BRCA2

General Information

Gene Name       : BRCA2
Gene ID             : ENSG00000139618.14
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: BRCA2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878BRCA2ENSG00000139618.1431.4328.7430.09ENCSR000AEF
HepG2BRCA2ENSG00000139618.145.349.957.64ENCSR985KAT
K562BRCA2ENSG00000139618.149.357.748.54ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for BRCA2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • BRCA2 RNA is bound by 5 proteins.  







eCLIP assay for BRCA2 is not avaliable on ENCORE database.





5 proteins are bound to BRCA2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr133288965732889754+5'-UTR5.521716.02643HepG2DDX3X
chr133290041832900510+CDS,intron-Proximal4.939614.24111K562EFTUD2
chr133291311732913181+CDS3.665504.74894HepG2HLTF
chr133290668432906747+CDS4.230863.25521K562LIN28B
chr133290669532906769+CDS4.229674.01886HepG2LIN28B
chr133295369332953802+intron-Distal,intron-Proximal4.071073.50357HepG2QKI
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for BRCA2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for BRCA2 is not available on ENCORE database.

  • 129 RBPs can affect the levels of BRCA2.  








The Knockdown/knockout RNA-Seq assay for BRCA2 is not available on ENCORE database.





129 RBPs can affect the gene expression of BRCA2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
BRCA2ENSG00000139618.10458.68350595.58820-0.376803.068602.26630HepG2AKAP8L
BRCA2ENSG00000139618.1095.38540244.65570-1.358909.293407.91200HepG2ASCC1
BRCA2ENSG00000139618.10440.72350768.73870-0.8026012.5326011.25760HepG2AUH
BRCA2ENSG00000139618.10265.90880555.15140-1.061908.581206.88920HepG2BCCIP
BRCA2ENSG00000139618.10240.51000482.42750-1.004207.849306.43050HepG2BCLAF1
BRCA2ENSG00000139618.1058.59230893.84270-3.93120110.03390107.60110HepG2BOP1
BRCA2ENSG00000139618.10460.34960760.46330-0.724108.514407.26630HepG2CALR
BRCA2ENSG00000139618.10205.46200592.68500-1.5284033.8471032.11280HepG2CKAP4
BRCA2ENSG00000139618.1055.27910141.27000-1.353603.465602.60330HepG2CNOT7
BRCA2ENSG00000139618.10341.74820820.57660-1.2637018.2286016.64730HepG2CPSF6
BRCA2ENSG00000139618.10434.86020636.40360-0.549405.987105.11020HepG2CELF1
BRCA2ENSG00000139618.10387.82330684.42980-0.8195012.2679010.88580HepG2DAZAP1
BRCA2ENSG00000139618.10724.47440497.666400.541705.762704.14920HepG2DDX1
BRCA2ENSG00000139618.10288.09170449.09720-0.640503.285702.55000HepG2DDX21
BRCA2ENSG00000139618.10304.22820439.09100-0.529402.473001.61260HepG2DDX24
BRCA2ENSG00000139618.10156.67770283.25110-0.854304.865904.05480HepG2DDX3X
BRCA2ENSG00000139618.10280.70190545.80600-0.959307.168405.99220HepG2DDX55
BRCA2ENSG00000139618.10112.07660243.28850-1.118206.194405.29960HepG2DDX6
BRCA2ENSG00000139618.10353.56340470.66680-0.412702.421101.50400HepG2DHX30
BRCA2ENSG00000139618.10376.95860567.11830-0.589205.926205.00480HepG2DKC1
BRCA2ENSG00000139618.10260.71580487.98630-0.9044010.661309.35620HepG2DNAJC21
BRCA2ENSG00000139618.10267.71460483.69580-0.8534011.5887010.35470HepG2DNAJC2
BRCA2ENSG00000139618.10263.65100413.22770-0.648303.501202.24690HepG2AGO1
BRCA2ENSG00000139618.1067.63520233.90890-1.7901013.3587012.12390HepG2EIF2S1
BRCA2ENSG00000139618.10234.18680371.92050-0.667303.948802.87830HepG2EIF3D
BRCA2ENSG00000139618.10358.25600251.669500.509402.011001.41890HepG2EIF4B
BRCA2ENSG00000139618.10526.09020675.11170-0.359803.264402.36920HepG2EIF4G1
BRCA2ENSG00000139618.10324.21250646.73540-0.9962011.8080010.20040HepG2EIF4G2
BRCA2ENSG00000139618.10549.44380882.60830-0.683809.698808.68320HepG2ETF1
BRCA2ENSG00000139618.10412.23670579.27940-0.490803.379102.45530HepG2EWSR1
BRCA2ENSG00000139618.10538.25630260.783501.045307.890506.76870HepG2FXR1
BRCA2ENSG00000139618.10419.27610256.818100.707104.705503.53060HepG2G3BP2
BRCA2ENSG00000139618.10505.27210930.13360-0.880409.196808.07410HepG2GPKOW
BRCA2ENSG00000139618.10215.86590492.66150-1.1905013.1439011.90770HepG2HNRNPA1
BRCA2ENSG00000139618.10414.96480628.94320-0.599906.874905.51770HepG2HNRNPA2B1
BRCA2ENSG00000139618.10265.26290548.00100-1.0468011.020009.71490HepG2HNRNPC
BRCA2ENSG00000139618.10245.65960122.357401.005505.745203.58040HepG2HNRNPD
BRCA2ENSG00000139618.10349.62430574.27070-0.715908.574907.40190HepG2HNRNPF
BRCA2ENSG00000139618.10389.48400623.50550-0.678808.157807.05560HepG2HNRNPL
BRCA2ENSG00000139618.10365.88920887.64850-1.2786018.7371017.31600HepG2HNRNPLL
BRCA2ENSG00000139618.10338.35150565.49310-0.741007.604906.46030HepG2IGF2BP1
BRCA2ENSG00000139618.1092.81280245.93270-1.4059010.044208.84310HepG2IGF2BP2
BRCA2ENSG00000139618.10456.84970556.06260-0.283502.153901.49820HepG2ILF2
BRCA2ENSG00000139618.10261.28390134.463200.958305.533003.76790HepG2KHDRBS1
BRCA2ENSG00000139618.10468.560101003.83120-1.099204.606003.52630HepG2LARP4
BRCA2ENSG00000139618.10739.43530260.874301.5030021.4348019.69870HepG2MAGOH
BRCA2ENSG00000139618.10610.58940262.341501.2187012.4734011.20260HepG2MATR3
BRCA2ENSG00000139618.10311.91360593.68540-0.928606.860805.29240HepG2PCBP2
BRCA2ENSG00000139618.10189.24010421.17070-1.154209.490608.09710HepG2PRPF8
BRCA2ENSG00000139618.10394.80740215.467300.873606.026205.28160HepG2PTBP1
BRCA2ENSG00000139618.10349.00300647.81280-0.892308.207807.25370HepG2PUF60
BRCA2ENSG00000139618.10558.90870687.16240-0.298001.873101.31550HepG2PUM2
BRCA2ENSG00000139618.10445.40070603.76440-0.438904.262003.52700HepG2PUS1
BRCA2ENSG00000139618.10211.37810737.69860-1.8032041.5117039.96960HepG2RBM22
BRCA2ENSG00000139618.10301.19850211.812100.507802.435001.79870HepG2RBM25
BRCA2ENSG00000139618.10311.50370136.395101.191407.933005.43060HepG2RBM47
BRCA2ENSG00000139618.10526.60510239.813701.1347014.7285013.66580HepG2NELFE
BRCA2ENSG00000139618.10553.09800223.318801.3083020.3216018.91300HepG2RECQL
BRCA2ENSG00000139618.10107.75260618.62500-2.5213050.4497048.42630HepG2RPLP0
BRCA2ENSG00000139618.10222.25060562.74860-1.3403011.9839010.16330HepG2RPS10
BRCA2ENSG00000139618.10139.14540361.93760-1.3791014.9553013.68240HepG2RPS19
BRCA2ENSG00000139618.10278.21180595.88200-1.098807.116705.87300HepG2RPS2
BRCA2ENSG00000139618.1083.47510141.71520-0.763602.540001.77270HepG2RPS3A
BRCA2ENSG00000139618.10125.11670416.63740-1.7355017.4193015.76050HepG2RRP9
BRCA2ENSG00000139618.10330.47200484.78860-0.552805.190004.35720HepG2SAFB2
BRCA2ENSG00000139618.10516.09840801.55680-0.635203.482202.72220HepG2SF3A3
BRCA2ENSG00000139618.10582.36460878.56560-0.593205.141604.20210HepG2SF3B1
BRCA2ENSG00000139618.10379.96020224.370900.759906.024605.20910HepG2SF3B4
BRCA2ENSG00000139618.10322.73920583.98820-0.855606.475504.96220HepG2SMNDC1
BRCA2ENSG00000139618.10710.91280977.56940-0.459502.223001.52640HepG2SNRNP70
BRCA2ENSG00000139618.10141.35830833.20580-2.5593084.9913083.21160HepG2SRFBP1
BRCA2ENSG00000139618.10800.62450234.177601.7734043.6438042.26070HepG2SRSF1
BRCA2ENSG00000139618.10160.05800564.20080-1.8176037.6887035.72560HepG2SRSF7
BRCA2ENSG00000139618.10436.26850723.42420-0.7296010.713909.83330HepG2SSB
BRCA2ENSG00000139618.10147.78190543.37790-1.8785023.2015021.58680HepG2SUPV3L1
BRCA2ENSG00000139618.10692.44340210.440801.7182036.8415035.09550HepG2TAF15
BRCA2ENSG00000139618.10249.71050865.32540-1.7930034.8883032.86560HepG2TARDBP
BRCA2ENSG00000139618.10456.46290184.854601.304003.765002.52780HepG2TBRG4
BRCA2ENSG00000139618.10176.07780364.22930-1.048606.943905.48750HepG2TFIP11
BRCA2ENSG00000139618.10281.64670193.416500.542102.878002.02670HepG2TIA1
BRCA2ENSG00000139618.10117.41840528.94140-2.1714041.9007040.38140HepG2TIAL1
BRCA2ENSG00000139618.10407.29270533.69450-0.389903.121302.53040HepG2TRIM56
BRCA2ENSG00000139618.10879.53570679.914200.371301.958501.42020HepG2U2AF1
BRCA2ENSG00000139618.10976.78940669.772300.544303.544902.59230HepG2UBE2L3
BRCA2ENSG00000139618.10187.88690321.01490-0.772804.628003.64200HepG2UCHL5
BRCA2ENSG00000139618.10272.52040710.85970-1.3832030.7929028.97920HepG2UPF1
BRCA2ENSG00000139618.10215.55850497.66370-1.207108.844207.01250HepG2UPF2
BRCA2ENSG00000139618.10450.33170730.65350-0.698209.367507.57540HepG2UTP18
BRCA2ENSG00000139618.10885.70880563.351800.652704.081702.54100HepG2XRCC5
BRCA2ENSG00000139618.10236.93590534.89480-1.1748011.066509.63280HepG2XRN2
BRCA2ENSG00000139618.10143.50930781.80760-2.4457086.5369084.62250HepG2ZNF622
BRCA2ENSG00000139618.10474.83920319.496800.571503.268201.97050K562AARS
BRCA2ENSG00000139618.10163.37430560.54520-1.7786010.784409.75740K562AGGF1
BRCA2ENSG00000139618.10324.18070615.84680-0.925804.900103.50430K562AKAP8
BRCA2ENSG00000139618.10211.52650583.24620-1.463308.230307.04330K562AKAP8L
BRCA2ENSG00000139618.10349.99280611.91570-0.806003.046502.08880K562ATP5C1
BRCA2ENSG00000139618.10377.00020560.50810-0.572203.906602.86900K562BOP1
BRCA2ENSG00000139618.10648.03820858.67710-0.406003.670602.38910K562CPEB4
BRCA2ENSG00000139618.10419.34720595.96460-0.507104.046703.09810K562CPSF6
BRCA2ENSG00000139618.10320.62160627.78070-0.969403.906702.84260K562DKC1
BRCA2ENSG00000139618.10401.20470512.60090-0.353502.366901.62810K562EIF3G
BRCA2ENSG00000139618.10491.54600262.182500.906705.919904.72910K562EIF4A3
BRCA2ENSG00000139618.10451.64330817.66840-0.856304.543703.43710K562FIP1L1
BRCA2ENSG00000139618.10421.01930606.41150-0.526402.135101.38010K562FMR1
BRCA2ENSG00000139618.10653.70280272.652901.2615013.2398012.01660K562FXR1
BRCA2ENSG00000139618.10250.95420427.13480-0.767306.502804.18910K562G3BP1
BRCA2ENSG00000139618.10416.64650568.98640-0.449603.008902.18190K562GPKOW
BRCA2ENSG00000139618.10429.63230835.27930-0.959205.081104.05550K562GRSF1
BRCA2ENSG00000139618.10225.34740507.93680-1.172506.227404.13920K562HNRNPA2B1
BRCA2ENSG00000139618.10803.70030349.854801.1998019.3140017.81540K562HNRNPC
BRCA2ENSG00000139618.10370.77280672.46950-0.858903.877002.76260K562HNRNPM
BRCA2ENSG00000139618.10610.21660436.537400.483104.251503.13640K562HNRNPU
BRCA2ENSG00000139618.10244.39220546.88740-1.162004.742901.85780K562HNRNPUL1
BRCA2ENSG00000139618.10599.965201108.68910-0.885904.822703.78120K562HSPD1
BRCA2ENSG00000139618.10251.35730446.76950-0.829805.643603.95950K562IGF2BP2
BRCA2ENSG00000139618.10303.23640454.42350-0.583604.358802.78490K562IGF2BP3
BRCA2ENSG00000139618.10278.53560619.06280-1.152206.699005.28680K562KIF1C
BRCA2ENSG00000139618.10307.68680485.87780-0.659103.564802.49060K562KRR1
BRCA2ENSG00000139618.10625.78400469.533300.414303.076702.18930K562MAGOH
BRCA2ENSG00000139618.10310.65450592.52020-0.931605.136203.51660K562MAK16
BRCA2ENSG00000139618.10656.14100468.580100.485603.990002.86720K562MATR3
BRCA2ENSG00000139618.10366.30290693.49370-0.920804.385003.19080K562MBNL1
BRCA2ENSG00000139618.10413.62150555.39970-0.425202.696801.83440K562METAP2
BRCA2ENSG00000139618.10184.39630486.08070-1.398406.909305.28170K562NAA15
BRCA2ENSG00000139618.10494.48460685.77270-0.471804.004003.12500K562NSUN2
BRCA2ENSG00000139618.10158.35360444.48520-1.489008.692606.60410K562PABPN1
BRCA2ENSG00000139618.10313.58420458.96920-0.549504.176002.49060K562PCBP1
BRCA2ENSG00000139618.10692.18880417.767600.728407.427905.79410K562PCBP2
BRCA2ENSG00000139618.101519.88810659.493301.2044019.5015017.37900K562PCBP3
BRCA2ENSG00000139618.101272.22090505.847001.3305011.6769010.08750K562POLR2G
BRCA2ENSG00000139618.10336.68430928.10800-1.462909.590207.81070K562PPIG
BRCA2ENSG00000139618.10226.69190528.62470-1.221506.124403.65750K562PPP1R8
BRCA2ENSG00000139618.10181.20060313.64950-0.791602.974902.03180K562PSIP1
BRCA2ENSG00000139618.101803.764401033.978000.8027012.2627010.53690K562PUF60
BRCA2ENSG00000139618.10138.31440578.60960-2.0646012.0146010.93000K562PUS1
BRCA2ENSG00000139618.10189.59300563.61090-1.571809.148908.09460K562RBM15
BRCA2ENSG00000139618.10637.11210466.006800.451103.032401.51350K562SDAD1
BRCA2ENSG00000139618.10152.11490406.59920-1.418406.626804.50080K562SF1
BRCA2ENSG00000139618.10540.58610676.57880-0.323702.291901.54420K562SF3A3
BRCA2ENSG00000139618.10212.98100466.78930-1.132005.194503.34100K562SNRNP200
BRCA2ENSG00000139618.10672.54300447.210200.588605.525604.53260K562SRSF1
BRCA2ENSG00000139618.10261.14740422.35740-0.693605.254403.72240K562SRSF5
BRCA2ENSG00000139618.10342.56330492.65440-0.524204.808203.24840K562SRSF7
BRCA2ENSG00000139618.10671.17550507.387200.403503.117802.24520K562SYNCRIP
BRCA2ENSG00000139618.10312.43370428.42570-0.455502.440401.42870K562TRA2A
BRCA2ENSG00000139618.10189.23070320.34200-0.759503.082002.07270K562TRIM56
BRCA2ENSG00000139618.10520.80850301.275400.789602.268501.54220K562U2AF2
BRCA2ENSG00000139618.10263.84610586.45830-1.152303.827602.22290K562UTP18
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for BRCA2 is not available on ENCORE database.





2 RBPs can affect the splicing of BRCA2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEBRCA2ENSG00000139618.10chr13+3294947932949543329451073294523732950806329509280.448000.001980.04695includedHepG2HNRNPK
SEBRCA2ENSG00000139618.10chr13+3294947932949543329451073294523732950806329509280.239000.000370.03090includedHepG2HNRNPL

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for BRCA2 is not avaliable on ENCORE database.