MED6

General Information

Gene Name       : MED6
Gene ID             : ENSG00000133997.11
Essential Gene : No

Functions

Localization

Domains (AlphaFold: MED6)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878MED6ENSG00000133997.1143.4043.5543.47ENCSR000AEF
HepG2MED6ENSG00000133997.1129.0749.0339.05ENCSR985KAT
K562MED6ENSG00000133997.1129.4425.3727.41ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for MED6 is not avaliable on ENCORE database.



Proteins bound to RNA
  • MED6 RNA is bound by 14 proteins.  







eCLIP assay for MED6 is not avaliable on ENCORE database.





14 proteins are bound to MED6 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr147105037471050473-3'-UTR,intron-Distal3.685819.66830K562KHSRP
chr147105144471051487-3'-UTR,intron-Distal,intron-Proximal4.117363.87995K562UCHL5
chr147105158271051658-3'-UTR,CDS,intron-Distal4.332514.69071HepG2GRWD1
chr147105145771051582-3'-UTR,CDS,intron-Distal,intron-Proximal3.138676.81934HepG2GRWD1
chr147105028671050336-3'-UTR,intron-Distal,intron-Proximal,polyA_site4.193684.29306HepG2KHSRP
chr147105146571051660-3'-UTR,CDS,intron-Distal,intron-Proximal4.784485.90379K562GRWD1
chr147105147071051530-3'-UTR,intron-Distal,intron-Proximal4.904325.23259HepG2BCLAF1
chr147105148771051595-3'-UTR,CDS,intron-Distal,intron-Proximal5.173237.60619K562UCHL5
chr147105036771050456-3'-UTR,intron-Distal4.647605.08199HepG2FUBP3
chr147105029071050344-3'-UTR,intron-Distal,intron-Proximal,polyA_site3.878687.05443K562KHSRP
chr147106725471067357-5'-UTR,CDS,intron-Distal5.027027.92973HepG2PRPF8
chr147105785571058034-CDS,intron-Distal,intron-Proximal5.156598.45448K562PRPF8
chr147106332471063370-CDS,intron-Distal,intron-Proximal3.496785.79905HepG2BCLAF1
chr147106005371060097-CDS,intron-Distal,intron-Proximal3.086453.13705K562BUD13
chr147106332371063398-CDS,intron-Distal,intron-Proximal3.000965.12345HepG2GRWD1
chr147105972371059765-CDS,intron-Distal,intron-Proximal4.521324.76003K562KHSRP
chr147105243871052511-CDS,intron-Distal,intron-Proximal5.370314.68690HepG2PRPF8
chr147106332171063387-CDS,intron-Distal,intron-Proximal3.453163.64266HepG2PPIG
chr147105241171052534-CDS,intron-Distal,intron-Proximal3.676914.95247K562PRPF8
chr147105245471052506-CDS,intron-Distal,intron-Proximal4.3168511.18589HepG2U2AF2
chr147105465571054724-intron-Distal4.103143.50357HepG2QKI
chr147105976571059794-intron-Distal,intron-Proximal5.6679912.51380K562KHSRP
chr147105985471059973-intron-Distal,intron-Proximal3.658059.07651K562KHSRP
chr147104901171049055-intron-Distal3.848023.39864HepG2SUGP2
chr147104975271049848-intron-Distal4.545077.91000K562TIA1
chr147105979471059854-intron-Distal,intron-Proximal4.8878314.43897K562KHSRP
chr147106319971063274-intron-Distal,intron-Proximal3.323893.16095HepG2U2AF2
chr147104959971049643-intron-Distal3.723513.25538K562KHSRP
chr147105184171051901-intron-Distal4.462405.62025K562KHSRP
chr147105250671052545-intron-Distal,intron-Proximal5.696659.27069HepG2U2AF2
chr147104879271048822-intron-Distal3.749743.25538K562KHSRP
chr147104910271049203-intron-Distal3.477534.36650HepG2SUGP2
chr147104975471049850-intron-Distal5.0892417.68778K562PTBP1
chr147104977071049843-intron-Distal3.875843.23532K562MATR3
chr147104976571049853-intron-Distal4.2633321.19150HepG2PTBP1
chr147104885771048910-intron-Distal3.375463.91859HepG2SUGP2
chr147104917371049193-intron-Distal3.396104.08242HepG2PTBP1
chr147104847871048552-intron-Distal3.696539.70788K562KHSRP
chr147104868371048751-intron-Distal3.432635.20123K562KHSRP
chr147104855271048673-intron-Distal5.8180317.85618K562KHSRP
chr147104998771050074-intron-Distal3.145465.42536K562KHSRP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for MED6 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for MED6 is not available on ENCORE database.

  • 47 RBPs can affect the levels of MED6.  








The Knockdown/knockout RNA-Seq assay for MED6 is not available on ENCORE database.





47 RBPs can affect the gene expression of MED6 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
MED6ENSG00000133997.7608.23440479.576800.342802.828502.21520HepG2ACO1
MED6ENSG00000133997.71095.55130757.444000.532303.753003.14680HepG2AKAP1
MED6ENSG00000133997.7549.77410405.170400.440202.720902.12700HepG2BOP1
MED6ENSG00000133997.7672.28770479.476500.487505.597004.71070HepG2CKAP4
MED6ENSG00000133997.7676.29200439.040500.623203.236602.40370HepG2CNOT7
MED6ENSG00000133997.7333.87530436.91190-0.388002.917502.25090HepG2DNAJC2
MED6ENSG00000133997.7374.20950599.21960-0.679204.974504.19250HepG2EIF2S1
MED6ENSG00000133997.7582.97700780.02550-0.420102.907002.07320HepG2EIF4G2
MED6ENSG00000133997.7589.67530468.635700.331402.013501.30350HepG2EWSR1
MED6ENSG00000133997.7310.65030536.62020-0.788606.114104.57680HepG2GNB2L1
MED6ENSG00000133997.7457.87760592.96250-0.373002.277401.62230HepG2HNRNPF
MED6ENSG00000133997.7467.72900583.89670-0.320002.082001.44800HepG2IGF2BP1
MED6ENSG00000133997.7369.67050612.70270-0.728905.880604.84060HepG2PABPC4
MED6ENSG00000133997.7458.61250622.36500-0.440503.949703.25110HepG2PCBP1
MED6ENSG00000133997.7785.77450537.997500.546403.003801.92270HepG2PCBP2
MED6ENSG00000133997.7462.09340633.30020-0.454703.935303.30800HepG2PTBP1
MED6ENSG00000133997.7438.57120781.26450-0.8330010.110709.06940HepG2PUF60
MED6ENSG00000133997.7669.79080829.34920-0.308302.963502.35440HepG2PUM1
MED6ENSG00000133997.7535.38940390.702300.454402.534601.77890HepG2RRP9
MED6ENSG00000133997.7324.38730437.88830-0.432803.214302.53030HepG2SAFB2
MED6ENSG00000133997.7565.08340749.11590-0.406704.283103.43760HepG2SLBP
MED6ENSG00000133997.7623.78380443.137900.493202.165801.47810HepG2SNRNP70
MED6ENSG00000133997.7918.81930688.192300.416904.529803.96190HepG2SRSF1
MED6ENSG00000133997.7334.16770482.06630-0.528704.867504.16210HepG2TRIM56
MED6ENSG00000133997.7656.10040416.820600.654404.863604.04350HepG2U2AF1
MED6ENSG00000133997.7604.04430807.90800-0.419502.452801.66900HepG2UBE2L3
MED6ENSG00000133997.7142.17430301.04160-1.082307.884406.60550HepG2UCHL5
MED6ENSG00000133997.7592.48050437.145500.438603.806703.12160HepG2UTP3
MED6ENSG00000133997.7366.50580497.97610-0.442203.916303.29620HepG2ZNF622
MED6ENSG00000133997.7575.75330387.365000.571705.438304.68550K562AGGF1
MED6ENSG00000133997.71296.53310667.950200.9567014.0173012.84040K562AQR
MED6ENSG00000133997.7445.76640298.489600.578503.800102.71810K562EFTUD2
MED6ENSG00000133997.7402.05040503.49410-0.324602.050701.41510K562EIF2S2
MED6ENSG00000133997.7466.40410361.022000.369402.368701.80070K562FXR1
MED6ENSG00000133997.7592.14540416.119900.508902.746802.04320K562G3BP2
MED6ENSG00000133997.7208.36420319.02740-0.614603.482502.82330K562HNRNPC
MED6ENSG00000133997.7596.51980424.099100.492103.034001.73810K562HNRNPK
MED6ENSG00000133997.7588.76090446.254800.399702.695101.86640K562MAGOH
MED6ENSG00000133997.7546.00820335.890900.700803.571702.53880K562NAA15
MED6ENSG00000133997.71117.65030789.799600.500804.342502.44520K562NOL12
MED6ENSG00000133997.7572.97660397.063200.529003.542102.43850K562PCBP2
MED6ENSG00000133997.7744.70770290.463601.3582019.2572017.25760K562PRPF8
MED6ENSG00000133997.7630.76090399.773800.657804.806004.11530K562PUS1
MED6ENSG00000133997.7579.18780389.482600.572405.078904.29770K562RBM15
MED6ENSG00000133997.7558.62110432.651500.368602.541101.72330K562SF3B4
MED6ENSG00000133997.7225.28490330.14980-0.551402.867601.79070K562SRSF4
MED6ENSG00000133997.7649.32340403.310400.686902.713501.63390K562U2AF1
MED6ENSG00000133997.7709.36880416.546600.768009.613208.11290K562U2AF2
MED6ENSG00000133997.7207.36800297.68200-0.521602.320301.39620K562UCHL5
MED6ENSG00000133997.7687.43520405.284200.762203.560202.03280K562UTP18
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for MED6 is not available on ENCORE database.





13 RBPs can affect the splicing of MED6 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEMED6ENSG00000133997.7chr14-710595967105970571057982710580987106001271060095-0.379000.000000.00000excludedK562SF3B4
SEMED6ENSG00000133997.7chr14-710524727105250071051381710516607105798271058098-0.163000.000000.00014excludedK562SF3B4
SEMED6ENSG00000133997.7chr14-710524727105250071051381710516607105798271058098-0.223000.000000.00028excludedK562PRPF8
SEMED6ENSG00000133997.7chr14-710595967105970571058004710580987106001271060095-0.144000.000000.00000excludedK562AQR
SEMED6ENSG00000133997.7chr14-710595967105970571057982710580987106001271060095-0.126000.000060.00152excludedK562PUS1
SEMED6ENSG00000133997.7chr14-710524727105250071051533710516607105798271058088-0.133000.000030.01976excludedK562BUD13
SEMED6ENSG00000133997.7chr14-710595967105970571057982710580987106001271060095-0.067000.001680.04581excludedHepG2SF3A3
SEMED6ENSG00000133997.7chr14-710524727105250071051381710516607105798271058088-0.090000.000030.00173excludedHepG2SF3A3
SEMED6ENSG00000133997.7chr14-710595967105970571057982710580987106001271060095-0.264000.000000.00017excludedK562U2AF2
SEMED6ENSG00000133997.7chr14-710595967105970571057982710580987106001271060095-0.319000.000000.00000excludedK562TARDBP
SEMED6ENSG00000133997.7chr14-710524727105250071051381710516607105798271058098-0.137000.000020.00190excludedK562TARDBP
SEMED6ENSG00000133997.7chr14-710595967105970571057982710580987106001271060095-0.201000.000040.00290excludedK562SF3B1
SEMED6ENSG00000133997.7chr14-710524727105250071051381710516607105798271058098-0.123000.001070.04249excludedK562SF3B1
SEMED6ENSG00000133997.7chr14-710524727105250071051381710516607105798271058098-0.097000.003550.05309excludedK562HNRNPC
A3SSMED6ENSG00000133997.7chr14-7105959671059726710595967105970571060012710600950.095000.000740.06880longerHepG2SRSF1
A3SSMED6ENSG00000133997.7chr14-7105959671059768710595967105970571060012710601760.319000.000000.00000longerK562AQR
A3SSMED6ENSG00000133997.7chr14-7106332771063459710633277106341971064334710644940.157000.000000.00000longerK562AQR
A3SSMED6ENSG00000133997.7chr14-7106001271060176710600127106009571063327710634480.064000.000050.00048longerK562AQR
A3SSMED6ENSG00000133997.7chr14-710595967105976871059596710597267106001271060176-0.667000.012670.06476shorterK562AQR
MXEMED6ENSG00000133997.7chr14-7105247271052500710579827105809871050305710516607105959671059705-0.115000.007830.096492includedHepG2FTO
MXEMED6ENSG00000133997.7chr14-71052472710525007105798271058088710515337105166071059596710597050.092000.000020.012241includedK562BUD13
MXEMED6ENSG00000133997.7chr14-7105798271058098710595967105970571050305710516607106001271060095-0.196000.002640.042872includedK562PUS1
MXEMED6ENSG00000133997.7chr14-7105798271058098710595967105972671050802710516607106001271060095-0.550000.008160.098792includedK562PUS1
MXEMED6ENSG00000133997.7chr14-71059596710597057106001271060142710580047105809871063327710634150.117000.000000.000001includedK562AQR
MXEMED6ENSG00000133997.7chr14-71059596710597057106001271060145710580047105809871063327710634150.114000.000000.000001includedK562AQR
MXEMED6ENSG00000133997.7chr14-71059596710597057106001271060176710580047105809871063327710634150.132000.000000.000001includedK562AQR
MXEMED6ENSG00000133997.7chr14-71059596710597057106001271060095710580047105809871063327710634150.114000.004280.031551includedK562AQR
MXEMED6ENSG00000133997.7chr14-71059596710597057106001271060129710580047105809871063327710634150.122000.000000.000001includedK562AQR
MXEMED6ENSG00000133997.7chr14-71052472710525797105798271058164710515337105166071059596710597050.384000.000000.000001includedK562AQR
MXEMED6ENSG00000133997.7chr14-71052472710525797105798271058098710515337105166071059596710597050.097000.003740.028181includedK562AQR
MXEMED6ENSG00000133997.7chr14-71052472710525797105798271058208710515337105166071059596710597050.380000.000000.000001includedK562AQR
MXEMED6ENSG00000133997.7chr14-71052472710525797105798271058190710515337105166071059596710597050.378000.000000.000001includedK562AQR
MXEMED6ENSG00000133997.7chr14-71052472710525797105798271058148710515337105166071059596710597050.378000.000000.000001includedK562AQR
MXEMED6ENSG00000133997.7chr14-71052472710525797105798271058132710515337105166071059596710597050.380000.000000.000001includedK562AQR
MXEMED6ENSG00000133997.7chr14-71052472710525007105959671059768710508027105166071060012710600950.063000.000000.000011includedK562AQR
MXEMED6ENSG00000133997.7chr14-71052472710525007105959671059726710508027105166071060012710600950.201000.000000.000001includedK562AQR
MXEMED6ENSG00000133997.7chr14-71052472710525007105798271058190710508027105166071060012710600950.291000.000000.000001includedK562AQR
MXEMED6ENSG00000133997.7chr14-71052472710525007105798271058164710508027105166071060012710600950.291000.000000.000001includedK562AQR
MXEMED6ENSG00000133997.7chr14-71052472710525007105959671059752710508027105166071060012710600950.064000.000000.000011includedK562AQR
MXEMED6ENSG00000133997.7chr14-71052472710525007105798271058132710508027105166071059596710597050.289000.000000.000001includedK562AQR
MXEMED6ENSG00000133997.7chr14-71052472710525007105798271058148710508027105166071059596710597050.287000.000000.000001includedK562AQR
MXEMED6ENSG00000133997.7chr14-71052472710525007105798271058164710508027105166071059596710597050.293000.000000.000001includedK562AQR
MXEMED6ENSG00000133997.7chr14-71052472710525007105798271058190710508027105166071059596710597050.287000.000000.000001includedK562AQR
MXEMED6ENSG00000133997.7chr14-71052472710525007105798271058208710508027105166071059596710597050.289000.000000.000001includedK562AQR
MXEMED6ENSG00000133997.7chr14-71052472710525007105798271058098710503057105166071059596710597050.104000.004240.031321includedK562AQR
MXEMED6ENSG00000133997.7chr14-71057982710580987106001271060095710524727105250071063327710634190.131000.003970.029661includedK562AQR
MXEMED6ENSG00000133997.7chr14-7105959671059705710600127106009571050305710516607106332771063419-0.081000.000020.000322includedK562AQR
MXEMED6ENSG00000133997.7chr14-7105798271058190710595967105970571051533710516607106001271060095-0.503000.000000.000002includedK562AQR
MXEMED6ENSG00000133997.7chr14-7105798271058098710600127106009571050802710516607106332771063419-0.345000.000000.000002includedK562AQR
MXEMED6ENSG00000133997.7chr14-7105798271058098710595967105970571051533710516607106001271060095-0.530000.000000.000002includedK562AQR
MXEMED6ENSG00000133997.7chr14-7105798271058164710595967105970571051533710516607106001271060095-0.503000.000000.000002includedK562AQR
MXEMED6ENSG00000133997.7chr14-7105798271058098710595967105970571052472710525007106001271060095-0.249000.000350.006932includedK562U2AF2
MXEMED6ENSG00000133997.7chr14-71052472710525007105798271058088710513817105166071059596710597050.061000.000020.001811includedHepG2SF3A3
MXEMED6ENSG00000133997.7chr14-7105798271058098710595967105970571050305710516607106001271060095-0.282000.000320.031042includedK562RBM22
MXEMED6ENSG00000133997.7chr14-7105798271058098710595967105970571052472710525007106001271060095-0.218000.001670.028862includedK562SF3B4
MXEMED6ENSG00000133997.7chr14-7105798271058098710595967105970571050305710516607106001271060095-0.599000.000000.000002includedK562SF3B4
MXEMED6ENSG00000133997.7chr14-7105798271058098710595967105970571050305710516607106001271060095-0.369000.000000.000062includedK562PRPF8

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for MED6 is not avaliable on ENCORE database.