ARHGEF1

General Information

Gene Name : ARHGEF1
Gene ID : ENSG00000076928.17
Essential Gene : No

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: ARHGEF1)

Not Available

Antibody Validation

View validation images for all ARHGEF1 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	ARHGEF1	ENSG00000076928.17	8.47	24.05	16.26	ENCSR000AEF
HepG2	ARHGEF1	ENSG00000076928.17	33.42	10.37	21.89	ENCSR985KAT
K562	ARHGEF1	ENSG00000076928.17	51.36	26.78	39.07	ENCSR000AEO

Assays

1 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	ARHGEF1-BGHcLV27-HepG2	ENCSR250QFO	ARHGEF1	HepG2	Released		ENCSR650TTU	CRISPR	KD% = 50.9,57.6

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
ARHGEF1	ENCAB133PSK	A302-701A	1	Released, ENCODE4	BGHcLV27-13, Released, ENCODE4	BGKcLV35-3, Released, ENCODE4
ARHGEF1		3669S	3	Submitted, ENCORE2	BGHcLV27-13, Released, ENCODE4	BGKcLV35-3, Submitted, ENCORE2
ARHGEF1	ENCAB432TOF	A302-702A	1	Released, ENCODE4	BGHcLV27-13, Released, ENCODE4	BGKcLV35-3, Submitted, ENCORE2

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
ARHGEF1	K562	CRISPR			BGKcLV26-29,BGKcLV26-30	BGKcLV26-1,BGKcLV26-2	33.3,25.2	NotSatisfied	ENCODE4
ARHGEF1	K562	CRISPR			ARHGEF1-BGKcLV35-3,ARHGEF1-BGKcLV35-4	NT-BGKcLV35-1,NT-BGKcLV35-2	69.7,68.6	Submitting	ENCORE2
ARHGEF1	HepG2	CRISPR	ENCSR250QFO	ENCSR650TTU	ARHGEF1-BGHcLV27-13,ARHGEF1-BGHcLV27-14	NT-BGHcLV27-1,NT-BGHcLV27-2	50.9,57.6	Released	ENCODE4

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
ARHGEF1	Product_ID: A302-701A Lot_ID: 1 Source: Bethyl Labs Target Name: ARHGEF1-human
ARHGEF1	Product_ID: A302-702A Lot_ID: 1 Source: Bethyl Labs Target Name: ARHGEF1-human
ARHGEF1	Product_ID: 3669S Lot_ID: 3 Source: Cell Signaling Technology Target Name: ARHGEF1-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for ARHGEF1 is not avaliable on ENCORE database.

Proteins bound to RNA

ARHGEF1 RNA is bound by 43 proteins.

CanvasJS.com

eCLIP assay for ARHGEF1 is not avaliable on ENCORE database.

43 proteins are bound to ARHGEF1 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr19	42401047	42401198	+	intron-Distal	7.47509	77.55970	HepG2	PCBP2
chr19	42401492	42401654	+	intron-Distal,intron-Proximal	6.20444	56.54033	HepG2	DDX59
chr19	42401928	42402016	+	CDS,intron-Distal,intron-Proximal	5.91381	49.51411	HepG2	PCBP2
chr19	42401825	42401884	+	intron-Distal	6.58377	39.18604	HepG2	PCBP2
chr19	42401770	42401825	+	intron-Distal	7.14679	37.82075	HepG2	PCBP2
chr19	42400702	42400874	+	intron-Distal	4.90774	35.13234	HepG2	PTBP1
chr19	42401270	42401328	+	intron-Distal	7.06454	31.93012	HepG2	PCBP2
chr19	42401205	42401337	+	intron-Distal	6.87029	30.71759	HepG2	HNRNPK
chr19	42401264	42401346	+	intron-Distal	5.13068	26.76422	HepG2	DDX59
chr19	42401388	42401457	+	intron-Distal,intron-Proximal	5.15273	26.44752	HepG2	DDX59
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 289 entries

eCLIP assay for ARHGEF1 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for ARHGEF1 is not available on ENCORE database.
110 RBPs can affect the levels of ARHGEF1.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for ARHGEF1 is not available on ENCORE database.

110 RBPs can affect the gene expression of ARHGEF1 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
ARHGEF1	ENSG00000076928.13	2276.80400	931.95150	1.28860	72.62800	70.46610	HepG2	PUM1
ARHGEF1	ENSG00000076928.13	1861.68250	866.82450	1.10270	36.33540	34.43680	HepG2	SRSF5
ARHGEF1	ENSG00000076928.13	1229.59940	576.17270	1.09350	33.14530	31.27340	HepG2	SAFB2
ARHGEF1	ENSG00000076928.13	1190.32580	2882.37750	-1.27590	29.97420	28.24540	K562	AQR
ARHGEF1	ENSG00000076928.13	1265.30640	634.32320	0.99610	27.08450	25.54830	HepG2	TRIM56
ARHGEF1	ENSG00000076928.13	1825.02890	877.95470	1.05560	26.62940	25.07040	HepG2	PCBP1
ARHGEF1	ENSG00000076928.13	1746.68070	930.03660	0.90920	26.15460	24.65330	HepG2	SF3B4
ARHGEF1	ENSG00000076928.13	1667.04180	893.42880	0.89980	24.92530	23.59570	HepG2	PTBP1
ARHGEF1	ENSG00000076928.13	2274.86930	1348.37120	0.75450	24.45080	23.04930	HepG2	ACO1
ARHGEF1	ENSG00000076928.13	1236.43660	577.07790	1.09930	22.69180	20.73970	HepG2	PPIL4
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 125 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for ARHGEF1 is not available on ENCORE database.

23 RBPs can affect the splicing of ARHGEF1 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	ARHGEF1	ENSG00000076928.13	chr19	+	42396095	42396194	42392822	42392936	42396401	42396444	-0.24800	0.00000	0.00010	excluded	K562	AKAP8L
SE	ARHGEF1	ENSG00000076928.13	chr19	+	42409326	42409413	42409100	42409188	42409911	42409979	-0.11100	0.00000	0.00000	excluded	HepG2	U2AF2
SE	ARHGEF1	ENSG00000076928.13	chr19	+	42410608	42410772	42410090	42410177	42410854	42410955	-0.20300	0.00000	0.00015	excluded	HepG2	PCBP1
SE	ARHGEF1	ENSG00000076928.13	chr19	+	42409326	42409413	42409100	42409188	42409911	42409979	-0.09300	0.00000	0.00000	excluded	K562	HNRNPC
A3SS	ARHGEF1	ENSG00000076928.13	chr19	+	42396095	42396444	42396401	42396444	42392822	42392936	-0.33400	0.00000	0.00102	shorter	K562	AKAP8L
RI	ARHGEF1	ENSG00000076928.13	chr19	+	42396095	42396444	42396095	42396194	42396401	42396444	0.19400	0.00000	0.00002	included	HepG2	PCBP1
RI	ARHGEF1	ENSG00000076928.13	chr19	+	42396095	42396444	42396095	42396194	42396401	42396444	0.36800	0.00000	0.00000	included	HepG2	TAF15
RI	ARHGEF1	ENSG00000076928.13	chr19	+	42396095	42396444	42396095	42396194	42396401	42396444	0.17700	0.00001	0.00019	included	HepG2	QKI
SE	ARHGEF1	ENSG00000076928.13	chr19	+	42398698	42398734	42398523	42398620	42399421	42399559	-0.19400	0.00002	0.00148	excluded	K562	PRPF8
SE	ARHGEF1	ENSG00000076928.13	chr19	+	42398698	42398734	42398523	42398620	42399421	42399559	-0.24400	0.00002	0.00335	excluded	HepG2	PRPF8

Showing 1 to 10 of 33 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

ARHGEF1

General Information

Functions

Localization

Domains (AlphaFold: ARHGEF1)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for ARHGEF1 is not avaliable on ENCORE database.

43 proteins are bound to ARHGEF1 RNA:

eCLIP assay for ARHGEF1 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for ARHGEF1 is not available on ENCORE database.

110 RBPs can affect the gene expression of ARHGEF1 :

The Knockdown/knockout RNA-Seq assay for ARHGEF1 is not available on ENCORE database.

23 RBPs can affect the splicing of ARHGEF1 :

The Knockdown/knockout RNA-Seq assay for ARHGEF1 is not avaliable on ENCORE database.