PABPC4

General Information

Gene Name : PABPC4
Gene ID : ENSG00000090621.13
Essential Gene : No

Functions

RNA stability & decay
RNA export

Localization(RBPImage: PABPC4)

Nuclei
Nucleolus
Cytoplasm
Cytosolic

Domains (AlphaFold: PABPC4)

RRM

Antibody Validation

View validation images for all PABPC4 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	PABPC4	ENSG00000090621.13	202.21	155.80	179.00	ENCSR000AEF
HepG2	PABPC4	ENSG00000090621.13	123.73	145.19	134.46	ENCSR985KAT
K562	PABPC4	ENSG00000090621.13	266.31	277.45	271.88	ENCSR000AEO

Assays

3 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 406	ENCSR958FKZ	PABPC4	K562	Released	ENCAB596MHX	ENCSR192TPA
knockdown followed by RNA-seq	PABPC4-BGKLV08-K562	ENCSR047EEG	PABPC4	K562	Released		ENCSR344XID	shRNA	KD% = 72.4,61.7
knockdown followed by RNA-seq	PABPC4-BGHLV12-HepG2	ENCSR455VZH	PABPC4	HepG2	Released		ENCSR603TCV	shRNA	KD% = 91.1,92.1

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
PABPC4	406	K562	ENCSR958FKZ	ENCSR192TPA	ENCAB596MHX	A301-466A	1	Released	ENCODE4

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
PABPC4	ENCAB596MHX	A301-466A	1		Released, ENCODE3	Released, ENCODE3	BGHLV12-53, Released, ENCODE3	BGKLV08-37, Released, ENCODE3
PABPC4	ENCAB000BFW	RN022P	1		Released, ENCODE3	Released, ENCODE3	BGHLV12-53, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project	Note
PABPC4	K562	shRNA	ENCSR047EEG	ENCSR344XID	PABPC4-LV08-37,PABPC4-LV08-38	Nontarget-LV08-1_00003531,nontarget-LV08-2_00003531	72.4,61.7	Released	ENCODE3
PABPC4	HepG2	shRNA	ENCSR455VZH	ENCSR603TCV	PABPC4-BGHLV12-53,PABPC4-BGHLV12-54	NT-BGHLV12-93,NT-BGHLV12-94	91.1,92.1	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

PABPC4: Click to RBP Image Database

Nuclei

Nucleolus

Cytoplasm

Cytosolic

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
PABPC4	Product_ID: A301-466A Lot_ID: 1 Source: Bethyl Labs Target Name: PABPC4-human
PABPC4	Product_ID: RN022P Lot_ID: 1 Source: MBLI Target Name: PABPC4-human

RNA Targets

PABPC4 protein binds to 5,876 RNA regions.

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Proteins bound to RNA

PABPC4 RNA is bound by 44 proteins.

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PABPC4 protein has 5,876 RNA targets:

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
PABPC4	chr19	38874086	38874132	+	7.63895	400.00000	K562	PSMD8	3'-UTR
PABPC4	chr11	5269561	5269569	-	5.57783	400.00000	K562	HBG1	3'-UTR,intron-Distal
PABPC4	chrX	153626836	153626839	+	4.56951	400.00000	K562	RPL10	5'-UTR,intron-Proximal
PABPC4	chr1	45242422	45242443	+	3.71237	400.00000	K562	RPS8	CDS,intron-Proximal
PABPC4	chr11	8704341	8704357	+	5.09526	400.00000	K562	RPL27A	5'-UTR
PABPC4	chr11	5274482	5274494	-	4.71735	400.00000	K562	HBG2	3'-UTR,intron-Distal
PABPC4	chr16	227469	227473	+	4.48114	400.00000	K562	HBA1	3'-UTR
PABPC4	chr17	37009312	37009320	-	3.94434	400.00000	K562	RPL23	5'-UTR,CDS,intron-Distal
PABPC4	chr11	63743813	63743840	+	5.90259	400.00000	K562	AP000721.4, COX8A	3'-UTR,intron-Distal
PABPC4	chrX	71496081	71496084	-	4.79820	400.00000	K562	RPS4X	CDS,intron-Distal,intron-Proximal

Showing 1 to 10 of 100 entries

44 proteins are bound to PABPC4 RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr1	40042344	40042390	-	5'-UTR,intron-Distal	5.88765	400.00000	K562	PABPC4
chr1	40042277	40042344	-	5'-UTR,intron-Distal	5.80963	400.00000	K562	PABPC4
chr1	40033159	40033163	-	intron-Distal	5.72319	400.00000	HepG2	DKC1
chr1	40033055	40033077	-	intron-Distal	4.24451	400.00000	HepG2	DKC1
chr1	40033112	40033115	-	intron-Distal	5.94097	400.00000	HepG2	DKC1
chr1	40033124	40033128	-	intron-Distal	5.58149	400.00000	HepG2	DKC1
chr1	40033061	40033083	-	intron-Distal	4.21153	400.00000	HepG2	NOLC1
chr1	40033077	40033083	-	intron-Distal	4.23699	400.00000	HepG2	DKC1
chr1	40033083	40033088	-	intron-Distal	3.49380	400.00000	HepG2	NOLC1
chr1	40033131	40033142	-	intron-Distal	5.63598	400.00000	HepG2	DKC1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 226 entries

The PABPC4 protein binds to its own RNA.

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
PABPC4	chr1	40042344	40042390	-	5.88765	400.00000	K562	PABPC4	5'-UTR,intron-Distal
PABPC4	chr1	40042277	40042344	-	5.80963	400.00000	K562	PABPC4	5'-UTR,intron-Distal
PABPC4	chr1	40026507	40026583	-	3.73117	69.17124	K562	PABPC4	3'-UTR,intron-Distal
PABPC4	chr1	40041847	40041907	-	3.60951	38.08646	K562	PABPC4	3'-UTR,5'-UTR,intron-Distal,intron-Proximal
PABPC4	chr1	40041784	40041833	-	3.63108	37.09998	K562	PABPC4	3'-UTR,5'-UTR,intron-Distal
PABPC4	chr1	40041977	40042023	-	3.30802	30.77307	K562	PABPC4	5'-UTR,intron-Distal,intron-Proximal
PABPC4	chr1	40042418	40042445	-	3.57553	11.81325	K562	PABPC4	5'-UTR,intron-Distal,intron-Proximal
PABPC4	chr1	40026751	40026783	-	3.18187	6.53646	K562	PABPC4	3'-UTR,CDS,intron-Distal

Showing 1 to 8 of 8 entries

Diffrential Expression

6,015 differentially expressed genes after Knockdown/Knockout PABPC4 protein.

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108 RBPs can affect the levels of PABPC4.

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6,015 differentially expressed genes after Knockdown/Knockout PABPC4 protein :

Only display 100 entries as example. Please click "View All" button to see all 6,015 entries.

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
MVP	ENSG00000013364.14	2846.70100	905.55420	1.65230	40.79980	38.09050	HepG2	PABPC4
ANLN	ENSG00000011426.6	461.05030	1370.43150	-1.57160	30.55830	28.22540	HepG2	PABPC4
TNFRSF12A	ENSG00000006327.9	1805.98930	540.36610	1.74070	27.99780	25.76880	HepG2	PABPC4
DPM1	ENSG00000000419.8	903.20830	2129.28830	-1.23720	22.82800	20.81380	HepG2	PABPC4
NCAPD2	ENSG00000010292.8	1424.92210	3153.58950	-1.14610	21.68630	19.72070	HepG2	PABPC4
ST3GAL1	ENSG00000008513.10	1172.11160	2554.53420	-1.12400	20.03710	18.14060	HepG2	PABPC4
RPS20	ENSG00000008988.5	6768.30420	13430.04480	-0.98860	18.82180	16.97990	HepG2	PABPC4
MBTD1	ENSG00000011258.11	902.62750	1944.84280	-1.10750	18.24500	16.44810	HepG2	PABPC4
CX3CL1	ENSG00000006210.6	6886.56040	3515.99240	0.96980	17.46350	15.69570	HepG2	PABPC4
VTA1	ENSG00000009844.11	1049.34290	2172.26010	-1.04970	17.05430	15.31370	HepG2	PABPC4
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

108 RBPs can affect the gene expression of PABPC4 :

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
PABPC4	ENSG00000090621.9	418.19620	3091.70500	-2.88620	107.36820	103.49520	HepG2	PABPC4
PABPC4	ENSG00000090621.9	814.52050	4664.50100	-2.51770	87.51280	83.15890	K562	PABPC4
PABPC4	ENSG00000090621.9	5540.41620	12011.07240	-1.11630	38.06140	35.17550	K562	GRSF1
PABPC4	ENSG00000090621.9	1511.81820	2823.49460	-0.90120	36.36320	34.43120	HepG2	UPF1
PABPC4	ENSG00000090621.9	2989.56170	5217.54650	-0.80340	33.04850	31.37330	HepG2	ETF1
PABPC4	ENSG00000090621.9	972.51420	2138.58610	-1.13690	32.45590	31.08450	HepG2	TIAL1
PABPC4	ENSG00000090621.9	3014.33320	4925.37150	-0.70840	30.84530	29.64250	HepG2	SRFBP1
PABPC4	ENSG00000090621.9	1586.83920	3536.64480	-1.15620	26.81390	24.95740	HepG2	CPSF6
PABPC4	ENSG00000090621.9	1887.39030	3127.22940	-0.72850	23.37840	21.73310	HepG2	SRSF7
PABPC4	ENSG00000090621.9	2116.82370	3450.17190	-0.70480	21.79720	20.55960	HepG2	NELFE
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 128 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

34 alternative splicing events after Knockdown/Knockout PABPC4 protein :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	BAG6	ENSG00000204463.8	chr6	-	31607276	31607423	31606804	31607003	31607975	31608083	0.22500	0.00000	0.00703	included	K562	PABPC4
SE	PARP12	ENSG00000059378.8	chr7	-	139733774	139733881	139728412	139728488	139734034	139734131	0.22300	0.00000	0.00516	included	K562	PABPC4
SE	CD55	ENSG00000196352.9	chr1	+	207504452	207504641	207500096	207500182	207510037	207510163	-0.08100	0.00000	0.01218	excluded	K562	PABPC4
SE	XPO1	ENSG00000082898.12	chr2	-	61729383	61729445	61726899	61727029	61749745	61749818	-0.12500	0.00000	0.00000	excluded	K562	PABPC4
SE	MELK	ENSG00000165304.3	chr9	+	36594624	36594768	36589532	36589649	36597218	36597287	-0.32200	0.00000	0.01218	excluded	K562	PABPC4
SE	ALDOC	ENSG00000109107.9	chr17	-	26902982	26903038	26902438	26902562	26903818	26903966	-0.07400	0.00000	0.00665	excluded	K562	PABPC4
SE	HMGCS1	ENSG00000112972.10	chr5	-	43298110	43298236	43297103	43297268	43298619	43299077	-0.11300	0.00000	0.00001	excluded	K562	PABPC4
SE	DDX21	ENSG00000165732.8	chr10	+	70731646	70731808	70729956	70730106	70733300	70733420	-0.08200	0.00000	0.00011	excluded	K562	PABPC4
SE	SLMO2	ENSG00000101166.11	chr20	-	57612245	57612335	57611744	57611815	57613520	57613689	-0.13700	0.00001	0.03259	excluded	K562	PABPC4
SE	ACOT9	ENSG00000123130.12	chrX	-	23731251	23731325	23725993	23726061	23739997	23740101	-0.12400	0.00001	0.02068	excluded	K562	PABPC4

Showing 1 to 10 of 34 entries

36 RBPs can affect the splicing of PABPC4 :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	PABPC4	ENSG00000090621.9	chr1	-	40030357	40030445	40030142	40030214	40030777	40031050	-0.05700	0.00011	excluded	K562	SF3B4
SE	PABPC4	ENSG00000090621.9	chr1	-	40030372	40030445	40030094	40030214	40030777	40030822	-0.07200	0.00033	excluded	K562	PRPF8
SE	PABPC4	ENSG00000090621.9	chr1	-	40029507	40029594	40029285	40029413	40030094	40030163	-0.25400	0.00000	excluded	K562	PRPF8
SE	PABPC4	ENSG00000090621.9	chr1	-	40029507	40029594	40029285	40029413	40030094	40030214	0.18700	0.00127	included	K562	WDR3
SE	PABPC4	ENSG00000090621.9	chr1	-	40029507	40029594	40029198	40029413	40030094	40030163	-0.44500	0.00000	excluded	HepG2	U2AF1
SE	PABPC4	ENSG00000090621.9	chr1	-	40029507	40029594	40029285	40029413	40030094	40030214	-0.36400	0.00000	excluded	HepG2	PRPF8
SE	PABPC4	ENSG00000090621.9	chr1	-	40029507	40029594	40029285	40029413	40030094	40030214	-0.15900	0.00000	excluded	HepG2	HNRNPK
SE	PABPC4	ENSG00000090621.9	chr1	-	40027994	40028118	40026487	40027875	40029285	40029413	-0.07600	0.00000	excluded	K562	AQR
SE	PABPC4	ENSG00000090621.9	chr1	-	40030357	40030445	40030142	40030214	40030777	40031050	-0.12700	0.00000	excluded	K562	AQR
SE	PABPC4	ENSG00000090621.9	chr1	-	40029507	40029594	40029285	40029413	40030094	40030214	-0.22500	0.00000	excluded	K562	FXR1

Showing 1 to 10 of 66 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

PABPC4

General Information

Functions

Localization(RBPImage: PABPC4)

Domains (AlphaFold: PABPC4)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

PABPC4 protein has 5,876 RNA targets:

44 proteins are bound to PABPC4 RNA:

The PABPC4 protein binds to its own RNA.

Diffrential Expression

6,015 differentially expressed genes after Knockdown/Knockout PABPC4 protein :

108 RBPs can affect the gene expression of PABPC4 :

34 alternative splicing events after Knockdown/Knockout PABPC4 protein :

36 RBPs can affect the splicing of PABPC4 :

No autoregularoty alternative splicing events between protein PABPC4 and its RNA.