SF3B2

General Information

Gene Name : SF3B2
Gene ID : ENSG00000087365.15
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: SF3B2)

Not Available

Antibody Validation

View validation images for all SF3B2 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	SF3B2	ENSG00000087365.15	139.13	150.70	144.91	ENCSR000AEF
HepG2	SF3B2	ENSG00000087365.15	130.59	147.78	139.19	ENCSR985KAT
K562	SF3B2	ENSG00000087365.15	170.70	165.42	168.06	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	SF3B2-BGKcLV33-K562		SF3B2	K562	Released			CRISPR	KD% = 95.5,97.0
knockdown followed by RNA-seq	SF3B2-BGKcLV33-K562	ENCSR447ARO	SF3B2	K562	Released		ENCSR271ZAB	CRISPR	KD% = no band on the position,

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
SF3B2	ENCAB244MZF	A301-605A	1			Released, ENCODE4	BGHcLV34-49, Released, ENCODE4	BGKcLV33-51, Released, ENCODE4
SF3B2	ENCAB840ZAV	A301-606A	1			Released, ENCODE4	BGHcLV34-49, Released, ENCODE4	BGKcLV33-51, Released, ENCODE4

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
SF3B2	K562	CRISPR			BGKcLV33-45,BGKcLV33-46	BGKcLV33-1,BGKcLV33-2	95.5,97.0	Released	ENCODE4
SF3B2	K562	CRISPR	ENCSR447ARO	ENCSR271ZAB	SF3B2-BGKcLV33-51,SF3B2-BGKcLV33-52	NT-BGKcLV33-1,NT-BGKcLV33-2	no band on the position,	Released	ENCODE4
SF3B2	HepG2	CRISPR			BGHcLV31-47,BGHcLV31-48	BGHcLV31-1,BGHcLV31-2	NO CLEAR BAND,	NotSatisfied	ENCODE4
SF3B2	HepG2	CRISPR			SF3B2-BGHcLV34-47,SF3B2-BGHcLV34-48	NT-BGHcLV34-1,NT-BGHcLV34-2	65.9,77.2	Submitting	ENCORE2

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
SF3B2	Product_ID: A301-605A Lot_ID: 1 Source: Bethyl Labs Target Name: SF3B2-human
SF3B2	Product_ID: A301-606A Lot_ID: 1 Source: Bethyl Labs Target Name: SF3B2-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for SF3B2 is not avaliable on ENCORE database.

Proteins bound to RNA

SF3B2 RNA is bound by 38 proteins.

CanvasJS.com

eCLIP assay for SF3B2 is not avaliable on ENCORE database.

38 proteins are bound to SF3B2 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr11	65826993	65827043	+	CDS	3.38442	73.58793	K562	ZNF800
chr11	65826306	65826392	+	CDS	4.66881	72.49662	K562	UCHL5
chr11	65827032	65827063	+	CDS	4.76126	62.10014	K562	UCHL5
chr11	65826243	65826365	+	CDS,intron-Proximal	3.81655	60.05535	K562	SF3B4
chr11	65826984	65827016	+	CDS,intron-Proximal	4.60043	48.34374	K562	UCHL5
chr11	65827035	65827058	+	CDS	3.93481	47.62035	K562	ZNF622
chr11	65836297	65836371	+	3'-UTR	4.66992	47.14425	K562	PUM2
chr11	65827252	65827290	+	CDS,intron-Proximal	4.94248	46.79877	K562	UCHL5
chr11	65830980	65831005	+	CDS	4.74830	45.77188	K562	UCHL5
chr11	65835427	65835465	+	CDS	4.77935	45.47899	K562	UCHL5
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 426 entries

eCLIP assay for SF3B2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for SF3B2 is not available on ENCORE database.
75 RBPs can affect the levels of SF3B2.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for SF3B2 is not available on ENCORE database.

75 RBPs can affect the gene expression of SF3B2 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
SF3B2	ENSG00000087365.10	21366.37300	10190.85700	1.06800	29.37970	27.59000	K562	PUS1
SF3B2	ENSG00000087365.10	3603.59630	6192.12000	-0.78100	27.12540	25.83500	HepG2	RBM22
SF3B2	ENSG00000087365.10	15458.31270	9876.14870	0.64630	19.36160	17.97640	K562	AGGF1
SF3B2	ENSG00000087365.10	17093.45530	9930.11980	0.78350	15.92710	14.48860	K562	RBM15
SF3B2	ENSG00000087365.10	4556.74230	3345.46080	0.44570	13.21100	11.96070	HepG2	SAFB2
SF3B2	ENSG00000087365.10	3524.60240	5456.35160	-0.63050	10.35610	9.29400	HepG2	BOP1
SF3B2	ENSG00000087365.10	15472.35850	10276.69270	0.59020	10.62510	9.23650	K562	AKAP8L
SF3B2	ENSG00000087365.10	3353.49310	4394.80770	-0.39010	9.24330	8.33880	HepG2	SRSF9
SF3B2	ENSG00000087365.10	15721.66190	10905.74580	0.52760	9.58000	7.79300	K562	KIF1C
SF3B2	ENSG00000087365.10	14685.78780	11057.75320	0.40930	9.61210	7.77680	K562	DKC1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 83 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for SF3B2 is not available on ENCORE database.

18 RBPs can affect the splicing of SF3B2 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
A3SS	SF3B2	ENSG00000087365.10	chr11	+	65835599	65835804	65835618	65835804	65835419	65835516	0.06400	0.00000	longer	HepG2	SF3A3
A3SS	SF3B2	ENSG00000087365.10	chr11	+	65830857	65831013	65830870	65831013	65830479	65830587	0.08700	0.00000	longer	K562	AQR
A3SS	SF3B2	ENSG00000087365.10	chr11	+	65835599	65835804	65835618	65835804	65835451	65835516	0.08900	0.00000	longer	K562	AQR
A5SS	SF3B2	ENSG00000087365.10	chr11	+	65825784	65825945	65825784	65825876	65826300	65826515	0.09300	0.00000	longer	K562	PUS1
A5SS	SF3B2	ENSG00000087365.10	chr11	+	65825758	65825956	65825758	65825876	65826300	65826516	0.07200	0.00000	longer	K562	AQR
A5SS	SF3B2	ENSG00000087365.10	chr11	+	65825784	65825945	65825784	65825876	65826300	65826515	-0.06000	0.00001	shorter	K562	KHSRP
A5SS	SF3B2	ENSG00000087365.10	chr11	+	65825784	65825945	65825784	65825876	65826300	65826515	0.07400	0.00000	longer	K562	AGGF1
A5SS	SF3B2	ENSG00000087365.10	chr11	+	65825784	65825945	65825784	65825876	65826300	65826515	-0.06600	0.00000	shorter	K562	PTBP1
A5SS	SF3B2	ENSG00000087365.10	chr11	+	65825784	65825945	65825784	65825876	65826300	65826515	0.08100	0.00000	longer	K562	RBM15
A5SS	SF3B2	ENSG00000087365.10	chr11	+	65825784	65825945	65825784	65825876	65826300	65826515	-0.08600	0.00000	shorter	K562	FXR1

Showing 1 to 10 of 21 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

SF3B2

General Information

Functions

Localization

Domains (AlphaFold: SF3B2)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for SF3B2 is not avaliable on ENCORE database.

38 proteins are bound to SF3B2 RNA:

eCLIP assay for SF3B2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for SF3B2 is not available on ENCORE database.

75 RBPs can affect the gene expression of SF3B2 :

The Knockdown/knockout RNA-Seq assay for SF3B2 is not available on ENCORE database.

18 RBPs can affect the splicing of SF3B2 :

The Knockdown/knockout RNA-Seq assay for SF3B2 is not avaliable on ENCORE database.