CLOCK

General Information

Gene Name : CLOCK
Gene ID : ENSG00000134852.14
Essential Gene : No

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: CLOCK)

Not Available

Antibody Validation

Not Avaiable

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	CLOCK	ENSG00000134852.14	6.52	4.96	5.74	ENCSR000AEF
HepG2	CLOCK	ENSG00000134852.14	4.77	7.37	6.07	ENCSR985KAT
K562	CLOCK	ENSG00000134852.14	5.44	6.29	5.87	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

No Antibody Primary Validation image or Secondary image available

KD RNA-Seq

No KD RNA-Seq experiment available

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for CLOCK is not avaliable on ENCORE database.

Proteins bound to RNA

CLOCK RNA is bound by 31 proteins.

eCLIP assay for CLOCK is not avaliable on ENCORE database.

31 proteins are bound to CLOCK RNA:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr4	56300995	56301066	-	3'-UTR,intron-Distal	4.46107	5.20626	K562	PUM2
chr4	56412096	56412146	-	5'-UTR,intron-Distal,intron-Proximal	4.33054	3.58113	K562	EWSR1
chr4	56412688	56412715	-	5'-UTR,intron-Distal,intron-Proximal	4.21381	3.48173	K562	GTF2F1
chr4	56412009	56412139	-	5'-UTR,intron-Distal,intron-Proximal	3.71979	3.41858	K562	FUS
chr4	56411814	56411864	-	5'-UTR,intron-Distal	4.52665	5.97467	K562	TIA1
chr4	56411916	56411973	-	5'-UTR,intron-Distal	3.33521	4.25264	K562	NONO
chr4	56412043	56412079	-	5'-UTR,intron-Distal	4.40622	5.59615	K562	NONO
chr4	56412655	56412700	-	5'-UTR,intron-Distal	3.36781	4.72468	HepG2	FAM120A
chr4	56412084	56412128	-	5'-UTR,intron-Distal,intron-Proximal	3.37809	3.48399	HepG2	CSTF2T
chr4	56411823	56411878	-	5'-UTR,intron-Distal	3.14097	4.98988	K562	NONO
chr4	56412651	56412729	-	5'-UTR,intron-Distal,intron-Proximal	3.03341	4.19174	HepG2	PRPF4
chr4	56412091	56412185	-	5'-UTR,intron-Distal,intron-Proximal	4.22398	7.95555	K562	NONO
chr4	56412083	56412110	-	5'-UTR,intron-Distal,intron-Proximal	4.11548	4.27402	K562	CSTF2T
chr4	56411811	56411870	-	5'-UTR,intron-Distal	4.90755	6.51015	K562	CSTF2T
chr4	56411987	56412043	-	5'-UTR,intron-Distal	4.12064	5.37486	K562	NONO
chr4	56314948	56315036	-	CDS,intron-Distal,intron-Proximal	3.13540	3.55138	K562	ZNF622
chr4	56304391	56304466	-	CDS,intron-Distal,intron-Proximal	4.28120	4.22101	K562	PRPF8
chr4	56344987	56345131	-	CDS,intron-Distal,intron-Proximal	4.65955	3.89826	HepG2	BCLAF1
chr4	56336850	56336916	-	CDS,intron-Distal,intron-Proximal	4.31005	4.04372	HepG2	BCLAF1
chr4	56310797	56310858	-	CDS,intron-Distal,intron-Proximal	3.19922	4.44630	K562	ZNF622
chr4	56309917	56310056	-	CDS,intron-Distal,intron-Proximal	4.56734	3.89826	HepG2	BCLAF1
chr4	56345802	56345869	-	CDS,intron-Distal,intron-Proximal	3.99094	5.51636	K562	GPKOW
chr4	56309994	56310064	-	CDS,intron-Distal,intron-Proximal	3.51817	4.74755	K562	ZNF622
chr4	56345807	56345872	-	CDS,intron-Distal,intron-Proximal	3.37663	4.56058	HepG2	BCLAF1
chr4	56316239	56316301	-	CDS,intron-Distal,intron-Proximal	5.05732	4.35676	HepG2	PRPF8
chr4	56304657	56304713	-	CDS,intron-Distal,intron-Proximal	4.77734	3.77802	HepG2	U2AF2
chr4	56412480	56412523	-	intron-Distal	3.33279	4.37279	HepG2	CSTF2T
chr4	56412566	56412631	-	intron-Distal	4.97568	8.57129	HepG2	PRPF4
chr4	56412743	56412789	-	intron-Distal,intron-Proximal	4.61806	5.40320	K562	NONO
chr4	56382525	56382665	-	intron-Distal	3.19874	3.55860	K562	SAFB2
chr4	56412355	56412446	-	intron-Distal	4.31251	3.90626	K562	XRN2
chr4	56412390	56412463	-	intron-Distal	4.48844	5.23978	HepG2	PRPF4
chr4	56412314	56412383	-	intron-Distal	4.52731	11.80524	HepG2	CSTF2T
chr4	56412743	56412793	-	intron-Distal,intron-Proximal	4.50106	4.70436	K562	EWSR1
chr4	56412553	56412617	-	intron-Distal	4.89791	10.29312	K562	FASTKD2
chr4	56399448	56399496	-	intron-Distal	3.83075	4.81774	K562	HNRNPM
chr4	56412543	56412604	-	intron-Distal	4.22659	8.28918	HepG2	CSTF2T
chr4	56412507	56412622	-	intron-Distal	3.36234	9.32791	K562	DROSHA
chr4	56343862	56344006	-	intron-Distal	4.11646	9.23478	K562	PTBP1
chr4	56412732	56412797	-	intron-Distal,intron-Proximal	6.05060	11.52233	K562	GTF2F1
chr4	56395237	56395296	-	intron-Distal	4.24973	3.01445	K562	EXOSC5
chr4	56412558	56412613	-	intron-Distal	4.10862	3.36882	K562	SLTM
chr4	56412535	56412603	-	intron-Distal	5.84117	16.88011	K562	CSTF2T
chr4	56395146	56395204	-	intron-Distal	4.02623	3.04182	K562	HNRNPM
chr4	56399492	56399577	-	intron-Distal	3.54602	4.61337	K562	EXOSC5
chr4	56412541	56412615	-	intron-Distal	4.78312	17.95770	HepG2	FAM120A
chr4	56398408	56398467	-	intron-Distal	4.36093	3.59909	K562	EXOSC5
chr4	56411061	56411151	-	intron-Distal	3.27859	5.35398	HepG2	QKI
chr4	56406497	56406591	-	intron-Distal	4.90270	5.77028	HepG2	PCBP2
chr4	56395104	56395225	-	intron-Distal	3.64337	4.94813	HepG2	HNRNPM
chr4	56412378	56412459	-	intron-Distal	3.96775	8.90751	K562	CSTF2T
chr4	56391511	56391577	-	intron-Distal	3.76962	3.24590	HepG2	ILF3
chr4	56349137	56349201	-	intron-Distal	4.47028	4.12401	HepG2	U2AF2
chr4	56399459	56399531	-	intron-Distal	3.62305	3.68481	HepG2	HNRNPM
chr4	56412729	56412793	-	intron-Distal,intron-Proximal	5.23876	10.08328	HepG2	PRPF4
chr4	56412739	56412794	-	intron-Distal,intron-Proximal	4.37219	8.80752	HepG2	FAM120A
chr4	56412559	56412613	-	intron-Distal	4.78485	6.42243	HepG2	GTF2F1
chr4	56403189	56403254	-	intron-Distal	4.14810	4.31512	K562	KHSRP
chr4	56412385	56412462	-	intron-Distal	5.06272	7.27892	K562	EWSR1
chr4	56412310	56412463	-	intron-Distal	4.79854	11.26712	K562	NONO
chr4	56391486	56391590	-	intron-Distal	4.57308	5.50179	K562	ILF3
chr4	56412383	56412457	-	intron-Distal	4.08547	15.48951	HepG2	CSTF2T
chr4	56399277	56399347	-	intron-Distal	3.62305	3.68481	HepG2	HNRNPM
chr4	56404533	56404619	-	intron-Distal	4.40637	9.85516	K562	KHSRP
chr4	56412364	56412468	-	intron-Distal	3.32346	5.03073	K562	FUS
chr4	56412311	56412378	-	intron-Distal	5.20425	8.31268	K562	CSTF2T
chr4	56412350	56412432	-	intron-Distal	3.41696	5.07384	K562	DROSHA
chr4	56412739	56412797	-	intron-Distal,intron-Proximal	3.58925	10.46768	K562	CSTF2T
chr4	56412541	56412617	-	intron-Distal	5.27866	12.51317	K562	GTF2F1
chr4	56412227	56412276	-	intron-Distal	3.70299	5.44474	HepG2	FAM120A
chr4	56412205	56412292	-	intron-Distal	5.35879	11.79564	HepG2	CSTF2T
chr4	56412531	56412617	-	intron-Distal	4.92999	4.42197	K562	EWSR1
chr4	56412353	56412455	-	intron-Distal	4.52051	16.19346	HepG2	FAM120A
chr4	56410258	56410355	-	intron-Distal	5.33523	9.43874	K562	TARDBP
chr4	56399288	56399385	-	intron-Distal	5.23027	6.88558	K562	HNRNPM
chr4	56343867	56343996	-	intron-Distal	5.07488	8.48075	HepG2	PTBP1
chr4	56399291	56399351	-	intron-Distal	3.46579	4.02241	K562	EXOSC5
chr4	56412551	56412616	-	intron-Distal	3.03970	4.99572	K562	AKAP8L
chr4	56412201	56412296	-	intron-Distal	3.73996	3.55447	K562	FUS
chr4	56412541	56412610	-	intron-Distal	4.93783	5.38606	K562	FAM120A
chr4	56369435	56369561	-	intron-Distal	3.36123	4.52210	K562	KHSRP
chr4	56412720	56412798	-	intron-Distal,intron-Proximal	3.22382	7.46255	HepG2	CSTF2T
chr4	56412745	56412772	-	intron-Distal,intron-Proximal	3.34096	4.41086	K562	DROSHA
chr4	56395047	56395146	-	intron-Distal	3.68719	4.57394	K562	HNRNPM
chr4	56412772	56412792	-	intron-Distal,intron-Proximal	3.39326	3.41957	K562	DROSHA
chr4	56406783	56406839	-	intron-Distal	7.77536	25.14915	K562	LARP7
chr4	56399496	56399530	-	intron-Distal	4.21974	3.29197	K562	HNRNPM
chr4	56314580	56314743	-	intron-Distal	4.40658	5.63065	K562	HNRNPL
chr4	56355891	56355999	-	intron-Distal	3.38255	3.68839	K562	KHSRP
chr4	56412490	56412524	-	intron-Distal	4.74125	5.62460	K562	CSTF2T
chr4	56412733	56412791	-	intron-Distal,intron-Proximal	4.87918	7.74707	K562	DDX51
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

eCLIP assay for CLOCK is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for CLOCK is not available on ENCORE database.
71 RBPs can affect the levels of CLOCK.

The Knockdown/knockout RNA-Seq assay for CLOCK is not available on ENCORE database.

71 RBPs can affect the gene expression of CLOCK :

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
CLOCK	ENSG00000134852.10	879.91400	698.82690	0.33230	2.48930	1.90730	HepG2	ACO1
CLOCK	ENSG00000134852.10	361.13870	656.74720	-0.86280	6.15670	4.73500	HepG2	BCCIP
CLOCK	ENSG00000134852.10	1352.93670	982.73070	0.46110	3.69770	3.01740	HepG2	BOP1
CLOCK	ENSG00000134852.10	485.16830	670.27510	-0.46630	3.16260	1.84800	HepG2	BUD13
CLOCK	ENSG00000134852.10	662.52270	829.10570	-0.32360	3.42460	2.61590	HepG2	DAZAP1
CLOCK	ENSG00000134852.10	423.22570	572.46870	-0.43580	2.88320	2.19240	HepG2	DDX21
CLOCK	ENSG00000134852.10	711.45290	560.13670	0.34490	2.31310	1.48550	HepG2	DDX24
CLOCK	ENSG00000134852.10	1183.99690	762.62220	0.63450	4.50590	3.72220	HepG2	DDX3X
CLOCK	ENSG00000134852.10	624.08900	821.92770	-0.39730	2.76630	1.75470	HepG2	DDX5
CLOCK	ENSG00000134852.10	450.91030	614.81800	-0.44730	4.73860	3.92260	HepG2	DNAJC2
CLOCK	ENSG00000134852.10	662.68720	412.75690	0.68290	5.46230	4.22330	HepG2	EIF3D
CLOCK	ENSG00000134852.10	530.84920	358.43860	0.56650	4.39390	3.41670	HepG2	FUBP3
CLOCK	ENSG00000134852.10	891.33550	651.37310	0.45240	2.08330	1.50230	HepG2	G3BP1
CLOCK	ENSG00000134852.10	727.17250	1022.82080	-0.49220	3.42280	2.71680	HepG2	GPKOW
CLOCK	ENSG00000134852.10	480.69400	696.57830	-0.53520	4.14250	3.30660	HepG2	HNRNPC
CLOCK	ENSG00000134852.10	661.00440	805.67140	-0.28550	2.52130	1.83550	HepG2	HNRNPF
CLOCK	ENSG00000134852.10	595.38420	755.25650	-0.34310	3.35490	2.61900	HepG2	HNRNPL
CLOCK	ENSG00000134852.10	729.51420	1146.98380	-0.65280	5.13580	3.99080	HepG2	LARP4
CLOCK	ENSG00000134852.10	954.50550	702.21120	0.44270	2.11670	1.54020	HepG2	MAGOH
CLOCK	ENSG00000134852.10	964.31840	578.88110	0.73610	13.05920	11.89450	HepG2	PCBP1
CLOCK	ENSG00000134852.10	367.86180	617.18500	-0.74650	9.24960	7.94580	HepG2	PPIL4
CLOCK	ENSG00000134852.10	865.91970	711.43100	0.28340	2.39880	1.67270	HepG2	PRPF4
CLOCK	ENSG00000134852.10	636.39930	498.30700	0.35280	2.21070	1.48610	HepG2	PRPF8
CLOCK	ENSG00000134852.10	853.77030	589.05290	0.53540	6.71620	5.93710	HepG2	PTBP1
CLOCK	ENSG00000134852.10	888.49090	711.82190	0.31970	2.28360	1.71090	HepG2	PUS1
CLOCK	ENSG00000134852.10	949.72360	637.91690	0.57400	6.82970	5.91330	HepG2	QKI
CLOCK	ENSG00000134852.10	1368.14920	619.04700	1.14400	9.64110	8.37940	HepG2	RAVER1
CLOCK	ENSG00000134852.10	1236.71180	578.96640	1.09490	21.43370	19.66490	HepG2	RBM25
CLOCK	ENSG00000134852.10	664.52260	492.95020	0.43080	2.75710	1.97140	HepG2	RRP9
CLOCK	ENSG00000134852.10	529.64410	403.10880	0.39380	2.31720	1.45300	HepG2	SERBP1
CLOCK	ENSG00000134852.10	1338.06510	966.17960	0.46970	4.42980	3.55610	HepG2	SF3B1
CLOCK	ENSG00000134852.10	495.66290	718.63430	-0.53590	6.91970	5.97350	HepG2	SMN1
CLOCK	ENSG00000134852.10	1072.72350	640.10920	0.74480	13.60090	12.72340	HepG2	SRSF1
CLOCK	ENSG00000134852.10	954.78880	774.86870	0.30110	2.79050	2.16200	HepG2	SRSF5
CLOCK	ENSG00000134852.10	867.74100	520.77530	0.73650	12.98140	11.94330	HepG2	SRSF9
CLOCK	ENSG00000134852.10	845.95270	578.50470	0.54810	2.96010	1.71490	HepG2	SUB1
CLOCK	ENSG00000134852.10	571.96430	798.10760	-0.48070	2.62100	1.33430	HepG2	SUGP2
CLOCK	ENSG00000134852.10	455.91000	610.04640	-0.42020	2.51080	1.61230	HepG2	SUPT6H
CLOCK	ENSG00000134852.10	806.98370	642.82640	0.32800	2.02130	1.43000	HepG2	SUPV3L1
CLOCK	ENSG00000134852.10	921.83500	575.39510	0.67990	9.61240	8.66900	HepG2	TAF15
CLOCK	ENSG00000134852.10	701.64380	528.66730	0.40830	2.23470	1.48150	HepG2	TIA1
CLOCK	ENSG00000134852.10	522.41810	672.38780	-0.36410	2.64490	2.15400	HepG2	TIAL1
CLOCK	ENSG00000134852.10	461.50040	678.39130	-0.55580	6.70470	5.89460	HepG2	TRIM56
CLOCK	ENSG00000134852.10	1000.79350	771.11180	0.37600	4.29230	3.57230	HepG2	UTP3
CLOCK	ENSG00000134852.10	899.17720	608.67950	0.56280	3.19410	1.82900	HepG2	XRCC5
CLOCK	ENSG00000134852.10	365.62200	632.79020	-0.79140	5.06490	4.09180	HepG2	XRN2
CLOCK	ENSG00000134852.10	618.21070	878.41450	-0.50680	7.52370	6.73660	HepG2	ZNF622
CLOCK	ENSG00000134852.10	932.67600	618.41800	0.59270	3.97440	2.38990	HepG2	ZRANB2
CLOCK	ENSG00000134852.10	1294.58720	1038.23200	0.31830	1.90930	1.40500	K562	AQR
CLOCK	ENSG00000134852.10	1255.57380	791.12780	0.66630	7.21660	5.78460	K562	BOP1
CLOCK	ENSG00000134852.10	1116.12550	841.16950	0.40790	3.71110	2.80430	K562	CPSF6
CLOCK	ENSG00000134852.10	662.43840	525.14400	0.33500	2.78590	1.45800	K562	DDX27
CLOCK	ENSG00000134852.10	1009.18330	674.52210	0.58120	6.53320	4.84840	K562	DDX3X
CLOCK	ENSG00000134852.10	1748.26530	1468.71060	0.25130	2.55090	1.71420	K562	DKC1
CLOCK	ENSG00000134852.10	614.32000	927.56730	-0.59450	5.93480	4.65750	K562	FIP1L1
CLOCK	ENSG00000134852.10	1214.76900	855.92100	0.50500	4.61980	3.51150	K562	FMR1
CLOCK	ENSG00000134852.10	983.92600	725.49240	0.43950	2.95430	2.00850	K562	FTO
CLOCK	ENSG00000134852.10	1310.47090	785.49860	0.73830	4.12260	3.21860	K562	G3BP2
CLOCK	ENSG00000134852.10	978.14680	776.13510	0.33360	2.92860	2.00970	K562	HNRNPU
CLOCK	ENSG00000134852.10	670.07760	894.52480	-0.41680	2.45340	1.50450	K562	IGF2BP2
CLOCK	ENSG00000134852.10	643.69130	938.17670	-0.54350	5.83300	4.42120	K562	MATR3
CLOCK	ENSG00000134852.10	1156.33790	793.23980	0.54360	8.54720	7.20090	K562	MTPAP
CLOCK	ENSG00000134852.10	956.85140	703.70490	0.44320	3.37460	2.00830	K562	NCBP2
CLOCK	ENSG00000134852.10	664.83860	1052.91600	-0.66330	7.29550	5.83680	K562	PPIG
CLOCK	ENSG00000134852.10	741.05460	550.00170	0.43000	2.90470	2.13770	K562	PRPF8
CLOCK	ENSG00000134852.10	1104.19810	749.43370	0.55900	2.86020	1.41530	K562	RAVER1
CLOCK	ENSG00000134852.10	1583.37660	1318.84410	0.26360	2.43320	1.87070	K562	RBM15
CLOCK	ENSG00000134852.10	654.84910	875.78630	-0.41940	3.27280	2.35240	K562	RBM22
CLOCK	ENSG00000134852.10	716.41510	968.08880	-0.43430	2.94890	1.91220	K562	RPS3
CLOCK	ENSG00000134852.10	1494.37730	800.03440	0.90130	3.63740	2.19620	K562	SF1
CLOCK	ENSG00000134852.10	1068.13210	763.84270	0.48360	3.38520	2.30780	K562	SF3B1
CLOCK	ENSG00000134852.10	1641.12370	918.93700	0.83650	3.98490	2.41550	K562	SNRNP200
CLOCK	ENSG00000134852.10	807.59410	532.65130	0.60030	4.82770	3.45410	K562	SUPV3L1
CLOCK	ENSG00000134852.10	674.82930	857.79180	-0.34610	2.29540	1.32120	K562	TRA2A
CLOCK	ENSG00000134852.10	1052.47530	761.26660	0.46720	2.33970	1.34500	K562	U2AF1
CLOCK	ENSG00000134852.10	1188.89260	786.26750	0.59640	8.02570	6.64690	K562	U2AF2
CLOCK	ENSG00000134852.10	1019.90680	831.54110	0.29450	3.02970	2.14520	K562	WDR43
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for CLOCK is not available on ENCORE database.

3 RBPs can affect the splicing of CLOCK :

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	CLOCK	ENSG00000134852.10	chr4	-	56376078	56376232	56355540	56355632	56412648	56412813	-0.54300	0.00870	0.08164	excluded	HepG2	U2AF2
SE	CLOCK	ENSG00000134852.10	chr4	-	56319843	56319991	56319220	56319296	56322063	56322170	-0.18500	0.00052	0.00993	excluded	K562	PUS1
SE	CLOCK	ENSG00000134852.10	chr4	-	56347375	56347434	56345806	56345866	56348905	56348995	0.07600	0.00034	0.05695	included	K562	EIF4G2
SE	CLOCK	ENSG00000134852.10	chr4	-	56344981	56345130	56342129	56342221	56345806	56345866	-0.52700	0.00000	0.00008	excluded	K562	U2AF2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

CLOCK

General Information

Functions

Localization

Domains (AlphaFold: CLOCK)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for CLOCK is not avaliable on ENCORE database.

31 proteins are bound to CLOCK RNA:

eCLIP assay for CLOCK is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for CLOCK is not available on ENCORE database.

71 RBPs can affect the gene expression of CLOCK :

The Knockdown/knockout RNA-Seq assay for CLOCK is not available on ENCORE database.

3 RBPs can affect the splicing of CLOCK :

The Knockdown/knockout RNA-Seq assay for CLOCK is not avaliable on ENCORE database.