EIF2D

General Information

Gene Name       : EIF2D
Gene ID             : ENSG00000143486.15
Essential Gene : No

Functions

Localization

Domains (AlphaFold: EIF2D)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878EIF2DENSG00000143486.1568.0774.0671.06ENCSR000AEF
HepG2EIF2DENSG00000143486.1542.3443.8743.11ENCSR985KAT
K562EIF2DENSG00000143486.1580.4086.3183.36ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
EIF2DA303-006A1BGHcLV39-53, Submitted, ENCORE2BGKcLV38-45, Submitted, ENCORE2


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
EIF2DK562CRISPREIF2D-BGKcLV38-45,EIF2D-BGKcLV38-46NT-BGKcLV38-1,NT-BGKcLV38-253.0,56.0SubmittingENCORE2
EIF2DHepG2CRISPREIF2D-BGHcLV39-53,EIF2D-BGHcLV39-54NT-BGHcLV39-1,NT-BGHcLV39-289.4,94.1SubmittingENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
EIF2DProduct_ID: A303-006A
Lot_ID: 1
Source: Bethyl Labs
Target Name: EIF2D-human		 EIF2D-HEPG2-CRISPR-A303-006A.png<br>Caption: Western blot following CRISPR against EIF2D in HepG2 whole cell lysate using EIF2D specific antibody. Lane 1 is a ladder, lane 2 is HepG2 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against EIF2D. EIF2D protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.
 EIF2D-K562-CRISPR-A303-006A.png<br>Caption: Western blot following CRISPR against EIF2D in K562 whole cell lysate using EIF2D specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against EIF2D. EIF2D protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for EIF2D is not avaliable on ENCORE database.



Proteins bound to RNA
  • EIF2D RNA is bound by 13 proteins.  







eCLIP assay for EIF2D is not avaliable on ENCORE database.





13 proteins are bound to EIF2D RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr1206785641206785698-5'-UTR,CDS,intron-Distal3.1375910.25312K562YBX3
chr1206773564206773625-CDS,intron-Distal,intron-Proximal4.9326211.82040K562AQR
chr1206773626206773676-CDS,intron-Distal,intron-Proximal4.277624.71174K562U2AF2
chr1206776261206776319-CDS,intron-Distal,intron-Proximal3.534103.18415HepG2PRPF8
chr1206784716206784726-CDS,intron-Distal3.888726.42513K562YBX3
chr1206770508206770519-CDS,intron-Distal,intron-Proximal3.152333.02345K562ZNF622
chr1206775798206775869-CDS,intron-Distal,intron-Proximal3.6975010.38328K562SF3B4
chr1206781585206781670-CDS,intron-Distal,intron-Proximal4.843606.56499HepG2PPIG
chr1206772373206772439-CDS,intron-Distal3.048045.96743K562BUD13
chr1206769074206769180-CDS,intron-Distal4.343804.26679K562GRWD1
chr1206775693206775741-CDS,intron-Distal,intron-Proximal4.088079.00050K562YBX3
chr1206785639206785641-CDS,intron-Distal3.498584.74241K562YBX3
chr1206775781206775859-CDS,intron-Distal,intron-Proximal3.361434.87883K562BUD13
chr1206767101206767141-CDS,intron-Distal3.379187.94302K562YBX3
chr1206776246206776320-CDS,intron-Distal,intron-Proximal3.4664210.90205K562PRPF8
chr1206767131206767177-CDS,intron-Distal,intron-Proximal3.992114.00320K562AQR
chr1206781612206781673-CDS,intron-Distal,intron-Proximal4.479435.66624K562LIN28B
chr1206773625206773682-CDS,intron-Distal,intron-Proximal3.577674.28285K562AQR
chr1206775640206775713-CDS,intron-Distal,intron-Proximal3.610564.78164HepG2PRPF8
chr1206769073206769184-CDS,intron-Distal3.627824.24070HepG2GRWD1
chr1206773098206773153-CDS,intron-Distal3.257167.47287K562LIN28B
chr1206775629206775704-CDS,intron-Distal,intron-Proximal3.184888.04989K562PRPF8
chr1206784673206784715-CDS,intron-Distal4.0501712.87748K562YBX3
chr1206775595206775694-CDS,intron-Distal,intron-Proximal3.948848.19973HepG2EFTUD2
chr1206768968206769068-CDS,intron-Distal,intron-Proximal3.360354.13620K562KHSRP
chr1206784674206784718-CDS,intron-Distal3.318703.55142K562METAP2
chr1206773631206773713-CDS,intron-Distal,intron-Proximal3.9841415.18333K562SF3B4
chr1206773608206773682-CDS,intron-Distal,intron-Proximal3.427837.52067K562EFTUD2
chr1206777149206777173-intron-Distal4.562555.62025K562KHSRP
chr1206773515206773608-intron-Distal,intron-Proximal4.508069.23680K562EFTUD2
chr1206775580206775684-intron-Distal,intron-Proximal4.172068.79285K562AQR
chr1206778709206778724-intron-Distal,intron-Proximal4.706368.52787K562AQR
chr1206778664206778709-intron-Distal,intron-Proximal3.768384.49024K562AQR
chr1206778745206778753-intron-Distal,intron-Proximal3.705623.94787K562AQR
chr1206775632206775679-intron-Distal,intron-Proximal4.533165.80866K562BUD13
chr1206777173206777209-intron-Distal3.775063.24603K562KHSRP
chr1206775579206775629-intron-Distal,intron-Proximal3.291914.98422K562PRPF8
chr1206778724206778745-intron-Distal,intron-Proximal4.538676.99120K562AQR
chr1206775531206775566-intron-Distal4.647133.92230K562EFTUD2
chr1206775591206775667-intron-Distal,intron-Proximal4.037818.36737K562EFTUD2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for EIF2D is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for EIF2D is not available on ENCORE database.

  • 101 RBPs can affect the levels of EIF2D.  








The Knockdown/knockout RNA-Seq assay for EIF2D is not available on ENCORE database.





101 RBPs can affect the gene expression of EIF2D :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
EIF2DENSG00000143486.11482.04540908.59440-0.9145019.7064018.40670HepG2ACO1
EIF2DENSG00000143486.11868.249501765.04070-1.0235013.3887012.31020HepG2AKAP1
EIF2DENSG00000143486.11639.59870912.80780-0.513106.790205.64330HepG2AKAP8L
EIF2DENSG00000143486.111065.737001484.78870-0.478407.379606.34670HepG2AUH
EIF2DENSG00000143486.11593.58700843.81260-0.507504.985303.98670HepG2CALR
EIF2DENSG00000143486.11543.97070908.33030-0.7397014.2522012.98820HepG2CKAP4
EIF2DENSG00000143486.11598.75460864.25300-0.529502.680701.92850HepG2CNOT7
EIF2DENSG00000143486.11822.25540540.156200.606105.250504.33180HepG2CPSF6
EIF2DENSG00000143486.11900.221201690.68110-0.9093012.4094011.17550HepG2DDX3X
EIF2DENSG00000143486.11225.21440613.39600-1.445507.410305.85180HepG2DDX59
EIF2DENSG00000143486.11677.87180978.30250-0.529304.543303.26330HepG2DDX5
EIF2DENSG00000143486.11427.922701452.55230-1.7632033.5275031.72260HepG2DDX6
EIF2DENSG00000143486.11622.08300869.26140-0.482705.663704.75880HepG2DKC1
EIF2DENSG00000143486.11541.70860797.07550-0.557206.496305.45430HepG2DNAJC21
EIF2DENSG00000143486.11661.35840872.58050-0.399902.607401.70980HepG2EEF2
EIF2DENSG00000143486.11542.13340727.32370-0.423902.839501.71780HepG2EFTUD2
EIF2DENSG00000143486.11504.21180822.12070-0.705305.404103.86660HepG2AGO1
EIF2DENSG00000143486.11643.186401396.15320-1.1181017.0013015.61980HepG2EIF2S1
EIF2DENSG00000143486.111213.529801542.80670-0.346302.073801.51800HepG2EIF4A3
EIF2DENSG00000143486.11572.745201502.34250-1.3912018.4119016.74630HepG2EIF4B
EIF2DENSG00000143486.111284.974301704.71610-0.407806.046905.21650HepG2ETF1
EIF2DENSG00000143486.11654.52260887.79990-0.439803.868602.88130HepG2EWSR1
EIF2DENSG00000143486.11300.64050541.13870-0.848003.216902.11850HepG2FTO
EIF2DENSG00000143486.11847.520701060.94700-0.324002.296901.57590HepG2FUBP3
EIF2DENSG00000143486.111024.308801556.95020-0.604106.148605.14350HepG2FXR1
EIF2DENSG00000143486.11651.190501444.12970-1.1490017.3343015.74020HepG2G3BP1
EIF2DENSG00000143486.111133.399101533.35080-0.436003.606502.58290HepG2G3BP2
EIF2DENSG00000143486.11260.27400612.23430-1.234108.534207.45130HepG2GPKOW
EIF2DENSG00000143486.11379.57370895.10340-1.2377019.6210017.93620HepG2HNRNPC
EIF2DENSG00000143486.11873.796801467.86590-0.748408.670007.54610HepG2IGF2BP2
EIF2DENSG00000143486.11759.333601377.77210-0.859503.336802.25520HepG2IGF2BP3
EIF2DENSG00000143486.111127.316101476.53520-0.389302.201001.31920HepG2KHSRP
EIF2DENSG00000143486.11927.052101306.56060-0.495103.275602.36960HepG2LARP4
EIF2DENSG00000143486.11825.310701557.49520-0.9162012.2857010.93810HepG2MAGOH
EIF2DENSG00000143486.11502.846601566.15980-1.6390030.9627029.02930HepG2MATR3
EIF2DENSG00000143486.11681.722501603.00890-1.2335020.4260018.80950HepG2NCBP2
EIF2DENSG00000143486.11417.18830665.52310-0.673803.661802.39100HepG2NONO
EIF2DENSG00000143486.11995.640801427.38780-0.519704.507403.59870HepG2PABPC4
EIF2DENSG00000143486.11985.709001498.10680-0.6039012.0791010.95400HepG2PCBP1
EIF2DENSG00000143486.11510.53830899.35260-0.816906.154004.65020HepG2PCBP2
EIF2DENSG00000143486.11334.87770558.74990-0.738606.069904.92440HepG2PRPF8
EIF2DENSG00000143486.11636.893701524.36120-1.2591042.3918040.78840HepG2PTBP1
EIF2DENSG00000143486.11412.881601333.56400-1.6915017.8008016.46880HepG2PUF60
EIF2DENSG00000143486.11879.481301415.76830-0.686904.912104.16780HepG2PUM1
EIF2DENSG00000143486.11992.458201414.65260-0.511403.300002.56770HepG2PUM2
EIF2DENSG00000143486.111003.823901650.96030-0.7178013.4966012.26820HepG2QKI
EIF2DENSG00000143486.11560.64960867.79080-0.630203.134902.38730HepG2RAVER1
EIF2DENSG00000143486.11729.652501424.83140-0.9655022.0451020.86500HepG2RBM22
EIF2DENSG00000143486.11639.170001498.33760-1.2291028.5777026.58590HepG2RBM25
EIF2DENSG00000143486.11700.713701061.15210-0.598705.681204.24340HepG2RBM27
EIF2DENSG00000143486.11961.184901696.48300-0.8197020.7625019.54970HepG2NELFE
EIF2DENSG00000143486.111059.663501580.01540-0.5763011.059209.95210HepG2RECQL
EIF2DENSG00000143486.11618.56270852.62730-0.463002.266601.40980HepG2RPS10
EIF2DENSG00000143486.11324.29510689.24980-1.0877015.7057014.40740HepG2RPS19
EIF2DENSG00000143486.11541.20930978.63330-0.8546010.644609.15990HepG2RPS2
EIF2DENSG00000143486.11703.76910999.00470-0.505404.408603.03710HepG2RPS5
EIF2DENSG00000143486.11293.87080552.70020-0.911307.843606.60250HepG2RRP9
EIF2DENSG00000143486.11981.15020791.852400.309103.263902.57510HepG2SAFB2
EIF2DENSG00000143486.11510.99950691.66960-0.436802.881501.92240HepG2SERBP1
EIF2DENSG00000143486.11391.693601017.43970-1.3771016.7990015.06390HepG2SF3A3
EIF2DENSG00000143486.11293.67270578.27200-0.977506.227105.20360HepG2SF3B1
EIF2DENSG00000143486.11514.238301587.09000-1.6259065.4272063.29090HepG2SF3B4
EIF2DENSG00000143486.11686.74360923.42380-0.427205.810804.93340HepG2SMN1
EIF2DENSG00000143486.11382.01520643.44450-0.752203.145302.31050HepG2SNRNP70
EIF2DENSG00000143486.111113.006101609.30200-0.5320010.427609.62350HepG2SRFBP1
EIF2DENSG00000143486.11953.529201656.56470-0.7968020.7137019.67330HepG2SRSF1
EIF2DENSG00000143486.11335.95680622.34530-0.889403.105902.03670HepG2SRSF3
EIF2DENSG00000143486.11510.926501316.85740-1.3659013.2534012.02080HepG2SRSF5
EIF2DENSG00000143486.11701.505101347.69200-0.9420026.0088024.64040HepG2SRSF9
EIF2DENSG00000143486.111026.344801397.26810-0.445106.952806.21040HepG2SSB
EIF2DENSG00000143486.11555.58260754.82790-0.442102.468901.43850HepG2STIP1
EIF2DENSG00000143486.111108.556901497.49510-0.433902.550801.94970HepG2SUCLG1
EIF2DENSG00000143486.11495.16390721.23820-0.542603.861003.08310HepG2SUPV3L1
EIF2DENSG00000143486.111027.538601488.94730-0.535108.304907.41820HepG2TAF15
EIF2DENSG00000143486.11398.612101141.86250-1.5183011.866609.84810HepG2TBRG4
EIF2DENSG00000143486.111099.780901368.17970-0.315002.845601.99790HepG2TIA1
EIF2DENSG00000143486.11547.43570863.97140-0.658308.110107.33580HepG2TIAL1
EIF2DENSG00000143486.11495.73820963.24730-0.9583012.1792010.83170HepG2U2AF1
EIF2DENSG00000143486.11345.78940655.91600-0.923602.508501.57340HepG2U2AF2
EIF2DENSG00000143486.11698.90350902.31610-0.368504.008603.19200HepG2UPF1
EIF2DENSG00000143486.11440.36320999.61240-1.1827032.7054030.88550HepG2ZC3H8
EIF2DENSG00000143486.11566.35180867.18460-0.614604.156902.53870HepG2ZRANB2
EIF2DENSG00000143486.113033.136902701.289900.167101.845301.36300K562AGGF1
EIF2DENSG00000143486.111773.819502994.89620-0.7556012.6708011.54690K562AQR
EIF2DENSG00000143486.112004.796902647.57630-0.401207.258506.27180K562DDX47
EIF2DENSG00000143486.11968.892201784.32200-0.8810013.9098011.69570K562EFTUD2
EIF2DENSG00000143486.111932.777802385.86060-0.303803.399902.61540K562EIF2S2
EIF2DENSG00000143486.111378.693601910.28580-0.470503.724802.50730K562EIF3D
EIF2DENSG00000143486.111554.466301259.100000.303903.033702.20060K562EIF3G
EIF2DENSG00000143486.112761.607401944.025500.506405.813404.55210K562FIP1L1
EIF2DENSG00000143486.111240.083801566.07760-0.336702.532201.71430K562FMR1
EIF2DENSG00000143486.111049.756101327.42130-0.338602.139701.34060K562FTO
EIF2DENSG00000143486.111051.780201340.87170-0.350301.904201.33020K562G3BP2
EIF2DENSG00000143486.111148.859201469.44540-0.355102.968202.14590K562GPKOW
EIF2DENSG00000143486.11606.942302007.82780-1.7260056.7633054.22760K562HNRNPC
EIF2DENSG00000143486.112155.768501687.350700.353302.708001.49110K562HNRNPK
EIF2DENSG00000143486.112161.222901599.184700.434403.597102.52380K562HNRNPM
EIF2DENSG00000143486.113265.529802635.411100.309202.212801.49900K562HSPD1
EIF2DENSG00000143486.11919.079401579.85450-0.7815012.018809.90230K562PCBP2
EIF2DENSG00000143486.111621.068902562.02340-0.660307.828806.42720K562PCBP3
EIF2DENSG00000143486.111301.898101965.18880-0.594109.578208.12620K562POLR2G
EIF2DENSG00000143486.112717.935402207.136100.300202.054401.35110K562PPIG
EIF2DENSG00000143486.11936.719601736.35530-0.8904013.7137012.03490K562PRPF8
EIF2DENSG00000143486.111306.454601725.33150-0.401204.458803.63610K562PTBP1
EIF2DENSG00000143486.112192.641304020.37220-0.8747017.7208015.60350K562PUF60
EIF2DENSG00000143486.113638.555202787.578700.384304.048903.41100K562PUS1
EIF2DENSG00000143486.112316.194503015.34560-0.380604.550802.48890K562RBM17
EIF2DENSG00000143486.11948.860601768.54090-0.8983011.8100010.09260K562RPS19
EIF2DENSG00000143486.11879.463801397.59640-0.668306.343504.83870K562SF3B1
EIF2DENSG00000143486.11948.116001393.41900-0.555505.644904.39730K562SF3B4
EIF2DENSG00000143486.111914.907802337.08750-0.287404.784303.59540K562SRPK2
EIF2DENSG00000143486.111234.573601691.48760-0.454305.311904.33820K562SRSF1
EIF2DENSG00000143486.111204.899401680.93050-0.480304.005602.76670K562SUPV3L1
EIF2DENSG00000143486.111352.949501711.70720-0.339302.604101.91580K562TARDBP
EIF2DENSG00000143486.111358.090701779.17640-0.389603.220202.11790K562UCHL5
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for EIF2D is not available on ENCORE database.





14 RBPs can affect the splicing of EIF2D :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEEIF2DENSG00000143486.11chr1-206773086206773190206772816206772966206773616206773662-0.054000.000080.00256excludedK562SF3B4
SEEIF2DENSG00000143486.11chr1-206772816206772966206772356206772446206773616206773662-0.171000.000010.00063excludedK562PRPF8
SEEIF2DENSG00000143486.11chr1-206773086206773190206772816206772966206773616206773662-0.061000.000590.01305excludedHepG2U2AF1
SEEIF2DENSG00000143486.11chr1-206773086206773190206772816206772966206773616206773662-0.063000.000020.00560excludedK562FMR1
SEEIF2DENSG00000143486.11chr1-206773086206773190206772356206772446206773616206773662-0.081000.001730.01941excludedK562AQR
SEEIF2DENSG00000143486.11chr1-206773086206773190206772356206772446206773616206773662-0.095000.000080.00548excludedK562FXR1
SEEIF2DENSG00000143486.11chr1-206772816206772966206772356206772446206773616206773662-0.103000.001460.09638excludedK562SUPV3L1
SEEIF2DENSG00000143486.11chr1-206772816206772966206772356206772446206773086206773190-0.089000.000050.00442excludedHepG2PTBP1
SEEIF2DENSG00000143486.11chr1-206772816206772966206772356206772446206773616206773662-0.229000.000000.00000excludedK562EFTUD2
SEEIF2DENSG00000143486.11chr1-206775689206775834206773616206773662206776304206776558-0.083000.000790.04340excludedK562EFTUD2
SEEIF2DENSG00000143486.11chr1-206773086206773190206772356206772446206773616206773662-0.159000.000010.00065excludedK562TARDBP
SEEIF2DENSG00000143486.11chr1-206778752206778860206773616206773662206781588206781679-0.121000.000130.00786excludedK562TARDBP
SEEIF2DENSG00000143486.11chr1-206778752206778860206773616206773662206781588206781679-0.107000.000000.00008excludedK562HNRNPU
SEEIF2DENSG00000143486.11chr1-206773086206773190206772816206772966206773616206773662-0.069000.000030.00245excludedK562SF3B1
SEEIF2DENSG00000143486.11chr1-206775689206775834206773616206773662206776304206776558-0.113000.001020.04066excludedK562SF3B1
SEEIF2DENSG00000143486.11chr1-206776304206776558206773616206773662206778752206778860-0.294000.000370.01994excludedHepG2HNRNPU
SEEIF2DENSG00000143486.11chr1-2067779622067780832067764362067765582067787522067788600.173000.000010.00070includedHepG2HNRNPC
SEEIF2DENSG00000143486.11chr1-206773086206773190206772356206772446206773616206773662-0.264000.000000.00002excludedHepG2HNRNPC
SEEIF2DENSG00000143486.11chr1-2067741112067742582067736162067736622067756892067758070.063000.000000.00000includedK562HNRNPC
SEEIF2DENSG00000143486.11chr1-2067779622067780832067764362067765582067787522067788600.486000.000000.00000includedK562HNRNPC
SEEIF2DENSG00000143486.11chr1-206773086206773190206772816206772966206773616206773662-0.250000.000000.00000excludedK562HNRNPC
SEEIF2DENSG00000143486.11chr1-206775689206775807206773616206773662206778752206778860-0.163000.000000.00000excludedK562HNRNPC
A5SSEIF2DENSG00000143486.11chr1-206781588206781788206781632206781788206778752206778860-0.076000.003120.04893shorterK562AQR
A5SSEIF2DENSG00000143486.11chr1-206784536206784727206784595206784727206782728206782812-0.058000.000350.00774shorterK562AQR
A5SSEIF2DENSG00000143486.11chr1-206781588206781648206781632206781648206778752206778860-0.132000.000150.02587shorterK562SUPV3L1
MXEEIF2DENSG00000143486.11chr1-206781632206781679206782728206782812206778752206778860206784536206784727-0.079000.002850.059072includedK562TARDBP
MXEEIF2DENSG00000143486.11chr1-206772816206772966206773086206773190206772356206772446206773616206773662-0.236000.018930.089072includedHepG2U2AF2
MXEEIF2DENSG00000143486.11chr1-2067763042067765582067787522067788602067756952067758072067815882067816790.174000.000040.001491includedK562HNRNPC
MXEEIF2DENSG00000143486.11chr1-206772816206772966206773086206773190206772356206772446206773616206773662-0.148000.002950.048012includedK562HNRNPC

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for EIF2D is not avaliable on ENCORE database.