PDCD4

General Information

Gene Name : PDCD4
Gene ID : ENSG00000150593.17
Essential Gene : No

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: PDCD4)

Not Available

Antibody Validation

View validation images for all PDCD4 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	PDCD4	ENSG00000150593.17	240.17	148.82	194.50	ENCSR000AEF
HepG2	PDCD4	ENSG00000150593.17	30.76	33.65	32.20	ENCSR985KAT
K562	PDCD4	ENSG00000150593.17	27.48	25.68	26.58	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	PDCD4-BGKcLV17-K562	ENCSR469UOO	PDCD4	K562	Released		ENCSR516TLX	CRISPR	KD% = 67.7,70.4
knockdown followed by RNA-seq	PDCD4-BGHcLV18-HepG2	ENCSR580XTY	PDCD4	HepG2	Released		ENCSR670KAS	CRISPR	KD% = 92.4,90.3

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
PDCD4	ENCAB961TZA	PA5-20309	TK2671263A			Released, ENCODE4	BGHcLV18-31, Released, ENCODE4	BGKcLV17-35, Released, ENCODE4
PDCD4		9535S	5			Submitted, ENCORE2	BGHcLV18-31, Released, ENCODE4	BGKcLV17-35, Submitted, ENCORE2

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project	Note
PDCD4	K562	CRISPR	ENCSR469UOO	ENCSR516TLX	PDCD4-BGKcLV17-35,PDCD4-BGKcLV17-36	NT-BGKcLV17-1,NT-BGKcLV17-2	67.7,70.4	Released	ENCODE4
PDCD4	HepG2	CRISPR	ENCSR580XTY	ENCSR670KAS	PDCD4-BGHcLV18-31,PDCD4-BGHcLV18-32	NT-BGHcLV18-1,NT-BGHcLV18-2	92.4,90.3	Released	ENCODE4

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
PDCD4	Product_ID: PA5-20309 Lot_ID: TK2671263A Source: Thermo Fisher Target Name: PDCD4-human
PDCD4	Product_ID: 9535S Lot_ID: 5 Source: Cell Signaling Technology Target Name: PDCD4-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for PDCD4 is not avaliable on ENCORE database.

Proteins bound to RNA

PDCD4 RNA is bound by 13 proteins.

CanvasJS.com

eCLIP assay for PDCD4 is not avaliable on ENCORE database.

13 proteins are bound to PDCD4 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr10	112647434	112647567	+	CDS	3.39695	23.07353	HepG2	BCLAF1
chr10	112631844	112631944	+	intron-Distal,intron-Proximal	3.58894	14.86716	HepG2	EFTUD2
chr10	112647427	112647566	+	CDS	4.80063	13.59932	HepG2	G3BP1
chr10	112644978	112645088	+	CDS,intron-Proximal	3.27044	10.23026	HepG2	U2AF2
chr10	112653884	112653950	+	CDS,intron-Distal	4.69475	9.74753	HepG2	BCLAF1
chr10	112642784	112642849	+	CDS	3.27486	9.03865	HepG2	BCLAF1
chr10	112654228	112654280	+	CDS,intron-Distal	3.25716	8.43208	HepG2	BCLAF1
chr10	112636864	112636982	+	intron-Distal	3.34548	8.32348	K562	KHSRP
chr10	112653868	112653919	+	CDS,intron-Distal	3.93112	7.24705	K562	LIN28B
chr10	112645034	112645083	+	CDS	3.74130	7.23562	HepG2	BCLAF1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 38 entries

eCLIP assay for PDCD4 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for PDCD4 is not available on ENCORE database.
118 RBPs can affect the levels of PDCD4.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for PDCD4 is not available on ENCORE database.

118 RBPs can affect the gene expression of PDCD4 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
PDCD4	ENSG00000150593.11	381.74820	1448.98060	-1.92430	100.96940	98.31750	HepG2	SMN1
PDCD4	ENSG00000150593.11	602.03190	1767.68080	-1.55390	83.38680	81.49250	HepG2	ZNF622
PDCD4	ENSG00000150593.11	611.57580	1488.10830	-1.28290	48.81250	46.88470	HepG2	PUS1
PDCD4	ENSG00000150593.11	635.70520	1516.05930	-1.25390	38.48170	36.38300	K562	FXR1
PDCD4	ENSG00000150593.11	778.26730	2321.57540	-1.57680	32.43830	30.44990	HepG2	MATR3
PDCD4	ENSG00000150593.11	755.77640	1551.74800	-1.03790	32.06750	30.37440	HepG2	UTP3
PDCD4	ENSG00000150593.11	3298.22950	1885.63940	0.80650	30.87030	29.57940	HepG2	SSB
PDCD4	ENSG00000150593.11	591.80180	1465.36160	-1.30810	26.43240	23.94500	K562	EIF3G
PDCD4	ENSG00000150593.11	1246.37500	3170.50970	-1.34700	24.36440	22.75780	K562	PUS1
PDCD4	ENSG00000150593.11	3401.73480	2171.83190	0.64730	21.83540	20.77680	HepG2	SRFBP1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 140 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for PDCD4 is not available on ENCORE database.

11 RBPs can affect the splicing of PDCD4 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	PDCD4	ENSG00000150593.11	chr10	+	112654169	112654280	112653848	112653956	112655705	112655845	-0.10600	0.00000	0.00007	excluded	K562	SF3B4
SE	PDCD4	ENSG00000150593.11	chr10	+	112636427	112636511	112635723	112635828	112640990	112641293	0.21400	0.00000	0.00167	included	K562	HNRNPA1
SE	PDCD4	ENSG00000150593.11	chr10	+	112653848	112653956	112650313	112650428	112654169	112654280	-0.07500	0.00000	0.00019	excluded	K562	U2AF1
SE	PDCD4	ENSG00000150593.11	chr10	+	112654169	112654280	112653848	112653956	112655705	112655845	-0.12600	0.00000	0.00001	excluded	HepG2	SF3A3
SE	PDCD4	ENSG00000150593.11	chr10	+	112636427	112636511	112635723	112635828	112640990	112641293	0.17500	0.00001	0.00014	included	K562	AQR
SE	PDCD4	ENSG00000150593.11	chr10	+	112636427	112636511	112635723	112635828	112640990	112641293	0.23500	0.00003	0.00489	included	K562	SUPV3L1
SE	PDCD4	ENSG00000150593.11	chr10	+	112635723	112635828	112631595	112631776	112640990	112641293	-0.09000	0.00004	0.00264	excluded	K562	AKAP8L
SE	PDCD4	ENSG00000150593.11	chr10	+	112635723	112635828	112631595	112631776	112640990	112641293	-0.08500	0.00004	0.00227	excluded	K562	RBM15
SE	PDCD4	ENSG00000150593.11	chr10	+	112636427	112636511	112635723	112635828	112640990	112641293	0.13200	0.00008	0.01709	included	K562	ZC3H8
SE	PDCD4	ENSG00000150593.11	chr10	+	112635723	112635828	112631595	112631776	112640990	112641293	-0.07700	0.00017	0.00684	excluded	K562	AGGF1

Showing 1 to 10 of 12 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

PDCD4

General Information

Functions

Localization

Domains (AlphaFold: PDCD4)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for PDCD4 is not avaliable on ENCORE database.

13 proteins are bound to PDCD4 RNA:

eCLIP assay for PDCD4 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for PDCD4 is not available on ENCORE database.

118 RBPs can affect the gene expression of PDCD4 :

The Knockdown/knockout RNA-Seq assay for PDCD4 is not available on ENCORE database.

11 RBPs can affect the splicing of PDCD4 :

The Knockdown/knockout RNA-Seq assay for PDCD4 is not avaliable on ENCORE database.