NUMB

General Information

Gene Name       : NUMB
Gene ID             : ENSG00000133961.20
Essential Gene : No

Functions

Localization

Domains (AlphaFold: NUMB)


Antibody Validation


Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878NUMBENSG00000133961.2037.5838.2937.94ENCSR000AEF
HepG2NUMBENSG00000133961.2036.2034.3535.28ENCSR985KAT
K562NUMBENSG00000133961.2031.9532.7232.34ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for NUMB is not avaliable on ENCORE database.



Proteins bound to RNA

  • NUMB RNA is bound by 29 proteins.  







eCLIP assay for NUMB is not avaliable on ENCORE database.





29 proteins are bound to NUMB RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr147374247773742553-3'-UTR,intron-Distal3.555485.65632K562UPF1
chr147374255373742680-3'-UTR,intron-Distal3.5567312.49828K562UPF1
chr147374312273743188-3'-UTR,intron-Distal,intron-Proximal3.256704.44982K562UPF1
chr147374255173742641-3'-UTR,intron-Distal4.6270636.85686K562PUM2
chr147374245173742497-3'-UTR,intron-Distal4.8850612.31980K562PUM2
chr147392517773925271-5'-UTR,intron-Distal,intron-Proximal3.205315.18770HepG2NCBP2
chr147376399473764068-5'-UTR,intron-Distal,intron-Proximal4.962503.91589K562SF3B4
chr147376553973765594-5'-UTR,intron-Distal3.225243.35050HepG2SUGP2
chr147392480273924879-5'-UTR,intron-Distal4.572506.08348HepG2CSTF2T
chr147375943673759486-5'-UTR,CDS,intron-Distal,intron-Proximal3.499723.93645HepG2PPIG
chr147392494373925028-5'-UTR,intron-Distal,intron-Proximal3.075186.99714HepG2CSTF2T
chr147392497073925009-5'-UTR,intron-Distal,intron-Proximal4.598974.49279K562DROSHA
chr147392493373925047-5'-UTR,intron-Distal,intron-Proximal3.406376.49835HepG2PRPF4
chr147392440673924496-5'-UTR,intron-Distal,intron-Proximal3.693243.02296K562HNRNPU
chr147376409373764215-5'-UTR,intron-Distal3.436386.75956HepG2U2AF2
chr147375953273759583-5'-UTR,CDS,intron-Distal,intron-Proximal3.045143.55800HepG2BCLAF1
chr147392438873924440-5'-UTR,intron-Distal3.598054.35339HepG2CSTF2T
chr147387670473876775-5'-UTR,intron-Distal4.645525.89060HepG2NCBP2
chr147376391873763932-5'-UTR,CDS,intron-Distal,intron-Proximal4.176663.02457HepG2BCLAF1
chr147392495973925059-5'-UTR,intron-Distal,intron-Proximal4.623894.97583HepG2GTF2F1
chr147374905873749192-CDS,intron-Distal,intron-Proximal3.884414.41267HepG2PPIG
chr147374353073743664-CDS,intron-Distal4.096203.39686HepG2G3BP1
chr147375377173753931-CDS,intron-Distal,intron-Proximal3.102544.24005HepG2BCLAF1
chr147378982873789913-CDS,intron-Distal,intron-Proximal3.149575.26696K562UCHL5
chr147374362173743802-CDS,intron-Distal3.496825.02896K562HNRNPK
chr147374370673743796-CDS,intron-Distal4.015765.97588K562PCBP1
chr147374363473743801-CDS,intron-Distal4.934556.32074HepG2HNRNPK
chr147375381373753930-CDS,intron-Distal,intron-Proximal3.093565.41277K562UCHL5
chr147378980673789910-CDS,intron-Distal,intron-Proximal3.308416.28230HepG2PPIG
chr147374902373749077-CDS,intron-Distal,intron-Proximal4.026559.97647HepG2PRPF8
chr147375386673754013-CDS,intron-Distal,intron-Proximal3.359485.89284K562RBM15
chr147378985273789914-CDS,intron-Distal,intron-Proximal3.308186.33024HepG2BCLAF1
chr147378979973789852-CDS,intron-Distal,intron-Proximal3.906383.87469HepG2BCLAF1
chr147374595173746038-CDS,intron-Distal,intron-Proximal3.664374.54206HepG2PRPF8
chr147378317773783310-intron-Distal,intron-Proximal3.102786.51847HepG2U2AF2
chr147387635073876414-intron-Distal4.267564.72162K562KHSRP
chr147378320573783313-intron-Distal,intron-Proximal4.348593.91671HepG2RBFOX2
chr147375380473753818-intron-Distal,intron-Proximal4.430986.77156K562AQR
chr147378477773784855-intron-Distal6.1073244.98564HepG2QKI
chr147377584973775941-intron-Distal3.509419.66740HepG2SUGP2
chr147392461273924686-intron-Distal,intron-Proximal3.363243.93915K562EWSR1
chr147378331373783399-intron-Distal4.580564.43431HepG2RBFOX2
chr147375074173750789-intron-Distal,intron-Proximal3.942345.35619K562AQR
chr147378877673788906-intron-Distal4.260514.70434HepG2RBFOX2
chr147386189173861945-intron-Distal3.995473.19026HepG2HNRNPL
chr147386580573865900-intron-Distal4.325025.19823K562KHSRP
chr147378478773784869-intron-Distal4.640043.93366K562RBFOX2
chr147374617073746265-intron-Distal,intron-Proximal4.426905.60352K562HNRNPL
chr147392504773925103-intron-Distal,intron-Proximal3.183193.72699HepG2PRPF4
chr147392462573924689-intron-Distal,intron-Proximal3.721134.95463K562GTF2F1
chr147392460473924695-intron-Distal,intron-Proximal4.789097.24177K562CSTF2T
chr147386562973865805-intron-Distal4.414825.62025K562KHSRP
chr147375374073753804-intron-Distal,intron-Proximal4.9211010.24966K562AQR
chr147377542373775482-intron-Distal3.687558.60624HepG2SUGP2
chr147382904273829125-intron-Distal3.524604.75362K562PTBP1
chr147377527273775363-intron-Distal4.491799.55684HepG2SUGP2
chr147378487073784953-intron-Distal4.552277.30165K562QKI
chr147374905373749067-intron-Distal,intron-Proximal4.549854.48002K562AQR
chr147378492873784972-intron-Distal4.9655212.54308HepG2QKI
chr147378905773789190-intron-Distal3.037046.44767HepG2HNRNPL
chr147392463073924706-intron-Distal,intron-Proximal4.099197.97774HepG2PRPF4
chr147392462573924699-intron-Distal,intron-Proximal4.416374.41148HepG2GTF2F1
chr147377573073775752-intron-Distal4.146474.28663HepG2SUGP2
chr147378486773784928-intron-Distal6.4000859.97497HepG2QKI
chr147376669073766732-intron-Distal4.571073.16986HepG2QKI
chr147374900373749053-intron-Distal,intron-Proximal3.932625.26367K562AQR
chr147378332073783411-intron-Distal4.8037611.12558HepG2QKI
chr147386174473861844-intron-Distal3.6694710.18251HepG2HNRNPL
chr147377563673775697-intron-Distal3.954635.78794HepG2SUGP2
chr147392460673924720-intron-Distal,intron-Proximal3.235415.49049HepG2FAM120A
chr147386561873865788-intron-Distal4.023173.20552HepG2KHSRP
chr147376665473766756-intron-Distal4.651818.20177K562QKI
chr147392462973924702-intron-Distal,intron-Proximal3.737663.80752K562AKAP8L
chr147376684073766933-intron-Distal3.526824.57279K562PTBP1
chr147383343173833519-intron-Distal,intron-Proximal3.881263.02234K562KHSRP
chr147376722873767297-intron-Distal4.191583.83958HepG2QKI
chr147377518373775221-intron-Distal4.272244.61447HepG2SUGP2
chr147377224073772336-intron-Distal4.264104.51735HepG2QKI
chr147386163373861744-intron-Distal4.129393.80299K562HNRNPL
chr147378403173784079-intron-Distal4.204313.60408HepG2XPO5
chr147377490173774961-intron-Distal3.343516.35394HepG2SUGP2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for NUMB is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for NUMB is not available on ENCORE database.

  • 41 RBPs can affect the levels of NUMB.  








The Knockdown/knockout RNA-Seq assay for NUMB is not available on ENCORE database.





41 RBPs can affect the gene expression of NUMB :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
NUMBENSG00000133961.151148.530801413.91310-0.299902.175601.64000HepG2BOP1
NUMBENSG00000133961.152045.769201640.003900.318804.115203.36150HepG2CELF1
NUMBENSG00000133961.151268.109401763.39940-0.4757010.201108.91770HepG2DAZAP1
NUMBENSG00000133961.15893.730401871.23540-1.0661016.9602015.55100HepG2DDX3X
NUMBENSG00000133961.152100.277801474.020000.510702.488001.56180HepG2DDX59
NUMBENSG00000133961.151645.400901362.897200.271703.092902.38250HepG2DKC1
NUMBENSG00000133961.151494.335201177.987600.343103.979703.14930HepG2DNAJC21
NUMBENSG00000133961.151279.585701027.621000.316302.110701.31290HepG2EIF3D
NUMBENSG00000133961.151551.227301171.421500.405003.848602.93050HepG2FUBP3
NUMBENSG00000133961.151813.543601471.390600.301501.837801.30870HepG2GPKOW
NUMBENSG00000133961.15973.867201618.40330-0.732809.627108.39070HepG2HNRNPK
NUMBENSG00000133961.152237.700801404.178300.672208.514307.47520HepG2HNRNPLL
NUMBENSG00000133961.15986.703101314.12190-0.413405.901905.04440HepG2HNRNPU
NUMBENSG00000133961.151066.783601432.15570-0.424902.223001.36010HepG2MTPAP
NUMBENSG00000133961.151100.635901774.05500-0.688707.400406.38960HepG2NCBP2
NUMBENSG00000133961.151625.283901245.098000.384303.272702.45970HepG2NSUN2
NUMBENSG00000133961.151760.942601433.212000.297003.633902.75790HepG2PRPF4
NUMBENSG00000133961.151188.98960863.343500.461603.580202.67370HepG2PRPF8
NUMBENSG00000133961.15665.188101300.71480-0.967506.295003.62770HepG2PSIP1
NUMBENSG00000133961.152415.639801770.612800.448106.337405.33690HepG2PUM2
NUMBENSG00000133961.151800.995401450.974600.311704.515303.76520HepG2PUS1
NUMBENSG00000133961.151603.831201186.395500.434801.957001.35420HepG2RAVER1
NUMBENSG00000133961.151518.210801796.89810-0.243102.453601.95800HepG2RBM22
NUMBENSG00000133961.151988.944701576.049400.335603.237702.51420HepG2RBM25
NUMBENSG00000133961.152108.879301731.596300.284302.246701.62230HepG2RPLP0
NUMBENSG00000133961.151435.530901669.38810-0.217702.094301.56870HepG2SF3B4
NUMBENSG00000133961.152258.297301742.486000.374006.485905.83570HepG2SRSF1
NUMBENSG00000133961.152830.763001762.142700.6838021.6670020.52920HepG2SSB
NUMBENSG00000133961.151631.571201114.091000.550304.713403.86670HepG2SUPV3L1
NUMBENSG00000133961.151805.021801439.135200.326703.214602.31820HepG2TIA1
NUMBENSG00000133961.152162.330001735.273500.317302.357201.77270HepG2U2AF1
NUMBENSG00000133961.152027.362101768.573100.196902.164901.53440HepG2UPF1
NUMBENSG00000133961.151775.340801414.421700.327805.104904.24040HepG2ZC3H8
NUMBENSG00000133961.15884.549201111.47530-0.329503.517202.00810K562DDX27
NUMBENSG00000133961.15930.560001195.40660-0.361303.171602.04870K562DDX3X
NUMBENSG00000133961.151522.181801187.496600.358102.282101.35350K562EIF3D
NUMBENSG00000133961.151034.849701298.82630-0.327803.425802.76240K562FXR1
NUMBENSG00000133961.151484.550802105.64770-0.504206.644505.46740K562GRSF1
NUMBENSG00000133961.151231.964401573.82070-0.353303.199902.29190K562MAGOH
NUMBENSG00000133961.15937.378901182.65760-0.335302.341301.51510K562PSIP1
NUMBENSG00000133961.151192.658501466.37820-0.298102.187801.44410K562RBM22
NUMBENSG00000133961.151353.150901079.077300.326402.818301.81790K562RCC2
NUMBENSG00000133961.152392.160401896.076800.335204.727403.68490K562SF3A3
NUMBENSG00000133961.151479.342701137.512000.379002.758001.82310K562TIAL1
NUMBENSG00000133961.151517.104501224.824400.308602.755301.95290K562U2AF2
NUMBENSG00000133961.152385.169202037.479600.227202.771402.05180K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for NUMB is not available on ENCORE database.





29 RBPs can affect the splicing of NUMB :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SENUMBENSG00000133961.15chr14-7378309773783130737639187376399373789837737899120.203000.002540.04418includedK562SRSF1
SENUMBENSG00000133961.15chr14-7374598873746132737419277374400173749066737492130.349000.000010.00027includedK562SRSF1
SENUMBENSG00000133961.15chr14-738336047383368973822333738224747387664473876779-0.204000.001380.07600excludedHepG2RBM22
SENUMBENSG00000133961.15chr14-737830977378313073763918737639937378983773789912-0.262000.000130.00347excludedHepG2U2AF1
SENUMBENSG00000133961.15chr14-737459887374613273741927737440017374906673749213-0.335000.000000.00000excludedHepG2U2AF1
SENUMBENSG00000133961.15chr14-737459887374613273741927737440017374906673749213-0.192000.000030.00209excludedK562AKAP8L
SENUMBENSG00000133961.15chr14-7374598873746132737419277374400173749066737492130.250000.000300.04307includedHepG2HNRNPM
SENUMBENSG00000133961.15chr14-7383360473833689738223337382247473876644738767790.189000.000190.04946includedHepG2ILF3
SENUMBENSG00000133961.15chr14-7374598873746132737419277374400173749066737492130.189000.000420.03851includedHepG2TBRG4
SENUMBENSG00000133961.15chr14-737830977378313073763918737639937378983773789912-0.439000.000000.00000excludedHepG2QKI
SENUMBENSG00000133961.15chr14-737830977378313073763918737639937378983773789912-0.321000.000000.00000excludedHepG2U2AF2
SENUMBENSG00000133961.15chr14-737459887374613273741927737440017374906673749213-0.597000.000000.00009excludedHepG2U2AF2
SENUMBENSG00000133961.15chr14-737830977378313073763918737639937378983773789912-0.207000.000180.00284excludedK562AQR
SENUMBENSG00000133961.15chr14-738766447387677673822333738224747392519873925228-0.266000.000010.00028excludedK562AQR
SENUMBENSG00000133961.15chr14-737459887374613273741927737440017374906673749213-0.157000.005420.04967excludedK562AQR
SENUMBENSG00000133961.15chr14-7374598873746132737419277374400173749066737492130.340000.000000.00006includedK562FXR1
SENUMBENSG00000133961.15chr14-7378309773783173737639187376399373789837737899120.158000.001050.04118includedK562FXR1
SENUMBENSG00000133961.15chr14-737459887374613273741927737440017374906673749213-0.308000.000040.00659excludedK562SUPV3L1
SENUMBENSG00000133961.15chr14-737459887374613273741927737440017374906673749213-0.152000.001100.01844excludedK562PUS1
SENUMBENSG00000133961.15chr14-738336047383368973822333738224747392519873925323-0.116000.008320.09121excludedK562PUS1
SENUMBENSG00000133961.15chr14-737459887374613273741927737440017374906673749213-0.440000.000000.00000excludedHepG2PTBP1
SENUMBENSG00000133961.15chr14-737459887374613273741927737440017374906673749213-0.247000.001460.06741excludedK562EFTUD2
SENUMBENSG00000133961.15chr14-738336047383368973822333738224747387664473876779-0.289000.000010.00158excludedK562EFTUD2
SENUMBENSG00000133961.15chr14-737830977378313073763918737639937378983773789912-0.106000.005840.09113excludedK562U2AF1
SENUMBENSG00000133961.15chr14-737459887374613273741927737440017374906673749213-0.200000.000030.06377excludedK562DDX6
SENUMBENSG00000133961.15chr14-7389129473891436738766447387677673925198739252520.051000.003130.06210includedHepG2SRSF1
SENUMBENSG00000133961.15chr14-737830977378313073763918737639937378983773789912-0.255000.000150.00657excludedHepG2SF3A3
SENUMBENSG00000133961.15chr14-737507887375108273748952737492137375381773754022-0.071000.000020.00865excludedK562EIF4G2
SENUMBENSG00000133961.15chr14-737830977378313073763918737639937378983773789912-0.107000.003670.08867excludedK562UTP18
SENUMBENSG00000133961.15chr14-737459887374613273741923737440017374906673749213-0.165000.000150.00792excludedK562UTP18
SENUMBENSG00000133961.15chr14-737459887374613273741927737440017374906673749213-0.303000.006250.08575excludedK562U2AF2
SENUMBENSG00000133961.15chr14-737507887375108273749066737492137375381773754022-0.185000.000000.00001excludedK562TARDBP
SENUMBENSG00000133961.15chr14-7383360473833689738223337382247473876644738767790.176000.002180.06821includedK562HNRNPU
SENUMBENSG00000133961.15chr14-737459887374613273741927737440017374906673749213-0.319000.000000.00000excludedK562HNRNPU
SENUMBENSG00000133961.15chr14-737507887375108273749066737492137375381773754022-0.078000.000330.01587excludedK562HNRNPU
SENUMBENSG00000133961.15chr14-737459887374613273741927737440017374906673749213-0.154000.002170.04891excludedK562RBM15
SENUMBENSG00000133961.15chr14-737459887374613273741927737440017374906673749213-0.179000.000070.00336excludedK562AGGF1
SENUMBENSG00000133961.15chr14-738336047383368973822333738224747387664473876779-0.270000.000000.00001excludedK562AGGF1
SENUMBENSG00000133961.15chr14-737459887374613273741927737440017374906673749213-0.265000.000120.03181excludedHepG2DDX55
SENUMBENSG00000133961.15chr14-737459887374613273741927737440017374906673749213-0.391000.000000.00006excludedHepG2HNRNPU
SENUMBENSG00000133961.15chr14-737507887375108273749066737492137375381773754022-0.091000.000500.02491excludedHepG2HNRNPU
SENUMBENSG00000133961.15chr14-7378309773783130737639187376399373789837737899120.352000.000170.04317includedK562SAFB
SENUMBENSG00000133961.15chr14-737459887374613273741927737440017374906673749213-0.252000.000040.01372excludedHepG2PRPF4
SENUMBENSG00000133961.15chr14-7374598873746132737419277374400173749066737492130.270000.000300.05369includedK562EIF3G
SENUMBENSG00000133961.15chr14-737459887374613273741927737440017374906673749213-0.215000.000050.00344excludedK562PTBP1
SENUMBENSG00000133961.15chr14-737459887374613273741927737440017374906673749213-0.350000.000000.00000excludedK562HNRNPC
A3SSNUMBENSG00000133961.15chr14-737509587375108273750958737510497375381773754022-0.081000.003000.08877shorterK562U2AF2
A3SSNUMBENSG00000133961.15chr14-7375096173751198737509617375108273753817737540620.066000.004200.02479longerK562AQR
A3SSNUMBENSG00000133961.15chr14-7375381773754062737538177375402273759441737595820.093000.000000.00000longerK562AQR
A3SSNUMBENSG00000133961.15chr14-7374906673749307737490667374921373750788737522700.223000.000000.00000longerK562AQR
MXENUMBENSG00000133961.15chr14-73749066737492137375381773754022737459887374613273759441737595820.167000.000000.000101includedHepG2U2AF1
MXENUMBENSG00000133961.15chr14-7375078873751082737538177375402273749066737492137375944173759582-0.161000.000600.013072includedK562DROSHA
MXENUMBENSG00000133961.15chr14-73750788737510827375381773754044737490667374921373759441737595820.116000.003650.027651includedK562AQR
MXENUMBENSG00000133961.15chr14-7382233373822474738766447387677673789837737899127392519873925236-0.179000.001950.057882includedHepG2SF3A3
MXENUMBENSG00000133961.15chr14-7382233373822474738766447387677673763918737639937392519873925236-0.140000.000050.003552includedHepG2SF3A3

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for NUMB is not avaliable on ENCORE database.