MKS1

General Information

Gene Name       : MKS1
Gene ID             : ENSG00000011143.16
Essential Gene : No

Functions

Localization

Domains (AlphaFold: MKS1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878MKS1ENSG00000011143.167.719.008.36ENCSR000AEF
HepG2MKS1ENSG00000011143.1625.7219.9722.84ENCSR985KAT
K562MKS1ENSG00000011143.1620.0720.8520.46ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for MKS1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • MKS1 RNA is bound by 9 proteins.  







eCLIP assay for MKS1 is not avaliable on ENCORE database.





9 proteins are bound to MKS1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr175629348456293561-3'-UTR,5'-UTR,CDS,intron-Distal4.238704.69071HepG2GRWD1
chr175628525356285293-3'-UTR,CDS,intron-Distal,intron-Proximal4.437704.97342HepG2PPIG
chr175629164256291730-3'-UTR,5'-UTR,CDS,intron-Distal4.366974.42734K562UCHL5
chr175628519756285284-3'-UTR,CDS,intron-Distal,intron-Proximal3.781204.58287K562PRPF8
chr175628308656283229-3'-UTR,intron-Distal,intron-Proximal3.106093.02335HepG2LSM11
chr175628374056283774-3'-UTR,CDS,intron-Distal,intron-Proximal4.399133.83072HepG2SF3A3
chr175628377456283843-3'-UTR,CDS,intron-Distal,intron-Proximal6.042019.59560HepG2SF3A3
chr175628520756285296-3'-UTR,CDS,intron-Distal,intron-Proximal4.2477613.40522HepG2PRPF8
chr175629162356291701-3'-UTR,5'-UTR,CDS,intron-Distal4.250244.04622HepG2GRWD1
chr175628969356289791-3'-UTR,CDS,intron-Distal,intron-Proximal4.657635.29191K562BUD13
chr175629351456293605-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.983406.61895K562ZNF622
chr175628531256285362-3'-UTR,CDS,intron-Distal3.167934.69671HepG2PPIG
chr175629402556294063-5'-UTR,CDS,intron-Distal,intron-Proximal3.333623.07653K562ZNF622
chr175629597856296035-5'-UTR,CDS,intron-Distal,intron-Proximal3.938423.34184HepG2GRWD1
chr175629404256294095-5'-UTR,CDS,intron-Distal3.294783.73423K562UCHL5
chr175629334956293429-intron-Distal,intron-Proximal4.419623.89565K562PRPF8
chr175628436556284446-intron-Distal,intron-Proximal5.424416.83960K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for MKS1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for MKS1 is not available on ENCORE database.

  • 25 RBPs can affect the levels of MKS1.  








The Knockdown/knockout RNA-Seq assay for MKS1 is not available on ENCORE database.





25 RBPs can affect the gene expression of MKS1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
MKS1ENSG00000011143.12317.25630426.59930-0.427203.007002.21100HepG2AKAP8L
MKS1ENSG00000011143.12346.77150481.36600-0.473102.586401.82540HepG2ASCC1
MKS1ENSG00000011143.12324.09950240.402900.430901.940501.43200HepG2BOP1
MKS1ENSG00000011143.12460.91960326.295800.498202.017301.36940HepG2CNOT7
MKS1ENSG00000011143.12740.96000482.066700.620105.214004.27820HepG2HNRNPK
MKS1ENSG00000011143.12152.41290238.73080-0.647402.879002.23850HepG2HNRNPLL
MKS1ENSG00000011143.12496.86980342.486300.536705.026804.23000HepG2HNRNPU
MKS1ENSG00000011143.12180.22000298.23880-0.726703.024102.09320HepG2PABPC1
MKS1ENSG00000011143.12375.21750481.48000-0.359702.338701.82830HepG2PTBP1
MKS1ENSG00000011143.12181.67820348.20570-0.938604.416003.53620HepG2RAVER1
MKS1ENSG00000011143.12765.39960637.709000.263201.759401.32240HepG2RBM22
MKS1ENSG00000011143.12260.81670473.26410-0.859608.244607.13000HepG2RBM25
MKS1ENSG00000011143.12302.86250412.52180-0.445801.904501.34220HepG2SF3A3
MKS1ENSG00000011143.12130.88300236.28520-0.852304.568103.67870HepG2SF3B1
MKS1ENSG00000011143.12187.27860390.30740-1.059408.270207.20260HepG2SUPV3L1
MKS1ENSG00000011143.12197.06130362.58860-0.879705.978405.07080HepG2U2AF1
MKS1ENSG00000011143.12433.41270596.59000-0.461002.206601.46400HepG2UBE2L3
MKS1ENSG00000011143.12413.80090875.51670-1.0812014.3436013.15380K562AQR
MKS1ENSG00000011143.12258.49150392.86370-0.603902.986201.80690K562FKBP4
MKS1ENSG00000011143.12228.60070357.72050-0.646003.320902.53290K562G3BP2
MKS1ENSG00000011143.12345.98950452.13450-0.386002.122101.59110K562HNRNPC
MKS1ENSG00000011143.12401.49970505.94870-0.333602.010101.42720K562PTBP1
MKS1ENSG00000011143.12900.015101126.79120-0.324202.407501.64820K562PUF60
MKS1ENSG00000011143.12155.22020253.09170-0.705302.296201.41870K562SF3B1
MKS1ENSG00000011143.12622.46120496.008700.327501.972101.36290K562SRSF1
MKS1ENSG00000011143.12290.25030426.81780-0.556303.090802.01610K562SUPV3L1
MKS1ENSG00000011143.12192.06650358.17270-0.899008.004606.62660K562U2AF2
MKS1ENSG00000011143.12763.49230986.32870-0.369502.880001.99610K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for MKS1 is not available on ENCORE database.





8 RBPs can affect the splicing of MKS1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEMKS1ENSG00000011143.12chr17-562921015629219956291619562917485629344856293604-0.297000.004430.06734excludedK562SF3B4
SEMKS1ENSG00000011143.12chr17-562921015629219956291619562917485629344856293604-0.330000.000000.00019excludedHepG2U2AF1
SEMKS1ENSG00000011143.12chr17-562921015629219956291619562917485629344856293604-0.487000.000000.00000excludedHepG2U2AF2
SEMKS1ENSG00000011143.12chr17-562921015629219956291619562917485629344856293604-0.327000.000430.01129excludedK562U2AF1
A3SSMKS1ENSG00000011143.12chr17-5628382556284014562838255628390856284445562845790.251000.000470.04388longerHepG2HNRNPK
A3SSMKS1ENSG00000011143.12chr17-5628546556285611562854655628553556285873562859770.102000.003380.09580longerK562U2AF2
A3SSMKS1ENSG00000011143.12chr17-5628834056288418562883405628838356289738562897950.066000.011980.06169longerK562AQR
A3SSMKS1ENSG00000011143.12chr17-5629402656294258562940265629409756295980562960900.071000.000140.00120longerK562AQR
A3SSMKS1ENSG00000011143.12chr17-5629210156292259562921015629219956293448562936040.085000.018950.09103longerK562AQR
A3SSMKS1ENSG00000011143.12chr17-5628546556285611562854655628553556285873562859440.118000.001180.05175longerK562U2AF1
MXEMKS1ENSG00000011143.12chr17-5628382556283908562844455628457956283643562837415628525456285362-0.392000.006010.076102includedK562SRSF1
MXEMKS1ENSG00000011143.12chr17-56283825562839085628444556284579562836435628374156285254562853620.459000.003220.095331includedK562FXR1
MXEMKS1ENSG00000011143.12chr17-5628364356283741562838255628390856283101562835315628444556284579-0.316000.000690.050112includedHepG2NOL12

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for MKS1 is not avaliable on ENCORE database.