LSM7

General Information

Gene Name       : LSM7
Gene ID             : ENSG00000130332.14
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: LSM7)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878LSM7ENSG00000130332.1421.8072.4947.14ENCSR000AEF
HepG2LSM7ENSG00000130332.14207.0462.79134.91ENCSR985KAT
K562LSM7ENSG00000130332.14174.5598.74136.65ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay TypeExp_NameENCODE IDTarget labelBiosampleStatusLinked AntibodyControlsMethodNote
knockdown followed by RNA-seq LSM7-BGKcLV21-K562ENCSR307KLILSM7K562ReleasedENCSR854OFV   CRISPRKD% = 67.9,71.0
knockdown followed by RNA-seq LSM7-BGHcLV22-HepG2ENCSR120WNJLSM7HepG2ReleasedENCSR704VPL   CRISPRKD% = 73.4,71.4






  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
LSM7ENCAB362WTJA305-097A1BGHcLV22-29, Released, ENCODE4BGKcLV21-27, Released, ENCODE4


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
LSM7K562CRISPRENCSR307KLIENCSR854OFVLSM7-BGKcLV21-27,LSM7-BGKcLV21-28NT-BGKcLV21-1,NT-BGKcLV21-267.9,71.0ReleasedENCODE4
LSM7HepG2CRISPRENCSR120WNJENCSR704VPLLSM7-BGHcLV22-29,LSM7-BGHcLV22-30NT-BGHcLV22-1,NT-BGHcLV22-273.4,71.4ReleasedENCODE4


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
LSM7Product_ID: A305-097A
Lot_ID: 1
Source: Bethyl Labs
Target Name: LSM7-human		 LSM7-HEPG2-CRISPR-A305-097A.png<br>Caption: Western blot following CRISPR against LSM7 in HepG2 whole cell lysate using LSM7 specific antibody. Lane 1 is a ladder, lane 2 is HepG2 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against LSM7. LSM7 protein appears as the green arrow, GAPDH serves as a control and appears in red arrow.
 LSM7-K562-CRISPR-A305-097A.png<br>Caption: Western blot following CRISPR against LSM7 in K562 whole cell lysate using LSM7 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against LSM7. LSM7 protein appears as the green arrow, GAPDH serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for LSM7 is not avaliable on ENCORE database.



Proteins bound to RNA
  • LSM7 RNA is bound by 22 proteins.  







eCLIP assay for LSM7 is not avaliable on ENCORE database.





22 proteins are bound to LSM7 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr1923215322321567-3'-UTR,intron-Distal,intron-Proximal5.7854629.01940K562PABPC4
chr1923241232324133-3'-UTR,CDS,intron-Distal,intron-Proximal4.818175.50419HepG2LARP4
chr1923216362321658-3'-UTR,intron-Distal4.8672110.89654HepG2LARP4
chr1923216122321680-3'-UTR,intron-Distal3.329044.41873K562ZNF800
chr1923217482321805-3'-UTR,CDS,intron-Distal3.502167.03584HepG2GRWD1
chr1923216182321676-3'-UTR,intron-Distal3.697288.12438K562PABPC4
chr1923218052321823-3'-UTR,CDS,intron-Distal3.272646.02862HepG2GRWD1
chr1923215912321712-3'-UTR,CDS,intron-Distal4.002553.45716HepG2AKAP1
chr1923241252324190-3'-UTR,CDS,intron-Distal3.884923.25521K562LIN28B
chr1923241642324195-3'-UTR,CDS,intron-Distal,intron-Proximal3.553578.33875K562GRWD1
chr1923216432321807-3'-UTR,CDS,intron-Distal4.5271319.69958HepG2RPS3
chr1923217842321823-3'-UTR,CDS,intron-Distal5.6897711.18896HepG2LARP4
chr1923217792321848-3'-UTR,CDS,intron-Distal3.740689.43801K562BUD13
chr1923241322324193-3'-UTR,CDS,intron-Distal,intron-Proximal3.7408212.53117K562PABPC4
chr1923241232324199-3'-UTR,CDS,intron-Distal,intron-Proximal3.308004.62149K562ZNF800
chr1923215292321562-3'-UTR,intron-Distal,intron-Proximal3.518313.37074K562TIA1
chr1923241332324197-3'-UTR,CDS,intron-Distal,intron-Proximal3.082578.33234K562DDX55
chr1923241312324164-3'-UTR,CDS,intron-Distal3.047094.28205K562GRWD1
chr1923217202321784-3'-UTR,CDS,intron-Distal4.7097022.88176HepG2LARP4
chr1923215342321626-3'-UTR,intron-Distal,intron-Proximal3.337345.44842K562PUM2
chr1923241382324233-3'-UTR,CDS,intron-Distal,intron-Proximal3.2803116.11300K562AQR
chr1923218192321876-3'-UTR,CDS,intron-Distal4.004977.33504K562SF3B4
chr1923241332324192-3'-UTR,CDS,intron-Distal,intron-Proximal4.0622212.48344HepG2LARP4
chr1923216982321720-3'-UTR,CDS,intron-Distal5.3482418.62309HepG2LARP4
chr1923215912321628-3'-UTR,intron-Distal3.856353.02919K562GRWD1
chr1923216582321697-3'-UTR,CDS,intron-Distal4.9123617.79951HepG2LARP4
chr1923217052321788-3'-UTR,CDS,intron-Distal3.7087816.05999K562RPS3
chr1923215842321636-3'-UTR,intron-Distal3.939558.56349HepG2LARP4
chr1923216932321733-3'-UTR,CDS,intron-Distal3.371325.93417K562PABPC4
chr1923241342324198-3'-UTR,CDS,intron-Distal,intron-Proximal4.254237.76379HepG2DDX55
chr1923261142326199-CDS,intron-Distal,intron-Proximal3.165474.95846K562HNRNPL
chr1923284042328432-CDS,intron-Distal,intron-Proximal4.1667213.82032K562GRWD1
chr1923283842328445-CDS,intron-Distal,intron-Proximal3.148493.85861K562PUM1
chr1923283842328404-CDS,intron-Distal,intron-Proximal3.9228311.31775K562GRWD1
chr1923283832328456-CDS,intron-Distal,intron-Proximal3.448809.22245HepG2GRWD1
chr1923284562328475-CDS,intron-Distal,intron-Proximal4.241284.94878HepG2GRWD1
chr1923284322328477-CDS,intron-Distal,intron-Proximal3.4625510.00318K562GRWD1
chr1923284642328478-CDS,intron-Distal,intron-Proximal3.014216.71317K562SRSF7
chr1923283832328476-CDS,intron-Distal,intron-Proximal3.0200020.91707K562UCHL5
chr1923283452328410-CDS,intron-Distal,intron-Proximal3.757136.74268HepG2PRPF8
chr1923284172328464-CDS,intron-Distal,intron-Proximal3.6324411.60958K562SRSF7
chr1923283852328427-CDS,intron-Distal,intron-Proximal3.644696.74069K562PABPC4
chr1923269772327027-intron-Distal5.6679211.08192K562AGGF1
chr1923262142326316-intron-Distal,intron-Proximal3.310134.76791K562GTF2F1
chr1923248322324908-intron-Distal,intron-Proximal4.464005.33511HepG2HNRNPK
chr1923239982324068-intron-Distal,intron-Proximal5.369557.28294K562AQR
chr1923239962324050-intron-Distal,intron-Proximal3.980816.34541K562BUD13
chr1923242222324279-intron-Distal,intron-Proximal5.0194311.66069K562SF3B4
chr1923253522325431-intron-Distal3.726574.12529K562GTF2F1
chr1923252512325296-intron-Distal4.568153.86413K562AGGF1
chr1923242172324278-intron-Distal,intron-Proximal5.1074917.69162HepG2SF3B4
chr1923262482326318-intron-Distal4.2348612.81600K562AGGF1
chr1923263212326387-intron-Distal4.167304.51091HepG2HNRNPL
chr1923239912324055-intron-Distal,intron-Proximal4.737094.75425K562EFTUD2
chr1923269252326948-intron-Distal4.636905.17468K562AGGF1
chr1923262122326309-intron-Distal,intron-Proximal5.6964814.20244K562HNRNPL
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for LSM7 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for LSM7 is not available on ENCORE database.

  • 78 RBPs can affect the levels of LSM7.  








The Knockdown/knockout RNA-Seq assay for LSM7 is not available on ENCORE database.





78 RBPs can affect the gene expression of LSM7 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
LSM7ENSG00000130332.10543.49070791.88690-0.543003.401502.65500HepG2AUH
LSM7ENSG00000130332.10669.21220335.444000.996309.315707.55150HepG2BCCIP
LSM7ENSG00000130332.10212.87180327.11690-0.619802.883301.48990HepG2CSTF2T
LSM7ENSG00000130332.10389.19690520.28200-0.418802.847902.19740HepG2CELF1
LSM7ENSG00000130332.10257.40600344.93780-0.422302.157501.36230HepG2DDX24
LSM7ENSG00000130332.10209.29890324.59080-0.633103.148601.95960HepG2AGO1
LSM7ENSG00000130332.10364.04990551.90390-0.600305.468504.35820HepG2EIF4G1
LSM7ENSG00000130332.10562.98510909.29450-0.691705.586804.78190HepG2ETF1
LSM7ENSG00000130332.10315.73400495.74820-0.650905.362504.27850HepG2FUBP3
LSM7ENSG00000130332.10786.09120525.763400.580204.439903.57800HepG2FXR1
LSM7ENSG00000130332.10346.49670487.60060-0.492902.763702.09910HepG2G3BP1
LSM7ENSG00000130332.10325.42700514.10160-0.659706.281204.97050HepG2HNRNPA2B1
LSM7ENSG00000130332.10298.14510406.93000-0.448802.861302.13320HepG2HNRNPF
LSM7ENSG00000130332.10694.04860584.980100.246501.842701.33030HepG2PCBP1
LSM7ENSG00000130332.10334.82600247.030300.438602.590201.87570HepG2PPIL4
LSM7ENSG00000130332.10226.40170313.63090-0.470202.727801.95840HepG2PRPF4
LSM7ENSG00000130332.10390.18240595.28210-0.609404.729804.05690HepG2PTBP1
LSM7ENSG00000130332.10695.57670562.104900.307303.009202.39650HepG2PUM1
LSM7ENSG00000130332.10433.58300561.67980-0.373402.058501.47440HepG2PUM2
LSM7ENSG00000130332.10340.30580491.88520-0.531505.026604.24080HepG2PUS1
LSM7ENSG00000130332.10417.24170644.61370-0.627606.043605.17020HepG2QKI
LSM7ENSG00000130332.10162.65710303.44800-0.899602.277501.63380HepG2RAVER1
LSM7ENSG00000130332.10263.62480390.95970-0.568503.743502.76270HepG2RBM15
LSM7ENSG00000130332.10488.15690336.405700.537002.269701.31160HepG2RCC2
LSM7ENSG00000130332.10478.86050617.05250-0.365802.237001.67570HepG2RECQL
LSM7ENSG00000130332.10293.85930438.29200-0.576803.357302.61510HepG2RPLP0
LSM7ENSG00000130332.10384.74670246.646800.641405.594804.73180HepG2SAFB2
LSM7ENSG00000130332.10388.94560619.68850-0.672007.381806.49150HepG2SF3B4
LSM7ENSG00000130332.1098.87600195.08710-0.980403.855402.92540HepG2SNRNP70
LSM7ENSG00000130332.10658.97530858.33230-0.381302.528402.04200HepG2SRFBP1
LSM7ENSG00000130332.10480.83660646.85200-0.427903.590303.06840HepG2SRSF1
LSM7ENSG00000130332.10312.16150399.77880-0.356901.966901.36910HepG2SRSF7
LSM7ENSG00000130332.10299.98150526.27560-0.8109010.143009.20240HepG2SRSF9
LSM7ENSG00000130332.10565.97930745.16980-0.396802.679002.17160HepG2SSB
LSM7ENSG00000130332.10320.76360581.50300-0.8583010.241009.27050HepG2TAF15
LSM7ENSG00000130332.10309.34890220.083200.491102.593801.62510HepG2TFIP11
LSM7ENSG00000130332.10356.21730534.22950-0.584704.688603.60840HepG2TIA1
LSM7ENSG00000130332.10366.78650269.101600.446702.113601.66520HepG2TIAL1
LSM7ENSG00000130332.10379.10020271.531300.481403.474802.85850HepG2TRIM56
LSM7ENSG00000130332.10266.58150193.971500.458602.159901.48880HepG2UCHL5
LSM7ENSG00000130332.10399.87270289.915600.463803.179702.54580HepG2UTP3
LSM7ENSG00000130332.10688.62810323.204901.0912012.1955010.69630HepG2XRN2
LSM7ENSG00000130332.10235.98780309.49920-0.391202.074801.48050HepG2ZC3H8
LSM7ENSG00000130332.101922.74420946.491401.0224025.9122024.28910K562AGGF1
LSM7ENSG00000130332.101482.592401040.143900.511202.451701.53550K562AKAP8
LSM7ENSG00000130332.101678.67820984.890100.769206.129305.13160K562AKAP8L
LSM7ENSG00000130332.101391.087301033.429900.428704.065002.93770K562ATP5C1
LSM7ENSG00000130332.101124.67870907.312100.309703.167401.97810K562CPEB4
LSM7ENSG00000130332.101120.52250938.814100.255202.278001.67780K562DDX47
LSM7ENSG00000130332.101208.88870878.554200.460406.006503.84180K562DDX6
LSM7ENSG00000130332.10709.70580466.491900.605302.417101.67170K562EIF3G
LSM7ENSG00000130332.101141.18790905.327700.333902.594901.79990K562EIF4A3
LSM7ENSG00000130332.101071.75030815.323800.394404.335202.83350K562EIF4B
LSM7ENSG00000130332.101133.14730790.276800.519806.910804.65920K562EWSR1
LSM7ENSG00000130332.10904.48970587.301800.622903.344002.40470K562FIP1L1
LSM7ENSG00000130332.10442.84030689.89490-0.639603.257702.01780K562FKBP4
LSM7ENSG00000130332.10151.20780466.16310-1.6243017.0263014.89240K562G3BP2
LSM7ENSG00000130332.102439.748801636.764200.575808.396107.06660K562GRSF1
LSM7ENSG00000130332.10508.58130793.55740-0.641904.332103.60200K562HNRNPC
LSM7ENSG00000130332.101080.41300848.441100.348602.820101.75160K562HNRNPL
LSM7ENSG00000130332.10763.07430483.161400.659203.151802.15320K562HNRNPM
LSM7ENSG00000130332.101186.12030796.119900.575102.877602.06680K562HSPD1
LSM7ENSG00000130332.101442.507501045.134500.464805.338504.11320K562KIF1C
LSM7ENSG00000130332.10188.88270289.40240-0.615602.563001.66800K562KRR1
LSM7ENSG00000130332.101137.47270677.316700.747803.587702.62320K562MAGOH
LSM7ENSG00000130332.101342.956001000.515800.424603.171801.99800K562MAK16
LSM7ENSG00000130332.101529.005201170.825800.385004.133002.98630K562MBNL1
LSM7ENSG00000130332.101532.32330615.567201.315609.710507.45670K562PABPN1
LSM7ENSG00000130332.10528.82600982.23110-0.893309.889208.32170K562PCBP3
LSM7ENSG00000130332.10488.50800753.40660-0.625006.479305.26080K562POLR2G
LSM7ENSG00000130332.101328.20590666.844100.994005.490804.27180K562PPIG
LSM7ENSG00000130332.101300.11160731.790000.829003.862002.03720K562PPP1R8
LSM7ENSG00000130332.101230.79140762.887200.689905.713904.63530K562PRPF8
LSM7ENSG00000130332.101233.19920976.577400.336502.565902.03860K562PUS1
LSM7ENSG00000130332.101395.73960951.662900.552405.956505.11340K562RBM15
LSM7ENSG00000130332.10451.42640694.04650-0.620505.184803.20980K562SDAD1
LSM7ENSG00000130332.101150.01910686.220900.744803.109001.69400K562SFPQ
LSM7ENSG00000130332.101140.63750645.214800.821904.272503.39970K562SRSF1
LSM7ENSG00000130332.10884.17170609.508000.536603.856302.57960K562SRSF5
LSM7ENSG00000130332.10578.16550857.56100-0.568806.667204.27560K562SRSF9
LSM7ENSG00000130332.10928.97330652.867800.508703.863203.02110K562TARDBP
LSM7ENSG00000130332.101024.39860629.799300.701706.954805.56430K562TIA1
LSM7ENSG00000130332.101050.75030618.332200.764905.315903.69430K562TRA2A
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for LSM7 is not available on ENCORE database.





11 RBPs can affect the splicing of LSM7 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SELSM7ENSG00000130332.10chr19-2324740232491123241232324195232838523284760.052000.000000.00000includedHepG2HNRNPK
SELSM7ENSG00000130332.10chr19-2325978232620023241232324191232838523284760.230000.000060.00120includedHepG2U2AF2
A3SSLSM7ENSG00000130332.10chr19-232412323241952324123232419123283852328476-0.114000.000040.00607shorterHepG2SF3A3
A3SSLSM7ENSG00000130332.10chr19-2324123232419523241232324191232838523284760.095000.000070.00991longerK562AKAP8L
A3SSLSM7ENSG00000130332.10chr19-232412323241952324123232419123283852328476-0.134000.000000.00180shorterHepG2DDX6
A3SSLSM7ENSG00000130332.10chr19-232412323241952324123232419123283852328476-0.110000.000010.00460shorterHepG2TIAL1
A3SSLSM7ENSG00000130332.10chr19-232412323241952324123232419123283852328476-0.078000.001000.00693shorterK562AQR
A3SSLSM7ENSG00000130332.10chr19-2324123232419523241232324191232838523284760.110000.000010.00086longerK562PUS1
A3SSLSM7ENSG00000130332.10chr19-232412323241952324123232419123283852328476-0.128000.000010.00169shorterK562HNRNPC
RILSM7ENSG00000130332.10chr19-2328410232858623284102328476232855923285860.067000.000030.00092includedK562SF3B4
RILSM7ENSG00000130332.10chr19-2328410232858623284102328476232855923285860.137000.001370.01750includedHepG2SF3A3
RILSM7ENSG00000130332.10chr19-2328410232858623284102328476232855923285860.062000.000000.00007includedK562HNRNPC
RILSM7ENSG00000130332.10chr19-2328410232858623284102328476232855923285860.088000.000050.00072includedHepG2SF3B4
RILSM7ENSG00000130332.10chr19-2328410232858623284102328476232855923285860.057000.000000.00000includedK562AQR
RILSM7ENSG00000130332.10chr19-2328364232858623283642328476232855923285860.063000.000830.01610includedK562FXR1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for LSM7 is not avaliable on ENCORE database.