ALS2

General Information

Gene Name       : ALS2
Gene ID             : ENSG00000003393.14
Essential Gene : No

Functions

Localization

Domains (AlphaFold: ALS2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878ALS2ENSG00000003393.1410.327.078.70ENCSR000AEF
HepG2ALS2ENSG00000003393.1412.6016.4214.51ENCSR985KAT
K562ALS2ENSG00000003393.149.179.379.27ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for ALS2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • ALS2 RNA is bound by 15 proteins.  







eCLIP assay for ALS2 is not avaliable on ENCORE database.





15 proteins are bound to ALS2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr2202633584202633646-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.937703.59112HepG2PPIG
chr2202645491202645639-5'-UTR,intron-Distal,intron-Proximal4.008395.64238K562PRPF8
chr2202645558202645642-5'-UTR,intron-Distal,intron-Proximal4.8339826.47837HepG2PRPF8
chr2202619323202619395-CDS,intron-Distal,intron-Proximal3.477556.60490HepG2BCLAF1
chr2202632009202632058-CDS,intron-Distal4.665304.78529HepG2BCLAF1
chr2202617874202617942-CDS,intron-Distal3.398693.86355HepG2PPIG
chr2202631915202631979-CDS,intron-Distal,intron-Proximal4.110565.93840HepG2PRPF8
chr2202588095202588164-CDS,intron-Distal4.344367.09561HepG2BCLAF1
chr2202626490202626550-CDS,intron-Distal,intron-Proximal4.000843.07225K562U2AF1
chr2202590148202590191-CDS,intron-Distal,intron-Proximal3.470283.32861HepG2U2AF2
chr2202619332202619431-CDS,intron-Distal,intron-Proximal4.009676.32636HepG2U2AF2
chr2202598033202598062-CDS,intron-Distal4.305353.45943HepG2BCLAF1
chr2202626495202626554-CDS,intron-Distal,intron-Proximal4.164683.96990K562BUD13
chr2202622123202622205-CDS,intron-Distal,intron-Proximal3.778323.01428K562UCHL5
chr2202621978202622126-CDS,intron-Distal,intron-Proximal3.953133.90026K562KHSRP
chr2202587765202587836-CDS,intron-Distal,intron-Proximal3.831597.23562HepG2BCLAF1
chr2202590082202590184-CDS,intron-Distal,intron-Proximal3.928103.01428K562UCHL5
chr2202590083202590127-CDS,intron-Distal4.810055.68196HepG2BCLAF1
chr2202589016202589030-CDS,intron-Distal,intron-Proximal4.461593.89826HepG2BCLAF1
chr2202626299202626377-CDS,intron-Distal,intron-Proximal3.345843.36945K562ZNF622
chr2202626462202626552-CDS,intron-Distal,intron-Proximal3.395954.28417K562U2AF2
chr2202617924202617966-CDS,intron-Distal,intron-Proximal4.602544.34038HepG2BCLAF1
chr2202608940202609002-CDS,intron-Distal,intron-Proximal4.130253.56873HepG2PRPF8
chr2202632067202632107-CDS,intron-Distal,intron-Proximal3.331594.85828HepG2BCLAF1
chr2202622121202622230-CDS,intron-Distal,intron-Proximal3.170198.01569HepG2BCLAF1
chr2202606531202606574-CDS,intron-Distal4.422593.45943HepG2BCLAF1
chr2202626338202626383-CDS,intron-Distal,intron-Proximal3.296394.56058HepG2BCLAF1
chr2202626436202626520-CDS,intron-Distal3.153733.79741HepG2GRWD1
chr2202626472202626554-CDS,intron-Distal,intron-Proximal4.2046712.08856HepG2U2AF2
chr2202622139202622234-CDS,intron-Distal3.904303.79347HepG2GRWD1
chr2202631944202632107-CDS,intron-Distal,intron-Proximal3.537203.01533HepG2SRSF1
chr2202588056202588095-CDS,intron-Distal3.602543.68471HepG2BCLAF1
chr2202638720202638837-intron-Distal3.987976.73795HepG2HNRNPL
chr2202576186202576227-intron-Distal3.540863.89405HepG2PTBP1
chr2202645480202645598-intron-Distal3.330724.31340HepG2RBM22
chr2202586819202586942-intron-Distal4.342005.46313K562KHSRP
chr2202576172202576280-intron-Distal5.3812817.83223HepG2U2AF2
chr2202576227202576309-intron-Distal5.246328.48075HepG2PTBP1
chr2202605405202605541-intron-Distal4.156043.16986HepG2QKI
chr2202577428202577477-intron-Distal4.759768.05592K562PTBP1
chr2202605634202605729-intron-Distal4.805634.64001HepG2U2AF2
chr2202577418202577476-intron-Distal4.4115918.70354HepG2PTBP1
chr2202577283202577426-intron-Distal3.432234.70908HepG2QKI
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for ALS2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for ALS2 is not available on ENCORE database.

  • 72 RBPs can affect the levels of ALS2.  








The Knockdown/knockout RNA-Seq assay for ALS2 is not available on ENCORE database.





72 RBPs can affect the gene expression of ALS2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
ALS2ENSG00000003393.102317.173601541.006700.5884013.8644012.53770HepG2AUH
ALS2ENSG00000003393.101973.166101165.526300.7594011.8235010.70110HepG2BOP1
ALS2ENSG00000003393.101793.928601180.764300.603309.455708.15360HepG2CALR
ALS2ENSG00000003393.101992.446101233.505000.691704.776203.76510HepG2CNOT7
ALS2ENSG00000003393.101509.135101070.023000.496004.710703.83470HepG2CPSF6
ALS2ENSG00000003393.10931.176001115.79170-0.260902.233201.32070HepG2YBX3
ALS2ENSG00000003393.101831.993201413.048700.374506.314705.26130HepG2DAZAP1
ALS2ENSG00000003393.101431.429801040.598000.459904.554403.70830HepG2DDX21
ALS2ENSG00000003393.101386.742401018.429000.445304.744303.53540HepG2DDX24
ALS2ENSG00000003393.102112.296501708.726200.305802.029801.48510HepG2DDX3X
ALS2ENSG00000003393.10730.12370964.73710-0.402002.343601.62530HepG2DDX55
ALS2ENSG00000003393.10907.809901095.65640-0.271302.354201.69910HepG2DNAJC21
ALS2ENSG00000003393.101284.31860958.342800.422302.569901.50860HepG2AGO1
ALS2ENSG00000003393.101877.955101411.065700.412303.221802.58420HepG2EIF2S1
ALS2ENSG00000003393.101814.800201393.901900.380605.385104.28220HepG2EIF4G1
ALS2ENSG00000003393.101935.374501356.246900.512904.159003.23040HepG2FIP1L1
ALS2ENSG00000003393.101809.762701071.843900.755602.867501.83320HepG2FTO
ALS2ENSG00000003393.101887.075801459.507300.370602.619901.97180HepG2G3BP1
ALS2ENSG00000003393.101529.090501212.971600.334002.093701.53270HepG2GPKOW
ALS2ENSG00000003393.10895.614401106.15260-0.304602.119701.54640HepG2HNRNPA1
ALS2ENSG00000003393.10896.538901230.37450-0.456704.167203.32930HepG2HNRNPC
ALS2ENSG00000003393.101210.242401477.65460-0.288001.914101.32740HepG2HNRNPK
ALS2ENSG00000003393.101095.821101287.23470-0.232302.284801.66410HepG2HNRNPL
ALS2ENSG00000003393.101462.605801157.559600.337402.377001.78840HepG2HNRNPLL
ALS2ENSG00000003393.101944.318801483.592200.390103.102702.39250HepG2IGF2BP2
ALS2ENSG00000003393.101708.244601202.483900.506403.154801.73380HepG2ILF3
ALS2ENSG00000003393.10994.430701582.62540-0.670406.427405.49850HepG2MATR3
ALS2ENSG00000003393.101485.854201097.642600.436804.438103.42870HepG2MSI2
ALS2ENSG00000003393.101424.438501026.385500.472704.395903.45810HepG2NSUN2
ALS2ENSG00000003393.101870.810701442.766300.374702.761702.04070HepG2PABPC4
ALS2ENSG00000003393.101031.844201209.82920-0.229602.037201.30110HepG2PARN
ALS2ENSG00000003393.10909.550501090.14420-0.261302.200101.53500HepG2PPIL4
ALS2ENSG00000003393.101326.412601021.351700.376904.726503.74460HepG2PRPF4
ALS2ENSG00000003393.101060.63150744.176500.511103.969003.02300HepG2PRPF8
ALS2ENSG00000003393.101239.608001470.16120-0.246102.683802.14360HepG2PTBP1
ALS2ENSG00000003393.102052.236501418.740200.532507.746506.64960HepG2PUM2
ALS2ENSG00000003393.102207.943901592.164800.471607.167106.23070HepG2QKI
ALS2ENSG00000003393.102335.582801478.793700.6593014.5808013.58150HepG2RBM22
ALS2ENSG00000003393.10686.261801015.18800-0.564903.976002.70250HepG2RCC2
ALS2ENSG00000003393.101300.790201523.86900-0.228402.193701.63670HepG2RECQL
ALS2ENSG00000003393.10974.20580736.140600.404102.376001.64120HepG2RRP9
ALS2ENSG00000003393.102270.913101713.105700.406602.132101.53890HepG2SF3A3
ALS2ENSG00000003393.102481.515801145.765301.1148024.5336022.67510HepG2SF3B1
ALS2ENSG00000003393.101781.233601530.580400.218702.256001.71530HepG2SF3B4
ALS2ENSG00000003393.102858.154501670.242200.7749028.0048026.84590HepG2SRFBP1
ALS2ENSG00000003393.101894.017701597.613800.245402.933702.45040HepG2SRSF1
ALS2ENSG00000003393.101534.050201320.500700.216201.857201.33020HepG2SRSF5
ALS2ENSG00000003393.101665.841601450.164300.199902.022201.56660HepG2SSB
ALS2ENSG00000003393.101971.125301501.834000.392206.817405.91620HepG2SUCLG1
ALS2ENSG00000003393.101204.12720915.790000.394803.624602.55760HepG2SUPT6H
ALS2ENSG00000003393.101610.09400960.369300.745407.666406.63290HepG2SUPV3L1
ALS2ENSG00000003393.102097.366101160.172600.8541013.3108011.89680HepG2U2AF1
ALS2ENSG00000003393.101830.139801382.919400.404102.659901.83900HepG2UBE2L3
ALS2ENSG00000003393.101764.990201519.261800.216202.398201.74050HepG2UPF1
ALS2ENSG00000003393.101733.930601466.789100.241302.673502.08480HepG2UTP3
ALS2ENSG00000003393.102259.062401670.898600.4350010.512509.61890HepG2ZNF622
ALS2ENSG00000003393.101360.520201008.757700.431503.657503.00120K562AQR
ALS2ENSG00000003393.10708.56970914.84680-0.368603.591802.53960K562ATP5C1
ALS2ENSG00000003393.10955.37440642.372000.572605.007803.82030K562BOP1
ALS2ENSG00000003393.10870.31580683.033900.349502.599701.83830K562CPSF6
ALS2ENSG00000003393.10728.47060938.38060-0.365303.737902.69840K562DKC1
ALS2ENSG00000003393.10639.47010497.640800.361702.211801.39580K562EFTUD2
ALS2ENSG00000003393.10465.20940597.01550-0.359902.597701.82460K562EIF3G
ALS2ENSG00000003393.10965.48330694.954900.474203.812102.80310K562FMR1
ALS2ENSG00000003393.10764.10900589.030100.375302.181901.37490K562FTO
ALS2ENSG00000003393.10727.14580542.209800.423304.008903.30030K562FXR1
ALS2ENSG00000003393.10822.821101038.34890-0.335602.349101.61200K562HSPD1
ALS2ENSG00000003393.10812.92870556.825500.545803.312902.28200K562KRR1
ALS2ENSG00000003393.10804.71460596.950300.430803.207602.15430K562PCBP2
ALS2ENSG00000003393.101259.04930830.337700.600504.095203.08150K562PCBP3
ALS2ENSG00000003393.10961.06620636.951400.593403.797502.85340K562POLR2G
ALS2ENSG00000003393.10643.18450484.259400.409402.551401.83100K562PRPF8
ALS2ENSG00000003393.10406.34390533.04060-0.391502.214701.41320K562PSIP1
ALS2ENSG00000003393.101917.914201385.941600.468604.791103.71980K562PUF60
ALS2ENSG00000003393.10959.57880620.180500.629605.094703.75250K562SF3B1
ALS2ENSG00000003393.10713.47990570.782700.321802.274601.50130K562SF3B4
ALS2ENSG00000003393.10992.94380638.926600.636007.596506.43260K562SRSF1
ALS2ENSG00000003393.10813.07750549.463900.565306.272105.06980K562U2AF2
ALS2ENSG00000003393.10652.70940496.306400.395102.449101.49740K562UCHL5
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for ALS2 is not available on ENCORE database.





5 RBPs can affect the splicing of ALS2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEALS2ENSG00000003393.10chr2-2026303752026305502026256032026265412026319512026321060.370000.000180.00525includedK562SRSF1
SEALS2ENSG00000003393.10chr2-2026302712026303262026263972026265412026319512026321060.209000.003400.05603includedHepG2U2AF1
SEALS2ENSG00000003393.10chr2-2025847082025848512025827992025829332025877652025878430.266000.000010.00311includedHepG2HNRNPM
SEALS2ENSG00000003393.10chr2-2025847082025848512025827992025829332025877652025878430.280000.000000.00000includedHepG2MATR3
SEALS2ENSG00000003393.10chr2-2026303752026305502026256032026265412026319512026321060.231000.000010.00058includedHepG2SRSF1
A3SSALS2ENSG00000003393.10chr2-2025691762025693562025691762025693262025698612025699640.224000.000540.00402longerK562AQR
A3SSALS2ENSG00000003393.10chr2-2025688442025690782025688442025689412025691762025693560.135000.001520.01012longerK562AQR
A3SSALS2ENSG00000003393.10chr2-2026319512026321382026319512026321062026335882026336680.134000.000510.00378longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for ALS2 is not avaliable on ENCORE database.