HFE

General Information

Gene Name : HFE
Gene ID : ENSG00000010704.18
Essential Gene : No

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: HFE)

Not Available

Antibody Validation

Not Avaiable

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	HFE	ENSG00000010704.18	3.19	1.51	2.35	ENCSR000AEF
HepG2	HFE	ENSG00000010704.18	4.09	4.16	4.12	ENCSR985KAT
K562	HFE	ENSG00000010704.18	0.56	0.60	0.58	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

No Antibody Primary Validation image or Secondary image available

KD RNA-Seq

No KD RNA-Seq experiment available

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for HFE is not avaliable on ENCORE database.

Proteins bound to RNA

HFE RNA is bound by 1 proteins.

CanvasJS.com

eCLIP assay for HFE is not avaliable on ENCORE database.

1 proteins are bound to HFE RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr6	26096568	26096686	+	3'-UTR	4.59758	10.16433	HepG2	UPF1
chr6	26095577	26095697	+	3'-UTR	4.52090	5.64948	HepG2	UPF1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 2 of 2 entries

eCLIP assay for HFE is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for HFE is not available on ENCORE database.
61 RBPs can affect the levels of HFE.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for HFE is not available on ENCORE database.

61 RBPs can affect the gene expression of HFE :

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
HFE	ENSG00000010704.14	78.01000	266.16590	-1.77060	17.98400	16.63160	HepG2	CELF1
HFE	ENSG00000010704.14	75.77840	4.29600	4.14060	15.81280	14.30450	K562	EIF2S2
HFE	ENSG00000010704.14	116.84940	267.47590	-1.19480	10.20330	9.02260	HepG2	AUH
HFE	ENSG00000010704.14	87.11180	192.67720	-1.14520	8.07700	7.14860	HepG2	ACO1
HFE	ENSG00000010704.14	76.35320	172.72880	-1.17770	7.61620	6.64820	HepG2	HNRNPU
HFE	ENSG00000010704.14	127.57480	256.69100	-1.00870	7.06270	6.32450	HepG2	RBM22
HFE	ENSG00000010704.14	286.50110	163.07770	0.81290	6.70170	5.94760	HepG2	ZNF622
HFE	ENSG00000010704.14	25.99490	89.77740	-1.78810	7.05570	5.83550	HepG2	UCHL5
HFE	ENSG00000010704.14	100.69540	241.75390	-1.26350	6.72350	5.68390	HepG2	EIF4B
HFE	ENSG00000010704.14	178.74270	70.07850	1.35070	6.29390	5.28680	HepG2	CPSF6
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 62 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for HFE is not available on ENCORE database.

3 RBPs can affect the splicing of HFE :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
MXE	HFE	ENSG00000010704.14	chr6	+	26091068	26091332	26091541	26091817	26087508	26087744	26092912	26093188	0.64200	0.00008	0.00450	1included	HepG2	HNRNPU
SE	HFE	ENSG00000010704.14	chr6	+	26091068	26091332			26087508	26087744	26091541	26091817	-0.40800	0.00052	0.01560	excluded	HepG2	HNRNPK
RI	HFE	ENSG00000010704.14	chr6	+	26091068	26091817			26091068	26091332	26091541	26091817	0.37000	0.00097	0.01220	included	HepG2	RBM22
MXE	HFE	ENSG00000010704.14	chr6	+	26091068	26091332	26091541	26091817	26087632	26087744	26092954	26093188	-0.42500	0.00205	0.04618	2included	HepG2	HNRNPK
MXE	HFE	ENSG00000010704.14	chr6	+	26091068	26091332	26091541	26091817	26087508	26087744	26092912	26093188	-0.37400	0.00219	0.04828	2included	HepG2	HNRNPK

Showing 1 to 5 of 5 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

HFE

General Information

Functions

Localization

Domains (AlphaFold: HFE)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for HFE is not avaliable on ENCORE database.

1 proteins are bound to HFE RNA:

eCLIP assay for HFE is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for HFE is not available on ENCORE database.

61 RBPs can affect the gene expression of HFE :

The Knockdown/knockout RNA-Seq assay for HFE is not available on ENCORE database.

3 RBPs can affect the splicing of HFE :

The Knockdown/knockout RNA-Seq assay for HFE is not avaliable on ENCORE database.