EDF1

General Information

Gene Name       : EDF1
Gene ID             : ENSG00000107223.12
Essential Gene : No

Functions

Localization

Domains (AlphaFold: EDF1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878EDF1ENSG00000107223.1261.88207.16134.52ENCSR000AEF
HepG2EDF1ENSG00000107223.12462.63218.91340.77ENCSR985KAT
K562EDF1ENSG00000107223.12277.58214.10245.84ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
EDF1A304-039A1BGHcLV39-39, Submitted, ENCORE2BGKcLV40-13, Submitted, ENCORE2


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
EDF1K562CRISPRBGKcLV38-31,BGKcLV38-32BGKcLV38-1,BGKcLV38-227.1,56.7NotSatisfiedENCORE2
EDF1K562CRISPREDF1-BGKcLV40-13,EDF1-BGKcLV40-14NT-BGKcLV40-1,NT-BGKcLV40-282.0,85.2SubmittingENCORE2
EDF1HepG2CRISPREDF1-BGHcLV39-39,EDF1-BGHcLV39-40NT-BGHcLV39-1,NT-BGHcLV39-289.8,82.3SubmittingENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
EDF1Product_ID: A304-039A
Lot_ID: 1
Source: Bethyl Labs
Target Name: EDF1-human		 EDF1-HEPG2-CRISPR-A304-039A.png<br>Caption: Western blot following CRISPR against EDF1 in HepG2 whole cell lysate using EDF1 specific antibody. Lane 1 is a ladder, lane 2 is HepG2 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against EDF1. EDF1 protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.
 EDF1-K562-CRISPR-A304-039A.png<br>Caption: Western blot following CRISPR against EDF1 in K562 whole cell lysate using EDF1 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against EDF1. EDF1 protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for EDF1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • EDF1 RNA is bound by 27 proteins.  







eCLIP assay for EDF1 is not avaliable on ENCORE database.





27 proteins are bound to EDF1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr9139756599139756643-3'-UTR,intron-Distal5.475515.18845K562PCBP1
chr9139757320139757357-3'-UTR,CDS,intron-Distal,intron-Proximal4.000767.75444K562PRPF8
chr9139756819139756862-3'-UTR,intron-Distal,intron-Proximal3.403484.52939HepG2PRPF4
chr9139756883139756922-3'-UTR,CDS,intron-Distal,intron-Proximal3.320013.93602K562EWSR1
chr9139756595139756643-3'-UTR,intron-Distal3.123324.45691HepG2LARP4
chr9139756813139756872-3'-UTR,intron-Distal,intron-Proximal3.721067.01627HepG2XRN2
chr9139756794139756804-3'-UTR,CDS,intron-Distal3.140224.63145K562BUD13
chr9139757249139757337-3'-UTR,CDS,intron-Distal,intron-Proximal4.3230711.64444HepG2EFTUD2
chr9139757041139757122-3'-UTR,intron-Distal3.294865.82267HepG2XPO5
chr9139757322139757359-3'-UTR,CDS,intron-Distal,intron-Proximal4.2350615.70997K562AQR
chr9139757317139757358-3'-UTR,CDS,intron-Distal,intron-Proximal6.1206127.98439HepG2AQR
chr9139756643139756714-3'-UTR,intron-Distal3.3618811.96198HepG2LARP4
chr9139756793139756848-3'-UTR,CDS,intron-Distal,intron-Proximal3.345145.64759K562NONO
chr9139756606139756706-3'-UTR,intron-Distal3.852495.17218HepG2UPF1
chr9139757274139757317-3'-UTR,intron-Distal,intron-Proximal3.094624.73672HepG2LSM11
chr9139757268139757320-3'-UTR,intron-Distal,intron-Proximal3.538064.20405K562EWSR1
chr9139757240139757320-3'-UTR,intron-Distal,intron-Proximal4.1399115.64319K562PRPF8
chr9139757296139757317-3'-UTR,intron-Distal,intron-Proximal5.5347010.32702HepG2AQR
chr9139756805139756867-3'-UTR,intron-Distal,intron-Proximal3.045855.74509K562EWSR1
chr9139756783139756797-3'-UTR,CDS,intron-Distal3.136076.38612K562YBX3
chr9139757246139757319-3'-UTR,intron-Distal,intron-Proximal3.9249920.13253HepG2BUD13
chr9139757254139757322-3'-UTR,intron-Distal,intron-Proximal5.0219219.32372K562AQR
chr9139756765139756826-3'-UTR,CDS,intron-Distal4.2451211.09624HepG2AQR
chr9139756807139756849-3'-UTR,intron-Distal,intron-Proximal3.128933.41934K562NOLC1
chr9139756783139756819-3'-UTR,CDS,intron-Distal4.230703.90256HepG2PRPF4
chr9139756789139756859-3'-UTR,CDS,intron-Distal,intron-Proximal3.119585.89725HepG2FAM120A
chr9139756800139756815-3'-UTR,intron-Distal5.729448.43521K562AQR
chr9139756792139756851-3'-UTR,CDS,intron-Distal,intron-Proximal4.094443.86455HepG2GTF2F1
chr9139756798139756843-3'-UTR,intron-Distal,intron-Proximal4.806285.26325K562LSM11
chr9139756985139757041-3'-UTR,intron-Distal3.048674.94554HepG2XPO5
chr9139757234139757282-3'-UTR,intron-Distal,intron-Proximal3.193019.26670HepG2PRPF8
chr9139757282139757357-3'-UTR,CDS,intron-Distal,intron-Proximal4.1200435.56173HepG2PRPF8
chr9139756643139756708-3'-UTR,intron-Distal4.001878.73667K562PCBP1
chr9139756775139756848-3'-UTR,CDS,intron-Distal,intron-Proximal3.5426518.35372HepG2BUD13
chr9139757298139757337-3'-UTR,CDS,intron-Distal,intron-Proximal3.390167.44928HepG2PPIG
chr9139756656139756694-3'-UTR,intron-Distal3.636576.62784K562PABPC4
chr9139760653139760730-5'-UTR,CDS,intron-Distal,intron-Proximal3.5173122.50834K562TROVE2
chr9139760632139760727-5'-UTR,CDS,intron-Distal,intron-Proximal4.1084641.10340K562DDX3X
chr9139757375139757391-CDS,intron-Distal4.0318315.09148K562YBX3
chr9139757391139757418-CDS,intron-Distal3.7955113.33991K562YBX3
chr9139757822139757875-CDS,intron-Distal3.9612711.53251HepG2GRWD1
chr9139757357139757408-CDS,intron-Distal,intron-Proximal3.091703.24162HepG2G3BP1
chr9139757382139757435-CDS,intron-Distal4.8905113.78461K562UCHL5
chr9139757357139757420-CDS,intron-Distal,intron-Proximal4.0562610.75945K562PABPC4
chr9139757365139757419-CDS,intron-Distal4.378973.60906K562SND1
chr9139757357139757375-CDS,intron-Distal,intron-Proximal4.2902213.94764K562YBX3
chr9139758273139758284-CDS,intron-Distal3.871726.18214HepG2GRWD1
chr9139757806139757867-CDS,intron-Distal3.001895.45711K562PUM1
chr9139757393139757434-CDS,intron-Distal3.612554.80070K562GRWD1
chr9139760632139760643-CDS,intron-Distal3.4241410.36268K562YBX3
chr9139757742139757783-CDS,intron-Distal4.466868.84200K562PABPC4
chr9139757340139757435-CDS,intron-Distal,intron-Proximal3.0643615.32923HepG2PPIG
chr9139757857139757873-CDS,intron-Distal3.4477713.98704K562YBX3
chr9139757419139757430-CDS,intron-Distal3.078528.34200K562YBX3
chr9139757840139757857-CDS,intron-Distal3.5009313.59035K562YBX3
chr9139760643139760708-CDS,intron-Distal3.291859.94245HepG2GRWD1
chr9139758292139758323-CDS,intron-Distal3.9230911.99546K562YBX3
chr9139757630139757688-intron-Distal,intron-Proximal3.435395.08364HepG2PRPF4
chr9139760588139760630-intron-Distal5.331157.81430K562AQR
chr9139758228139758272-intron-Distal,intron-Proximal4.5358416.60780K562AQR
chr9139759894139760029-intron-Distal6.1748512.61220HepG2FAM120A
chr9139759618139759695-intron-Distal3.573875.61462HepG2PRPF4
chr9139759604139759687-intron-Distal3.318674.61081K562GTF2F1
chr9139758151139758216-intron-Distal,intron-Proximal4.771676.67793HepG2EFTUD2
chr9139759901139759970-intron-Distal4.210384.10564HepG2CSTF2T
chr9139759818139760004-intron-Distal5.6460214.87839HepG2PRPF4
chr9139758175139758224-intron-Distal,intron-Proximal5.9598410.04245K562AQR
chr9139759888139759965-intron-Distal3.800403.57928K562GTF2F1
chr9139759923139760001-intron-Distal4.422545.60464K562CSTF2T
chr9139757903139757932-intron-Distal,intron-Proximal5.188277.28294K562AQR
chr9139757634139757664-intron-Distal,intron-Proximal3.202773.41462K562EWSR1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for EDF1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for EDF1 is not available on ENCORE database.

  • 90 RBPs can affect the levels of EDF1.  








The Knockdown/knockout RNA-Seq assay for EDF1 is not available on ENCORE database.





90 RBPs can affect the gene expression of EDF1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
EDF1ENSG00000107223.81799.430801578.824600.188601.997501.46520HepG2ACO1
EDF1ENSG00000107223.81076.01930809.092800.411202.547501.59070HepG2ADAR
EDF1ENSG00000107223.82708.320102169.905700.319701.926901.47370HepG2AKAP1
EDF1ENSG00000107223.81342.765401795.29470-0.419002.597501.83570HepG2ASCC1
EDF1ENSG00000107223.81808.428401199.678100.592004.143203.00020HepG2BCCIP
EDF1ENSG00000107223.82981.720902324.950900.358803.458502.79800HepG2BOP1
EDF1ENSG00000107223.81894.417601578.275100.263303.786903.03110HepG2CKAP4
EDF1ENSG00000107223.81010.91710829.731800.284802.278501.35640HepG2YBX3
EDF1ENSG00000107223.82634.297501768.834300.574507.447106.48710HepG2CELF1
EDF1ENSG00000107223.81215.367402078.34770-0.774007.500706.51570HepG2DDX3X
EDF1ENSG00000107223.82424.112901871.836300.372903.608502.13420HepG2DDX47
EDF1ENSG00000107223.81914.621401179.633600.698605.876404.80050HepG2DDX55
EDF1ENSG00000107223.82488.974901906.017400.384903.538202.40000HepG2DDX5
EDF1ENSG00000107223.82853.917001785.950800.676207.097406.14660HepG2DDX6
EDF1ENSG00000107223.81044.17450814.687300.357903.622602.82380HepG2DNAJC21
EDF1ENSG00000107223.81247.26600807.561800.6270013.8912012.54680HepG2DNAJC2
EDF1ENSG00000107223.81798.841501393.946800.367802.764701.84510HepG2EEF2
EDF1ENSG00000107223.82626.584401928.741400.445405.613503.98750HepG2EIF2S2
EDF1ENSG00000107223.83123.523602464.003400.342103.234002.59260HepG2ETF1
EDF1ENSG00000107223.81479.328301776.45620-0.264102.096001.40410HepG2FUBP3
EDF1ENSG00000107223.8595.342401507.20040-1.3401049.8658046.60720HepG2HDGF
EDF1ENSG00000107223.81064.42690709.604100.584903.877702.23630HepG2HNRNPA0
EDF1ENSG00000107223.81149.09890822.493000.482304.727803.91370HepG2HNRNPA1
EDF1ENSG00000107223.82444.277701732.127600.4968014.4620013.03160HepG2HNRNPL
EDF1ENSG00000107223.81041.846501771.36480-0.7657013.2867011.46230HepG2HNRNPM
EDF1ENSG00000107223.81266.09340908.843700.478207.669706.69770HepG2HNRNPU
EDF1ENSG00000107223.81393.86070928.349900.5862013.3664011.88690HepG2ILF2
EDF1ENSG00000107223.81148.99900817.464100.491102.752901.43940HepG2ILF3
EDF1ENSG00000107223.81143.46390799.532700.516103.555102.17180HepG2KHDRBS1
EDF1ENSG00000107223.81310.154101970.75090-0.589004.928404.09540HepG2NCBP2
EDF1ENSG00000107223.81612.789302047.35450-0.344202.717201.97470HepG2NSUN2
EDF1ENSG00000107223.81229.09490766.504100.681103.955902.88160HepG2PABPC1
EDF1ENSG00000107223.81195.659101754.54640-0.553304.918403.96500HepG2PABPC4
EDF1ENSG00000107223.81281.18690899.571200.510107.991506.67140HepG2PARN
EDF1ENSG00000107223.81571.769301808.37880-0.202302.041301.50740HepG2PCBP1
EDF1ENSG00000107223.81363.34860810.612000.7500010.577509.18400HepG2PPIL4
EDF1ENSG00000107223.81139.265601501.44620-0.398205.514904.46030HepG2PRPF4
EDF1ENSG00000107223.82348.533601910.998000.297304.373803.66490HepG2PUM1
EDF1ENSG00000107223.81999.066701608.105100.313904.811704.04100HepG2PUS1
EDF1ENSG00000107223.81386.547101992.84330-0.523308.224107.23490HepG2QKI
EDF1ENSG00000107223.81496.595202059.40670-0.460504.971604.32800HepG2RBM22
EDF1ENSG00000107223.81350.491501808.65100-0.421404.624203.77190HepG2RBM25
EDF1ENSG00000107223.81473.81930999.896700.559602.807401.73930HepG2RCC2
EDF1ENSG00000107223.81752.004402047.85310-0.225102.411401.90010HepG2NELFE
EDF1ENSG00000107223.81434.011401907.32980-0.411506.671905.77470HepG2RECQL
EDF1ENSG00000107223.81141.04840842.510400.437502.492101.73130HepG2RPS3A
EDF1ENSG00000107223.81325.70920809.352100.7118012.9218011.68190HepG2SAFB2
EDF1ENSG00000107223.81137.03360793.352900.519103.538202.06950HepG2SART3
EDF1ENSG00000107223.81427.275401104.978800.369102.597201.68730HepG2SERBP1
EDF1ENSG00000107223.83311.282702430.294600.446202.012001.43530HepG2SF3A3
EDF1ENSG00000107223.81653.627901915.75800-0.212302.152201.62080HepG2SF3B4
EDF1ENSG00000107223.81711.32050943.818700.8584029.4254027.68990HepG2SMN1
EDF1ENSG00000107223.81710.913201087.221800.654002.780201.82060HepG2SMNDC1
EDF1ENSG00000107223.81241.213002542.84680-1.0347010.648109.12130HepG2SNRNP70
EDF1ENSG00000107223.81382.580001626.83760-0.234702.595802.05740HepG2SRSF9
EDF1ENSG00000107223.81020.02550733.106500.476402.972201.82710HepG2STIP1
EDF1ENSG00000107223.82586.216602021.365900.355407.725306.77240HepG2SUCLG1
EDF1ENSG00000107223.8895.401401797.41000-1.0053027.1369025.61730HepG2TAF15
EDF1ENSG00000107223.81208.178201651.52790-0.451005.462604.29940HepG2TIA1
EDF1ENSG00000107223.81259.78700883.026100.512606.482405.77710HepG2TIAL1
EDF1ENSG00000107223.81678.46950891.011400.9135017.2350015.98730HepG2TRIM56
EDF1ENSG00000107223.81177.832901861.77120-0.660506.188904.90670HepG2UBE2L3
EDF1ENSG00000107223.81859.136202155.29510-0.213302.582101.90390HepG2UPF1
EDF1ENSG00000107223.81789.609801074.747900.735503.475302.34310HepG2UPF2
EDF1ENSG00000107223.82688.011302080.859800.369306.887206.01400HepG2UTP3
EDF1ENSG00000107223.81868.955801155.826600.693206.109405.04570HepG2XRN2
EDF1ENSG00000107223.83190.388302370.418600.4285012.1723011.22860HepG2ZNF622
EDF1ENSG00000107223.82016.992002600.40670-0.366503.092502.47920K562AQR
EDF1ENSG00000107223.83700.006204857.12750-0.392603.933102.17520K562DDX19B
EDF1ENSG00000107223.81840.958601517.632100.278502.904801.55380K562DDX6
EDF1ENSG00000107223.81665.246801132.641900.555902.490501.62710K562EFTUD2
EDF1ENSG00000107223.83242.088402251.390300.5260011.236209.93260K562EIF2S2
EDF1ENSG00000107223.81041.59540752.496800.468905.341404.25050K562EIF3G
EDF1ENSG00000107223.82592.601202145.828400.272802.108601.36460K562FIP1L1
EDF1ENSG00000107223.81475.924401996.34760-0.435704.205103.14970K562FMR1
EDF1ENSG00000107223.81392.650801013.840200.457903.476901.83340K562G3BP1
EDF1ENSG00000107223.8133.08090636.00990-2.2567022.7331020.11670K562G3BP2
EDF1ENSG00000107223.82255.727202721.74130-0.270903.082401.87600K562GLRX3
EDF1ENSG00000107223.81297.882101719.01570-0.405404.207303.48700K562HNRNPC
EDF1ENSG00000107223.82539.648801764.931100.524904.951003.66430K562HNRNPM
EDF1ENSG00000107223.84884.559802909.348500.7474013.1376011.44780K562HSPD1
EDF1ENSG00000107223.81768.466701061.180900.736705.024803.47260K562IGF2BP2
EDF1ENSG00000107223.81157.627101599.55090-0.466503.051102.06570K562KRR1
EDF1ENSG00000107223.82874.796403179.42360-0.145302.105401.44470K562NSUN2
EDF1ENSG00000107223.83070.940702435.877200.334102.877502.03990K562PPIG
EDF1ENSG00000107223.81765.088101102.205300.679204.239503.31210K562PRPF8
EDF1ENSG00000107223.81622.162201082.805900.583006.362105.39040K562PTBP1
EDF1ENSG00000107223.83011.803903978.70300-0.401704.505203.46880K562PUF60
EDF1ENSG00000107223.85686.276704271.939100.412504.889804.19410K562PUS1
EDF1ENSG00000107223.8931.01570660.954200.494204.825203.68310K562SF3B4
EDF1ENSG00000107223.82483.960303214.25650-0.371808.635707.08230K562SRPK2
EDF1ENSG00000107223.81552.909101002.833100.630804.001502.69790K562SRSF5
EDF1ENSG00000107223.8260.62580624.28660-1.260203.984502.09820K562TAF15
EDF1ENSG00000107223.81882.310001074.212600.809105.492104.47770K562TARDBP
EDF1ENSG00000107223.81704.920201036.251700.718204.452003.37660K562TIA1
EDF1ENSG00000107223.81559.214501017.342500.615902.877601.75850K562TRA2A
EDF1ENSG00000107223.8355.75330636.40570-0.839109.205407.73230K562U2AF2
EDF1ENSG00000107223.81781.231402472.36490-0.473004.197802.71120K562UTP3
EDF1ENSG00000107223.82185.599302999.71170-0.4568011.400909.81730K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for EDF1 is not available on ENCORE database.





15 RBPs can affect the splicing of EDF1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSEDF1ENSG00000107223.8chr9-1397565701397569481397565701397567971397573571397574510.094000.000030.00475longerHepG2SF3A3
A3SSEDF1ENSG00000107223.8chr9-1397565701397569481397565701397567971397573571397574510.094000.000000.00003longerK562EFTUD2
A3SSEDF1ENSG00000107223.8chr9-1397565701397569481397565701397567971397573571397574510.055000.000340.05704longerK562RBM22
A3SSEDF1ENSG00000107223.8chr9-139756570139756948139756570139756797139757357139757451-0.073000.000030.02717shorterK562PPIL4
A3SSEDF1ENSG00000107223.8chr9-1397565701397569481397565701397567971397573571397574510.071000.000000.00217longerHepG2MATR3
A3SSEDF1ENSG00000107223.8chr9-1397565701397569481397565701397567971397573571397574510.157000.000000.00000longerHepG2U2AF2
A3SSEDF1ENSG00000107223.8chr9-1397565701397569481397565701397567971397573571397574510.057000.000220.05337longerHepG2NCBP2
A3SSEDF1ENSG00000107223.8chr9-1397565701397569481397565701397567971397573571397574510.074000.000630.08684longerHepG2TIAL1
A3SSEDF1ENSG00000107223.8chr9-1397565701397569481397565701397567971397573571397574510.058000.000100.01367longerHepG2RBM22
A3SSEDF1ENSG00000107223.8chr9-1397565701397569481397565701397567971397573571397574510.109000.000060.09693longerK562DHX30
A3SSEDF1ENSG00000107223.8chr9-1397565701397569481397565701397567971397573571397574510.078000.000000.00042longerK562PTBP1
A3SSEDF1ENSG00000107223.8chr9-1397565701397569481397565701397567971397573571397574510.223000.000000.00000longerHepG2FTO
A3SSEDF1ENSG00000107223.8chr9-1397565701397569481397565701397567971397573571397574510.105000.000060.03630longerHepG2CDC40
A3SSEDF1ENSG00000107223.8chr9-1397565701397569481397565701397567971397573571397574510.144000.000000.00004longerHepG2U2AF1
A3SSEDF1ENSG00000107223.8chr9-1397565701397569481397565701397567971397573571397574510.052000.000360.04991longerHepG2PCBP1
A3SSEDF1ENSG00000107223.8chr9-1397565701397569481397565701397567971397573571397574510.076000.000010.00183longerK562PRPF8

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for EDF1 is not avaliable on ENCORE database.