATR3
SRPRBENSG00000144867.7989.76750616.288200.683408.110806.79120HepG2MSI2
SRPRBENSG00000144867.7668.856901007.97880-0.591703.624302.50440HepG2MTPAP
SRPRBENSG00000144867.71325.544101030.297500.363402.367601.77940HepG2NCBP2
SRPRBENSG00000144867.7957.73930626.846600.611403.911302.21640HepG2NKRF
SRPRBENSG00000144867.7902.68640626.939900.525802.429601.60820HepG2PABPC1
SRPRBENSG00000144867.71273.54920917.568300.472903.713502.88500HepG2PABPC4
SRPRBENSG00000144867.7814.99940605.331700.429004.518003.46520HepG2PARN
SRPRBENSG00000144867.71533.618601021.825000.5857011.2129010.12460HepG2PCBP1
SRPRBENSG00000144867.7828.503701076.41680-0.377704.678003.94930HepG2PUM1
SRPRBENSG00000144867.7657.35110810.62720-0.302402.766902.15100HepG2PUS1
SRPRBENSG00000144867.7913.605901126.10750-0.301702.634602.02230HepG2QKI
SRPRBENSG00000144867.71899.448501322.722500.522008.992908.18100HepG2RBM22
SRPRBENSG00000144867.7794.145201021.98590-0.363903.040102.33700HepG2RBM25
SRPRBENSG00000144867.7951.757401157.12630-0.281902.737202.19810HepG2NELFE
SRPRBENSG00000144867.7863.755401077.65150-0.319203.312902.64680HepG2RECQL
SRPRBENSG00000144867.7797.346701081.20220-0.439403.695002.92410HepG2RPLP0
SRPRBENSG00000144867.7884.61620544.602100.6997012.1169010.91610HepG2SAFB2
SRPRBENSG00000144867.7630.41740371.236300.763907.013505.53380HepG2SERBP1
SRPRBENSG00000144867.71904.50290905.931901.0718010.946409.54260HepG2SF3A3
SRPRBENSG00000144867.7811.56160972.33480-0.260802.229701.58840HepG2SLBP
SRPRBENSG00000144867.71650.620501129.906900.5467010.120909.34290HepG2SRSF1
SRPRBENSG00000144867.71371.316201001.200800.453707.237906.29100HepG2SRSF5
SRPRBENSG00000144867.7830.03220986.10940-0.248602.007401.40420HepG2SRSF7
SRPRBENSG00000144867.7788.53960919.21660-0.221201.873601.40340HepG2SRSF9
SRPRBENSG00000144867.71627.079201297.202600.326803.742103.16590HepG2SSB
SRPRBENSG00000144867.71375.012701138.590300.272103.493702.80980HepG2SUCLG1
SRPRBENSG00000144867.7639.65920514.184700.314902.164201.32730HepG2SUPT6H
SRPRBENSG00000144867.7604.06070954.19870-0.659604.772403.92040HepG2SUPV3L1
SRPRBENSG00000144867.7845.106601015.53100-0.265002.188701.67990HepG2TAF15
SRPRBENSG00000144867.7689.74940963.29300-0.481903.926803.08060HepG2TARDBP
SRPRBENSG00000144867.7484.72180594.29310-0.294001.821001.39760HepG2TIAL1
SRPRBENSG00000144867.7776.04980599.516000.372303.566402.94400HepG2TRIM56
SRPRBENSG00000144867.71171.12340651.389400.8462010.392009.15580HepG2U2AF1
SRPRBENSG00000144867.71058.30110803.421400.397404.999704.10350HepG2UPF1
SRPRBENSG00000144867.71652.74070775.674301.0912036.6054034.79350HepG2UTP3
SRPRBENSG00000144867.7500.04710602.51860-0.268901.910001.33730HepG2ZC3H8
SRPRBENSG00000144867.71340.01020883.612100.6007013.4910012.51090HepG2ZNF622
SRPRBENSG00000144867.7610.39440451.686000.434302.936701.71550K562AARS
SRPRBENSG00000144867.71690.204901249.372800.435903.389402.01180K562APOBEC3C
SRPRBENSG00000144867.7498.75040803.65690-0.688309.311606.79960K562BCCIP
SRPRBENSG00000144867.7638.83250776.62830-0.281802.278401.40870K562BCLAF1
SRPRBENSG00000144867.7674.78660962.33200-0.512102.460501.46930K562CNOT7
SRPRBENSG00000144867.71571.63630952.919500.721709.600208.47310K562DDX47
SRPRBENSG00000144867.7602.28780326.700200.882405.436203.98760K562EIF3A
SRPRBENSG00000144867.7924.65230648.555200.511602.407701.66380K562EIF3G
SRPRBENSG00000144867.71117.842201415.88420-0.341003.494802.44100K562EIF4G2
SRPRBENSG00000144867.7996.12300749.782600.409803.111002.47480K562FXR1
SRPRBENSG00000144867.7527.62510847.58570-0.683808.240706.47050K562HNRNPA1
SRPRBENSG00000144867.7354.67120494.17200-0.478503.054002.43020K562HNRNPC
SRPRBENSG00000144867.71223.22800843.397200.536304.758703.10050K562HNRNPK
SRPRBENSG00000144867.71117.39640716.254600.641505.823504.40680K562HNRNPM
SRPRBENSG00000144867.71772.075701180.606300.585806.891205.64470K562HSPD1
SRPRBENSG00000144867.7681.92390478.624900.510604.055002.31580K562LARP7
SRPRBENSG00000144867.7349.53980501.26210-0.520103.272701.65060K562LIN28B
SRPRBENSG00000144867.7588.68790772.60210-0.392204.343103.43170K562NSUN2
SRPRBENSG00000144867.71180.84900658.051300.8435010.950409.44460K562PRPF8
SRPRBENSG00000144867.71958.351901544.856400.342103.068702.21060K562PUF60
SRPRBENSG00000144867.71158.865301643.05660-0.503706.495704.79960K562PUM1
SRPRBENSG00000144867.71349.466501610.01360-0.254702.167701.31720K562PUM2
SRPRBENSG00000144867.71463.32230670.384301.1261013.0314011.23420K562RPS19
SRPRBENSG00000144867.7687.42360480.158700.517604.219002.87080K562SAFB
SRPRBENSG00000144867.7918.87830720.220400.351303.026302.13140K562SF3B4
SRPRBENSG00000144867.7787.337501044.98310-0.408402.801801.54190K562STAU1
SRPRBENSG00000144867.7419.01480637.28780-0.604904.066002.81570K562SUPV3L1
SRPRBENSG00000144867.7946.25760540.500100.8078012.0613010.34530K562SYNCRIP
SRPRBENSG00000144867.7661.86080855.44370-0.370102.479701.80760K562TARDBP
SRPRBENSG00000144867.7315.05010426.16890-0.435802.174001.35430K562TIAL1
SRPRBENSG00000144867.7784.258501018.60670-0.377202.693701.33660K562TRIP6
SRPRBENSG00000144867.7740.97540921.71250-0.314903.140801.78350K562TROVE2
SRPRBENSG00000144867.7892.17480693.367100.363603.112202.26020K562U2AF2
SRPRBENSG00000144867.7562.87960700.96810-0.316502.066801.31170K562WDR3
SRPRBENSG00000144867.71180.815901726.42800-0.548006.776105.33130K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SRPRB is not available on ENCORE database.





5 RBPs can affect the splicing of SRPRB :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESRPRBENSG00000144867.7chr3+133529960133530043133526589133526667133534433133534570-0.051000.004120.05375excludedK562PUS1
SESRPRBENSG00000144867.7chr3+133529960133530043133526589133526667133534433133534570-0.149000.000060.00205excludedK562U2AF1
SESRPRBENSG00000144867.7chr3+133529960133530043133526589133526667133534433133534570-0.058000.001740.04151excludedK562RBM15
SESRPRBENSG00000144867.7chr3+133529960133530043133526589133526667133534433133534570-0.069000.000670.02019excludedK562AGGF1
A3SSSRPRBENSG00000144867.7chr3+1335357021335357761335357211335357761335344331335345700.088000.000000.00000longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SRPRB is not avaliable on ENCORE database.