EIF4G2

General Information

Gene Name : EIF4G2
Gene ID : ENSG00000110321.16
Essential Gene : Yes

Functions

Ribosome & basic translation
Translation regulation

Localization(RBPImage: EIF4G2)

Nuclei
Nucleoplasm
PML bodies
Cajal bodies
Unknown Nuclear Foci
Cytoplasm
Compartment/Organelle
Mitochondria

Domains (AlphaFold: EIF4G2)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

View validation images for all EIF4G2 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	EIF4G2	ENSG00000110321.16	577.18	553.13	565.15	ENCSR000AEF
HepG2	EIF4G2	ENSG00000110321.16	326.35	539.10	432.73	ENCSR985KAT
K562	EIF4G2	ENSG00000110321.16	478.79	512.41	495.60	ENCSR000AEO

Assays

4 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 260	ENCSR307YIW	EIF4G2	K562	Released	ENCAB000BFJ	ENCSR651NUF
knockdown followed by RNA-seq	EIF4G2-BGKLV25-K562	ENCSR040FSN	EIF4G2	K562	Released		ENCSR620PUP	shRNA	KD% = 88.4,85.7
knockdown followed by RNA-seq	EIF4G2-BGHLV23-HepG2	ENCSR152MON	EIF4G2	HepG2	Released		ENCSR042QTH	shRNA	KD% = 92.2,74.0
RNA Bind-n-Seq	RBNS: EIF4G2	ENCSR600HIW	EIF4G2	cell-free sample	Released

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
EIF4G2	260	K562	ENCSR307YIW	ENCSR651NUF	ENCAB000BFJ	RN003P	1	Released	ENCODE3

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
EIF4G2	ENCAB000BFJ	RN003P	1	Released, ENCODE3	BGHLV23-15, Released, ENCODE3	BGKLV25-17, Released, ENCODE3
EIF4G2	ENCAB038YNO	702479	NotAvailable		BGHLV23-15, Released, ENCODE3	BGKLV25-17, Released, ENCODE4
EIF4G2	ENCAB363IRI	PA5-21377	TK2671326	Released, ENCODE4	BGHLV23-15, Released, ENCODE3	BGKLV25-17, Released, ENCODE4
EIF4G2		5169S	1	Submitted, ENCORE2	BGHLV23-15, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project	Note
EIF4G2	K562	shRNA	ENCSR040FSN	ENCSR620PUP	EIF4G2_BGKLV25-17,EIF4G2_BGKLV25-18	NT_BGKLV25-1,NT_BGKLV25-2	88.4,85.7	Released	ENCODE3
EIF4G2	HepG2	shRNA	ENCSR152MON	ENCSR042QTH	EIF4G2-BGHLV23-15,EIF4G2-BGHLV23-16	non-target-BGHLV23-1,non-target-BGHLV23-2	92.2,74.0	Released	ENCODE3

RNA Bind-n-Seqn

GeneName	gene_aliases	Status	Project	Note
EIF4G2	EIF4G2		Released	ENCODE3

Localization Image in HepG2

EIF4G2: Click to RBP Image Database

Nuclei

Nucleoplasm

PML bodies

Cajal bodies

Unknown Nuclear Foci

Cytoplasm

Compartment/Organelle

Mitochondria

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
EIF4G2	Product_ID: PA5-21377 Lot_ID: TK2671326 Source: Thermo Fisher Target Name: EIF4G2-human
EIF4G2	Product_ID: RN003P Lot_ID: 1 Source: MBLI Target Name: EIF4G2-human
EIF4G2	Product_ID: 5169S Lot_ID: 1 Source: Cell Signaling Technology Target Name: EIF4G2-human
EIF4G2	Product_ID: 702479 Lot_ID: NotAvailable Source: Thermo Fisher Target Name: EIF4G2-human

RNA Targets

EIF4G2 protein binds to 4,526 RNA regions.

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The binding motifs of EIF4G2

Proteins bound to RNA

EIF4G2 RNA is bound by 55 proteins.

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EIF4G2 protein has 4,526 RNA targets:

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
EIF4G2	chr11	93454806	93454863	+	4.72146	400.00000	K562	KIAA1731	intron-Distal
EIF4G2	chr19	28917559	28917649	-	5.44522	400.00000	K562	AC005307.1	intron-Distal
EIF4G2	chr16	89370242	89370348	-	5.17424	58.44306	K562	ANKRD11	intron-Distal
EIF4G2	chr9	100689400	100689459	-	3.30976	56.96823	K562	HEMGN	3'-UTR,intron-Distal
EIF4G2	chr11	68832628	68832715	+	7.77162	44.05847	K562	TPCN2	intron-Distal
EIF4G2	chr7	50851055	50851177	-	6.71360	41.20453	K562	GRB10	intron-Distal
EIF4G2	chr6	31703567	31703600	-	5.83253	40.36669	K562	CLIC1	intron-Distal
EIF4G2	chr22	20110316	20110330	+	6.76260	33.07393	K562	RANBP1	intron-Distal,intron-Proximal
EIF4G2	chr9	140618019	140618110	+	7.21160	31.45845	K562	EHMT1	intron-Distal
EIF4G2	chr1	1276367	1276406	-	6.45689	30.58786	K562	DVL1	intron-Distal

Showing 1 to 10 of 100 entries

55 proteins are bound to EIF4G2 RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr11	10819096	10819152	-	3'-UTR,intron-Distal	5.22947	400.00000	K562	PABPC4
chr11	10819152	10819170	-	3'-UTR,intron-Distal,intron-Proximal	5.36074	400.00000	K562	PABPC4
chr11	10830250	10830298	-	5'-UTR,intron-Distal,intron-Proximal	5.75330	400.00000	HepG2	DDX59
chr11	10830261	10830346	-	5'-UTR,intron-Distal,intron-Proximal	5.46037	400.00000	HepG2	HNRNPK
chr11	10830263	10830314	-	5'-UTR,intron-Distal,intron-Proximal	7.26147	400.00000	HepG2	PCBP2
chr11	10830314	10830324	-	5'-UTR,intron-Distal,intron-Proximal	7.20080	400.00000	HepG2	PCBP2
chr11	10830266	10830346	-	5'-UTR,intron-Distal,intron-Proximal	3.99899	400.00000	K562	PCBP1
chr11	10830298	10830346	-	5'-UTR,intron-Distal,intron-Proximal	5.84261	400.00000	HepG2	DDX59
chr11	10830324	10830346	-	5'-UTR,intron-Distal,intron-Proximal	7.03131	400.00000	HepG2	PCBP2
chr11	10828878	10828929	-	5'-UTR,intron-Distal,intron-Proximal	5.85461	400.00000	HepG2	DDX59
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 235 entries

No autoregularoty interactions between protein EIF4G2 and its RNA.

Diffrential Expression

8,652 differentially expressed genes after Knockdown/Knockout EIF4G2 protein.

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111 RBPs can affect the levels of EIF4G2.

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8,652 differentially expressed genes after Knockdown/Knockout EIF4G2 protein :

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
MAPK8IP2	ENSG00000008735.10	506.30960	56.49370	3.16380	60.20390	57.23670	HepG2	EIF4G2
ANLN	ENSG00000011426.6	1559.54210	3463.46040	-1.15110	27.47810	25.18580	HepG2	EIF4G2
FYN	ENSG00000010810.13	457.26050	1192.52080	-1.38290	27.21890	24.93370	HepG2	EIF4G2
NCAPD2	ENSG00000010292.8	2889.20320	5725.33700	-0.98670	21.63300	19.55180	HepG2	EIF4G2
ITGAL	ENSG00000005844.13	429.76340	76.37650	2.49220	19.72020	17.70540	HepG2	EIF4G2
BRCA1	ENSG00000012048.15	627.30400	1293.25290	-1.04380	16.98970	15.10170	HepG2	EIF4G2
TACC3	ENSG00000013810.14	845.48130	1632.67480	-0.94940	15.45600	13.65020	HepG2	EIF4G2
UTP18	ENSG00000011260.9	844.02850	1574.40120	-0.89940	14.24590	12.50320	HepG2	EIF4G2
CD74	ENSG00000019582.10	1102.10660	1969.11310	-0.83730	12.99830	11.32380	HepG2	EIF4G2
SLC25A39	ENSG00000013306.11	3725.25420	2223.48470	0.74440	12.52930	10.88040	HepG2	EIF4G2
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

111 RBPs can affect the gene expression of EIF4G2 :

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
EIF4G2	ENSG00000110321.11	3597.94940	12283.63530	-1.77150	220.42760	216.77040	HepG2	SAFB2
EIF4G2	ENSG00000110321.11	2023.08580	17927.06350	-3.14750	204.66320	200.28100	HepG2	EIF4G2
EIF4G2	ENSG00000110321.11	23148.60530	9601.46790	1.26950	85.41150	82.50330	K562	FXR1
EIF4G2	ENSG00000110321.11	6257.98500	21353.89400	-1.77070	75.78030	72.99100	HepG2	TARDBP
EIF4G2	ENSG00000110321.11	3271.14970	14097.16810	-2.10750	69.11570	66.60410	HepG2	EIF2S1
EIF4G2	ENSG00000110321.11	8837.26450	16172.77610	-0.87190	55.03500	52.89710	HepG2	UTP3
EIF4G2	ENSG00000110321.11	10968.60060	17279.69300	-0.65570	44.60550	42.31440	HepG2	HNRNPL
EIF4G2	ENSG00000110321.11	5547.12840	9706.67610	-0.80720	35.68900	32.16470	K562	EIF2S1
EIF4G2	ENSG00000110321.11	25169.59580	13018.21350	0.95110	30.56110	28.45180	K562	PTBP1
EIF4G2	ENSG00000110321.11	27889.89110	13245.60580	1.07410	28.53180	26.76790	K562	PUS1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 134 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

549 alternative splicing events after Knockdown/Knockout EIF4G2 protein :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	RPS24	ENSG00000138326.14	chr10	+	79799961	79799983	79796951	79797062	79800372	79800455	0.10000	0.00000	included	K562	EIF4G2
SE	AC079466.1	ENSG00000266976.1	chr19	+	29101166	29101238	29097594	29098011	29103345	29106136	0.10500	0.00012	included	K562	EIF4G2
SE	SNRNP70	ENSG00000104852.10	chr19	+	49605370	49606844	49604646	49604728	49607890	49607992	0.05600	0.00000	included	K562	EIF4G2
SE	AP3D1	ENSG00000065000.11	chr19	-	2132469	2132577	2130406	2130536	2137009	2137090	0.06900	0.00011	included	K562	EIF4G2
SE	TANGO2	ENSG00000183597.11	chr22	+	20040959	20041074	20039987	20040107	20043465	20043536	0.18200	0.00268	included	K562	EIF4G2
SE	MYL6	ENSG00000092841.14	chr12	+	56554409	56554454	56554026	56554104	56555170	56555358	0.10700	0.00118	included	K562	EIF4G2
SE	SGMS1	ENSG00000198964.9	chr10	-	52100146	52100224	52086990	52087082	52103251	52104006	0.07200	0.00089	included	K562	EIF4G2
SE	IVNS1ABP	ENSG00000116679.11	chr1	-	185275616	185275757	185274667	185274775	185276145	185276271	0.13200	0.00000	included	K562	EIF4G2
SE	SREK1	ENSG00000153914.11	chr5	+	65451892	65454760	65449290	65449424	65455046	65455162	0.28600	0.00000	included	K562	EIF4G2
SE	TNNT1	ENSG00000105048.12	chr19	-	55657801	55657834	55656911	55656933	55658048	55658075	0.24700	0.00000	included	K562	EIF4G2

Showing 1 to 10 of 100 entries

42 RBPs can affect the splicing of EIF4G2 :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	EIF4G2	ENSG00000110321.11	chr11	-	10823207	10823321	10822508	10822634	10823595	10823756	-0.09800	0.00095	excluded	K562	TAF15
SE	EIF4G2	ENSG00000110321.11	chr11	-	10823207	10823321	10822508	10822634	10823595	10823756	0.08300	0.00000	included	HepG2	RBM22
SE	EIF4G2	ENSG00000110321.11	chr11	-	10828366	10828432	10827453	10827594	10828801	10828928	-0.16800	0.00000	excluded	HepG2	U2AF1
SE	EIF4G2	ENSG00000110321.11	chr11	-	10823207	10823321	10822508	10822634	10823595	10823756	-0.31400	0.00000	excluded	HepG2	U2AF1
SE	EIF4G2	ENSG00000110321.11	chr11	-	10823207	10823321	10822508	10822634	10823595	10823756	0.11100	0.00000	included	HepG2	HNRNPK
SE	EIF4G2	ENSG00000110321.11	chr11	-	10823207	10823321	10822508	10822634	10823595	10823756	-0.13900	0.00000	excluded	HepG2	DDX59
SE	EIF4G2	ENSG00000110321.11	chr11	-	10828366	10828432	10827453	10827594	10828801	10828928	-0.32900	0.00000	excluded	HepG2	U2AF2
SE	EIF4G2	ENSG00000110321.11	chr11	-	10823207	10823321	10822508	10822634	10823595	10823756	-0.49200	0.00000	excluded	HepG2	U2AF2
SE	EIF4G2	ENSG00000110321.11	chr11	-	10828366	10828457	10827461	10827594	10828801	10829037	-0.07600	0.00000	excluded	K562	AQR
SE	EIF4G2	ENSG00000110321.11	chr11	-	10823207	10823321	10822508	10822634	10823595	10823756	-0.10200	0.00000	excluded	K562	AQR

Showing 1 to 10 of 144 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The EIF4G2 protein affects to its own RNA splicing after knockdown/knockout.

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
A5SS	EIF4G2	ENSG00000110321.11	chr11	-	10823207	10823756	10823595	10823756	10822496	10822634	-0.12800	0.00000	0.00273	shorter	K562	EIF4G2
RI	EIF4G2	ENSG00000110321.11	chr11	-	10821098	10821895	10821098	10821303	10821636	10821895	0.20400	0.00000	0.00000	included	K562	EIF4G2
RI	EIF4G2	ENSG00000110321.11	chr11	-	10823207	10823756	10823207	10823321	10823595	10823756	0.06800	0.00000	0.00000	included	K562	EIF4G2
RI	EIF4G2	ENSG00000110321.11	chr11	-	10825833	10826562	10825833	10825965	10826459	10826562	0.06900	0.00000	0.00000	included	K562	EIF4G2
RI	EIF4G2	ENSG00000110321.11	chr11	-	10825026	10825597	10825026	10825137	10825445	10825597	0.08700	0.00000	0.00000	included	K562	EIF4G2
SE	EIF4G2	ENSG00000110321.11	chr11	-	10823207	10823321	10822508	10822634	10823595	10823756	-0.07800	0.00001	0.00523	excluded	K562	EIF4G2
SE	EIF4G2	ENSG00000110321.11	chr11	-	10821636	10821665	10821098	10821303	10821790	10821895	-0.12200	0.00037	0.06118	excluded	K562	EIF4G2

Showing 1 to 7 of 7 entries