KLHL22

General Information

Gene Name       : KLHL22
Gene ID             : ENSG00000099910.16
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: KLHL22)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878KLHL22ENSG00000099910.168.539.549.04ENCSR000AEF
HepG2KLHL22ENSG00000099910.169.805.837.82ENCSR985KAT
K562KLHL22ENSG00000099910.1611.1211.1311.12ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for KLHL22 is not avaliable on ENCORE database.



Proteins bound to RNA
  • KLHL22 RNA is bound by 32 proteins.  







eCLIP assay for KLHL22 is not avaliable on ENCORE database.





32 proteins are bound to KLHL22 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr222082577420825800-3'-UTR,CDS,intron-Distal4.435464.16554HepG2PPIG
chr222084324920843309-5'-UTR,CDS,intron-Distal,intron-Proximal3.743033.98203HepG2PRPF8
chr222085002320850048-5'-UTR,intron-Distal4.874885.69951K562AQR
chr222084326320843414-5'-UTR,CDS,intron-Distal,intron-Proximal3.413733.47879HepG2PPIG
chr222084346520843518-5'-UTR,CDS,intron-Distal,intron-Proximal4.5194710.40953K562RBM15
chr222084576620845807-5'-UTR,intron-Distal4.067293.80512K562CSTF2T
chr222081967620819722-CDS,intron-Distal,intron-Proximal4.119903.73926K562RBM15
chr222081203620812097-CDS,intron-Distal,intron-Proximal4.253896.48405K562AQR
chr222080079720800881-CDS,intron-Distal6.2814112.34622K562XRCC6
chr222081931220819359-CDS,intron-Distal,intron-Proximal3.864373.05875K562RBM15
chr222081941120819522-CDS,intron-Distal,intron-Proximal4.498565.17013K562RBM15
chr222083768820837692-intron-Distal4.704945.72435K562SLTM
chr222079152820791558-intron-Distal4.025853.40229HepG2CSTF2T
chr222084359320843703-intron-Distal,intron-Proximal4.342874.16295K562FUS
chr222084359920843662-intron-Distal,intron-Proximal3.062093.78791K562RBM15
chr222081073820810826-intron-Distal3.897653.79154K562FUS
chr222083729820837331-intron-Distal3.850503.00828K562YWHAG
chr222080425120804334-intron-Distal4.582395.32699K562SLTM
chr222084928620849358-intron-Distal4.026779.50920K562NONO
chr222078516620785256-CDS,intron-Distal,intron-Proximal3.378994.21158HepG2CSTF2T
chr222079026820790319-intron-Distal3.494523.23466HepG2CSTF2T
chr222084987620849918-intron-Distal5.347077.85689K562NONO
chr222082491920825024-intron-Distal3.411687.34740K562AGGF1
chr222079094520791023-intron-Distal3.872194.33898HepG2FAM120A
chr222082372120823840-intron-Distal3.365103.72310K562HNRNPK
chr222079093720791050-intron-Distal4.9850215.31748HepG2CSTF2T
chr222084970120849762-intron-Distal4.421668.40323K562NONO
chr222084856420848605-intron-Distal4.370264.58544K562ILF3
chr222083807720838123-intron-Distal3.941917.64085K562SLTM
chr222083733020837492-intron-Distal3.585007.32655K562UCHL5
chr222084983120849912-intron-Distal4.416724.46451HepG2DGCR8
chr222084293920843006-intron-Distal4.872346.76922HepG2PTBP1
chr222083813020838199-intron-Distal4.824276.65708K562YWHAG
chr222084950620849568-intron-Distal3.882137.90586K562NONO
chr222083641820836461-intron-Distal3.727143.60615K562SLTM
chr222079095520791053-intron-Distal4.527464.88485HepG2NKRF
chr222084797520848021-intron-Distal3.660993.43840K562HNRNPC
chr222078515620785265-CDS,intron-Distal,intron-Proximal5.141798.79061HepG2EFTUD2
chr222079140020791465-intron-Distal3.943923.79474HepG2FAM120A
chr222078586620785950-intron-Distal,intron-Proximal5.702927.66714HepG2EFTUD2
chr222083645120836502-intron-Distal3.268753.39217K562YWHAG
chr222084497720845027-intron-Distal3.873053.14375HepG2RBFOX2
chr222084986220849947-intron-Distal3.354277.85761K562SLTM
chr222082502420825110-intron-Distal3.752769.90990K562AGGF1
chr222084940620849485-intron-Distal3.317063.77732HepG2DGCR8
chr222082917320829245-intron-Distal3.441914.61518K562SLTM
chr222079372020793849-intron-Distal4.342964.70168K562CSTF2T
chr222079206120792107-5'-UTR,intron-Distal4.181275.66448HepG2DDX3X
chr222079141020791510-intron-Distal4.146024.10323HepG2PRPF4
chr222084842020848472-intron-Distal3.801543.18711HepG2ILF3
chr222084679320846870-intron-Distal3.554756.75245K562NONO
chr222084966420849701-intron-Distal4.866576.40665K562NONO
chr222084985520850004-intron-Distal3.6346612.30297K562GEMIN5
chr222084286620842992-intron-Distal5.8063810.65318HepG2PCBP2
chr222084854620848664-intron-Distal4.756446.79267HepG2ILF3
chr222079160920791653-intron-Distal3.051674.68402HepG2CSTF2T
chr222083735420837401-intron-Distal3.324273.39217K562YWHAG
chr222079194320792061-5'-UTR,CDS,intron-Distal4.6201421.20599HepG2DDX3X
chr222084843020848496-intron-Distal3.416816.37256K562ILF3
chr222083777520837798-intron-Distal4.817436.12311K562SLTM
chr222079062120790659-intron-Distal4.477545.41529HepG2CSTF2T
chr222084977820849996-intron-Distal3.140733.18404K562FUS
chr222084922120849286-intron-Distal5.6378314.58421K562NONO
chr222084981120849902-intron-Distal4.374673.34123HepG2FKBP4
chr222084922320849269-intron-Distal3.097663.37074K562TIA1
chr222083979920839839-intron-Distal4.183793.55849K562YWHAG
chr222084956820849651-intron-Distal5.8371214.19767K562NONO
chr222084976220849858-intron-Distal5.4946919.23682K562NONO
chr222082511020825174-intron-Distal3.122674.30181K562AGGF1
chr222078983120789884-intron-Distal3.438243.92299HepG2CSTF2T
chr222084294220842999-intron-Distal3.939646.86368K562PTBP1
chr222079105020791151-intron-Distal4.0096111.39119HepG2CSTF2T
chr222084997720850025-intron-Distal5.012077.60866K562NONO
chr222078587720785973-intron-Distal,intron-Proximal3.616314.69054HepG2CSTF2T
chr222084935820849482-intron-Distal4.6066517.81256K562NONO
chr222084915920849221-intron-Distal5.0853417.47156K562NONO
chr222079140720791467-intron-Distal3.872705.80161HepG2CSTF2T
chr222084057620840641-intron-Distal3.421423.48567K562SLTM
chr222083814820838228-intron-Distal4.3448611.43233K562SLTM
chr222084051820840667-intron-Distal5.228378.33469K562YWHAG
chr222084284720842932-intron-Distal4.453597.56720K562PTBP1
chr222078672520786824-intron-Distal4.447194.87774HepG2HNRNPK
chr222083750420837583-intron-Distal3.430663.44687K562SRSF1
chr222078612420786192-CDS,intron-Distal,intron-Proximal3.425776.71496HepG2CSTF2T
chr222084982120849970-intron-Distal4.445419.51399K562DDX51
chr222078588620785961-intron-Distal,intron-Proximal4.964225.22378HepG2XRN2
chr222085000320850023-intron-Distal3.955114.98250K562AQR
chr222083674920836824-intron-Distal4.654345.80325K562YWHAG
chr222083757720837622-intron-Distal3.642185.78686K562SLTM
chr222079056420790621-intron-Distal5.009618.29600HepG2CSTF2T
chr222080834020808449-intron-Distal3.732793.37208HepG2ILF3
chr222084938120849435-intron-Distal3.973198.99606K562GEMIN5
chr222083893820838980-intron-Distal4.571624.93122K562SLTM
chr222083824720838315-intron-Distal3.7664910.29897K562SLTM
chr222084916520849218-intron-Distal3.077344.77974K562TIA1
chr222084974520849858-intron-Distal3.909423.87714K562DDX52
chr222083801720838183-intron-Distal3.488617.21479K562UCHL5
chr222084978820849854-intron-Distal3.550714.76898K562CSTF2T
chr222083809320838130-intron-Distal3.066563.13477K562YWHAG
chr222084070920840820-intron-Distal4.768756.08730K562YWHAG
chr222079130220791361-intron-Distal4.908798.08715HepG2CSTF2T
chr222084057420840655-intron-Distal3.285324.48636K562SAFB2
chr222083728220837360-intron-Distal4.4465810.69177K562SLTM
chr222081033120810420-intron-Distal,intron-Proximal3.718563.01619K562FUS
chr222082354920823688-intron-Distal4.211383.62737K562HNRNPK
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for KLHL22 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for KLHL22 is not available on ENCORE database.

  • 78 RBPs can affect the levels of KLHL22.  








The Knockdown/knockout RNA-Seq assay for KLHL22 is not available on ENCORE database.





78 RBPs can affect the gene expression of KLHL22 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
KLHL22ENSG00000099910.12423.44080296.523200.513902.426901.54530HepG2ABCF1
KLHL22ENSG00000099910.12526.99510395.086300.415503.252302.51730HepG2AUH
KLHL22ENSG00000099910.12341.45060256.049400.415202.760802.01970HepG2DAZAP1
KLHL22ENSG00000099910.12513.32800386.289400.410101.834701.31390HepG2DDX3X
KLHL22ENSG00000099910.12203.77040141.085200.530302.393701.73370HepG2DNAJC21
KLHL22ENSG00000099910.12231.41710139.860800.726404.927204.09650HepG2DNAJC2
KLHL22ENSG00000099910.12491.68570318.993300.624103.967303.26570HepG2EIF2S1
KLHL22ENSG00000099910.12110.31950167.71030-0.604302.149201.34370HepG2EIF3D
KLHL22ENSG00000099910.12500.59240352.471900.506002.732902.09770HepG2EIF4A3
KLHL22ENSG00000099910.12181.45730299.41570-0.722503.450102.59670HepG2FIP1L1
KLHL22ENSG00000099910.12265.17410142.437000.896505.146104.30250HepG2HNRNPA1
KLHL22ENSG00000099910.12301.64580206.579600.546102.893701.92120HepG2HNRNPM
KLHL22ENSG00000099910.12254.43620157.393900.692804.644403.87600HepG2HNRNPU
KLHL22ENSG00000099910.12336.02880234.375900.519703.154802.38530HepG2IGF2BP1
KLHL22ENSG00000099910.12241.13880160.771500.584803.603702.77710HepG2ILF2
KLHL22ENSG00000099910.12460.13520306.008700.588402.862901.59410HepG2KRR1
KLHL22ENSG00000099910.12541.26300355.915400.604703.968803.18380HepG2MAGOH
KLHL22ENSG00000099910.12237.79570140.381600.760304.856903.90890HepG2PPIL4
KLHL22ENSG00000099910.12324.92820242.380300.422702.157501.62240HepG2PUF60
KLHL22ENSG00000099910.12362.74480257.309500.495402.934702.32790HepG2PUM1
KLHL22ENSG00000099910.12397.56860257.114000.628704.764103.89560HepG2PUM2
KLHL22ENSG00000099910.12323.83690221.480200.548002.370901.62590HepG2RPS2
KLHL22ENSG00000099910.1269.39280144.80180-1.061204.016503.09030HepG2RRP9
KLHL22ENSG00000099910.12224.74000140.162100.681103.993903.24410HepG2SAFB2
KLHL22ENSG00000099910.12284.07200115.058201.303803.741602.11700HepG2SF1
KLHL22ENSG00000099910.12216.71080357.22310-0.721103.970503.15640HepG2SF3A3
KLHL22ENSG00000099910.12317.57090232.429800.450202.875602.16150HepG2SLBP
KLHL22ENSG00000099910.12233.94520163.445600.517302.657302.02370HepG2SMN1
KLHL22ENSG00000099910.12301.71700195.790000.623802.986501.98740HepG2SMNDC1
KLHL22ENSG00000099910.12214.92490357.93600-0.735905.730905.11180HepG2SRSF1
KLHL22ENSG00000099910.12152.65640232.87020-0.609202.222601.33710HepG2SRSF3
KLHL22ENSG00000099910.12305.85340239.329800.353701.883301.35330HepG2SRSF5
KLHL22ENSG00000099910.12179.43010291.20560-0.698605.132504.42260HepG2SRSF9
KLHL22ENSG00000099910.12635.57890371.788400.7735010.718609.83760HepG2SSB
KLHL22ENSG00000099910.12379.18900272.171400.478303.502102.81750HepG2SUCLG1
KLHL22ENSG00000099910.12207.36350321.74500-0.633803.992203.33760HepG2TAF15
KLHL22ENSG00000099910.12299.71640213.166000.491502.216001.55740HepG2TARDBP
KLHL22ENSG00000099910.12285.55190152.910900.901006.578305.86770HepG2TIAL1
KLHL22ENSG00000099910.12249.58720154.306500.693604.624203.93240HepG2TRIM56
KLHL22ENSG00000099910.12402.85650250.678100.684303.744302.76440HepG2UBE2L3
KLHL22ENSG00000099910.12231.83420305.86050-0.399802.100701.56470HepG2UTP3
KLHL22ENSG00000099910.12310.62540185.984400.739903.597202.77850HepG2XRN2
KLHL22ENSG00000099910.12527.54010309.891600.767406.477504.60810K562ABCF1
KLHL22ENSG00000099910.12326.53000594.71820-0.8650011.5006010.43880K562AGGF1
KLHL22ENSG00000099910.12485.78330653.43850-0.427702.524901.59380K562AKAP8
KLHL22ENSG00000099910.12301.33130618.81480-1.0382010.808209.40090K562AKAP8L
KLHL22ENSG00000099910.12404.24960649.25460-0.683507.528505.90940K562ATP5C1
KLHL22ENSG00000099910.12429.16030319.291300.426502.965501.97310K562BCLAF1
KLHL22ENSG00000099910.12368.10800665.99220-0.8554011.671309.63360K562DKC1
KLHL22ENSG00000099910.12429.82400308.449400.478602.676001.49320K562EIF2S1
KLHL22ENSG00000099910.12183.03300301.32300-0.719203.912702.65730K562EIF3D
KLHL22ENSG00000099910.12466.23500293.428800.667902.846702.01350K562EIF4A3
KLHL22ENSG00000099910.12424.16120313.870900.434302.698801.45060K562EXOSC5
KLHL22ENSG00000099910.1268.59170131.99050-0.944303.362102.56890K562G3BP2
KLHL22ENSG00000099910.12693.11560498.753700.474703.538702.68700K562GRSF1
KLHL22ENSG00000099910.12370.69370255.493700.536802.995602.37790K562HNRNPC
KLHL22ENSG00000099910.12385.74080228.243400.757005.498403.81660K562HNRNPF
KLHL22ENSG00000099910.12555.61250410.604000.436203.041701.92860K562HNRNPL
KLHL22ENSG00000099910.12611.77110472.708500.371902.573701.71000K562HNRNPU
KLHL22ENSG00000099910.12363.91540656.77480-0.851804.067803.04040K562KIF1C
KLHL22ENSG00000099910.12156.41780247.67240-0.663003.102501.61430K562LARP7
KLHL22ENSG00000099910.12364.21500247.244000.558803.524502.57010K562MAGOH
KLHL22ENSG00000099910.12414.53550628.64830-0.600804.944003.37430K562MAK16
KLHL22ENSG00000099910.12353.03690246.747900.516703.220402.21840K562MATR3
KLHL22ENSG00000099910.12454.16090735.74570-0.696007.665306.00310K562MBNL1
KLHL22ENSG00000099910.12310.91930189.885100.711304.276203.17240K562METAP2
KLHL22ENSG00000099910.12566.84500353.357700.681707.807906.51030K562MTPAP
KLHL22ENSG00000099910.12192.53610515.69940-1.4214011.281309.02130K562NAA15
KLHL22ENSG00000099910.12561.98150392.626500.517305.267404.28490K562NSUN2
KLHL22ENSG00000099910.12914.11690399.241601.1950012.2393010.49900K562PCBP3
KLHL22ENSG00000099910.12692.73840306.222001.1776018.7359016.75850K562POLR2G
KLHL22ENSG00000099910.12123.44860273.92720-1.149907.824206.55700K562PRPF8
KLHL22ENSG00000099910.12934.85560739.061100.338902.801201.83680K562PUM2
KLHL22ENSG00000099910.12186.18100613.81220-1.7211024.3900022.78270K562PUS1
KLHL22ENSG00000099910.12236.93480597.97000-1.3356021.6142019.89660K562RBM15
KLHL22ENSG00000099910.12335.47680224.534900.579203.248901.70590K562RBM34
KLHL22ENSG00000099910.12351.62580242.404900.536502.993401.85190K562NELFE
KLHL22ENSG00000099910.12511.89050396.898500.367002.621501.70600K562SRPK2
KLHL22ENSG00000099910.12298.20610193.791500.621702.798001.73890K562SRSF4
KLHL22ENSG00000099910.12804.29180618.741600.378302.955701.39990K562SUCLG1
KLHL22ENSG00000099910.12449.19290238.332000.914308.306406.99390K562TARDBP
KLHL22ENSG00000099910.12406.18650229.895800.821107.056805.65340K562TIA1
KLHL22ENSG00000099910.12329.74850234.216100.493402.295301.44650K562TRIM56
KLHL22ENSG00000099910.12383.08330260.523100.556103.156301.65430K562TRIP6
KLHL22ENSG00000099910.12504.53000280.652000.846106.917105.22190K562UCHL5
KLHL22ENSG00000099910.12680.98890416.309100.709904.557703.65940K562UPF1
KLHL22ENSG00000099910.12345.97550622.22250-0.846803.874702.25370K562UTP18
KLHL22ENSG00000099910.12732.02370567.144100.368102.687801.42020K562WRN
KLHL22ENSG00000099910.12411.69020285.855000.526202.873501.63870K562XRN2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for KLHL22 is not available on ENCORE database.






No RBPs affect the alternative splcing events of KLHL22 on ENCORE database.





The Knockdown/knockout RNA-Seq assay for KLHL22 is not avaliable on ENCORE database.