EIF2AK2

General Information

Gene Name : EIF2AK2
Gene ID : ENSG00000055332.17
Essential Gene : No

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: EIF2AK2)

Not Available

Antibody Validation

View validation images for all EIF2AK2 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	EIF2AK2	ENSG00000055332.17	53.93	45.51	49.72	ENCSR000AEF
HepG2	EIF2AK2	ENSG00000055332.17	12.58	25.55	19.07	ENCSR985KAT
K562	EIF2AK2	ENSG00000055332.17	10.60	13.12	11.86	ENCSR000AEO

Assays

1 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	EIF2AK2-BGKcLV13-K562	ENCSR628AFF	EIF2AK2	K562	Released		ENCSR712CQC	CRISPR	KD% = 73.6,74.5

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
EIF2AK2	ENCAB399AJN	700286	SA2330331					BGKcLV13-53, Released, ENCODE4
EIF2AK2		12297S	3			Submitted, ENCORE2	BGHcLV43-15, Submitted, ENCORE2	BGKcLV42-27, Submitted, ENCORE2

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
EIF2AK2	K562	CRISPR			BGKcLV13-51,BGKcLV13-52	BGKcLV13-1,BGKcLV13-2	52.3,53.3	NotSatisfied	ENCODE4
EIF2AK2	K562	CRISPR	ENCSR628AFF	ENCSR712CQC	EIF2AK2-BGKcLV13-53,EIF2AK2-BGKcLV13-54	NT-BGKcLV13-1,NT-BGKcLV13-2	73.6,74.5	Released	ENCODE4
EIF2AK2	K562	CRISPR			EIF2AK2-BGKcLV42-27,EIF2AK2-BGKcLV42-28	NT-BGKcLV42-1,NT-BGKcLV42-2	70.6,69.3	Submitting	ENCORE2
EIF2AK2	HepG2	CRISPR			BGHcLV14-51,BGHcLV14-52	BGHcLV14-1,BGHcLV14-2	29.3,1.1	NotSatisfied	ENCODE4
EIF2AK2	HepG2	CRISPR			BGHcLV14-53,BGHcLV14-54	BGHcLV14-1,BGHcLV14-2	30.5,48.1	NotSatisfied	ENCODE4
EIF2AK2	HepG2	CRISPR			BGHcLV20-17,BGHcLV20-18	BGHcLV20-1,BGHcLV20-2		NotSatisfied	ENCODE4
EIF2AK2	HepG2	CRISPR			BGHcLV20-19,BGHcLV20-20	BGHcLV20-1,BGHcLV20-2		NotSatisfied	ENCODE4
EIF2AK2	HepG2	CRISPR			EIF2AK2-BGHcLV43-15,EIF2AK2-BGHcLV43-16	NT-BGHcLV43-1,NT-BGHcLV43-2	81.8,87.1	Submitting	ENCORE2

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
EIF2AK2	Product_ID: 12297S Lot_ID: 3 Source: Cell Signaling Technology Target Name: EIF2AK2-human
EIF2AK2	Product_ID: 700286 Lot_ID: SA2330331 Source: Thermo Fisher Target Name: EIF2AK2-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for EIF2AK2 is not avaliable on ENCORE database.

Proteins bound to RNA

EIF2AK2 RNA is bound by 16 proteins.

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eCLIP assay for EIF2AK2 is not avaliable on ENCORE database.

16 proteins are bound to EIF2AK2 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr2	37360052	37360080	-	intron-Distal	6.17724	19.03931	K562	RPS11
chr2	37329980	37330095	-	3'-UTR,intron-Distal	5.33165	11.15661	HepG2	HNRNPL
chr2	37349692	37349817	-	CDS,intron-Distal,intron-Proximal	5.55903	9.86388	K562	PUM2
chr2	37383960	37384033	-	intron-Distal	5.34839	9.65239	HepG2	EFTUD2
chr2	37349648	37349778	-	CDS,intron-Distal,intron-Proximal	3.14538	9.29726	HepG2	BCLAF1
chr2	37347154	37347249	-	CDS,intron-Distal	3.80535	8.19964	HepG2	BCLAF1
chr2	37353460	37353552	-	CDS,intron-Distal	4.30181	7.97334	HepG2	BCLAF1
chr2	37334434	37334544	-	CDS,intron-Distal,intron-Proximal	3.38347	7.01246	HepG2	BCLAF1
chr2	37328765	37328827	-	3'-UTR,intron-Distal	3.82660	6.87319	HepG2	ILF3
chr2	37368743	37368845	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.72304	6.60490	HepG2	BCLAF1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 31 entries

eCLIP assay for EIF2AK2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for EIF2AK2 is not available on ENCORE database.
87 RBPs can affect the levels of EIF2AK2.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for EIF2AK2 is not available on ENCORE database.

87 RBPs can affect the gene expression of EIF2AK2 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
EIF2AK2	ENSG00000055332.12	2149.43670	1205.41520	0.83430	16.31320	14.94280	K562	HNRNPC
EIF2AK2	ENSG00000055332.12	1509.86610	2162.70500	-0.51840	13.72950	12.29140	HepG2	DAZAP1
EIF2AK2	ENSG00000055332.12	2539.68820	1779.07860	0.51340	12.20470	11.36290	HepG2	SRSF1
EIF2AK2	ENSG00000055332.12	3681.47910	2613.52140	0.49420	11.91830	10.66910	K562	DDX47
EIF2AK2	ENSG00000055332.12	1492.38730	634.47990	1.23390	12.46020	10.35560	K562	EIF3A
EIF2AK2	ENSG00000055332.12	859.69450	1687.09050	-0.97260	12.48770	10.14290	K562	HNRNPM
EIF2AK2	ENSG00000055332.12	1371.67090	2328.44300	-0.76340	11.78850	9.74390	K562	PPIG
EIF2AK2	ENSG00000055332.12	1143.27890	1565.64350	-0.45360	8.98050	7.88570	HepG2	DNAJC2
EIF2AK2	ENSG00000055332.12	1113.04490	1579.59830	-0.50500	7.93720	6.79480	HepG2	DNAJC21
EIF2AK2	ENSG00000055332.12	1844.11690	1107.65660	0.73530	8.19250	6.77190	K562	RPS19
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 96 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for EIF2AK2 is not available on ENCORE database.

4 RBPs can affect the splicing of EIF2AK2 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	EIF2AK2	ENSG00000055332.12	chr2	-	37341873	37342002			37336336	37336438	37347101	37347282	-0.10000	0.00098	0.01391	excluded	HepG2	U2AF2
MXE	EIF2AK2	ENSG00000055332.12	chr2	-	37349648	37349807	37353431	37353554	37347101	37347282	37362626	37362689	0.08200	0.00489	0.02998	1included	HepG2	U2AF2
A3SS	EIF2AK2	ENSG00000055332.12	chr2	-	37374830	37375016			37374830	37374965	37375999	37376058	0.08000	0.00550	0.03146	longer	K562	AQR
MXE	EIF2AK2	ENSG00000055332.12	chr2	-	37349648	37349807	37353431	37353554	37347101	37347282	37362626	37362689	0.10800	0.00559	0.07848	1included	HepG2	FTO
A3SS	EIF2AK2	ENSG00000055332.12	chr2	-	37375999	37376400			37375999	37376166	37384050	37384190	0.13600	0.00758	0.04158	longer	K562	AQR
MXE	EIF2AK2	ENSG00000055332.12	chr2	-	37349648	37349807	37353431	37353554	37347101	37347282	37362626	37362689	0.10200	0.00989	0.09610	1included	K562	HNRNPUL1
MXE	EIF2AK2	ENSG00000055332.12	chr2	-	37349648	37349807	37353431	37353554	37347101	37347282	37362626	37362689	-0.14800	0.01126	0.06970	2included	K562	AQR

Showing 1 to 7 of 7 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

EIF2AK2

General Information

Functions

Localization

Domains (AlphaFold: EIF2AK2)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for EIF2AK2 is not avaliable on ENCORE database.

16 proteins are bound to EIF2AK2 RNA:

eCLIP assay for EIF2AK2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for EIF2AK2 is not available on ENCORE database.

87 RBPs can affect the gene expression of EIF2AK2 :

The Knockdown/knockout RNA-Seq assay for EIF2AK2 is not available on ENCORE database.

4 RBPs can affect the splicing of EIF2AK2 :

The Knockdown/knockout RNA-Seq assay for EIF2AK2 is not avaliable on ENCORE database.