EXOSC1

General Information

Gene Name       : EXOSC1
Gene ID             : ENSG00000171311.12
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: EXOSC1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878EXOSC1ENSG00000171311.1250.8156.7753.79ENCSR000AEF
HepG2EXOSC1ENSG00000171311.1226.3830.8128.59ENCSR985KAT
K562EXOSC1ENSG00000171311.1249.3455.3752.36ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
EXOSC1A303-885A1BGKcLV40-35, Submitted, ENCORE2


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
EXOSC1K562CRISPREXOSC1-BGKcLV40-35,EXOSC1-BGKcLV40-36NT-BGKcLV40-1,NT-BGKcLV40-254.5,51.3SubmittingENCORE2
EXOSC1HepG2CRISPRBGHcLV41-55,BGHcLV41-56BGHcLV41-1,BGHcLV41-20.0,0.0NotSatisfiedENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
EXOSC1Product_ID: A303-885A
Lot_ID: 1
Source: Bethyl Labs
Target Name: EXOSC1-human		 EXOSC1-K562-CRISPR-A303-885A.png<br>Caption: Western blot following CRISPR against EXOSC1 in K562 whole cell lysate using EXOSC1 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against EXOSC1. EXOSC1 protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for EXOSC1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • EXOSC1 RNA is bound by 3 proteins.  







eCLIP assay for EXOSC1 is not avaliable on ENCORE database.





3 proteins are bound to EXOSC1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr109919698799197017-CDS,intron-Distal,intron-Proximal3.179685.34378K562YBX3
chr109920303599203091-CDS,intron-Distal,intron-Proximal3.717193.95921HepG2U2AF2
chr109919695699196987-CDS,intron-Distal,intron-Proximal3.100297.37965K562YBX3
chr109920555299205601-CDS,intron-Distal,intron-Proximal3.354963.32039HepG2PPIG
chr109920548999205539-CDS,intron-Distal3.795593.19539K562YBX3
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for EXOSC1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for EXOSC1 is not available on ENCORE database.

  • 22 RBPs can affect the levels of EXOSC1.  








The Knockdown/knockout RNA-Seq assay for EXOSC1 is not available on ENCORE database.





22 RBPs can affect the gene expression of EXOSC1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
EXOSC1ENSG00000171311.8293.43290189.071100.634003.448402.78850HepG2BOP1
EXOSC1ENSG00000171311.8423.92960314.667300.429902.157501.46880HepG2CIRBP
EXOSC1ENSG00000171311.8273.73740403.58080-0.560103.153002.28580HepG2EIF4G2
EXOSC1ENSG00000171311.8377.30390500.93690-0.408902.704102.10860HepG2ETF1
EXOSC1ENSG00000171311.872.92310196.77910-1.432107.990106.94070HepG2GPKOW
EXOSC1ENSG00000171311.8176.31450260.92710-0.565503.331502.48970HepG2PRPF4
EXOSC1ENSG00000171311.8430.46520249.664400.785804.376102.86350HepG2PRPF6
EXOSC1ENSG00000171311.8315.87040428.76500-0.440902.435101.80660HepG2PUM2
EXOSC1ENSG00000171311.8122.91100229.19680-0.899003.365502.59010HepG2RAVER1
EXOSC1ENSG00000171311.8356.21800249.906000.511302.261001.65070HepG2SF3A3
EXOSC1ENSG00000171311.8260.60610351.03990-0.429802.262901.72140HepG2SF3B4
EXOSC1ENSG00000171311.8298.67510410.58730-0.459103.310302.76070HepG2SSB
EXOSC1ENSG00000171311.8238.41710148.040500.687403.502202.65230HepG2UCHL5
EXOSC1ENSG00000171311.8359.29330243.748600.559704.451703.80060HepG2ZNF622
EXOSC1ENSG00000171311.8518.86670803.14000-0.630305.490604.71320K562AQR
EXOSC1ENSG00000171311.8747.25060973.56470-0.381702.884801.38820K562DDX19B
EXOSC1ENSG00000171311.8785.27960981.03850-0.321102.707901.77760K562EIF4G2
EXOSC1ENSG00000171311.8167.91960331.44920-0.981007.664206.33870K562GPKOW
EXOSC1ENSG00000171311.8300.08930410.92120-0.453502.528601.95450K562HNRNPC
EXOSC1ENSG00000171311.8544.69920692.41240-0.346202.718001.83290K562HNRNPU
EXOSC1ENSG00000171311.8897.82120582.291000.624604.019703.06640K562HSPD1
EXOSC1ENSG00000171311.8731.61840487.641500.585205.201804.02080K562PPIG
EXOSC1ENSG00000171311.8916.491801115.46400-0.283502.395101.50070K562PUM2
EXOSC1ENSG00000171311.8565.15290372.657400.600703.888702.91850K562RPS19
EXOSC1ENSG00000171311.8438.32400567.50020-0.372603.034602.06020K562SRPK2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for EXOSC1 is not available on ENCORE database.





11 RBPs can affect the splicing of EXOSC1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEEXOSC1ENSG00000171311.8chr10-992029939920306899200927992010169920548899205604-0.432000.000000.00000excludedK562SF3B4
SEEXOSC1ENSG00000171311.8chr10-991984269919846099197456991975079920092799201016-0.070000.000010.00022excludedK562AQR
SEEXOSC1ENSG00000171311.8chr10-992029939920306899200927992010169920548899205604-0.087000.011140.08842excludedK562AQR
SEEXOSC1ENSG00000171311.8chr10-991984199919846099196152991963089920092799201016-0.113000.005740.06911excludedK562PUS1
SEEXOSC1ENSG00000171311.8chr10-992029939920306899200927992010169920548899205604-0.191000.001280.02463excludedK562U2AF2
SEEXOSC1ENSG00000171311.8chr10-992029939920306899200927992010169920548899205604-0.215000.000000.00008excludedK562TARDBP
SEEXOSC1ENSG00000171311.8chr10-992029939920306899200927992010169920548899205604-0.289000.000000.00000excludedK562HNRNPU
SEEXOSC1ENSG00000171311.8chr10-991984269919846099197456991975079920092799201016-0.202000.000720.03303excludedHepG2HNRNPU
MXEEXOSC1ENSG00000171311.8chr10-99200927992010169920299399203068991974569919750799205488992056040.173000.003220.040921includedK562DROSHA
MXEEXOSC1ENSG00000171311.8chr10-9920092799201016992029939920306899197456991975079920548899205604-0.169000.002710.043662includedK562PUS1
MXEEXOSC1ENSG00000171311.8chr10-9920092799201016992029939920306899197456991975079920548899205604-0.141000.000340.003562includedK562AQR
MXEEXOSC1ENSG00000171311.8chr10-9920092799201008992029939920306899197456991975079920548899205604-0.089000.000000.000022includedK562AQR
MXEEXOSC1ENSG00000171311.8chr10-9920092799201016992029939920306899197456991975079920548899205604-0.364000.000180.004072includedK562U2AF2
MXEEXOSC1ENSG00000171311.8chr10-9920092799201016992029939920306899197456991975079920548899205604-0.217000.000000.000222includedK562TARDBP
MXEEXOSC1ENSG00000171311.8chr10-9919745699197507991984269919846099196947991970329920092799201016-0.159000.000420.076142includedK562NCBP2
MXEEXOSC1ENSG00000171311.8chr10-9920092799201016992029939920306899197456991975079920548899205604-0.287000.000000.000002includedK562HNRNPU
MXEEXOSC1ENSG00000171311.8chr10-9919745699197507992009209920101699196947991970329920299399203068-0.145000.000030.003102includedK562HNRNPU
MXEEXOSC1ENSG00000171311.8chr10-9920092799201016992029939920306899197456991975079920548899205604-0.269000.002930.070952includedHepG2HNRNPU
MXEEXOSC1ENSG00000171311.8chr10-9920092799201016992029939920306899197456991975079920548899205604-0.169000.003240.055792includedK562PRPF8
MXEEXOSC1ENSG00000171311.8chr10-9919841999198460992029939920306899197456991975079920548899205604-0.142000.005140.081742includedK562SUPV3L1
MXEEXOSC1ENSG00000171311.8chr10-99200927992010169920299399203068991974569919750799205488992056040.163000.003890.054471includedK562HNRNPUL1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for EXOSC1 is not avaliable on ENCORE database.