ENCORE
Encyclopedia of RNA Elements
Genomes encompass all the information necessary to specify the development and function of an organism.
In addition to genes, genomes also contain a myriad of functional elements that control various steps
in gene expression. A major class of these elements function only when transcribed into RNA as they
serve as the binding sites for RNA binding proteins (RBPs), which act to control post-transcriptional
processes including splicing, cleavage and polyadenylation, RNA editing, RNA localization, stability,
and translation. Despite the importance of these functional RNA elements encoded in the genome, they
have been much less studied than genes and DNA elements. Here, we describe the mapping and characterization
of RNA elements recognized by a large collection of human RBPs in K562 and HepG2 cells. These data expand
the catalog of functional elements encoded in the human genome by addition of a large set of elements that
function at the RNA level through interaction with RBPs.
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