DIS3

General Information

Gene Name : DIS3
Gene ID : ENSG00000083520.14
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: DIS3)

Not Available

Antibody Validation

View validation images for all DIS3 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	DIS3	ENSG00000083520.14	43.04	38.65	40.84	ENCSR000AEF
HepG2	DIS3	ENSG00000083520.14	12.47	22.30	17.39	ENCSR985KAT
K562	DIS3	ENSG00000083520.14	26.83	27.75	27.29	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
DIS3		A303-764A	1					BGKcLV46-21, Submitted, ENCORE2
DIS3		A303-765A	1					BGKcLV46-21, Submitted, ENCORE2

KD RNA-Seq

GeneName	Cell_Line	Method	Sample_reps	Control_reps	KD%	Status	Project
DIS3	K562	CRISPR	BGKcLV38-15,BGKcLV38-16	BGKcLV38-1,BGKcLV38-2	no clear band on the position,	NotSatisfied	ENCORE2
DIS3	K562	CRISPR	DIS3-BGKcLV46-21,DIS3-BGKcLV46-22	NT-BGKcLV46-1,NT-BGKcLV46-2	81.8,85.2	Submitting	ENCORE2
DIS3	K562	CRISPR	BGKcLV46-23,BGKcLV46-24	BGKcLV46-1,BGKcLV46-2	88.4,86.4	NotSatisfied	ENCORE2
DIS3	HepG2	CRISPR	BGHcLV39-23,BGHcLV39-24	BGHcLV39-1,BGHcLV39-2	no clear band on the position,	NotSatisfied	ENCORE2
DIS3	HepG2	CRISPR	BGHcLV47-19,BGHcLV47-20	BGHcLV47-1,BGHcLV47-2	NO CLEAR BAND ON THE POSITION,	NotSatisfied	ENCORE2

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
DIS3	Product_ID: A303-764A Lot_ID: 1 Source: Bethyl Labs Target Name: DIS3-human
DIS3	Product_ID: A303-765A Lot_ID: 1 Source: Bethyl Labs Target Name: DIS3-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for DIS3 is not avaliable on ENCORE database.

Proteins bound to RNA

DIS3 RNA is bound by 14 proteins.

CanvasJS.com

eCLIP assay for DIS3 is not avaliable on ENCORE database.

14 proteins are bound to DIS3 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr13	73355584	73355704	-	intron-Distal,intron-Proximal	4.93263	13.71476	HepG2	EFTUD2
chr13	73352822	73352972	-	intron-Distal	4.99329	13.54317	K562	KHSRP
chr13	73355842	73355893	-	5'-UTR,CDS,intron-Distal	3.49963	11.08616	K562	YBX3
chr13	73355893	73355901	-	5'-UTR,CDS,intron-Distal	5.25431	10.97360	K562	YBX3
chr13	73349349	73349498	-	CDS,intron-Distal	4.12785	9.93259	HepG2	BCLAF1
chr13	73348122	73348198	-	CDS,intron-Distal,intron-Proximal	5.47606	9.64872	K562	UCHL5
chr13	73351557	73351632	-	CDS,intron-Distal,intron-Proximal	3.94396	9.17402	K562	UCHL5
chr13	73352478	73352562	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.15790	9.06734	HepG2	U2AF2
chr13	73333121	73333190	-	3'-UTR,intron-Distal,intron-Proximal,polyA_site	3.41838	8.99831	K562	PUM2
chr13	73345949	73346011	-	CDS,intron-Distal,intron-Proximal	5.25026	8.41647	HepG2	BCLAF1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 32 entries

eCLIP assay for DIS3 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for DIS3 is not available on ENCORE database.
81 RBPs can affect the levels of DIS3.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for DIS3 is not available on ENCORE database.

81 RBPs can affect the gene expression of DIS3 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
DIS3	ENSG00000083520.10	471.63160	1022.20630	-1.11600	28.80630	27.22690	HepG2	TRIM56
DIS3	ENSG00000083520.10	1880.83700	1063.64840	0.82230	22.85790	21.78280	HepG2	SRSF1
DIS3	ENSG00000083520.10	675.77660	1193.73550	-0.82090	20.86650	19.18380	HepG2	HNRNPL
DIS3	ENSG00000083520.10	489.14500	1179.61300	-1.27000	19.79580	18.28500	HepG2	DDX3X
DIS3	ENSG00000083520.10	465.04190	928.21680	-0.99710	13.41790	11.47110	HepG2	ADAR
DIS3	ENSG00000083520.10	853.51190	1558.18510	-0.86840	13.96050	11.47000	K562	TRIM56
DIS3	ENSG00000083520.10	560.38180	1118.30720	-0.99680	12.35830	11.07070	HepG2	NCBP2
DIS3	ENSG00000083520.10	624.49510	977.54370	-0.64650	11.28800	10.18780	HepG2	PUS1
DIS3	ENSG00000083520.10	3236.61630	2230.08140	0.53730	10.78760	9.64040	K562	RBM15
DIS3	ENSG00000083520.10	1091.21980	1691.87320	-0.63270	9.41570	7.38500	K562	DDX3X
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 91 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for DIS3 is not available on ENCORE database.

18 RBPs can affect the splicing of DIS3 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	DIS3	ENSG00000083520.10	chr13	-	73354983	73355141	73352324	73352518	73355426	73355494	-0.27300	0.00000	0.00000	excluded	K562	AKAP8L
SE	DIS3	ENSG00000083520.10	chr13	-	73354983	73355141	73352324	73352518	73355426	73355494	-0.24700	0.00000	0.00017	excluded	HepG2	DDX59
SE	DIS3	ENSG00000083520.10	chr13	-	73354983	73355141	73352324	73352518	73355426	73355494	0.35400	0.00000	0.00006	included	K562	FXR1
SE	DIS3	ENSG00000083520.10	chr13	-	73354983	73355141	73352324	73352518	73355426	73355494	-0.18800	0.00000	0.00041	excluded	K562	HNRNPUL1
A3SS	DIS3	ENSG00000083520.10	chr13	-	73346296	73346460	73346296	73346413	73346830	73347006	0.05100	0.00000	0.00000	longer	K562	AQR
A3SS	DIS3	ENSG00000083520.10	chr13	-	73347821	73347999	73347821	73347959	73348083	73348234	0.14100	0.00000	0.00000	longer	K562	AQR
A3SS	DIS3	ENSG00000083520.10	chr13	-	73345218	73345314	73345218	73345283	73345932	73346068	0.07300	0.00000	0.00000	longer	K562	AQR
A3SS	DIS3	ENSG00000083520.10	chr13	-	73334666	73334864	73334666	73334789	73335500	73335677	0.16900	0.00000	0.00000	longer	K562	AQR
A3SS	DIS3	ENSG00000083520.10	chr13	-	73335500	73335691	73335500	73335659	73335783	73335952	0.07700	0.00001	0.00015	longer	K562	AQR
SE	DIS3	ENSG00000083520.10	chr13	-	73354983	73355141	73352324	73352518	73355426	73355494	0.31500	0.00002	0.00069	included	K562	SRSF1

Showing 1 to 10 of 28 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

DIS3

General Information

Functions

Localization

Domains (AlphaFold: DIS3)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for DIS3 is not avaliable on ENCORE database.

14 proteins are bound to DIS3 RNA:

eCLIP assay for DIS3 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for DIS3 is not available on ENCORE database.

81 RBPs can affect the gene expression of DIS3 :

The Knockdown/knockout RNA-Seq assay for DIS3 is not available on ENCORE database.

18 RBPs can affect the splicing of DIS3 :

The Knockdown/knockout RNA-Seq assay for DIS3 is not avaliable on ENCORE database.