CNOT10

General Information

Gene Name : CNOT10
Gene ID : ENSG00000182973.18
Essential Gene : No

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: CNOT10)

Not Available

Antibody Validation

Bethyl Labs: A304-899A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	CNOT10	ENSG00000182973.18	36.49	30.11	33.30	ENCSR000AEF
HepG2	CNOT10	ENSG00000182973.18	16.43	22.80	19.62	ENCSR985KAT
K562	CNOT10	ENSG00000182973.18	62.88	74.46	68.67	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	CNOT10-BGKcLV21-K562	ENCSR644LYC	CNOT10	K562	Released		ENCSR854OFV	CRISPR	KD% = 74.8,76.6
knockdown followed by RNA-seq	CNOT10-BGHcLV22-HepG2	ENCSR002NQQ	CNOT10	HepG2	Released		ENCSR704VPL	CRISPR	KD% = 92.2,89.5

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
CNOT10	ENCAB805LWE	A304-899A	1				BGHcLV22-9, Released, ENCODE4	BGKcLV21-7, Released, ENCODE4

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project	Note
CNOT10	K562	CRISPR	ENCSR644LYC	ENCSR854OFV	CNOT10-BGKcLV21-7,CNOT10-BGKcLV21-8	NT-BGKcLV21-1,NT-BGKcLV21-2	74.8,76.6	Released	ENCODE4
CNOT10	HepG2	CRISPR	ENCSR002NQQ	ENCSR704VPL	CNOT10-BGHcLV22-9,CNOT10-BGHcLV22-10	NT-BGHcLV22-1,NT-BGHcLV22-2	92.2,89.5	Released	ENCODE4

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
CNOT10	Product_ID: A304-899A Lot_ID: 1 Source: Bethyl Labs Target Name: CNOT10-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for CNOT10 is not avaliable on ENCORE database.

Proteins bound to RNA

CNOT10 RNA is bound by 18 proteins.

CanvasJS.com

eCLIP assay for CNOT10 is not avaliable on ENCORE database.

18 proteins are bound to CNOT10 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr3	32754718	32754823	+	CDS,intron-Distal,intron-Proximal	4.82230	30.33866	K562	PUM2
chr3	32774926	32775014	+	5'-UTR,CDS	4.30593	13.46848	K562	PUM2
chr3	32815001	32815030	+	3'-UTR,CDS	3.75792	12.74366	K562	YBX3
chr3	32815143	32815170	+	3'-UTR	5.34947	12.66140	K562	YBX3
chr3	32815042	32815159	+	3'-UTR,CDS	4.90686	10.95110	K562	PABPC4
chr3	32815122	32815143	+	3'-UTR	3.78189	10.74560	K562	YBX3
chr3	32814981	32815001	+	3'-UTR,CDS	3.12062	9.91876	K562	YBX3
chr3	32800691	32800791	+	intron-Distal	3.74974	7.64049	K562	KHSRP
chr3	32762565	32762611	+	intron-Distal	3.88232	7.33269	K562	PTBP1
chr3	32726853	32726941	+	5'-UTR	4.78873	7.13477	K562	DDX3X
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 29 entries

eCLIP assay for CNOT10 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for CNOT10 is not available on ENCORE database.
61 RBPs can affect the levels of CNOT10.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for CNOT10 is not available on ENCORE database.

61 RBPs can affect the gene expression of CNOT10 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
CNOT10	ENSG00000182973.14	3832.57140	2351.56730	0.70460	15.70280	13.87440	K562	POLR2G
CNOT10	ENSG00000182973.14	5060.25300	3065.85220	0.72280	10.03600	8.45730	K562	PCBP3
CNOT10	ENSG00000182973.14	2566.34340	3340.03650	-0.38010	7.82790	6.69280	K562	UPF1
CNOT10	ENSG00000182973.14	2218.84040	2898.75120	-0.38560	7.29980	6.44230	K562	AGGF1
CNOT10	ENSG00000182973.14	4748.82030	3746.27470	0.34200	6.74120	5.78900	K562	DDX47
CNOT10	ENSG00000182973.14	357.37380	606.45580	-0.76300	6.62640	5.57910	HepG2	HNRNPK
CNOT10	ENSG00000182973.14	1188.85370	866.87330	0.45560	6.39250	5.54080	HepG2	ETF1
CNOT10	ENSG00000182973.14	1784.06330	2493.87440	-0.48320	6.60510	5.52170	K562	SRSF1
CNOT10	ENSG00000182973.14	657.55270	456.88180	0.52520	5.99700	5.15270	HepG2	PUS1
CNOT10	ENSG00000182973.14	482.94180	679.12470	-0.49180	5.84890	4.89950	HepG2	HNRNPL
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 67 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for CNOT10 is not available on ENCORE database.

17 RBPs can affect the splicing of CNOT10 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	CNOT10	ENSG00000182973.14	chr3	+	32805946	32805982			32804224	32804355	32806173	32806301	-0.10800	0.00000	0.00000	excluded	K562	SF3B4
SE	CNOT10	ENSG00000182973.14	chr3	+	32761605	32761723			32758645	32758729	32766941	32767091	-0.07100	0.00000	0.00000	excluded	K562	AQR
A3SS	CNOT10	ENSG00000182973.14	chr3	+	32745334	32745454			32745359	32745454	32726855	32726974	0.08300	0.00000	0.00000	longer	K562	AQR
MXE	CNOT10	ENSG00000182973.14	chr3	+	32745334	32745454	32746302	32746464	32726855	32726974	32750161	32750312	0.08400	0.00000	0.00000	1included	K562	AQR
MXE	CNOT10	ENSG00000182973.14	chr3	+	32758614	32758729	32761548	32761723	32757716	32757803	32766941	32767091	0.10300	0.00000	0.00000	1included	K562	AQR
MXE	CNOT10	ENSG00000182973.14	chr3	+	32758614	32758729	32761605	32761723	32757716	32757803	32766941	32767091	0.10300	0.00000	0.00000	1included	K562	AQR
SE	CNOT10	ENSG00000182973.14	chr3	+	32805946	32805982			32804224	32804355	32806173	32806301	-0.07600	0.00002	0.00061	excluded	K562	U2AF2
SE	CNOT10	ENSG00000182973.14	chr3	+	32778901	32778982			32776291	32776468	32800949	32801063	0.12700	0.00003	0.00248	included	K562	FXR1
SE	CNOT10	ENSG00000182973.14	chr3	+	32746302	32746464			32745359	32745454	32750161	32750312	-0.05200	0.00006	0.00408	excluded	K562	HNRNPU
MXE	CNOT10	ENSG00000182973.14	chr3	+	32776291	32776468	32778901	32778982	32774914	32775036	32800949	32801063	0.17000	0.00007	0.00178	1included	K562	U2AF2

Showing 1 to 10 of 28 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

CNOT10

General Information

Functions

Localization

Domains (AlphaFold: CNOT10)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for CNOT10 is not avaliable on ENCORE database.

18 proteins are bound to CNOT10 RNA:

eCLIP assay for CNOT10 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for CNOT10 is not available on ENCORE database.

61 RBPs can affect the gene expression of CNOT10 :

The Knockdown/knockout RNA-Seq assay for CNOT10 is not available on ENCORE database.

17 RBPs can affect the splicing of CNOT10 :

The Knockdown/knockout RNA-Seq assay for CNOT10 is not avaliable on ENCORE database.